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Sugimoto, A., Saito, Y., Wang, G., Sun, Q., Yin, C., Lee, K. H., Geng, Y., Rajbhandari, P., Hernandez, C., Steffani, M., Qie, J., Savage, T., Goyal, D. M., Ray, K. C., Neelakantan, T. V., Yin, D., Melms, J., Lehrich, B. M., Yasaka, T. M., … Schwabe, R. F. (2025). Hepatic stellate cells control liver zonation, size and functions via R-spondin 3. Nature. https://doi.org/10.1038/s41586-025-08677-w
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Kapadia, C. D., Williams, N., Dawson, K. J., Watson, C., Yousefzadeh, M. J., Le, D., Nyamondo, K., Kodavali, S., Cagan, A., Waldvogel, S., Zhang, X., De La Fuente, J., Leongamornlert, D., Mitchell, E., Florez, M. A., Sosnowski, K., Aguilar, R., Martell, A., Guzman, A., … Nangalia, J. (2025). Clonal dynamics and somatic evolution of haematopoiesis in mouse. Nature. https://doi.org/10.1038/s41586-025-08625-8
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Zhi, X., Wu, F., Qian, J., Ochiai, Y., Lian, G., Malagola, E., Zheng, B., Tu, R., Zeng, Y., Kobayashi, H., Xia, Z., Wang, R., Peng, Y., Shi, Q., Chen, D., Ryeom, S. W., & Wang, T. C. (2025). Nociceptive neurons promote gastric tumour progression via a CGRP–RAMP1 axis. Nature. https://doi.org/10.1038/s41586-025-08591-1
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Fang, Y., Chung, S. S. W., Xu, L., Xue, C., Liu, X., Jiang, D., Li, R., Korogi, Y., Yuan, K., Saqi, A., Hibshoosh, H., Huang, Y., Lin, C.-S., Tsukui, T., Sheppard, D., Sun, X., & Que, J. (2025). RUNX2 promotes fibrosis via an alveolar-to-pathological fibroblast transition. Nature. https://doi.org/10.1038/s41586-024-08542-2
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Borck, P. C., Boyle, I., Jankovic, K., Bick, N., Foster, K., Lau, A. C., Parker-Burns, L. I., Lubicki, D. A., Li, T., Borah, A. A., Lofaso, N. J., Das Sharma, S., Chan, T., Kishen, R. V., Adeagbo, A., Raghavan, S., Aquilanti, E., Prensner, J. R., Krill-Burger, J. M., … Vazquez, F. (2025). SKI complex loss renders 9p21.3-deleted or MSI-H cancers dependent on PELO. Nature, 638(8052), 1104–1111. https://doi.org/10.1038/s41586-024-08509-3
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Fu, X., Mo, S., Buendia, A., Laurent, A. P., Shao, A., Alvarez-Torres, M. del M., Yu, T., Tan, J., Su, J., Sagatelian, R., Ferrando, A. A., Ciccia, A., Lan, Y., Owens, D. M., Palomero, T., Xing, E. P., & Rabadan, R. (2025). A foundation model of transcription across human cell types. Nature, 637(8047), 965–973. https://doi.org/10.1038/s41586-024-08391-z
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Furuhashi, K., Kakiuchi, M., Ueda, R., Oda, H., Ummarino, S., Ebralidze, A. K., Bassal, M. A., Meng, C., Sato, T., Lyu, J., Han, M., Maruyama, S., Watanabe, Y., Sawa, Y., Kato, D., Wake, H., Reizis, B., Frangos, J. A., Owens, D. M., … Fujisaki, J. (2025). Bone marrow niches orchestrate stem-cell hierarchy and immune tolerance. Nature. https://doi.org/10.1038/s41586-024-08352-6
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Stewart, O., Gruber, C., Randolph, H. E., Patel, R., Ramba, M., Calzoni, E., Huang, L. H., Levy, J., Buta, S., Lee, A., Sazeides, C., Prue, Z., Hoytema van Konijnenburg, D. P., Chinn, I. K., Pedroza, L. A., Lupski, J. R., Schmitt, E. G., Cooper, M. A., Puel, A., … Bogunovic, D. (2025). Monoallelic expression can govern penetrance of inborn errors of immunity. Nature, 637(8048), 1186–1197. https://doi.org/10.1038/s41586-024-08346-4
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Blattman, S. B., Jiang, W., McGarrigle, E. R., Liu, M., Oikonomou, P., & Tavazoie, S. (2024). Identification and genetic dissection of convergent persister cell states. Nature, 636(8042), 438–446. https://doi.org/10.1038/s41586-024-08124-2
