Regulatory T Cell Development and Function

Displaying 1 - 49 of 49CSV
Caron, D. P., Specht, W. L., Chen, D., Wells, S. B., Szabo, P. A., Jensen, I. J., Farber, D. L., & Sims, P. A. (2025). Multimodal hierarchical classification of CITE-seq data delineates immune cell states across lineages and tissues. Cell Reports Methods, 5(1), 100938. https://doi.org/10.1016/j.crmeth.2024.100938
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Diehl, C., Soberón, V., Baygün, S., Chu, Y., Mandelbaum, J., Kraus, L., Engleitner, T., Rudelius, M., Fangazio, M., Daniel, C., Bortoluzzi, S., Helmrath, S., Singroul, P., Gölling, V., Osorio Barrios, F., Seyhan, G., Oßwald, L., Kober-Hasslacher, M., Zeng, T., … Schmidt-Supprian, M. (2024). Hyperreactive B cells instruct their elimination by T cells to curb autoinflammation and lymphomagenesis. Immunity. https://doi.org/10.1016/j.immuni.2024.11.023
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Hertel, A., Aguiar, T., Mashiko, S., Núñez, S., Moore, C., Gao, B., Ausmeier, M., Roy, P., & Zorn, E. (2024). Clones reactive to apoptotic cells and specific chemical adducts are prevalent among human thymic B cells. Frontiers in Immunology, 15. https://doi.org/10.3389/fimmu.2024.1462126
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Bullock, M. E., Hogan, T., Williams, C., Morris, S., Nowicka, M., Sharjeel, M., van Dorp, C., Yates, A. J., & Seddon, B. (2024). The dynamics and longevity of circulating CD4+ memory T cells depend on cell age and not the chronological age of the host. PLOS Biology, 22(8), e3002380. https://doi.org/10.1371/journal.pbio.3002380
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Firdessa-Fite, R., Johnson, S. N., Bechi Genzano, C., Leon, M. A., Ku, A., Ocampo Gonzalez, F. A., Milner, J. D., Sestak, J. O., Berkland, C., & Creusot, R. J. (2024). Soluble antigen arrays provide increased efficacy and safety over free peptides for tolerogenic immunotherapy. Frontiers in Immunology, 15. https://doi.org/10.3389/fimmu.2024.1258369
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Gray, J. I., Caron, D. P., Wells, S. B., Guyer, R., Szabo, P., Rainbow, D., Ergen, C., Rybkina, K., Bradley, M. C., Matsumoto, R., Pethe, K., Kubota, M., Teichmann, S., Jones, J., Yosef, N., Atkinson, M., Brusko, M., Brusko, T. M., Connors, T. J., … Farber, D. L. (2024). Human γδ T cells in diverse tissues exhibit site-specific maturation dynamics across the life span. Science Immunology, 9(96). https://doi.org/10.1126/sciimmunol.adn3954
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Randolph, H. E., Aracena, K. A., Lin, Y., Mu, Z., & Barreiro, L. B. (2024). Shaping immunity: The influence of natural selection on population immune diversity. Immunological Reviews, 323(1), 227–240. Portico. https://doi.org/10.1111/imr.13329
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Benavente, M. C. R., Hakeem, Z. A., Davis, A. R., Murray, N. B., Azadi, P., Mace, E. M., & Barb, A. W. (2024). Distinct CD16a features on human NK cells observed by flow cytometry correlate with increased ADCC. Scientific Reports, 14(1). https://doi.org/10.1038/s41598-024-58541-6
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He, S., Jin, Y., Nazaret, A., Shi, L., Chen, X., Rampersaud, S., Dhillon, B. S., Valdez, I., Friend, L. E., Fan, J. L., Park, C. Y., Mintz, R. L., Lao, Y.-H., Carrera, D., Fang, K. W., Mehdi, K., Rohde, M., McFaline-Figueroa, J. L., Blei, D., … Azizi, E. (2024). Starfysh integrates spatial transcriptomic and histologic data to reveal heterogeneous tumor–immune hubs. Nature Biotechnology. https://doi.org/10.1038/s41587-024-02173-8
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Gartshteyn, Y., Geraldino-Pardilla, L., Khalili, L., Bukhari, S., Lerrer, S., Winchester, R. J., Askanase, A. D., & Mor, A. (2024). SAP-expressing T peripheral helper cells identify systemic lupus erythematosus patients with lupus nephritis. Frontiers in Immunology, 15. https://doi.org/10.3389/fimmu.2024.1327437
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Babushku, T., Lechner, M., Ehrenberg, S., Rambold, U., Schmidt-Supprian, M., Yates, A. J., Rane, S., Zimber-Strobl, U., & Strobl, L. J. (2024). Notch2 controls developmental fate choices between germinal center and marginal zone B cells upon immunization. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-46024-1
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Tenggara, M. K., Oh, S.-H., Yang, C., Nariya, H. K., Metz, A. M., Upadhyay, A. A., Gudipati, D. R., Guo, L., McGhee, E. G., Gill, K., Viox, E. G., Mason, R. D., Doria-Rose, N. A., Foulds, K. E., Mascola, J. R., Du, Y., Fu, H., Altman, J. D., Yan, Q., … Kong, R. (2024). Frequency-potency analysis of IgG+ memory B cells delineates neutralizing antibody responses at single-cell resolution. Cell Reports, 43(3), 113948. https://doi.org/10.1016/j.celrep.2024.113948
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Straube, J., Bukhari, S., Lerrer, S., Winchester, R. J., Gartshteyn, Y., Henick, B. S., Dragovich, M. A., & Mor, A. (2024). PD-1 signaling uncovers a pathogenic subset of T cells in inflammatory arthritis. Arthritis Research & Therapy, 26(1). https://doi.org/10.1186/s13075-023-03259-5
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Borna, Š., Lee, E., Nideffer, J., Ramachandran, A., Wang, B., Baker, J., Mavers, M., Lakshmanan, U., Narula, M., Garrett, A. K., Schulze, J., Olek, S., Marois, L., Gernez, Y., Bhatia, M., Chong, H. J., Walter, J., Kitcharoensakkul, M., Lang, A., … Bacchetta, R. (2023). Identification of unstable regulatory and autoreactive effector T cells that are expanded in patients with FOXP3 mutations. Science Translational Medicine, 15(727). https://doi.org/10.1126/scitranslmed.adg6822
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Van, N. T., Zhang, K., Wigmore, R. M., Kennedy, A. I., DaSilva, C. R., Huang, J., Ambelil, M., Villagomez, J. H., O’Connor, G. J., Longman, R. S., Cao, M., Snook, A. E., Platten, M., Kasenty, G., Sigal, L. J., Prendergast, G. C., & Kim, S. V. (2023). Dietary L-Tryptophan consumption determines the number of colonic regulatory T cells and susceptibility to colitis via GPR15. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-43211-4
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Wang, X. K., Uzuni, A., Belay, K., Harle, D. W., Gordillo, C. A., Macedo, R. J., Chakrabarti, S., Shi, L., Pressler, M., Fuller, J., Azizi, E., & Reshef, R. (2023). Characteristics of Alloreactive T-Cell Clones That Predict Early Development of Acute GvHD Following Allogeneic HCT. Blood, 142(Supplement 1), 2042–2042. https://doi.org/10.1182/blood-2023-187932
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Adeuyan, O., Gordon, E. R., Lapolla, B. A., Schreidah, C. M., Fahmy, L. M., Chen, C., & Geskin, L. J. (2023). 254 Cutaneous T-cell lymphoma and atopic dermatitis: a tale of two inflammatory skin conditions from a single cell RNA sequencing perspective. Journal of Investigative Dermatology, 143(11), S375. https://doi.org/10.1016/j.jid.2023.09.262
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Sellyei, J., Yan, X., Qiu, W., Vasilescu, E., & Vlad, G. (2023). A novel HLA‐B*58:141 allele identified by next‐generation sequencing in a potential hematopoietic cell recipient. HLA, 103(1). Portico. https://doi.org/10.1111/tan.15237
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Berton, R. R., McGonagil, P. W., Jensen, I. J., Ybarra, T. K., Bishop, G. A., Harty, J. T., Griffith, T. S., & Badovinac, V. P. (2023). Sepsis leads to lasting changes in phenotype and function of naïve CD8 T cells. PLOS Pathogens, 19(10), e1011720. https://doi.org/10.1371/journal.ppat.1011720
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Al Malki, M. M., London, K., Baez, J., Akahoshi, Y., Hogan, W. J., Etra, A., Choe, H., Hexner, E., Langston, A., Abhyankar, S., Ponce, D. M., DeFilipp, Z., Kitko, C. L., Adekola, K., Reshef, R., Ayuk, F., Capellini, A., Chanswangphuwana, C., Eder, M., … Levine, J. E. (2023). Phase 2 study of natalizumab plus standard corticosteroid treatment for high-risk acute graft-versus-host disease. Blood Advances, 7(17), 5189–5198. https://doi.org/10.1182/bloodadvances.2023009853
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Qin, Y., Mace, E. M., & Barton, J. P. (2023). An inference model gives insights into innate immune adaptation and repertoire diversity. Proceedings of the National Academy of Sciences, 120(38). https://doi.org/10.1073/pnas.2305859120
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Connors, T. J., Matsumoto, R., Verma, S., Szabo, P. A., Guyer, R., Gray, J., Wang, Z., Thapa, P., Dogra, P., Poon, M. M. L., Rybkina, K., Bradley, M. C., Idzikowski, E., McNichols, J., Kubota, M., Pethe, K., Shen, Y., Atkinson, M. A., Brusko, M., … Farber, D. L. (2023). Site-specific development and progressive maturation of human tissue-resident memory T cells over infancy and childhood. Immunity, 56(8), 1894-1909.e5. https://doi.org/10.1016/j.immuni.2023.06.008
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Lukas, E., Hogan, T., Williams, C., Seddon, B., & Yates, A. J. (2023). Quantifying cellular dynamics in mice using a novel fluorescent division reporter system. Frontiers in Immunology, 14. https://doi.org/10.3389/fimmu.2023.1157705
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Lee, E. Y., Dai, Z., Jaiswal, A., Wang, E. H. C., Anandasabapathy, N., & Christiano, A. M. (2023). Functional interrogation of lymphocyte subsets in alopecia areata using single-cell RNA sequencing. Proceedings of the National Academy of Sciences, 120(29). https://doi.org/10.1073/pnas.2305764120
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Heidarian, M., Jensen, I. J., Kannan, S. K., Pewe, L. L., Hassert, M., Park, S., Xue, H.-H., Harty, J. T., & Badovinac, V. P. (2023). Sublethal whole-body irradiation induces permanent loss and dysfunction in pathogen-specific circulating memory CD8 T cell populations. Proceedings of the National Academy of Sciences, 120(27). https://doi.org/10.1073/pnas.2302785120
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Long, K. D., & Fu, J. (2023). Chimerism and phenotypic analysis of intraepithelial and lamina propria T cells isolated from human ileal biopsies after intestinal transplantation. STAR Protocols, 4(2), 102192. https://doi.org/10.1016/j.xpro.2023.102192
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Mashiko, S., Shihab, R. R., See, S. B., Schahadat, L. G. Z., Aguiar, T. F. M., Roy, P., Porcheray, F., & Zorn, E. (2023). Broad responses to chemical adducts shape the natural antibody repertoire in early infancy. Science Advances, 9(19). https://doi.org/10.1126/sciadv.ade8872
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Rancan, C., Arias-Badia, M., Dogra, P., Chen, B., Aran, D., Yang, H., Luong, D., Ilano, A., Li, J., Chang, H., Kwek, S. S., Zhang, L., Lanier, L. L., Meng, M. V., Farber, D. L., & Fong, L. (2023). Exhausted intratumoral Vδ2− γδ T cells in human kidney cancer retain effector function. Nature Immunology, 24(4), 612–624. https://doi.org/10.1038/s41590-023-01448-7
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Gartshteyn, Y., Askanase, A. D., Song, R., Bukhari, S., Dragovich, M., Adam, K., & Mor, A. (2022). SLAMF6 compartmentalization enhances T cell functions. Life Science Alliance, 6(2), e202201533. https://doi.org/10.26508/lsa.202201533
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Poon, M. M. L., Caron, D. P., Wang, Z., Wells, S. B., Chen, D., Meng, W., Szabo, P. A., Lam, N., Kubota, M., Matsumoto, R., Rahman, A., Luning Prak, E. T., Shen, Y., Sims, P. A., & Farber, D. L. (2023). Tissue adaptation and clonal segregation of human memory T cells in barrier sites. Nature Immunology, 24(2), 309–319. https://doi.org/10.1038/s41590-022-01395-9
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Moioffer, S. J., Berton, R. R., McGonagill, P. W., Jensen, I. J., Griffith, T. S., & Badovinac, V. P. (2023). Inefficient Recovery of Repeatedly Stimulated Memory CD8 T Cells after Polymicrobial Sepsis Induction Leads to Changes in Memory CD8 T Cell Pool Composition. The Journal of Immunology, 210(2), 168–179. https://doi.org/10.4049/jimmunol.2200676
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Anandakumaran, P. N., Ayers, A. G., Muranski, P., Creusot, R. J., & Sia, S. K. (2022). Rapid video-based deep learning of cognate versus non-cognate T cell-dendritic cell interactions. Scientific Reports, 12(1). https://doi.org/10.1038/s41598-021-04286-5
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Strazza, M., Moore, E. K., Adam, K., Azoulay-Alfaguter, I., & Mor, A. (2022). Neutralization of the adaptor protein PAG by monoclonal antibody limits murine tumor growth. Molecular Therapy - Methods & Clinical Development, 27, 380–390. https://doi.org/10.1016/j.omtm.2022.10.012
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Dei Zotti, F., Moriconi, C., Qiu, A., Miller, A., & Hudson, K. E. (2022). Distinct CD4+ T cell signature in ANA-positive young adult patients. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.972127
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Gilbert, P. B., Huang, Y., deCamp, A. C., Karuna, S., Zhang, Y., Magaret, C. A., Giorgi, E. E., Korber, B., Edlefsen, P. T., Rossenkhan, R., Juraska, M., Rudnicki, E., Kochar, N., Huang, Y., Carpp, L. N., Barouch, D. H., Mkhize, N. N., Hermanus, T., Kgagudi, P., … Morris, L. (2022). Neutralization titer biomarker for antibody-mediated prevention of HIV-1 acquisition. Nature Medicine, 28(9), 1924–1932. https://doi.org/10.1038/s41591-022-01953-6
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Fu, J., Wang, Z., Martinez, M., Jiao, W., Frangaj, K., Jones, R., Guo, X. V., Zhang, Y., Kuo, W.-I., Obradovic, A., Ma, W., Rogers, K., Kato, T., Shen, Y., & Sykes, M. (2022). 425.3: Single-Cell Immune Profiling of Human Intestinal Allografts Reveals Differential Phenotypes of Alloreactive T-Cell Clones in Quiescent vs Chronically Rejecting Allografts. Transplantation, 106(9S), S485–S485. https://doi.org/10.1097/01.tp.0000888048.23424.42
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Liu, C., Lin, B., Wu, M., Song, Y., Ke, T., Chou, Y., Liu, C., Lin, C., Radojcic, V., Drake, C., & Yen, H. (2022). Adoptive transfer of IL‐4 reprogrammed Tc17 cells elicits anti‐tumour immunity through functional plasticity. Immunology, 166(3), 310–326. Portico. https://doi.org/10.1111/imm.13473
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Yang, J.-M., Ren, Y., Kumar, A., Xiong, X., Das, J. K., Peng, H.-Y., Wang, L., Ren, X., Zhang, Y., Ji, C., Cheng, Y., Zhang, L., Alaniz, R. C., de Figueiredo, P., Fang, D., Zhou, H., Liu, X., Wang, J., & Song, J. (2022). NAC1 modulates autoimmunity by suppressing regulatory T cell–mediated tolerance. Science Advances, 8(26). https://doi.org/10.1126/sciadv.abo0183
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Rane, S., Hogan, T., Lee, E., Seddon, B., & Yates, A. J. (2022). Towards a unified model of naive T cell dynamics across the lifespan. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.78168
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Domínguez Conde, C., Xu, C., Jarvis, L. B., Rainbow, D. B., Wells, S. B., Gomes, T., Howlett, S. K., Suchanek, O., Polanski, K., King, H. W., Mamanova, L., Huang, N., Szabo, P. A., Richardson, L., Bolt, L., Fasouli, E. S., Mahbubani, K. T., Prete, M., Tuck, L., … Teichmann, S. A. (2022). Cross-tissue immune cell analysis reveals tissue-specific features in humans. Science, 376(6594). https://doi.org/10.1126/science.abl5197
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Postigo-Fernandez, J., Firdessa-Fite, R., & Creusot, R. J. (2022). Preclinical evaluation of a precision medicine approach to DNA vaccination in type 1 diabetes. Proceedings of the National Academy of Sciences, 119(15). https://doi.org/10.1073/pnas.2110987119
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Snyder, M. E., Moghbeli, K., Bondonese, A., Craig, A., Popescu, I., Fan, L., Tabib, T., Lafyatis, R., Chen, K., Trejo Bittar, H. E., Lendermon, E., Pilewski, J., Johnson, B., Kilaru, S., Zhang, Y., Sanchez, P. G., Alder, J. K., Sims, P. A., & McDyer, J. F. (2022). Modulation of tissue resident memory T cells by glucocorticoids after acute cellular rejection in lung transplantation. Journal of Experimental Medicine, 219(4). https://doi.org/10.1084/jem.20212059
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Jensen, I. J., Martin, M. D., Tripathy, S. K., & Badovinac, V. P. (2022). Novel Mouse Model of Murine Cytomegalovirus–Induced Adaptive NK Cells. ImmunoHorizons, 6(1), 8–15. https://doi.org/10.4049/immunohorizons.2100113
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