Aging

Subject Vocabulary
MeSH
Unique ID
D000375

Aging reshapes the adaptive immune system from healer to saboteur

Delgado-Pulido, S., Yousefzadeh, M. J., & Mittelbrunn, M. (2025). Aging reshapes the adaptive immune system from healer to saboteur. Nature aging, 5(8), 1393–1403. https://doi.org/10.1038/s43587-025-00906-1

Authors:
Sandra Delgado-Pulido
Matthew J Yousefzadeh
Maria Mittelbrunn
Affiliated Authors:
Matthew J Yousefzadeh
Maria Mittelbrunn
Columbia Affiliation:
Subjects:
Aging (MeSH)
Adaptive Immunity (MeSH)
Author Keywords:
gamma interferon
immunoglobulin
toll like receptor
interleukin 10
transcription factor foxp3
tumor necrosis factor
adaptive immunity
aging
alzheimer disease
article
autoimmunity
cancer epidemiology
cd4+ t lymphocyte
cd8+ t lymphocyte
cell aging
chronic inflammation
cytotoxic t lymphocyte
degenerative disease
dysbiosis
healthy aging
human
immunocompetent cell
immunological monitoring
immunological tolerance
immunomodulation
immunoregulation
immunosuppressive treatment
immunosurveillance
inflammaging
lymphocyte
major histocompatibility complex
natural killer cell
phenotype
senescence
single cell rna seq
tfh cell
tissue injury
tissue regeneration
tissue repair
Publication Type:
Article
Unique ID:
10.1038/s43587-025-00906-1
PMID:
40813808
DOI:
10.1038/s43587-025-00906-1
Journal:
Nature Aging
Publication Date:
Data Source:
PubMed
Source Link:
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Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age

Wells, S. B., Rainbow, D. B., Mark, M., Szabo, P. A., Ergen, C., Caron, D. P., Maceiras, A. R., Rahmani, E., Benuck, E., Valiollah Pour Amiri, V., Chen, D., Wagner, A., Howlett, S. K., Jarvis, L. B., Ellis, K. L., Kubota, M., Matsumoto, R., Mahbubani, K., Saeb-Parsy, K., … Yosef, N. (2025). Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age. Nature Immunology, 26(9), 1612–1625. https://doi.org/10.1038/s41590-025-02241-4
Authors:
Steven B Wells
Daniel B Rainbow
Michal Mark
Peter A Szabo
Can Ergen
Daniel P Caron
Ana Raquel Maceiras
Elior Rahmani
Eli Benuck
Valeh Valiollah Pour Amiri
David Chen
Allon Wagner
Sarah K Howlett
Lorna B Jarvis
Karen L Ellis
Masaru Kubota
Rei Matsumoto
Krishnaa Mahbubani
Kouresh Saeb-Parsy
Cecilia Dominguez Conde
Laura Richardson
Chuan Xu
Shuang Li
Lira Mamanova
Liam Bolt
Alicja Wilk
Sarah A Teichmann
Donna L Farber
Peter A Sims
Joanne L Jones
Nir Yosef
Affiliated Authors:
Steven B Wells
Peter A Szabo
Daniel P Caron
David Chen
Masaru Kubota
Rei Matsumoto
Donna L Farber
Peter A Sims
Columbia Affiliation:
Subjects:
Comprehensive Integration of Single-Cell Transcriptomic Data (OpenAlex Topic)
Macrophage Activation and Polarization (OpenAlex Topic)
Regulatory T Cell Development and Function (OpenAlex Topic)
Aging (MeSH)
Publication Type:
Article
Unique ID:
10.1038/s41590-025-02241-4
PMID:
40804529
DOI:
10.1038/s41590-025-02241-4
Journal:
Nature Immunology
Publication Date:
Data Source:
PubMed
Source Link:
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Cumulative psychosocial factors and epigenetic age acceleration in the Hispanic Community Health Study/Study of Latinos

Abrishamcar, S., Aqua, J. K., Dye, C., Jones-Antwi, R., Chen, Y., Gallo, L. C., Llabre, M. M., Perreira, K. M., Daviglus, M. L., Argos, M., Thyagarajan, B., Hüls, A., Baccarelli, A., Cai, J., Isasi, C. R., Kaplan, R. C., Conneely, K. N., & Suglia, S. F. (2025). Cumulative psychosocial factors and epigenetic age acceleration in the Hispanic Community Health Study/Study of Latinos. Epigenomics, 17(13), 865–877. https://doi.org/10.1080/17501911.2025.2540260
Authors:
Sarina Abrishamcar
Jasmine K Aqua
Christian Dye
Rebecca Jones-Antwi
Yinxian Chen
Linda C Gallo
Maria M Llabre
Krista M Perreira
Martha L Daviglus
Maria Argos
Bharat Thyagarajan
Anke Hüls
Andrea Baccarelli
Jianwen Cai
Carmen R Isasi
Robert C Kaplan
Karen N Conneely
Shakira F Suglia
Affiliated Authors:
Christian Dye
Columbia Affiliation:
Subjects:
Aging (MeSH)
DNA Methylation (MeSH)
Epigenesis, Genetic (MeSH)
Hispanic or Latino (MeSH)
Stress, Psychological (MeSH)
Author Keywords:
psychosocial factors
dna methylation age
epigenetic age acceleration
hispanic/latino health
longitudinal
self-organizing maps
grimage
dunedinpace
Publication Type:
Article
Unique ID:
10.1080/17501911.2025.2540260
PMID:
40747766
DOI:
10.1080/17501911.2025.2540260
Journal:
Epigenomics
Publication Date:
Data Source:
PubMed
Source Link:
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PTSD and epigenetic aging: a longitudinal meta-analysis

Zhao, X., Katrinli, S., McCormick, B. M., Miller, M. W., Nugent, N. R., Wani, A. H., Zannas, A. S., Aiello, A. E., Baker, D. G., Boks, M. P., Chen, C.-Y., Fortier, C. B., Gelernter, J., Geuze, E., Koenen, K. C., Linnstaedt, S. D., Luykx, J. J., Maihofer, A. X., McLean, S. A., … Wolf, E. J. (2025). PTSD and epigenetic aging: a longitudinal meta-analysis. Psychological Medicine, 55. https://doi.org/10.1017/s0033291725000558
Authors:
Xiang Zhao
Seyma Katrinli
Beth M McCormick
Mark W Miller
Nicole R Nugent
Agaz H Wani
Anthony S Zannas
Allison E Aiello
Dewleen G Baker
Marco P Boks
Chia-Yen Chen
Catherine B Fortier
Joel Gelernter
Elbert Geuze
Karestan C Koenen
Sarah D Linnstaedt
Jurjen J Luykx
Adam X Maihofer
Samuel A McLean
William P Milberg
Andrew Ratanatharathorn
Kerry J Ressler
Victoria B Risbrough
Bart P F Rutten
Jordan W Smoller
Murray B Stein
Robert J Ursano
Eric Vermetten
Christiaan H Vinkers
Erin B Ware
Derek E Wildman
Ying Zhao
Mark W Logue
Caroline M Nievergelt
Alicia K Smith
Monica Uddin
Erika J Wolf
Affiliated Authors:
Allison E Aiello
Andrew Ratanatharathorn
Columbia Affiliation:
Subjects:
Stress Disorders, Post-Traumatic (MeSH)
Aging (MeSH)
Epigenesis, Genetic (MeSH)
DNA Methylation (MeSH)
Author Keywords:
accelerated aging
dna methylation
longitudinal
meta-analysis
ptsd
adult
aging
female
genetic epigenesis
genetics
human
longitudinal study
male
meta analysis
middle aged
pathophysiology
posttraumatic stress disorder
severity of illness index
epigenesis, genetic
humans
longitudinal studies
stress disorders, post-traumatic
Publication Type:
Article
Unique ID:
10.1017/s0033291725000558
PMID:
40366073
DOI:
10.1017/s0033291725000558
Journal:
Psychological Medicine
Publication Date:
Data Source:
PubMed
Source Link:
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The temporal onset of associations of cortical proteins with cognitive resilience vary during late life

Zammit, A. R., Wang, T., Yu, L., Oveisgharan, S., Petyuk, V. A., De Jager, P. L., Schneider, J. A., Bennett, D. A., & Buchman, A. S. (2025). The temporal onset of associations of cortical proteins with cognitive resilience vary during late life. Neurobiology of Disease, 211, 106927. https://doi.org/10.1016/j.nbd.2025.106927
Authors:
Andrea R Zammit
Tianhao Wang
Lei Yu
Shahram Oveisgharan
Vladislav A Petyuk
Philip L De Jager
Julie A Schneider
David A Bennett
Aron S Buchman
Affiliated Authors:
Philip L De Jager
Columbia Affiliation:
Subjects:
Analysis of Brain Functional Connectivity Networks (OpenAlex Topic)
Effects of Ketogenic Diet on Health (OpenAlex Topic)
Molecular Mechanisms of Neurodegenerative Diseases (OpenAlex Topic)
Cognition (MeSH)
Aging (MeSH)
Cognitive Reserve (MeSH)
Prefrontal Cortex (MeSH)
Cognitive Dysfunction (MeSH)
Cerebral Cortex (MeSH)
Resilience, Psychological (MeSH)
Author Keywords:
cognitive resilience
cortical proteins
non-linear decline
temporal onset
brain protein
cortical protein
unclassified drug
aged
article
cognition
cognitive aging
cognitive defect
cohort analysis
dorsolateral prefrontal cortex
female
follow up
human
male
proteomics
psychological resilience
very elderly
aging
brain cortex
cognitive reserve
metabolism
physiology
prefrontal cortex
psychology
aged, 80 and over
cerebral cortex
cognitive dysfunction
cohort studies
humans
resilience, psychological
Publication Type:
Article
Unique ID:
10.1016/j.nbd.2025.106927
PMID:
40306440
DOI:
10.1016/j.nbd.2025.106927
Journal:
Neurobiology of Disease
Publication Date:
Data Source:
PubMed
Source Link:
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Vascular-related biological stress, DNA methylation, allostatic load and domain-specific cognition: an integrated machine learning and causal inference approach

Waziry, R., Williams, O. A., Tiemeier, H., & Miles, C. (2025). Vascular-related biological stress, DNA methylation, allostatic load and domain-specific cognition: an integrated machine learning and causal inference approach. BMC Neurology, 25(1). https://doi.org/10.1186/s12883-025-04185-6
Authors:
Reem Waziry
Olajide A Williams
Henning Tiemeier
Caleb Miles
Affiliated Authors:
Reem Waziry
Olajide A Williams
Caleb Miles
Columbia Affiliation:
Subjects:
DNA Methylation (MeSH)
Allostasis (MeSH)
Machine Learning (MeSH)
Aging (MeSH)
Stress, Physiological (MeSH)
Cognition (MeSH)
Vascular Diseases (MeSH)
Author Keywords:
age span
biomarkers
vascular
adrd
biological stress
dna methylation
allostatic load
cognition
episodic memory
executive function
Publication Type:
Article
Unique ID:
10.1186/s12883-025-04185-6
PMID:
40269737
DOI:
10.1186/s12883-025-04185-6
Journal:
BMC Neurology
Publication Date:
Data Source:
PubMed
Source Link:
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Cross-Sectional Brain Age Assessments Are Limited in Predicting Future Brain Change