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Meyer, C., Garzia, A., Miller, M. W., Huggins, D. J., Myers, R. W., Hoffmann, H.-H., Ashbrook, A. W., Jannath, S. Y., Liverton, N., Kargman, S., Zimmerman, M., Nelson, A. M., Sharma, V., Dolgov, E., Cangialosi, J., Penalva-Lopez, S., Alvarez, N., Chang, C.-W., Oswal, N., … Tuschl, T. (2024). Small-molecule inhibition of SARS-CoV-2 NSP14 RNA cap methyltransferase. Nature. https://doi.org/10.1038/s41586-024-08320-0
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Zhuang, X., Wang, Q., Joost, S., Ferrena, A., Humphreys, D. T., Li, Z., Blum, M., Krause, K., Ding, S., Landais, Y., Zhan, Y., Zhao, Y., Chaligne, R., Lee, J.-H., Carrasco, S. E., Bhanot, U. K., Koche, R. P., Bott, M. J., Katajisto, P., … Tammela, T. (2024). Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis. Nature, 637(8044), 184–194. https://doi.org/10.1038/s41586-024-08285-0
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Xia, F., Fascianelli, V., Vishwakarma, N., Ghinger, F. G., Kwon, A., Gergues, M. M., Lalani, L. K., Fusi, S., & Kheirbek, M. A. (2024). Understanding the neural code of stress to control anhedonia. Nature. https://doi.org/10.1038/s41586-024-08241-y
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Huynh, P., Hoffmann, J. D., Gerhardt, T., Kiss, M. G., Zuraikat, F. M., Cohen, O., Wolfram, C., Yates, A. G., Leunig, A., Heiser, M., Gaebel, L., Gianeselli, M., Goswami, S., Khamhoung, A., Downey, J., Yoon, S., Chen, Z., Roudko, V., Dawson, T., … McAlpine, C. S. (2024). Myocardial infarction augments sleep to limit cardiac inflammation and damage. Nature, 635(8037), 168–177. https://doi.org/10.1038/s41586-024-08100-w
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Redenti, A., Im, J., Redenti, B., Li, F., Rouanne, M., Sheng, Z., Sun, W., Gurbatri, C. R., Huang, S., Komaranchath, M., Jang, Y., Hahn, J., Ballister, E. R., Vincent, R. L., Vardoshivilli, A., Danino, T., & Arpaia, N. (2024). Probiotic neoantigen delivery vectors for precision cancer immunotherapy. Nature, 635(8038), 453–461. https://doi.org/10.1038/s41586-024-08033-4
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Salunkhe, S., Daley, J. M., Kaur, H., Tomimatsu, N., Xue, C., Raina, V. B., Jasper, A. M., Rogers, C. M., Li, W., Zhou, S., Mojidra, R., Kwon, Y., Fang, Q., Ji, J.-H., Badamchi Shabestari, A., Fitzgerald, O., Dinh, H., Mukherjee, B., Habib, A. A., … Sung, P. (2024). Promotion of DNA end resection by BRCA1–BARD1 in homologous recombination. Nature, 634(8033), 482–491. https://doi.org/10.1038/s41586-024-07910-2
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Engreitz, J. M., Lawson, H. A., Singh, H., Starita, L. M., Hon, G. C., Carter, H., Sahni, N., Reddy, T. E., Lin, X., Li, Y., Munshi, N. V., Chahrour, M. H., Boyle, A. P., Hitz, B. C., Mortazavi, A., Craven, M., Mohlke, K. L., … Samer, E. K. (2024). Deciphering the impact of genomic variation on function. Nature, 633(8028), 47–57. https://doi.org/10.1038/s41586-024-07510-0
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Green, G. S., Fujita, M., Yang, H.-S., Taga, M., Cain, A., McCabe, C., Comandante-Lou, N., White, C. C., Schmidtner, A. K., Zeng, L., Sigalov, A., Wang, Y., Regev, A., Klein, H.-U., Menon, V., Bennett, D. A., Habib, N., & De Jager, P. L. (2024). Cellular communities reveal trajectories of brain ageing and Alzheimer’s disease. Nature, 633(8030), 634–645. https://doi.org/10.1038/s41586-024-07871-6
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Lee, C. S., Chen, S., Berry, C. T., Kelly, A. R., Herman, P. J., Oh, S., O’Connor, R. S., Payne, A. S., & Ellebrecht, C. T. (2024). Fate induction in CD8 CAR T cells through asymmetric cell division. Nature, 633(8030), 670–677. https://doi.org/10.1038/s41586-024-07862-7
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Imada, S., Khawaled, S., Shin, H., Meckelmann, S. W., Whittaker, C. A., Corrêa, R. O., Alquati, C., Lu, Y., Tie, G., Pradhan, D., Calibasi-Kocal, G., Nascentes Melo, L. M., Allies, G., Rösler, J., Wittenhofer, P., Krystkiewicz, J., Schmitz, O. J., Roper, J., Vinolo, M. A. R., … