Center for Translational and Computational Neuroimmunology

Displaying 1 - 50 of 136CSV
Arnold, M., Buyukozkan, M., Doraiswamy, P. M., Nho, K., Wu, T., Gudnason, V., Launer, L. J., Wang-Sattler, R., Adamski, J., De Jager, P. L., Ertekin-Taner, N., Bennett, D. A., Saykin, A. J., Peters, A., Suhre, K., Kaddurah-Daouk, R., Kastenmüller, G., & Krumsiek, J. (2025). Individual bioenergetic capacity as a potential source of resilience to Alzheimer’s disease. Nature Communications, 16(1). https://doi.org/10.1038/s41467-025-57032-0
Publication Date
Lee, H., Pearse, R. V., Lish, A. M., Pan, C., Augur, Z. M., Terzioglu, G., Gaur, P., Liao, M., Fujita, M., Tio, E. S., Duong, D. M., Felsky, D., Seyfried, N. T., Menon, V., Bennett, D. A., De Jager, P. L., & Young‐Pearse, T. L. (2025). Contributions of Genetic Variation in Astrocytes to Cell and Molecular Mechanisms of Risk and Resilience to Late‐Onset Alzheimer’s Disease. Glia. Portico. https://doi.org/10.1002/glia.24677
Publication Date
Simani, L., Tozlu, C., Lee, S., Dworkin, J., Ratzan, A. S., Buyukturkoglu, K., Onomichi, K., Mata, J., Riley, C. S., & Leavitt, V. M. (2025). Longitudinal investigation of neuroimaging changes related to memory decline in multiple sclerosis: Testing a mechanistic model. Multiple Sclerosis Journal, 31(2), 207–217. https://doi.org/10.1177/13524585241303491
Publication Date
Heneka, M. T., van der Flier, W. M., Jessen, F., Hoozemanns, J., Thal, D. R., Boche, D., Brosseron, F., Teunissen, C., Zetterberg, H., Jacobs, A. H., Edison, P., Ramirez, A., Cruchaga, C., Lambert, J.-C., Laza, A. R., Sanchez-Mut, J. V., Fischer, A., Castro-Gomez, S., Stein, T. D., … Riechers, S.-P. (2024). Neuroinflammation in Alzheimer disease. Nature Reviews Immunology. https://doi.org/10.1038/s41577-024-01104-7
Publication Date
Wu, Y., Libby, J. B., Dumitrescu, L., De Jager, P. L., Menon, V., Schneider, J. A., Bennett, D. A., & Hohman, T. J. (2024). Association of ten VEGF family genes with Alzheimer’s disease endophenotypes at single cell resolution. Alzheimer’s & Dementia. Portico. https://doi.org/10.1002/alz.14419
Publication Date
Wang, T., Archer, D. B., Ali, M., Wu, Y., Mormino, E., Buckley, R. F., Lee, A. J., Saykin, A. J., De Jager, P. L., Schneider, J. A., Bennett, D. A., Barnes, L. L., Vardarajan, B. N., Mayeux, R., Kunkle, B. W., Bush, W. S., Keene, C. D., Seshadri, S., … Sperling, R. A. (2024). Multimodal Genetic Analysis of Brain Amyloidosis. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.090566
Publication Date
McIntire, L. B., Mares, J., Costa, A. P., Lazarian, A., Wartchow, K. M., Dartora, W., Nuriel, T., & Menon, V. (2024). Commonalities in the lipid profile shift in ApoE ε4 risk variant and mild cognitive impairment highlight acyl chain remodeling. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.087508
Publication Date
Grodstein, F., Lemos, B., Yang, J., de Paiva Lopes, K., Vialle, R. A., Seyfried, N., Wang, Y., Shireby, G., Hannon, E., Thomas, A., Brookes, K., Mill, J., De Jager, P. L., & Bennett, D. A. (2024). Genetic architecture of epigenetic cortical clock age in brain tissue from older individuals: alterations in CD46 and other loci. Epigenetics, 19(1). https://doi.org/10.1080/15592294.2024.2392050
Publication Date
Tayran, H., Yilmaz, E., Bhattarai, P., Min, Y., Wang, X., Ma, Y., Nelson, N., Kassara, N., Cosacak, M. I., Dogru, R. M., Reyes‐Dumeyer, D., Reddy, J. S., Qiao, M. N., Flaherty, D., Yang, Z., Gunasekaran, T. I., Teich, A. F., Vardarajan, B. N., Tosto, G., … Kizil, C. (2024). ABCA7‐dependent Neuropeptide‐Y signalling is a resilience mechanism required for synaptic integrity in Alzheimer’s disease. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.089273
Publication Date
Taga, M., Fujita, M., Parghi, N., & De Jager, P. L. (2024). Automated image segmentation uncovers the association of a microglial subtype defined by High CD74 Expression with cognitive decline. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.092664
Publication Date
Gomez, M. L., Beecham, G., Montine, T. J., Cuccaro, M. L., Toga, A. W., Keene, C. D., Crane, P. K., Mukherjee, S., Panizzon, M. S., Biber, S. A., Kukull, W. A., Bennett, D. A., Barnes, L. L., Schneider, J. A., De Jager, P. L., Menon, V., Hohman, T. J., & Dumitrescu, L. C. (2024). Sex Specific Association of Apolipoprotein E Alleles with Autopsy Measures of Arteriolosclerosis and Atherosclerosis among Older Adults. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.091485
Publication Date
Lee, A. J., Cui, Z., Song, Z., Reyes‐Dumeyer, D., De Jager, P. L., Bennett, D. A., Schneider, J. A., Menon, V., Wang, Y., Lantigua, R. A., Medrano, M., Mejia, D. R., Jiménez‐Velázquez, I. Z., Kukull, W. A., Biber, S. A., Brickman, A. M., Tosto, G., Kizil, C., Farrer, L. A., … Mayeux, R. (2024). Multi‐ancestry Genome‐wide Gene‐Vascular Risk Factors Interaction Analyses in Alzheimer’s Disease. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.093041
Publication Date
Reddy, J. S., Heath, L. M., Allen, M., Poehlman, W. L., Wang, Y., Johnson, R., Wang, E., Ma, Y., Ho, C. C. G., Lopes, K. de P., Linden, A. V., Quicksall, Z., Chen, X., Baheti, S., Nguyen, T., Yepez‐Sisalema, G., Mitchell, A. O., Oatman, S. R., … Wang, X. (2024). Multi‐omics profiling of Alzheimer’s disease in multi‐ethnic populations. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.090590
Publication Date
Luquez, T., Sreenivas, D., Bennett, D. A., De Jager, P. L., & Menon, V. (2024). Cell type‐specific signatures of resilience to cognitive decline in the presence of brain pathologies. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.088929
Publication Date
Libby, J. B., Beecham, G., Montine, T. J., Toga, A. W., Cuccaro, M. L., Keene, C. D., Larson, E. B., Crane, P. K., Mukherjee, S., Panizzon, M. S., Biber, S. A., Kukull, W. A., Bennett, D. A., Schneider, J. A., Barnes, L. L., De Jager, P. L., Menon, V., Hohman, T. J., & Dumitrescu, L. C. (2024). Genetically predicted levels of sex hormones are associated with cerebrovascular disease pathology in the Alzheimer’s disease brain. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.092453
Publication Date
Chatila, Z. K., Mares, J., Vardarajan, B. N., Elyaman, W., Menon, V., & Bradshaw, E. M. (2024). Microglial Activation Alters Chromatin Accessibility of AD‐Associated Transcription Factors. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.085990
Publication Date
Wu, Y., Dumitrescu, L. C., De Jager, P. L., Menon, V., Schneider, J. A., Bennett, D. A., & Hohman, T. J. (2024). Cell‐type specific contribution to sex differences in Alzheimer’s Disease revealed using single‐cell transcriptomes. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.092518
Publication Date
Roy, N., Haq, I., Ngo, J. C., Bennett, D. A., Teich, A. F., De Jager, P. L., Olah, M., & Sher, F. (2024). Elevated expression of the retrotransposon LINE-1 drives Alzheimer’s disease-associated microglial dysfunction. Acta Neuropathologica, 148(1). https://doi.org/10.1007/s00401-024-02835-6
Publication Date
Protopapa, M., Steffen, F., Schraad, M., Ruck, T., Öztürk, M., Hanuscheck, N., Shin, J., Brummer, T., Pape, K., Uphaus, T., Meuth, S. G., Fleischer, V., Teunissen, C. E., De Jager, P. L., Luessi, F., Bittner, S., & Zipp, F. (2024). Increased Disability Progression in rs10191329AA Carriers with Multiple Sclerosis Is Preceded by Neurofilament Light Chain Elevations. Annals of Neurology. Portico. https://doi.org/10.1002/ana.27144
Publication Date
Fowler, S. L., Behr, T. S., Turkes, E., O’Brien, D. P., Cauhy, P. M., Rawlinson, I., Edmonds, M., Foiani, M. S., Schaler, A., Crowley, G., Bez, S., Ficulle, E., Tsefou, E., Fischer, R., Geary, B., Gaur, P., Miller, C., D’Acunzo, P., Levy, E., … Ryskeldi-Falcon, B. (2024). Tau filaments are tethered within brain extracellular vesicles in Alzheimer’s disease. Nature Neuroscience. https://doi.org/10.1038/s41593-024-01801-5
Publication Date
Buonfiglioli, A., Kübler, R., Missall, R., De Jong, R., Chan, S., Haage, V., Wendt, S., Lin, A. J., Mattei, D., Graziani, M., Latour, B., Gigase, F., Chiu, R., Zhang, Y., Nygaard, H. B., De Jager, P. L., & De Witte, L. D. (2025). A microglia-containing cerebral organoid model to study early life immune challenges. Brain, Behavior, and Immunity, 123, 1127–1146. https://doi.org/10.1016/j.bbi.2024.11.008
Publication Date
García-Marín, L. M., Campos, A. I., Diaz-Torres, S., Rabinowitz, J. A., Ceja, Z., Mitchell, B. L., Grasby, K. L., Thorp, J. G., Agartz, I., Alhusaini, S., Ames, D., Amouyel, P., Andreassen, O. A., Arfanakis, K., Arias-Vasquez, A., Armstrong, N. J., Athanasiu, L., Bastin, M. E., Beiser, A. S., … Rentería, M. E. (2024). Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries. Nature Genetics, 56(11), 2333–2344. https://doi.org/10.1038/s41588-024-01951-z
Publication Date
Lee, W., Choi, S. H., Shea, M. G., Cheng, P., Dombroski, B. A., Pitsillides, A. N., Heard‐Costa, N. L., Wang, H., Bulekova, K., Kuzma, A. B., Leung, Y. Y., Farrell, J. J., Lin, H., Kunkle, B. W., Naj, A., Blue, E. E., Nusetor, F., Wang, D., Boerwinkle, E., … Peloso, G. M. (2024). Association of common and rare variants with Alzheimer’s disease in more than 13,000 diverse individuals with whole‐genome sequencing from the Alzheimer’s Disease Sequencing Project. Alzheimer’s & Dementia. Portico. https://doi.org/10.1002/alz.14283
Publication Date
Tuddenham, J. F., Taga, M., Haage, V., Marshe, V. S., Roostaei, T., White, C., Lee, A. J., Fujita, M., Khairallah, A., Zhang, Y., Green, G., Hyman, B., Frosch, M., Hopp, S., Beach, T. G., Serrano, G. E., Corboy, J., Habib, N., Klein, H.-U., … De Jager, P. L. (2024). A cross-disease resource of living human microglia identifies disease-enriched subsets and tool compounds recapitulating microglial states. Nature Neuroscience, 27(12), 2521–2537. https://doi.org/10.1038/s41593-024-01764-7
Publication Date
Jones, A. A., Ramos‐Miguel, A., Gicas, K. M., Petyuk, V. A., Leurgans, S. E., De Jager, P. L., Schneider, J. A., Bennett, D. A., Honer, W. G., & Casaletto, K. B. (2024). A multilayer network analysis of Alzheimer’s disease pathogenesis: Roles for p‐tau, synaptic peptides, and physical activity. Alzheimer’s & Dementia, 20(11), 8012–8027. Portico. https://doi.org/10.1002/alz.14286
Publication Date
Kelly, C., Trumpff, C., Acosta, C., Assuras, S., Baker, J., Basarrate, S., Behnke, A., Bo, K., Bobba-Alves, N., Champagne, F. A., Conklin, Q., Cross, M., De Jager, P., Engelstad, K., Epel, E., Franklin, S. G., Hirano, M., Huang, Q., Junker, A., … Picard, M. (2024). A platform to map the mind–mitochondria connection and the hallmarks of psychobiology: the MiSBIE study. Trends in Endocrinology & Metabolism, 35(10), 884–901. https://doi.org/10.1016/j.tem.2024.08.006
Publication Date
Nho, K., Risacher, S. L., Apostolova, L. G., Bice, P. J., Brosch, J. R., Deardorff, R., Faber, K., Farlow, M. R., Foroud, T., Gao, S., Rosewood, T., Kim, J. P., Nudelman, K., Yu, M., Aisen, P., Sperling, R., Hooli, B., Shcherbinin, S., Svaldi, D., … Saykin, A. J. (2024). CYP1B1-RMDN2 Alzheimer’s disease endophenotype locus identified for cerebral tau PET. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-52298-2
Publication Date
Straus Farber, R., Walker, E. L., Diallo, F., Onomichi, K., Riley, C., Zhang, L., Zhu, W., De Jager, P. L., & Xia, Z. (2024). A randomized cross-over trial of prebiotics and probiotics in multiple sclerosis: Trial feasibility, supplement tolerability and symptom abatement. Multiple Sclerosis and Related Disorders, 89, 105762. https://doi.org/10.1016/j.msard.2024.105762
Publication Date
Bebo, B. F., Banwell, B. L., Whitacre, C. C., Coetzee, T., Dalgas, U., De Jager, P. L., Proebstel, A.-K., Yong, V. W., Benveniste, E. N., & Thompson, A. J. (2024). The refined Pathways to Cures Research Roadmap for multiple sclerosis cures. Multiple Sclerosis Journal, 30(10), 1242–1251. https://doi.org/10.1177/13524585241266483
Publication Date
Green, G. S., Fujita, M., Yang, H.-S., Taga, M., Cain, A., McCabe, C., Comandante-Lou, N., White, C. C., Schmidtner, A. K., Zeng, L., Sigalov, A., Wang, Y., Regev, A., Klein, H.-U., Menon, V., Bennett, D. A., Habib, N., & De Jager, P. L. (2024). Cellular communities reveal trajectories of brain ageing and Alzheimer’s disease. Nature, 633(8030), 634–645. https://doi.org/10.1038/s41586-024-07871-6
Publication Date
Chen, Q., Aguirre, L., Liang, G., Zhao, H., Dong, T., Borrego, F., de Rojas, I., Hu, Q., Reyes, C., Su, L.-Y., Zhang, B., Lechleiter, J. D., Göring, H. H. H., De Jager, P. L., Kleinman, J. E., Hyde, T. M., Li, P. P., Ruiz, A., Weinberger, D. R., … Ma, L. (2024). Identification of a specific APOE transcript and functional elements associated with Alzheimer’s disease. Molecular Neurodegeneration, 19(1). https://doi.org/10.1186/s13024-024-00751-7
Publication Date
Pavešković, M., De-Paula, R. B., Ojelade, S. A., Tantry, E. K., Kochukov, M. Y., Bao, S., Veeraragavan, S., Garza, A. R., Srivastava, S., Song, S.-Y., Fujita, M., Duong, D. M., Bennett, D. A., De Jager, P. L., Seyfried, N. T., Dickinson, M. E., Heaney, J. D., Arenkiel, B. R., & Shulman, J. M. (2024). Alzheimer’s disease risk gene CD2AP is a dose-sensitive determinant of synaptic structure and plasticity. Human Molecular Genetics. https://doi.org/10.1093/hmg/ddae115
Publication Date
Li, J., Capuano, A. W., Agarwal, P., Arvanitakis, Z., Wang, Y., De Jager, P. L., Schneider, J. A., Tasaki, S., de Paiva Lopes, K., Hu, F. B., Bennett, D. A., Liang, L., & Grodstein, F. (2024). The MIND diet, brain transcriptomic alterations, and dementia. Alzheimer’s & Dementia, 20(9), 5996–6007. Portico. https://doi.org/10.1002/alz.14062
Publication Date
Parrish, R. L., Buchman, A. S., Tasaki, S., Wang, Y., Avey, D., Xu, J., De Jager, P. L., Bennett, D. A., Epstein, M. P., & Yang, J. (2024). SR-TWAS: leveraging multiple reference panels to improve transcriptome-wide association study power by ensemble machine learning. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-50983-w
Publication Date
Kharaghani, A., Tio, E. S., Milic, M., Bennett, D. A., De Jager, P. L., Schneider, J. A., Sun, L., & Felsky, D. (2024). Association of whole-person eigen-polygenic risk scores with Alzheimer’s disease. Human Molecular Genetics, 33(15), 1315–1327. https://doi.org/10.1093/hmg/ddae067
Publication Date
Deffner, M., Schneider-Hohendorf, T., Schulte-Mecklenbeck, A., Falk, S., Lu, I.-N., Ostkamp, P., Müller-Miny, L., Schumann, E. M., Goelz, S., Cahir-McFarland, E., Thakur, K. T., De Jager, P. L., Klotz, L., Meyer zu Hörste, G., Gross, C. C., Wiendl, H., Grauer, O. M., & Schwab, N. (2024). Chemokine-mediated cell migration into the central nervous system in progressive multifocal leukoencephalopathy. Cell Reports Medicine, 5(7), 101622. https://doi.org/10.1016/j.xcrm.2024.101622
Publication Date
Wang, Q., Antone, J., Alsop, E., Reiman, R., Funk, C., Bendl, J., Dudley, J. T., Liang, W. S., Karr, T. L., Roussos, P., Bennett, D. A., De Jager, P. L., Serrano, G. E., Beach, T. G., Van Keuren-Jensen, K., Mastroeni, D., Reiman, E. M., & Readhead, B. P. (2024). Single cell transcriptomes and multiscale networks from persons with and without Alzheimer’s disease. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-49790-0
Publication Date
Chia, R., Ray, A., Shah, Z., Ding, J., Ruffo, P., Fujita, M., Menon, V., Saez-Atienzar, S., Reho, P., Kaivola, K., Walton, R. L., Reynolds, R. H., Karra, R., Sait, S., Akcimen, F., Diez-Fairen, M., Alvarez, I., Fanciulli, A., Stefanova, N., … Scholz, S. W. (2024). Genome sequence analyses identify novel risk loci for multiple system atrophy. Neuron, 112(13), 2142-2156.e5. https://doi.org/10.1016/j.neuron.2024.04.002
Publication Date
Oveisgharan, S., Yu, L., de Paiva Lopes, K., Tasaki, S., Wang, Y., Menon, V., Schneider, J. A., Seyfried, N. T., & Bennett, D. A. (2024). Proteins linking APOE ɛ4 with Alzheimer’s disease. Alzheimer’s & Dementia, 20(7), 4499–4511. Portico. https://doi.org/10.1002/alz.13867
Publication Date
Mares, J., Costa, A. P., Dartora, W. J., Wartchow, K. M., Lazarian, A., Bennett, D. A., Nuriel, T., Menon, V., & McIntire, L. B. J. (2024). Brain and serum lipidomic profiles implicate Lands cycle acyl chain remodeling association with APOEε4 and mild cognitive impairment. Frontiers in Aging Neuroscience, 16. https://doi.org/10.3389/fnagi.2024.1419253
Publication Date
Qu, W., Lam, M., McInvale, J. J., Mares, J. A., Kwon, S., Humala, N., Mahajan, A., Nguyen, T., Jakubiak, K. A., Mun, J.-Y., Tedesco, T. G., Al-Dalahmah, O., Hussaini, S. A., Sproul, A. A., Siegelin, M. D., De Jager, P. L., Canoll, P., Menon, V., & Hargus, G. (2024). Xenografted human iPSC-derived neurons with the familial Alzheimer’s disease APPV717I mutation reveal dysregulated transcriptome signatures linked to synaptic function and implicate LINGO2 as a disease signaling mediator. Acta Neuropathologica, 147(1). https://doi.org/10.1007/s00401-024-02755-5
Publication Date
Trumpff, C., Monzel, A. S., Sandi, C., Menon, V., Klein, H.-U., Fujita, M., Lee, A., Petyuk, V. A., Hurst, C., Duong, D. M., Seyfried, N. T., Wingo, A. P., Wingo, T. S., Wang, Y., Thambisetty, M., Ferrucci, L., Bennett, D. A., De Jager, P. L., & Picard, M. (2024). Psychosocial experiences are associated with human brain mitochondrial biology. Proceedings of the National Academy of Sciences, 121(27). https://doi.org/10.1073/pnas.2317673121
Publication Date
Suryadevara, V., Hudgins, A. D., Rajesh, A., Pappalardo, A., Karpova, A., Dey, A. K., Hertzel, A., Agudelo, A., Rocha, A., Soygur, B., Schilling, B., Carver, C. M., Aguayo-Mazzucato, C., Baker, D. J., Bernlohr, D. A., Jurk, D., Mangarova, D. B., Quardokus, E. M., Enninga, E. A. L., … Neretti, N. (2024). SenNet recommendations for detecting senescent cells in different tissues. Nature Reviews Molecular Cell Biology. https://doi.org/10.1038/s41580-024-00738-8
Publication Date
Yang, M., Matan-Lithwick, S., Wang, Y., De Jager, P. L., Bennett, D. A., & Felsky, D. (2023). Multi-omic integration via similarity network fusion to detect molecular subtypes of ageing. Brain Communications, 5(2). https://doi.org/10.1093/braincomms/fcad110
Publication Date
Oveisgharan, S., Yu, L., de Paiva Lopes, K., Petyuk, V. A., Tasaki, S., Vialle, R., Menon, V., Wang, Y., De Jager, P. L., Schneider, J. A., & Bennett, D. A. (2024). G-protein coupled estrogen receptor 1, amyloid-β, and tau tangles in older adults. Communications Biology, 7(1). https://doi.org/10.1038/s42003-024-06272-9
Publication Date
Lincoln, M. R., Connally, N., Axisa, P.-P., Gasperi, C., Mitrovic, M., van Heel, D., Wijmenga, C., Withoff, S., Jonkers, I. H., Padyukov, L., Beecham, A. H., Patsopoulos, N. A., Cotsapas, C., Booth, D., Goris, A., Oturai, A., Saarela, J., Fontaine, B., … Cotsapas, C. (2024). Genetic mapping across autoimmune diseases reveals shared associations and mechanisms. Nature Genetics, 56(5), 838–845. https://doi.org/10.1038/s41588-024-01732-8
Publication Date