Korbmacher, M., Vidal‐Pineiro, D., Wang, M., van der Meer, D., Wolfers, T., Nakua, H., Eikefjord, E., Andreassen, O. A., Westlye, L. T., & Maximov, I. I. (2025). Cross‐Sectional Brain Age Assessments Are Limited in Predicting Future Brain Change. Human Brain Mapping, 46(6). Portico. https://doi.org/10.1002/hbm.70203
Authors:
Max Korbmacher
Didac Vidal-Pineiro
Meng-Yun Wang
Dennis van der Meer
Thomas Wolfers
Hajer Nakua
Eli Eikefjord
Ole A Andreassen
Lars T Westlye
Ivan I Maximov
Affiliated Authors:
Hajer Nakua
Columbia Affiliation:
Subjects:
Diffusion Magnetic Resonance Imaging (OpenAlex Topic)
Analysis of Brain Functional Connectivity Networks (OpenAlex Topic)
Magnetic Resonance Imaging Applications in Medicine (OpenAlex Topic)
Aging (MeSH)
Brain (MeSH)
Neuroimaging (MeSH)
Publication Type:
Article
Unique ID:
10.1002/hbm.70203
PMID:
40235434
DOI:
10.1002/hbm.70203
Journal:
Human Brain Mapping
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
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Record Created:

No Consistent Evidence that Ageism Is Linked to Biological Aging Status in the US Health and Retirement Study

Liu, M., Cohen, A. A., Legault, V., Honfo, S. H., Tanner, K., Fulop, T., & Levasseur, M. (2025). No Consistent Evidence that Ageism Is Linked to Biological Aging Status in the US Health and Retirement Study. Gerontology, 71(3), 185–202. Portico. https://doi.org/10.1159/000543253
Authors:
Mingxin Liu
Alan A. Cohen
Veronique Legault
Sewanou Hermann Honfo
Tamas Fulop
Melanie Levasseur
Kamaryn Tanner
Affiliated Authors:
Kamaryn Tanner
Columbia Affiliation:
Subjects:
Ageism (MeSH)
Aging (MeSH)
Author Keywords:
age discrimination
homeostatic dysregulation
· epigenetic age · association
· self-perception of aging ·
aged
ageism
aging
article
epigenetics
female
human
male
racism
secondary analysis
self concept
sexism
telomere length
united states
middle aged
physiology
psychology
retirement
very elderly
aged, 80 and over
humans
association
epigenetic age
self-perception of aging
Publication Type:
Article
Unique ID:
10.1159/000543253
DOI:
10.1159/000543253
Journal:
Gerontology
Publication Date:
Data Source:
Web of Science
Source Link:
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Record Created:

Surgery impairs glymphatic activity and cognitive function in aged mice

Chen, K., Du, X., Chao, M. A., Xie, Z., & Yang, G. (2025). Surgery impairs glymphatic activity and cognitive function in aged mice. Molecular Brain, 18(1). https://doi.org/10.1186/s13041-025-01177-y
Authors:
Kai Chen
Xingyu Du
Melody Chao
Zhongcong Xie
Guang Yang
Affiliated Authors:
Kai Chen
Xingyu Du
Melody Chao
Guang Yang
Columbia Affiliation:
Subjects:
Aging (MeSH)
Glymphatic System (MeSH)
Cognition (MeSH)
Mice, Inbred C57BL (MeSH)
Brain Fluid Dynamics and Waste Clearance Mechanisms (OpenAlex Topic)
Management and Pathophysiology of Traumatic Brain Injury (OpenAlex Topic)
Spina Bifida (OpenAlex Topic)
Author Keywords:
postoperative delirium
glymphatic system
in vivo two-photon imaging
surgery
Publication Type:
Article
Unique ID:
10.1186/s13041-025-01177-y
PMID:
39856767
DOI:
10.1186/s13041-025-01177-y
Journal:
Molecular Brain
Publication Date:
Data Source:
OpenAlex
Source Link:
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Characterizing the Microstructural Transition at the Gray Matter-White Matter Interface: Implementation and Demonstration of Age-Associated Differences

Song, J. Y., Fleysher, R., Ye, K., Kim, M., Zimmerman, M. E., Lipton, R. B., & Lipton, M. L. (2025). Characterizing the microstructural transition at the gray matter-white matter interface: Implementation and demonstration of age-associated differences. NeuroImage, 306, 121019. https://doi.org/10.1016/j.neuroimage.2025.121019
Authors:
Joan Song
Roman Fleysher
Kenny Ye
Mimi Kim
Molly E. Zimmerman
Richard B. Lipton
Michael L Lipton
Affiliated Authors:
Roman Fleysher
Michael L Lipton
Columbia Affiliation:
Subjects:
White Matter (MeSH)
Gray Matter (MeSH)
Aging (MeSH)
Diffusion Magnetic Resonance Imaging (MeSH)
Cerebral Cortex (MeSH)
Diffusion Magnetic Resonance Imaging (OpenAlex Topic)
Analysis of Brain Functional Connectivity Networks (OpenAlex Topic)
Theoretical and Computational Physics (OpenAlex Topic)
Author Keywords:
aging
diffusion mri
dti
gm-wm
gray matter- white matter interface
interface
slope
3.0t philips achieva tx scanner
adult
age
aged
article
axial diffusivity
brain region
brain tissue
cohort analysis
diffusion
diffusion tensor imaging
echo planar imaging
female
fractional anisotropy
gray matter
human
human experiment
image segmentation
implementation science
inflammation
intracellular volume fraction
lifespan
male
microstructural transition
nerve fiber degeneration
neuroimaging
nuclear magnetic resonance imaging
orientation dispersion index
structure analysis
white matter
adolescent
brain
cross-sectional study
diagnostic imaging
diffusion weighted imaging
middle aged
pathology
physiology
procedures
very elderly
young adult
aged, 80 and over
cross-sectional studies
diffusion magnetic resonance imaging
humans
white matter interface
Publication Type:
Article
Unique ID:
10.1016/j.neuroimage.2025.121019
PMID:
39809374
DOI:
10.1016/j.neuroimage.2025.121019
Journal:
NeuroImage
Publication Date:
Data Source:
OpenAlex
Source Link:
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Biological sex matters in brain aging

Dubal, D. B., Murphy, C. T., Suh, Y., & Benayoun, B. A. (2025). Biological sex matters in brain aging. Neuron, 113(1), 2–6. https://doi.org/10.1016/j.neuron.2024.12.005
Authors:
Dena B Dubal
Coleen T Murphy
Yousin Suh
Bérénice A Benayoun
Affiliated Authors:
Yousin Suh
Columbia Affiliation:
Subjects:
Aging (MeSH)
Brain (MeSH)
Sex Characteristics (MeSH)
Publication Type:
Article
Unique ID:
10.1016/j.neuron.2024.12.005
PMID:
39788086
DOI:
10.1016/j.neuron.2024.12.005
Journal:
Neuron
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record

Record Created:

Mexican Health and Aging Study Biomarker and Genetic Data Profile

Samper-Ternent, R., Zazueta-Borboa, J. D., Michaels-Obregon, A., Reyes-Dumeyer, D., Barral, S., Tosto, G., & Wong, R. (2024). Mexican Health and Aging Study Biomarker and Genetic Data Profile. The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences, 80(1). https://doi.org/10.1093/gerona/glae270
Authors:
Rafael Samper-Ternent
Jesús Daniel Zazueta-Borboa
Alejandra Michaels-Obregon
Dolly Reyes-Dumeyer
Sandra Barral
Giuseppe Tosto
Rebeca Wong
Affiliated Authors:
Dolly Reyes-Dumeyer
Sandra Barral
Giuseppe Tosto
Columbia Affiliation:
Subjects:
Biomarkers (MeSH)
Aging (MeSH)
Author Keywords:
anthropometric measures
biomarkers
genetic data
mexico
mhas
biological marker
aged
aging
blood
female
genetics
human
longitudinal study
male
middle aged
very elderly
aged, 80 and over
humans
longitudinal studies
Grants:
R01AG018016 (NIH – National Institute On Aging)
Publication Type:
Article
Unique ID:
10.1093/gerona/glae270
PMID:
39692026
DOI:
10.1093/gerona/glae270
Journal:
Journals of Gerontology, Series A: Biological Sciences and Medical Sciences
Publication Date:
Data Source:
PubMed
Source Link:
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Association between ultra-processed food intake and biological ageing in US adults: findings from National Health and Nutrition Examination Survey (NHANES) 2003-2010

Cardoso, B. R., Liu, J., Machado, P., Kwon, D., Belsky, D. W., & Martinez Steele, E. (2024). Association between ultra-processed food intake and biological ageing in US adults: findings from National Health and Nutrition Examination Survey (NHANES) 2003–2010. Age and Ageing, 53(12). https://doi.org/10.1093/ageing/afae268
Authors:
Barbara Rita Cardoso
Junxiu Liu
Priscila Machado
Dayoon Kwon
Daniel W Belsky
Euridice Martinez Steele
Affiliated Authors:
Daniel W Belsky
Columbia Affiliation:
Subjects:
Nutrition Surveys (MeSH)
Aging (MeSH)
Fast Foods (MeSH)
Author Keywords:
ageing
biological ageing
diets
older people
ultra-processed food
Publication Type:
Article
Unique ID:
10.1093/ageing/afae268
PMID:
39657624
DOI:
10.1093/ageing/afae268
Journal:
Age and Ageing
Publication Date:
Data Source:
PubMed
Source Link:
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Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis

Zhuang, X., Wang, Q., Joost, S., Ferrena, A., Humphreys, D. T., Li, Z., Blum, M., Krause, K., Ding, S., Landais, Y., Zhan, Y., Zhao, Y., Chaligne, R., Lee, J.-H., Carrasco, S. E., Bhanot, U. K., Koche, R. P., Bott, M. J., Katajisto, P., … Tammela, T. (2024). Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis. Nature, 637(8044), 184–194. https://doi.org/10.1038/s41586-024-08285-0
Authors:
Xueqian Zhuang
Qing Wang
Simon Joost
Alexander Ferrena
David T Humphreys
Zhuxuan Li
Melissa Blum
Klavdija Krause
Selena Ding
Yuna Landais
Yingqian Zhan
Yang Zhao
Ronan Chaligne
Joo-Hyeon Lee
Sebastian E Carrasco
Umeshkumar K Bhanot
Richard P Koche
Matthew J Bott
Pekka Katajisto
Yadira M Soto-Feliciano
Thomas Pisanic
Tiffany Thomas
Deyou Zheng
Emily S Wong
Tuomas Tammela
Affiliated Authors:
Tiffany Thomas
Columbia Affiliation:
Subjects:
Iron (MeSH)
Homeostasis (MeSH)
Aging (MeSH)
Carcinogenesis (MeSH)
DNA Methylation (MeSH)
Basic Helix-Loop-Helix Transcription Factors (MeSH)
Lung Neoplasms (MeSH)
Lipocalin-2 (MeSH)
Author Keywords:
iron
basic helix-loop-helix transcription factors
lipocalin-2
neoplasm proteins
cfx 96 touch real-time pcr detection system
dneasy blood and tissue kit
ez dna methylation-lightning kit
flowjo software v.10.8.1
hams f-12
imagene red c12rg lacz gene expression kit
kapa hyper prep kit
mirax midi-scanner
mp-7401-50
mp-7405-50
mp-7802-15
nebnext ultra ii dna library prep kit for illumina
novaseq 6000 platform
pyromark assay design software
rnascope multiplex fluorescent reagent kit
rneasy mini kit
smart-seq v.4 ultra low input rna kit
superfrost microscope slide
tissue-tek oct compound
neutrophil gelatinase associated lipocalin
transcription factor
transcription factor nupr1
unclassified drug
basic helix loop helix transcription factor
tumor protein
cancer
cell
dna
gene expression
homeostasis
inhibition
methylation
phenotype
adult
aged
aging
animal cell
animal experiment
animal model
animal tissue
article
carcinogenesis
cell proliferation
cell stemness
computer model
controlled study
crispr-cas9 system
deep neural network
differential gene expression
dissociation
dna methylation
ex vivo study
flow cytometry
fluorescence activated cell sorting
fluorescence intensity
gene set enrichment analysis
genetically engineered mouse strain
genotype
histology
histopathology
human
human cell
human tissue
humidity
hyperoxia
hyperoxia lung injury
immunofluorescence
immunohistochemistry
in situ hybridization
inductively coupled plasma mass spectrometry
iron homeostasis
iron supplementation
lethargy
lung adenocarcinoma
lung alveolus cell
lung cancer
lung dissociation
lung injury
lung tumor
middle aged
mouse
multiplicity of infection
nonhuman
plaque forming unit
pyrosequencing
quality control
real time polymerase chain reaction
suffocation
supplementation
tissue microarray
very elderly
animal
female
ferroptosis
genetics
lung alveolus epithelium cell
male
metabolism
pathology
alveolar epithelial cells
animals
humans
lung neoplasms
mice
Publication Type:
Article
Unique ID:
10.1038/s41586-024-08285-0
PMID:
39633048
DOI:
10.1038/s41586-024-08285-0
Journal:
Nature
Publication Date:
Data Source:
PubMed
Source Link:
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Genetic architecture of epigenetic cortical clock age in brain tissue from older individuals: alterations in CD46 and other loci

Grodstein, F., Lemos, B., Yang, J., de Paiva Lopes, K., Vialle, R. A., Seyfried, N., Wang, Y., Shireby, G., Hannon, E., Thomas, A., Brookes, K., Mill, J., De Jager, P. L., & Bennett, D. A. (2024). Genetic architecture of epigenetic cortical clock age in brain tissue from older individuals: alterations in CD46 and other loci. Epigenetics, 19(1). https://doi.org/10.1080/15592294.2024.2392050
Authors:
Francine Grodstein
Bernardo Lemos
Jingyun Yang
Katia de Paiva Lopes
Ricardo A Vialle
Nicholas Seyfried
Yanling Wang
Gemma Shireby
Eilis Hannon
Alan Thomas
Keeley Brookes
Jonathan Mill
Philip L De Jager
David A Bennett
Affiliated Authors:
Philip L De Jager
Columbia Affiliation:
Subjects:
Epigenesis, Genetic (MeSH)
Polymorphism, Single Nucleotide (MeSH)
Aging (MeSH)
Genome-Wide Association Study (MeSH)
Author Keywords:
aging
epigenetics
brain
dementia
Grants:
U01AG046152 (NIH – National Institute On Aging)
P30AG072975 (NIH – National Institute On Aging)
U01AG046161 (NIH – National Institute On Aging)
P30AG010161 (NIH – National Institute On Aging)
U01AG061357 (NIH – National Institute On Aging)
R01AG017917 (NIH – National Institute On Aging)
R01AG069904 (NIH – National Institute On Aging)
R01AG015819 (NIH – National Institute On Aging)
U01AG061356 (NIH – National Institute On Aging)
R01AG036042 (NIH – National Institute On Aging)
Publication Type:
Article
Unique ID:
10.1080/15592294.2024.2392050
PMID:
39169872
DOI:
10.1080/15592294.2024.2392050
Journal:
Epigenetics
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
View Web of Science Record

Record Created:

Molecular and genetic insights into human ovarian aging from single-nuclei multi-omics analyses

Jin, C., Wang, X., Yang, J., Kim, S., Hudgins, A. D., Gamliel, A., Pei, M., Contreras, D., Devos, M., Guo, Q., Vijg, J., Conti, M., Hoeijmakers, J., Campisi, J., Lobo, R., Williams, Z., Rosenfeld, M. G., & Suh, Y. (2024). Molecular and genetic insights into human ovarian aging from single-nuclei multi-omics analyses. Nature Aging. https://doi.org/10.1038/s43587-024-00762-5
Authors:
Chen Jin
Xizhe Wang
Jiping Yang
Seung-Soo Kim
Adam D. Hudgins
Amir Gamliel
Mingzhuo Pei
Daniela Contreras
Melody Devos
Qinghua Guo
Jan Vijg
Marco Conti
Jan H.J. Hoeijmakers
Judith Campisi
Rogerio A. Løbo
Zev Williams
Michael G. Rosenfeld
Yousin Suh
Affiliated Authors:
Chen Jin
Xizhe Wang
Jiping Yang
Seung-Soo Kim
Adam D. Hudgins
Mingzhuo Pei
Daniela Contreras
Melody Devos
Qinghua Guo
Rogerio A. Løbo
Zev Williams
Yousin Suh
Columbia Affiliation:
Subjects:
Aging (MeSH)
Ovary (MeSH)
Gene Regulatory Networks (MeSH)
Molecular Mechanisms of Aging and Longevity (OpenAlex Topic)
Fertility Preservation in Cancer Patients (OpenAlex Topic)
Comprehensive Integration of Single-Cell Transcriptomic Data (OpenAlex Topic)
Author Keywords:
cd144 microbead
quant- studio 3d digital pcr system
taqman genotyping master mix
adult
aging
apoptosis
article
bioinformatics
cell cycle
cell differentiation
controlled study
female
flow cytometry
fluorescence activated cell sorting
gene expression
genetic analysis
genetic transcription
granulosa cell
high throughput sequencing
histology
human
human cell
human tissue
immunofluorescence
in situ hybridization
in vitro study
ovary
phenotype
polymerase chain reaction
protein expression
real time polymerase chain reaction
rna extraction
rna sequencing
sanger sequencing
single nucleus multiomics
theca cell
western blotting
Publication Type:
Article
Unique ID:
10.1038/s43587-024-00762-5
PMID:
39578560
DOI:
10.1038/s43587-024-00762-5
Journal:
Nature Aging
Publication Date:
Data Source:
OpenAlex
Source Link:
View OpenAlex Record
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Record Created:

Metabolite signatures of chronological age, aging, survival, and longevity

Sebastiani, P., Monti, S., Lustgarten, M. S., Song, Z., Ellis, D., Tian, Q., Schwaiger-Haber, M., Stancliffe, E., Leshchyk, A., Short, M. I., Ardisson Korat, A. V., Gurinovich, A., Karagiannis, T., Li, M., Lords, H. J., Xiang, Q., Marron, M. M., Bae, H., Feitosa, M. F., … Patti, G. J. (2024). Metabolite signatures of chronological age, aging, survival, and longevity. Cell Reports, 43(11), 114913. https://doi.org/10.1016/j.celrep.2024.114913
Authors:
Paola Sebastiani
Stefano Monti
Michael S. Lustgarten
Zeyuan Song
Dylan Ellis
Qu Tian
Michaela Schwaiger-Haber
Ethan Stancliffe
Anastasia Leshchyk
Meghan I. Short
Andres V Ardisson Korat
Anastasia Gurinovich
Tanya T. Karagiannis
Mengze Li
Hannah Lords
Qingyan Xiang
Megan M. Marron
Harold Bae
Mary F. Feitosa
Mary K. Wojczynski
Jeffrey R. O’Connell
May E. Montasser
Nicole Schupf
Konstantin G. Arbeev
Anatoliy I. Yashin
Nicholas J. Schork
Kaare Christensen
Stacy L. Andersen
Luigi Ferrucci
Noa Rappaport
Thomas T. Perls
Gary J. Patti
Affiliated Authors:
Nicole Schupf
Columbia Affiliation:
Subjects:
Longevity (MeSH)
Aging (MeSH)
Advances in Metabolomics Research (OpenAlex Topic)
Effects of Ketogenic Diet on Health (OpenAlex Topic)
Brown Adipose Tissue Function and Physiology (OpenAlex Topic)
Author Keywords:
aging
centenarians
cp: metabolism
longevity
metabolomics
Grants:
KL2TR002545 (NIH – National Center for Advancing Translational Sciences)
U19AG023122 (NIH – National Institute On Aging)
UH3AG064704 (NIH – National Institute On Aging)
UH3AG064706 (NIH – National Institute On Aging)
R01AG061844 (NIH – National Institute On Aging)
U19AG063893 (NIH – National Institute On Aging)
UH2AG064704 (NIH – National Institute On Aging)
U19AG065169 (NIH – National Institute On Aging)
Publication Type:
Article
Unique ID:
10.1016/j.celrep.2024.114913
PMID:
39504246
DOI:
10.1016/j.celrep.2024.114913
Journal:
Cell Reports
Publication Date:
Data Source:
OpenAlex
Source Link:
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Record Created:

The brain-body energy conservation model of aging

Shaulson, E. D., Cohen, A. A., & Picard, M. (2024). The brain–body energy conservation model of aging. Nature Aging, 4(10), 1354–1371. https://doi.org/10.1038/s43587-024-00716-x
Authors:
Evan D Shaulson
Alan A Cohen
Martin Picard
Affiliated Authors:
Evan D Shaulson
Alan A Cohen
Martin Picard
Columbia Affiliation:
Subjects:
Energy Metabolism (MeSH)
Aging (MeSH)
Brain (MeSH)
Grants:
R01MH119336 (NIH – National Institute of Mental Health)
RF1AG076821 (NIH – National Institute On Aging)
R01AG066828 (NIH – National Institute On Aging)
Publication Type:
Article
Unique ID:
10.1038/s43587-024-00716-x
PMID:
39379694
DOI:
10.1038/s43587-024-00716-x
Journal:
Nature Aging
Publication Date:
Data Source:
PubMed
Source Link:
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Record Created:

Extracellular microRNAs associated with psychiatric symptoms in the Normative Aging Study

Qiu, X., Danesh Yazdi, M., Wang, C., Kosheleva, A., Wu, H., Vokonas, P. S., Spiro, A., Laurent, L. C., DeHoff, P., Kubzansky, L. D., Weisskopf, M. G., Baccarelli, A. A., & Schwartz, J. D. (2024). Extracellular microRNAs associated with psychiatric symptoms in the Normative Aging Study. Journal of Psychiatric Research, 178, 270–277. https://doi.org/10.1016/j.jpsychires.2024.08.017
Authors:
Xinye Qiu
Mahdieh Danesh Yazdi
Cuicui Wang
Anna Kosheleva
Haotian Wu
Pantel S Vokonas
Avron Spiro
Louise C Laurent
Peter DeHoff
Laura D Kubzansky
Marc G Weisskopf
Andrea A Baccarelli
Joel D Schwartz
Affiliated Authors:
Haotian Wu
Andrea A Baccarelli
Columbia Affiliation:
Subjects:
MicroRNAs (MeSH)
Aging (MeSH)
Author Keywords:
biological pathways
biomarker
extracellular micrornas
psychiatric health
Publication Type:
Article
Unique ID:
10.1016/j.jpsychires.2024.08.017
PMID:
39173451
DOI:
10.1016/j.jpsychires.2024.08.017
Journal:
Journal of Psychiatric Research
Publication Date:
Data Source:
PubMed
Source Link:
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Record Created:

Challenges and recommendations for the translation of biomarkers of aging

Herzog, C. M. S., Goeminne, L. J. E., Poganik, J. R., Barzilai, N., Belsky, D. W., Betts-LaCroix, J., Chen, B. H., Chen, M., Cohen, A. A., Cummings, S. R., Fedichev, P. O., Ferrucci, L., Fleming, A., Fortney, K., Furman, D., Gorbunova, V., Higgins-Chen, A., Hood, L., … Gladyshev, V. N. (2024). Challenges and recommendations for the translation of biomarkers of aging. Nature Aging, 4(10), 1372–1383. https://doi.org/10.1038/s43587-024-00683-3
Authors:
Chiara M S Herzog
Ludger J E Goeminne
Jesse R Poganik
Nir Barzilai
Daniel W Belsky
Joe Betts-LaCroix
Brian H Chen
Michelle Chen
Alan A Cohen
Steven R Cummings
Peter O Fedichev
Luigi Ferrucci
Alexander Fleming
Kristen Fortney
David Furman
Vera Gorbunova
Albert Higgins-Chen
Lee Hood
Steve Horvath
Jamie N Justice
Douglas P Kiel
George A Kuchel
Jessica Lasky-Su
Nathan K LeBrasseur
Andrea B Maier
Birgit Schilling
Vittorio Sebastiano
P Eline Slagboom
Michael P Snyder
Eric Verdin
Martin Widschwendter
Alex Zhavoronkov
Mahdi Moqri
Vadim N Gladyshev
Affiliated Authors:
Daniel W Belsky
Alan A Cohen
Columbia Affiliation:
Subjects:
Aging (MeSH)
Biomarkers (MeSH)
Translational Research, Biomedical (MeSH)
Grants:
U54AG075932 (NIH – National Institute On Aging)
U01AG060906 (NIH – National Institute On Aging)
R01AG064223 (NIH – National Institute On Aging)
R01AG065403 (NIH – National Institute On Aging)
R56AG076607 (NIH – National Institute On Aging)
R01AG027237 (NIH – National Institute On Aging)
Publication Type:
Article
Unique ID:
10.1038/s43587-024-00683-3
PMID:
39285015
DOI:
10.1038/s43587-024-00683-3
Journal:
Nature Aging
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
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Record Created:

Cellular communities reveal trajectories of brain ageing and Alzheimer's disease

Green, G. S., Fujita, M., Yang, H.-S., Taga, M., Cain, A., McCabe, C., Comandante-Lou, N., White, C. C., Schmidtner, A. K., Zeng, L., Sigalov, A., Wang, Y., Regev, A., Klein, H.-U., Menon, V., Bennett, D. A., Habib, N., & De Jager, P. L. (2024). Cellular communities reveal trajectories of brain ageing and Alzheimer’s disease. Nature, 633(8030), 634–645. https://doi.org/10.1038/s41586-024-07871-6
Authors:
Gilad Sahar Green
Masashi Fujita
Hyun-Sik Yang
Mariko Taga
Anael Cain
Cristin McCabe
Natacha Comandante-Lou
Charles C White
Anna K Schmidtner
Lu Zeng
Alina Sigalov
Yangling Wang
Aviv Regev
Hans-Ulrich Klein
Vilas Menon
David A Bennett
Naomi Habib
Philip L De Jager
Affiliated Authors:
Masashi Fujita
Mariko Taga
Natacha Comandante-Lou
Lu Zeng
Alina Sigalov
Hans-Ulrich Klein
Vilas Menon
Philip L De Jager
Columbia Affiliation:
Subjects:
Aging (MeSH)
Alzheimer Disease (MeSH)
Cell Biology (MeSH)
Prefrontal Cortex (MeSH)
Publication Type:
Article
Unique ID:
10.1038/s41586-024-07871-6
PMID:
39198642
DOI:
10.1038/s41586-024-07871-6
Journal:
Nature
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
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Record Created:

Hypothalamic MRI-derived microstructure is associated with neurocognitive aging in humans

Aleksic, S., Fleysher, R., Weiss, E. F., Tal, N., Darby, T., Blumen, H. M., Vazquez, J., Ye, K. Q., Gao, T., Siegel, S. M., Barzilai, N., Lipton, M. L., & Milman, S. (2024). Hypothalamic MRI-derived microstructure is associated with neurocognitive aging in humans. Neurobiology of Aging, 141, 102–112. https://doi.org/10.1016/j.neurobiolaging.2024.05.018
Authors:
Sandra Aleksic
Roman Fleysher
Erica F Weiss
Noa Tal
Timothy Darby
Helena M Blumen
Juan Vazquez
Kenny Q Ye
Tina Gao
Shira M Siegel
Nir Barzilai
Michael L Lipton
Sofiya Milman
Affiliated Authors:
Roman Fleysher
Shira M Siegel
Michael L Lipton
Columbia Affiliation:
Subjects:
Hypothalamus (MeSH)
Cognitive Aging (MeSH)
Aging (MeSH)
Cognition (MeSH)
Author Keywords:
aging
cognition
cortical thickness
human
hypothalamus
magnetic resonance imaging (mri)
Grants:
KL2TR002558 (NIH – National Center for Advancing Translational Sciences)
R01NS123374 (NIH – National Institute of Neurological Disorders and Stroke)
R01NS123445 (NIH – National Institute of Neurological Disorders and Stroke)
K76AG083274 (NIH – National Institute On Aging)
R01AG061155 (NIH – National Institute On Aging)
R56AG044829 (NIH – National Institute On Aging)
R01AG057909 (NIH – National Institute On Aging)
R01AG062659 (NIH – National Institute On Aging)
Publication Type:
Article
Unique ID:
10.1016/j.neurobiolaging.2024.05.018
PMID:
38850591
DOI:
10.1016/j.neurobiolaging.2024.05.018
Journal:
Neurobiology of Aging
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
View Web of Science Record
View Scopus Record

Record Created:

The relationship between cortical thickness and white matter hyperintensities in mid to late life

Jiménez-Balado, J., Habeck, C., Stern, Y., & Eich, T. (2024). The relationship between cortical thickness and white matter hyperintensities in mid to late life. Neurobiology of Aging, 141, 129–139. https://doi.org/10.1016/j.neurobiolaging.2024.05.014
Authors:
Joan Jiménez-Balado
Christian Habeck
Yaakov Stern
Teal Eich
Affiliated Authors:
Christian Habeck
Yaakov Stern
Teal Eich
Columbia Affiliation:
Subjects:
White Matter (MeSH)
Aging (MeSH)
Cerebral Cortex (MeSH)
Author Keywords:
cerebrovascular disease
cognitive impairment
cortical thickness
neuroimaging
white matter hyperintensities
Grants:
R01AG038465 (NIH – National Institute On Aging)
R01AG026158 (NIH – National Institute On Aging)
R00AG055684 (NIH – National Institute On Aging)
K99AG055684 (NIH – National Institute On Aging)
RF1AG038465 (NIH – National Institute On Aging)
R56AG026158 (NIH – National Institute On Aging)
Publication Type:
Article
Unique ID:
10.1016/j.neurobiolaging.2024.05.014
PMID:
38909430
DOI:
10.1016/j.neurobiolaging.2024.05.014
Journal:
Neurobiology of Aging
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
View Web of Science Record
View Scopus Record

Record Created:

The dynamics and longevity of circulating CD4+ memory T cells depend on cell age and not the chronological age of the host

Bullock, M. E., Hogan, T., Williams, C., Morris, S., Nowicka, M., Sharjeel, M., van Dorp, C., Yates, A. J., & Seddon, B. (2024). The dynamics and longevity of circulating CD4+ memory T cells depend on cell age and not the chronological age of the host. PLOS Biology, 22(8), e3002380. https://doi.org/10.1371/journal.pbio.3002380
Authors:
M. Elise Bullock
Thea Hogan
Cayman Williams
Sinead E. Morris
Christiaan H. van Dorp
Andrew J. Yates
Christiaan H. van Dorp
Andrew J. Yates
Benedict Seddon
Affiliated Authors:
M. Elise Bullock
Sinead E. Morris
Christiaan H. van Dorp
Christiaan H. van Dorp
Andrew J. Yates
Columbia Affiliation:
Subjects:
Memory T Cells (MeSH)
CD4-Positive T-Lymphocytes (MeSH)
Cellular Senescence (MeSH)
Aging (MeSH)
Regulatory T Cell Development and Function (OpenAlex Topic)
Natural Killer Cells in Immunity (OpenAlex Topic)
Role of Microglia in Neurological Disorders (OpenAlex Topic)
Grants:
U01AI150680 (NIH – National Institute of Allergy and Infectious Diseases)
R01AI093870 (NIH – National Institute of Allergy and Infectious Diseases)
Publication Type:
Article
Unique ID:
10.1371/journal.pbio.3002380
PMID:
39137219
DOI:
10.1371/journal.pbio.3002380
Journal:
PLOS Biology
Publication Date:
Data Source:
OpenAlex
Source Link:
View OpenAlex Record
View PubMed Record
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Record Created:

Maternal Adverse Childhood Experiences and Biological Aging During Pregnancy and in Newborns

Dye, C. K., Alschuler, D. M., Wu, H., Duarte, C., Monk, C., Belsky, D. W., Lee, S., O’Donnell, K., Baccarelli, A. A., & Scorza, P. (2024). Maternal Adverse Childhood Experiences and Biological Aging During Pregnancy and in Newborns. JAMA Network Open, 7(8), e2427063. https://doi.org/10.1001/jamanetworkopen.2024.27063
Authors:
Christian K Dye
Daniel M Alschuler
Haotian Wu
Cristiane Duarte
Catherine Monk
Daniel W Belsky
Seonjoo Lee
Kieran O'Donnell
Andrea A Baccarelli
Pamela Scorza
Affiliated Authors:
Christian K Dye
Daniel M Alschuler
Haotian Wu
Catherine Monk
Daniel W Belsky
Seonjoo Lee
Andrea A Baccarelli
Pamela Scorza
Columbia Affiliation:
Subjects:
Adverse Childhood Experiences (MeSH)
Aging (MeSH)
Grants:
T32HL115505 (NIH – National Heart, Lung, and Blood Institute)
Publication Type:
Article
Unique ID:
10.1001/jamanetworkopen.2024.27063
PMID:
39120899
DOI:
10.1001/jamanetworkopen.2024.27063
Journal:
JAMA Network Open
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
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Record Created:

Sociodemographic and Lifestyle Factors and Epigenetic Aging in US Young Adults: NIMHD Social Epigenomics Program

Harris, K. M., Levitt, B., Gaydosh, L., Martin, C., Meyer, J. M., Mishra, A. A., Kelly, A. L., & Aiello, A. E. (2024). Sociodemographic and Lifestyle Factors and Epigenetic Aging in US Young Adults. JAMA Network Open, 7(7), e2427889. https://doi.org/10.1001/jamanetworkopen.2024.27889
Authors:
Kathleen Mullan Harris
Brandt Levitt
Lauren Gaydosh
Chantel Martin
Jess M Meyer
Aura Ankita Mishra
Audrey L Kelly
Allison E Aiello
Affiliated Authors:
Allison E Aiello
Columbia Affiliation:
Subjects:
Life Style (MeSH)
Aging (MeSH)
Epigenesis, Genetic (MeSH)
Grants:
P30ES010126 (NIH – National Institute of Environmental Health Sciences)
Publication Type:
Article
Unique ID:
10.1001/jamanetworkopen.2024.27889
PMID:
39073811
DOI:
10.1001/jamanetworkopen.2024.27889
Journal:
JAMA Network Open
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
View Web of Science Record

Record Created:

Epigenetic Aging and Musculoskeletal Outcomes in a Cohort of Women Living With HIV

Shiau, S., Zumpano, F., Wang, Z., Shah, J., Tien, P. C., Ross, R. D., Sharma, A., & Yin, M. T. (2024). Epigenetic Aging and Musculoskeletal Outcomes in a Cohort of Women Living With HIV. The Journal of Infectious Diseases, 229(6), 1803–1811. https://doi.org/10.1093/infdis/jiae016
Authors:
Stephanie Shiau
Francesca Zumpano
Ziyi Wang
Jayesh Shah
Phyllis C Tien
Ryan D Ross
Anjali Sharma
Michael T Yin
Affiliated Authors:
Jayesh Shah
Michael T Yin
Columbia Affiliation:
Subjects:
HIV Infections (MeSH)
Epigenesis, Genetic (MeSH)
DNA Methylation (MeSH)
Aging (MeSH)
Bone Density (MeSH)
Author Keywords:
bone mineral density
epigenetic aging
hiv
osteoporosis
physical function
Grants:
K24AI155230 (NIH – National Institute of Allergy and Infectious Diseases)
R01AI095089 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI069470 (NIH – National Institute of Allergy and Infectious Diseases)
U01AI069470 (NIH – National Institute of Allergy and Infectious Diseases)
Publication Type:
Article
Unique ID:
10.1093/infdis/jiae016
PMID:
38366369
DOI:
10.1093/infdis/jiae016
Journal:
Journal of Infectious Diseases
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
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Record Created:

Accelerated biological aging six decades after prenatal famine exposure

Cheng, M., Conley, D., Kuipers, T., Li, C., Ryan, C. P., Taeubert, M. J., Wang, S., Wang, T., Zhou, J., Schmitz, L. L., Tobi, E. W., Heijmans, B. T., Lumey, L. H., & Belsky, D. W. (2024). Accelerated biological aging six decades after prenatal famine exposure. Proceedings of the National Academy of Sciences, 121(24). https://doi.org/10.1073/pnas.2319179121
Authors:
Mengling Cheng
Dalton Conley
Tom Kuipers
Chihua Li
Calen P Ryan
M Jazmin Taeubert
Shuang Wang
Tian Wang
Jiayi Zhou
Lauren L Schmitz
Elmar W Tobi
Bas Heijmans
L H Lumey
Daniel W Belsky
Affiliated Authors:
Mengling Cheng
Chihua Li
Calen P Ryan
Shuang Wang
Tian Wang
Jiayi Zhou
L H Lumey
Daniel W Belsky
Columbia Affiliation:
Subjects:
Famine (MeSH)
Prenatal Exposure Delayed Effects (MeSH)
Aging (MeSH)
DNA Methylation (MeSH)
Author Keywords:
biological aging
dutch famine
epigenetic clock
fetal origins
natural experiment
Grants:
R00AG056599 (NIH – National Institute On Aging)
R01AG066887 (NIH – National Institute On Aging)
R01AG042190 (NIH – National Institute On Aging)
Publication Type:
Article
Unique ID:
10.1073/pnas.2319179121
PMID:
38833467
DOI:
10.1073/pnas.2319179121
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Publication Date:
Data Source:
PubMed
Source Link:
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Record Created:

The 2022 symposium on dementia and brain aging in low- and middle-income countries: Highlights on research, diagnosis, care, and impact

Kalaria, R., Maestre, G., Mahinrad, S., Acosta, D. M., Akinyemi, R. O., Alladi, S., Allegri, R. F., Arshad, F., Babalola, D. O., Baiyewu, O., Bak, T. H., Bellaj, T., Brodie‐Mends, D. K., Carrillo, M. C., Celestin, K., Damasceno, A., de Silva, R. K., de Silva, R., Djibuti, M., … Ismail, O. (2024). The 2022 symposium on dementia and brain aging in low‐ and middle‐income countries: Highlights on research, diagnosis, care, and impact. Alzheimer’s & Dementia, 20(6), 4290–4314. Portico. https://doi.org/10.1002/alz.13836
Authors:
Raj Kalaria
Gladys Maestre
Simin Mahinrad
Daisy M Acosta
Rufus Olusola Akinyemi
Suvarna Alladi
Ricardo F Allegri
Faheem Arshad
David Oluwasayo Babalola
Olusegun Baiyewu
Thomas H Bak
Tarek Bellaj
David K Brodie-Mends
Maria C Carrillo
Kaputu-Kalala-Malu Celestin
Albertino Damasceno
Ranil Karunamuni de Silva
Rohan de Silva
Mamuka Djibuti
Anna Jane Dreyer
Ratnavalli Ellajosyula
Temitope H Farombi
Robert P Friedland
Noe Garza
Antoine Gbessemehlan
Eliza Eleni-Zacharoula Georgiou
Ishtar Govia
Lea T Grinberg
Maëlenn Guerchet
Seid Ali Gugssa
Joy Louise Gumikiriza-Onoria
Eef Hogervorst
Michael Hornberger
Agustin Ibanez
Masafumi Ihara
Thomas Gregor Issac
Linus Jönsson
Wambui M Karanja
Joseph H Lee
Iracema Leroi
Gill Livingston
Facundo Francisco Manes
Lingani Mbakile-Mahlanza
Bruce L Miller
Christine Wayua Musyimi
Victoria N Mutiso
Noeline Nakasujja
David M Ndetei
Sam Nightingale
Gabriela Novotni
Primrose Nyamayaro
Solomon Nyame
Julius A Ogeng'o
Adesola Ogunniyi
Maira Okada de Oliveira
Njideka U Okubadejo
Martin Orrell
Stella-Maria Paddick
Margaret A Pericak-Vance
Zvezdan Pirtosek
Felix Claude Victor Potocnik
Rema Raman
Mie Rizig
Mónica Rosselli
Marufjon Salokhiddinov
Claudia L Satizabal
Diego Sepulveda-Falla
Sudha Seshadri
Claire E Sexton
Ingmar Skoog
Peter H St George-Hyslop
Claudia Kimie Suemoto
Prekshy Thapa
Chinedu Theresa Udeh-Momoh
Victor Valcour
Jeffery M Vance
Mathew Varghese
Jaime H Vera
Richard W Walker
Henrik Zetterberg
Yared Z Zewde
Ozama Ismail
Affiliated Authors:
Joseph H Lee
Peter H St George-Hyslop
Columbia Affiliation:
Subjects:
Dementia (MeSH)
Developing Countries (MeSH)
Aging (MeSH)
Author Keywords:
alzheimer's disease
dementia
diversity
high‐income countries
low‐ and middle‐income countries
risk factors
vascular dementia
Grants:
P01HD035897 (NIH – Eunice Kennedy Shriver National Institute of Child Health & Human Development)
D43TW011532 (NIH – Fogarty International Center)
R25TW011214 (NIH – Fogarty International Center)
UL1TR001873 (NIH – National Center for Advancing Translational Sciences)
U01HG010273 (NIH – National Human Genome Research Institute)
UH3NS100605 (NIH – National Institute of Neurological Disorders and Stroke)
R01NS050915 (NIH – National Institute of Neurological Disorders and Stroke)
UF1NS125513 (NIH – National Institute of Neurological Disorders and Stroke)
R56AG074467 (NIH – National Institute On Aging)
RF1AG059421 (NIH – National Institute On Aging)
R01AG068472 (NIH – National Institute On Aging)
DP1AG069870 (NIH – National Institute On Aging)
R01AG070864 (NIH – National Institute On Aging)
U01AG052409 (NIH – National Institute On Aging)
R01AG058464 (NIH – National Institute On Aging)
RF1AG063507 (NIH – National Institute On Aging)
U19AG074865 (NIH – National Institute On Aging)
U01AG051412 (NIH – National Institute On Aging)
R01AG070883 (NIH – National Institute On Aging)
U19AG068054 (NIH – National Institute On Aging)
P01AG019724 (NIH – National Institute On Aging)
R13AG066391 (NIH – National Institute On Aging)
R35AG072362 (NIH – National Institute On Aging)
R01AG057234 (NIH – National Institute On Aging)
P30AG066546 (NIH – National Institute On Aging)
RF1AG061872 (NIH – National Institute On Aging)
R01AG066524 (NIH – National Institute On Aging)
R56AG061837 (NIH – National Institute On Aging)
U19AG063893 (NIH – National Institute On Aging)
R21AG069252 (NIH – National Institute On Aging)
R01AG062588 (NIH – National Institute On Aging)
R01AG062562 (NIH – National Institute On Aging)
P30AG059305 (NIH – National Institute On Aging)
P30AG062422 (NIH – National Institute On Aging)
U01AG058589 (NIH – National Institute On Aging)
RF1AG059018 (NIH – National Institute On Aging)
U19AG078109 (NIH – National Institute On Aging)
R01AG054076 (NIH – National Institute On Aging)
P30AG066506 (NIH – National Institute On Aging)
R01AG075775 (NIH – National Institute On Aging)
U19AG078558 (NIH – National Institute On Aging)
R01AG072547 (NIH – National Institute On Aging)
R01AG058918 (NIH – National Institute On Aging)
R01AG080468 (NIH – National Institute On Aging)
R01AG052496 (NIH – National Institute On Aging)
Publication Type:
Article
Unique ID:
10.1002/alz.13836
PMID:
38696263
DOI:
10.1002/alz.13836
Journal:
Alzheimer's and Dementia
Publication Date:
Data Source:
PubMed
Source Link:
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Record Created:

Aging in Heart Failure: Embracing Biology Over Chronology: JACC Family Series

Goyal, P., Maurer, M. S., & Roh, J. (2024). Aging in Heart Failure. JACC: Heart Failure, 12(5), 795–809. https://doi.org/10.1016/j.jchf.2024.02.021
Authors:
Parag Goyal
Mathew S Maurer
Jason Roh
Affiliated Authors:
Mathew S Maurer
Columbia Affiliation:
Subjects:
Heart Failure (MeSH)
Aging (MeSH)
Author Keywords:
aging biology
geriatrics
heart failure
Grants:
R01HL139671 (NIH – National Heart, Lung, and Blood Institute)
R01HL170058 (NIH – National Heart, Lung, and Blood Institute)
K76AG064328 (NIH – National Institute On Aging)
R21AG077092 (NIH – National Institute On Aging)
K76AG064428 (NIH – National Institute On Aging)
R01AG081582 (NIH – National Institute On Aging)
Publication Type:
Article
Unique ID:
10.1016/j.jchf.2024.02.021
PMID:
38597865
DOI:
10.1016/j.jchf.2024.02.021
Journal:
JACC: Heart Failure
Publication Date:
Data Source:
PubMed
Source Link:
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Record Created:

Pregnancy is linked to faster epigenetic aging in young women

Ryan, C. P., Lee, N. R., Carba, D. B., MacIsaac, J. L., Lin, D. T. S., Atashzay, P., Belsky, D. W., Kobor, M. S., & Kuzawa, C. W. (2024). Pregnancy is linked to faster epigenetic aging in young women. Proceedings of the National Academy of Sciences, 121(16). https://doi.org/10.1073/pnas.2317290121
Authors:
Calen P Ryan
Nanette R Lee
Delia B Carba
Julie L MacIsaac
David T S Lin
Parmida Atashzay
Daniel W Belsky
Michael S Kobor
Christopher W Kuzawa
Affiliated Authors:
Calen P Ryan
Daniel W Belsky
Columbia Affiliation:
Subjects:
Aging (MeSH)
Reproduction (MeSH)
Author Keywords:
costs of reproduction
biological aging
pregnancy
fatherhood
Grants:
R01AG066887 (NIH – National Institute On Aging)
R01AG061006 (NIH – National Institute On Aging)
Publication Type:
Article
Unique ID:
10.1073/pnas.2317290121
PMID:
38588424
DOI:
10.1073/pnas.2317290121
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Publication Date:
Data Source:
PubMed
Source Link:
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Record Created:

Educational Mobility, Pace of Aging, and Lifespan Among Participants in the Framingham Heart Study

Graf, G. H. J., Aiello, A. E., Caspi, A., Kothari, M., Liu, H., Moffitt, T. E., Muennig, P. A., Ryan, C. P., Sugden, K., & Belsky, D. W. (2024). Educational Mobility, Pace of Aging, and Lifespan Among Participants in the Framingham Heart Study. JAMA Network Open, 7(3), e240655. https://doi.org/10.1001/jamanetworkopen.2024.0655
Authors:
Gloria H J Graf
Allison E Aiello
Avshalom Caspi
Meeraj Kothari
Hexuan Liu
Terrie E Moffitt
Peter A Muennig
Calen P Ryan
Karen Sugden
Daniel W Belsky
Affiliated Authors:
Gloria H J Graf
Allison E Aiello
Peter A Muennig
Daniel W Belsky
Columbia Affiliation:
Subjects:
Longevity (MeSH)
Aging (MeSH)
Grants:
T32ES023772 (NIH – National Institute of Environmental Health Sciences)
R01AG073207 (NIH – National Institute On Aging)
R21AG078627 (NIH – National Institute On Aging)
R01AG073402 (NIH – National Institute On Aging)
Publication Type:
Article
Unique ID:
10.1001/jamanetworkopen.2024.0655
PMID:
38427354
DOI:
10.1001/jamanetworkopen.2024.0655
Journal:
JAMA Network Open
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
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Record Created:

Diet, Pace of Biological Aging, and Risk of Dementia in the Framingham Heart Study

Thomas, A., Ryan, C. P., Caspi, A., Liu, Z., Moffitt, T. E., Sugden, K., Zhou, J., Belsky, D. W., & Gu, Y. (2024). Diet, Pace of Biological Aging, and Risk of Dementia in the Framingham Heart Study. Annals of Neurology, 95(6), 1069–1079. Portico. https://doi.org/10.1002/ana.26900
Authors:
Aline Thomas
Calen P Ryan
Avshalom Caspi
Zhonghua Liu
Terrie E Moffitt
Karen Sugden
Jiayi Zhou
Daniel W Belsky
Yian Gu
Affiliated Authors:
Aline Thomas
Calen P Ryan
Zhonghua Liu
Jiayi Zhou
Daniel W Belsky
Yian Gu
Columbia Affiliation:
Subjects:
Dementia (MeSH)
Aging (MeSH)
Grants:
R01AG059013 (NIH – National Institute On Aging)
R01AG061008 (NIH – National Institute On Aging)
R01AG049789 (NIH – National Institute On Aging)
R01AG073402 (NIH – National Institute On Aging)
R01AG061378 (NIH – National Institute On Aging)
R01AG073207 (NIH – National Institute On Aging)
Publication Type:
Article
Unique ID:
10.1002/ana.26900
PMID:
38407506
DOI:
10.1002/ana.26900
Journal:
Annals of Neurology
Publication Date:
Data Source:
PubMed
Source Link:
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Record Created:

IgG is an aging factor that drives adipose tissue fibrosis and metabolic decline

Yu, L., Wan, Q., Liu, Q., Fan, Y., Zhou, Q., Skowronski, A. A., Wang, S., Shao, Z., Liao, C.-Y., Ding, L., Kennedy, B. K., Zha, S., Que, J., LeDuc, C. A., Sun, L., Wang, L., & Qiang, L. (2024). IgG is an aging factor that drives adipose tissue fibrosis and metabolic decline. Cell Metabolism, 36(4), 793-807.e5. https://doi.org/10.1016/j.cmet.2024.01.015
Authors:
Lexiang Yu
Qianfen Wan
Qiongming Liu
Yong Fan
Qiuzhong Zhou
Alicja A Skowronski
Summer Wang
Zhengping Shao
Chen-Yu Liao
Lei Ding
Brian K Kennedy
Shan Zha
Jianwen Que
Charles A LeDuc
Lei Sun
Liheng Wang
Li Qiang
Affiliated Authors:
Lexiang Yu
Qianfen Wan
Qiongming Liu
Yong Fan
Alicja A Skowronski
Summer Wang
Zhengping Shao
Lei Ding
Shan Zha
Jianwen Que
Charles A LeDuc
Li Qiang
Columbia Affiliation:
Subjects:
Adipose Tissue (MeSH)
Aging (MeSH)
Author Keywords:
adipose tissue
aging
fibrosis
igg
metabolic dysfunction
Grants:
R01DK134471 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
P30DK063608 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
R01DK112943 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
Publication Type:
Article
Unique ID:
10.1016/j.cmet.2024.01.015
PMID:
38378001
DOI:
10.1016/j.cmet.2024.01.015
Journal:
Cell Metabolism
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
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Record Created:

Impact of driving cessation on health-related quality of life trajectories

Mielenz, T. J., Jia, H., DiGuiseppi, C., Molnar, L. J., Strogatz, D., Hill, L. L., Andrews, H. F., Eby, D. W., Jones, V. C., & Li, G. (2024). Impact of driving cessation on health-related quality of life trajectories. Health and Quality of Life Outcomes, 22(1). https://doi.org/10.1186/s12955-024-02231-4
Authors:
Thelma J Mielenz
Haomiao Jia
Carolyn DiGuiseppi
Lisa J Molnar
David Strogatz
Linda L Hill
Howard F Andrews
David W Eby
Vanya C Jones
Guohua Li
Affiliated Authors:
Thelma J Mielenz
Haomiao Jia
Howard F Andrews
Guohua Li
Columbia Affiliation:
Subjects:
Aging (MeSH)
Quality of Life (MeSH)
Automobile Driving (MeSH)
Author Keywords:
health-related quality of life and driving cessation
Grants:
R49CE002096 (NIH – National Center for Injury Prevention and Control)
Publication Type:
Article
Unique ID:
10.1186/s12955-024-02231-4
PMID:
38302929
DOI:
10.1186/s12955-024-02231-4
Journal:
Health and Quality of Life Outcomes
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
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View Scopus Record

Record Created:

Examining racial differences in the network structure and properties of specific cognitive domains among older adults

Min, S. H., Schnall, R., Lee, C., & Topaz, M. (2023). Examining racial differences in the network structure and properties of specific cognitive domains among older adults. GeroScience, 46(1), 1395–1406. https://doi.org/10.1007/s11357-023-00912-4
Authors:
Se Hee Min
Rebecca Schnall
Chiyoung Lee
Maxim Topaz
Affiliated Authors:
Se Hee Min
Rebecca Schnall
Maxim Topaz
Columbia Affiliation:
Subjects:
Aging (MeSH)
Cognition (MeSH)
Author Keywords:
aging
cognition
older adults
Grants:
T32NR007969 (NIH – National Institute of Nursing Research)
Publication Type:
Article
Unique ID:
10.1007/s11357-023-00912-4
PMID:
37594597
DOI:
10.1007/s11357-023-00912-4
Journal:
GeroScience
Publication Date:
Data Source:
PubMed
Source Link:
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Record Created:

"As I Grew Older, My Life Got Better": Conceptions of Successful Aging among Older Women Living with or at Risk of HIV

Rubtsova, A. A., Taylor, T. N., Wingood, G., Ofotokun, I., Gustafson, D., Vance, D. E., & Holstad, M. (2024). “As I Grew Older, My Life Got Better”: Conceptions of Successful Aging among Older Women Living with or at Risk of HIV. AIDS and Behavior, 28(5), 1581–1593. https://doi.org/10.1007/s10461-024-04270-w
Authors:
Anna A Rubtsova
Tonya N Taylor
Gina Wingood
Ighovwerha Ofotokun
Deborah Gustafson
David E Vance
Marcia Holstad
Affiliated Authors:
Gina Wingood
Columbia Affiliation:
Subjects:
HIV Infections (MeSH)
Aging (MeSH)
Focus Groups (MeSH)
Qualitative Research (MeSH)
Interviews as Topic (MeSH)
Author Keywords:
chronic disease
healthy aging
aging well
older adults
well-being
mental health
qualitative study
Grants:
U01HL146241 (NIH – National Heart, Lung, and Blood Institute)
Publication Type:
Article
Unique ID:
10.1007/s10461-024-04270-w
PMID:
38231362
DOI:
10.1007/s10461-024-04270-w
Journal:
AIDS and Behavior
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
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Record Created:

Serum Proteomic Signatures of Common Health Outcomes among Older Adults

Roberts, J. A., Basu-Roy, S., Shin, J., Varma, V. R., Williamson, A., Blackshear, C., Griswold, M. E., Candia, J., Elango, P., Karikkineth, A. C., Tanaka, T., Ferrucci, L., & Thambisetty, M. (2024). Serum Proteomic Signatures of Common Health Outcomes among Older Adults. Gerontology, 70(3), 269–278. Portico. https://doi.org/10.1159/000534753
Authors:
Jackson A Roberts
Sayantani Basu-Roy
Jong Shin
Vijay R Varma
Andrew Williamson
Chad Blackshear
Michael E Griswold
Julián Candia
Palchamy Elango
Ajoy C Karikkineth
Toshiko Tanaka
Luigi Ferrucci
Madhav Thambisetty
Affiliated Authors:
Jackson A Roberts
Columbia Affiliation:
Subjects:
Proteomics (MeSH)
Aging (MeSH)
Author Keywords:
proteomics
aging
diabetes
health
physical activity
Grants:
ZIAAG001050 (NIH – National Institute On Aging)
Publication Type:
Article
Unique ID:
10.1159/000534753
PMID:
38219723
DOI:
10.1159/000534753
Journal:
Gerontology
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
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Record Created:

Transitions in Social Networks From Young-Old to Old-Old Stage of Life Using Latent Transition Analysis

Min, S. H., Lee, C., Scroggins, J. K., & Yang, Q. (2023). Transitions in Social Networks From Young-Old to Old-Old Stage of Life Using Latent Transition Analysis. Journal of Aging and Health, 36(1–2), 110–119. https://doi.org/10.1177/08982643231177400
Authors:
Se Hee Min
Chiyoung Lee
Jihye Kim Scroggins
Qing Yang
Affiliated Authors:
Se Hee Min
Columbia Affiliation:
Subjects:
Social Support (MeSH)
Aging (MeSH)
Author Keywords:
aging
methodology
older adults
social network
Grants:
T32NR007969 (NIH – National Institute of Nursing Research)
Publication Type:
Article
Unique ID:
10.1177/08982643231177400
PMID:
37207348
DOI:
10.1177/08982643231177400
Journal:
Journal of Aging and Health
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
View Scopus Record

Record Created:

Patterns and Life Course Determinants of Black-White Disparities in Biological Age Acceleration: A Decomposition Analysis

Boen, C. E., Yang, Y. C., Aiello, A. E., Dennis, A. C., Harris, K. M., Kwon, D., & Belsky, D. W. (2023). Patterns and Life Course Determinants of Black–White Disparities in Biological Age Acceleration: A Decomposition Analysis. Demography, 60(6), 1815–1841. https://doi.org/10.1215/00703370-11057546
Authors:
Courtney E Boen
Y Claire Yang
Allison E Aiello
Alexis C Dennis
Kathleen Mullan Harris
Dayoon Kwon
Daniel W Belsky
Affiliated Authors:
Allison E Aiello
Daniel W Belsky
Columbia Affiliation:
Subjects:
Aging (MeSH)
Life Change Events (MeSH)
Black or African American (MeSH)
White (MeSH)
Health Status Disparities (MeSH)
Author Keywords:
aging
biological aging
life course
racialized disparities
weathering
Grants:
P2CHD044964 (NIH – Eunice Kennedy Shriver National Institute of Child Health & Human Development)
R21HD095448 (NIH – Eunice Kennedy Shriver National Institute of Child Health & Human Development)
R24HD044964 (NIH – Eunice Kennedy Shriver National Institute of Child Health & Human Development)
U01AG009740 (NIH – National Institute On Aging)
R01AG057800 (NIH – National Institute On Aging)
Publication Type:
Article
Unique ID:
10.1215/00703370-11057546
PMID:
37982570
DOI:
10.1215/00703370-11057546
Journal:
Demography
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record

Record Created:

Update on the epidemiology and treatment of eating disorders among older people

Mangweth-Matzek, B., Kummer, K. K., & Hoek, H. W. (2023). Update on the epidemiology and treatment of eating disorders among older people. Current Opinion in Psychiatry, 36(6), 405–411. https://doi.org/10.1097/yco.0000000000000893
Authors:
Barbara Mangweth-Matzek
Kai K Kummer
Hans W Hoek
Affiliated Authors:
Hans W Hoek
Columbia Affiliation:
Subjects:
Aging (MeSH)
Feeding and Eating Disorders (MeSH)
Publication Type:
Article
Unique ID:
10.1097/yco.0000000000000893
PMID:
37471308
DOI:
10.1097/yco.0000000000000893
Journal:
Current Opinion in Psychiatry
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record

Record Created:

Association between infectious exposures in infancy and epigenetic age acceleration in young adulthood in metropolitan Cebu, Philippines

McDade, T. W., Ryan, C. P., Adair, L. S., Lee, N. R., Carba, D. B., MacIsaac, J. L., Dever, K., Atashzay, P., Kobor, M. S., & Kuzawa, C. W. (2023). Association between infectious exposures in infancy and epigenetic age acceleration in young adulthood in metropolitan Cebu, Philippines. American Journal of Human Biology, 35(11). Portico. https://doi.org/10.1002/ajhb.23948
Authors:
Thomas W McDade
Calen P Ryan
Linda S Adair
Nanette R Lee
Delia B Carba
Julia L MacIsaac
Kristy Dever
Parmida Atashzay
Michael S Kobor
Christopher W Kuzawa
Affiliated Authors:
Calen P Ryan
Columbia Affiliation:
Subjects:
Aging (MeSH)
Communicable Diseases (MeSH)
Grants:
P2CHD050924 (NIH – Eunice Kennedy Shriver National Institute of Child Health & Human Development)
R01AG061006 (NIH – National Institute On Aging)
Publication Type:
Article
Unique ID:
10.1002/ajhb.23948
PMID:
37338007
DOI:
10.1002/ajhb.23948
Journal:
American Journal of Human Biology
Publication Date:
Data Source:
PubMed
Source Link:
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Record Created:

Association of Cognitive Polygenic Index and Cognitive Performance with Age in Cognitively Healthy Adults

Tsapanou, A., Gacheru, M., Lee, S., Mourtzi, N., Gazes, Y., Habeck, C., Belsky, D. W., & Stern, Y. (2023). Association of Cognitive Polygenic Index and Cognitive Performance with Age in Cognitively Healthy Adults. Genes, 14(9), 1814. https://doi.org/10.3390/genes14091814
Authors:
Angeliki Tsapanou
Margaret Gacheru
Seonjoo Lee
Niki Mourtzi
Yunglin Gazes
Christian Habeck
Daniel W. Belsky
Yaakov Stern
Affiliated Authors:
Angeliki Tsapanou
Margaret Gacheru
Seonjoo Lee
Yunglin Gazes
Christian Habeck
Daniel W. Belsky
Yaakov Stern
Columbia Affiliation:
Subjects:
Aging (MeSH)
Genome-Wide Association Study (MeSH)
Genomic Studies and Association Analyses (OpenAlex Topic)
Effects of Working Memory Training on Cognitive Abilities (OpenAlex Topic)
Molecular Basis of Rett Syndrome and Related Disorders (OpenAlex Topic)
Author Keywords:
cognition
normal aging
polygenic index
Grants:
K99AG071930 (NIH – National Institute On Aging)
R01AG026158 (NIH – National Institute On Aging)
R01AG038465 (NIH – National Institute On Aging)
R01AG062578 (NIH – National Institute On Aging)
K01AG051777 (NIH – National Institute On Aging)
Publication Type:
Article
Unique ID:
10.3390/genes14091814
PMID:
37761954
DOI:
10.3390/genes14091814
Journal:
Genes
Publication Date:
Data Source:
OpenAlex
Source Link:
View OpenAlex Record
View PubMed Record
View Scopus Record

Record Created:

Deciphering the decline of metabolic elasticity in aging and obesity

Zhou, Q., Yu, L., Cook, J. R., Qiang, L., & Sun, L. (2023). Deciphering the decline of metabolic elasticity in aging and obesity. Cell Metabolism, 35(9), 1661-1671.e6. https://doi.org/10.1016/j.cmet.2023.08.001
Authors:
Qiuzhong Zhou
Lexiang Yu
Joshua R Cook
Li Qiang
Lei Sun
Affiliated Authors:
Lexiang Yu
Joshua R Cook
Li Qiang
Columbia Affiliation:
Subjects:
Obesity (MeSH)
Aging (MeSH)
Adaptation, Physiological (MeSH)
Author Keywords:
adipocyte
adipose tissue
aging
gene elasticity
liver
metabolic decline
metabolic elasticity
muscle
nutrient challenge
obesity
Grants:
P01HL087123 (NIH – National Heart, Lung, and Blood Institute)
R01DK128848 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
R01DK112943 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
R01DK131169 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
Publication Type:
Article
Unique ID:
10.1016/j.cmet.2023.08.001
PMID:
37625407
DOI:
10.1016/j.cmet.2023.08.001
Journal:
Cell Metabolism
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
View Scopus Record

Record Created:

Negative wealth shocks in later life and subsequent cognitive function in older adults in China, England, Mexico, and the USA, 2012-18: a population-based, cross-nationally harmonised, longitudinal study

Cho, T.-C., Yu, X., Gross, A. L., Zhang, Y. S., Lee, J., Langa, K. M., & Kobayashi, L. C. (2023). Negative wealth shocks in later life and subsequent cognitive function in older adults in China, England, Mexico, and the USA, 2012–18: a population-based, cross-nationally harmonised, longitudinal study. The Lancet Healthy Longevity, 4(9), e461–e469. https://doi.org/10.1016/s2666-7568(23)00113-7
Authors:
Tsai-Chin Cho
Xuexin Yu
Alden L Gross
Yuan S Zhang
Jinkook Lee
Kenneth M Langa
Lindsay C Kobayashi
Affiliated Authors:
Yuan S Zhang
Columbia Affiliation:
Subjects:
Aging (MeSH)
Cognition (MeSH)
Grants:
R01AG030153 (NIH – National Institute On Aging)
P30AG012846 (NIH – National Institute On Aging)
U01AG009740 (NIH – National Institute On Aging)
R01AG070953 (NIH – National Institute On Aging)
R00AG070274 (NIH – National Institute On Aging)
R01AG069128 (NIH – National Institute On Aging)
K99AG070274 (NIH – National Institute On Aging)
Publication Type:
Article
Unique ID:
10.1016/s2666-7568(23)00113-7
PMID:
37544315
DOI:
10.1016/s2666-7568(23)00113-7
Journal:
Lancet: Healthy Longevity
Publication Date:
Data Source:
PubMed
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Biomarkers of aging for the identification and evaluation of longevity interventions

Moqri, M., Herzog, C., Poganik, J. R., Justice, J., Belsky, D. W., Higgins-Chen, A., Moskalev, A., Fuellen, G., Cohen, A. A., Bautmans, I., Widschwendter, M., Ding, J., Fleming, A., Mannick, J., Han, J.-D. J., Zhavoronkov, A., Barzilai, N., Kaeberlein, M., Cummings, S., … Gladyshev, V. N. (2023). Biomarkers of aging for the identification and evaluation of longevity interventions. Cell, 186(18), 3758–3775. https://doi.org/10.1016/j.cell.2023.08.003
Authors:
Mahdi Moqri
Chiara Herzog
Jesse R Poganik
Jamie Justice
Daniel W Belsky
Albert Higgins-Chen
Alexey Moskalev
Georg Fuellen
Alan A Cohen
Ivan Bautmans
Martin Widschwendter
Jingzhong Ding
Alexander Fleming
Joan Mannick
Jing-Dong Jackie Han
Alex Zhavoronkov
Nir Barzilai
Matt Kaeberlein
Steven Cummings
Brian K Kennedy
Luigi Ferrucci
Steve Horvath
Eric Verdin
Andrea B Maier
Michael P Snyder
Vittorio Sebastiano
Vadim N Gladyshev
Affiliated Authors:
Daniel W Belsky
Alan A Cohen
Columbia Affiliation:
Subjects:
Longevity (MeSH)
Aging (MeSH)
Publication Type:
Article
Unique ID:
10.1016/j.cell.2023.08.003
PMID:
37657418
DOI:
10.1016/j.cell.2023.08.003
Journal:
Cell
Publication Date:
Data Source:
PubMed
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Metal mixtures and DNA methylation measures of biological aging in American Indian populations

Boyer, K., Domingo-Relloso, A., Jiang, E., Haack, K., Goessler, W., Zhang, Y., Umans, J. G., Belsky, D. W., Cole, S. A., Navas-Acien, A., & Kupsco, A. (2023). Metal mixtures and DNA methylation measures of biological aging in American Indian populations. Environment International, 178, 108064. https://doi.org/10.1016/j.envint.2023.108064
Authors:
Kaila Boyer
Arce Domingo-Relloso
Enoch Jiang
Karin Haack
Walter Goessler
Ying Zhang
Jason G Umans
Daniel W Belsky
Shelley A Cole
Ana Navas-Acien
Allison Kupsco
Affiliated Authors:
Kaila Boyer
Arce Domingo-Relloso
Enoch Jiang
Daniel W Belsky
Ana Navas-Acien
Allison Kupsco
Columbia Affiliation:
Subjects:
Aging (MeSH)
DNA Methylation (MeSH)
Metals (MeSH)
Author Keywords:
american indians
dna methylation
epigenetic age acceleration
epigenetic clocks
metals exposure
Grants:
R01HL109284 (NIH – National Heart, Lung, and Blood Institute)
R01HL109315 (NIH – National Heart, Lung, and Blood Institute)
R01HL109319 (NIH – National Heart, Lung, and Blood Institute)
R01HL090863 (NIH – National Heart, Lung, and Blood Institute)
R01HL109282 (NIH – National Heart, Lung, and Blood Institute)
R01HL109301 (NIH – National Heart, Lung, and Blood Institute)
P42ES033719 (NIH – National Institute of Environmental Health Sciences)
P30ES009089 (NIH – National Institute of Environmental Health Sciences)
R01ES021367 (NIH – National Institute of Environmental Health Sciences)
R01ES025216 (NIH – National Institute of Environmental Health Sciences)
R25ES025505 (NIH – National Institute of Environmental Health Sciences)
Publication Type:
Article
Unique ID:
10.1016/j.envint.2023.108064
PMID:
37364305
DOI:
10.1016/j.envint.2023.108064
Journal:
Environment International
Publication Date:
Data Source:
PubMed
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Spatial mapping of cellular senescence: emerging challenges and opportunities

Gurkar, A. U., Gerencser, A. A., Mora, A. L., Nelson, A. C., Zhang, A. R., Lagnado, A. B., Enninful, A., Benz, C., Furman, D., Beaulieu, D., Jurk, D., Thompson, E. L., Wu, F., Rodriguez, F., Barthel, G., Chen, H., Phatnani, H., Heckenbach, I., Chuang, J. H., … Passos, J. F. (2023). Spatial mapping of cellular senescence: emerging challenges and opportunities. Nature Aging, 3(7), 776–790. https://doi.org/10.1038/s43587-023-00446-6
Authors:
Aditi U Gurkar
Akos A Gerencser
Ana L Mora
Andrew C Nelson
Anru R Zhang
Anthony B Lagnado
Archibald Enninful
Christopher Benz
David Furman
Delphine Beaulieu
Diana Jurk
Elizabeth L Thompson
Fei Wu
Fernanda Rodriguez
Grant Barthel
Hao Chen
Hemali Phatnani
Indra Heckenbach
Jeffrey H Chuang
Jeremy Horrell
Joana Petrescu
Jonathan K Alder
Jun Hee Lee
Laura J Niedernhofer
Manoj Kumar
Melanie Königshoff
Marta Bueno
Miiko Sokka
Morten Scheibye-Knudsen
Nicola Neretti
Oliver Eickelberg
Peter D Adams
Qianjiang Hu
Quan Zhu
Rebecca A Porritt
Runze Dong
Samuel Peters
Stella Victorelli
Thomas Pengo
Timur Khaliullin
Vidyani Suryadevara
Xiaonan Fu
Ziv Bar-Joseph
Zhicheng Ji
João F Passos
Affiliated Authors:
Hemali Phatnani
Joana Petrescu
Columbia Affiliation:
Subjects:
Cellular Senescence (MeSH)
Aging (MeSH)
Grants:
U24CA268108 (NIH – National Cancer Institute)
UG3CA268096 (NIH – National Cancer Institute)
UG3CA268091 (NIH – National Cancer Institute)
UH3CA268091 (NIH – National Cancer Institute)
UG3CA268202 (NIH – National Cancer Institute)
UG3CA268103 (NIH – National Cancer Institute)
UG3CA268112 (NIH – National Cancer Institute)
U54AG076041 (NIH – National Institute On Aging)
U54AG075936 (NIH – National Institute On Aging)
U54AG075931 (NIH – National Institute On Aging)
U54AG076040 (NIH – National Institute On Aging)
U54AG079758 (NIH – National Institute On Aging)
U54AG075932 (NIH – National Institute On Aging)
U54AG075941 (NIH – National Institute On Aging)
Publication Type:
Article
Unique ID:
10.1038/s43587-023-00446-6
PMID:
37400722
DOI:
10.1038/s43587-023-00446-6
Journal:
Nature Aging
Publication Date:
Data Source:
PubMed
Source Link:
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Mitigating age-related somatic mutation burden

Vijg, J., Schumacher, B., Abakir, A., Antonov, M., Bradley, C., Cagan, A., Church, G., Gladyshev, V. N., Gorbunova, V., Maslov, A. Y., Reik, W., Sharifi, S., Suh, Y., & Walsh, K. (2023). Mitigating age-related somatic mutation burden. Trends in Molecular Medicine, 29(7), 530–540. https://doi.org/10.1016/j.molmed.2023.04.002
Authors:
Jan Vijg
Björn Schumacher
Abdulkadir Abakir
Michael Antonov
Chris Bradley
Alex Cagan
George Church
Vadim N Gladyshev
Vera Gorbunova
Alexander Y Maslov
Wolf Reik
Samim Sharifi
Yousin Suh
Kenneth Walsh
Affiliated Authors:
Yousin Suh
Columbia Affiliation:
Subjects:
Aging (MeSH)
DNA Repair (MeSH)
Author Keywords:
aging
cancer
chromatin organization
clonal hematopoiesis
germline versus somatic genome
somatic mutations
Grants:
P01AG047200 (NIH – National Institute On Aging)
Publication Type:
Article
Unique ID:
10.1016/j.molmed.2023.04.002
PMID:
37121869
DOI:
10.1016/j.molmed.2023.04.002
Journal:
Trends in Molecular Medicine
Publication Date:
Data Source:
PubMed
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Taurine deficiency as a driver of aging

Singh, P., Gollapalli, K., Mangiola, S., Schranner, D., Yusuf, M. A., Chamoli, M., Shi, S. L., Lopes Bastos, B., Nair, T., Riermeier, A., Vayndorf, E. M., Wu, J. Z., Nilakhe, A., Nguyen, C. Q., Muir, M., Kiflezghi, M. G., Foulger, A., Junker, A., Devine, J., … Yadav, V. K. (2023). Taurine deficiency as a driver of aging. Science, 380(6649). https://doi.org/10.1126/science.abn9257
Authors:
Parminder Singh
Kishore Gollapalli
Stefano Mangiola
Daniela Schranner
Mohd Aslam Yusuf
Manish Chamoli
Sting L. Shi
Bruno Lopes-Bastos
Tripti Nair
Annett Riermeier
Elena Vayndorf
Judy Wu
Aishwarya Nilakhe
Christina Q. Nguyen
Michael Muir
Michael G. Kiflezghi
Anna Foulger
Alex Junker
Jack Devine
Kunal Sharan
Shankar J. Chinta
Swati Rajput
Anand Rane
Philipp Baumert
Martin Schönfelder
Francescopaolo Iavarone
Giorgia Di Lorenzo
Swati Kumari
Apurba Gupta
Rajesh Sarkar
Costerwell Khyriem
Amanpreet Singh Chawla
Ankur Sharma
Nazan Sarper
Naibedya Chattopadhyay
B.K. Biswal
Carmine Settembre
Perumal Nagarajan
Kimara L. Targoff
Martin Picard
Sarika Gupta
Vidya Velagapudi
Anthony T. Papenfuss
Alaattin Kaya
Miguel Godinho Ferreira
Brian K. Kennedy
Julie K. Andersen
Gordon J. Lithgow
Abdullah Mahmood Ali
Arnab Mukhopadhyay
Aarno Palotie
Gabi Kastenmüller
Matt Kaeberlein
Henning Wackerhage
Bhupinder Pal
Vijay K. Yadav
Affiliated Authors:
Kishore Gollapalli
Sting L. Shi
Alex Junker
Jack Devine
Kimara L. Targoff
Martin Picard
Abdullah Mahmood Ali
Vijay K. Yadav
Columbia Affiliation:
Subjects:
Aging (MeSH)
Taurine (MeSH)
Cellular Response to Osmotic Stress and Metabolism (OpenAlex Topic)
Brown Adipose Tissue Function and Physiology (OpenAlex Topic)
Physiology and Pathophysiology of Carnosine (OpenAlex Topic)
Grants:
R01HD107574 (NIH – Eunice Kennedy Shriver National Institute of Child Health & Human Development)
P30AG013280 (NIH – National Institute On Aging)
T32AG066574 (NIH – National Institute On Aging)
Publication Type:
Article
Unique ID:
10.1126/science.abn9257
PMID:
37289866
DOI:
10.1126/science.abn9257
Journal:
Science
Publication Date:
Data Source:
OpenAlex
Source Link:
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Record Created:

CSV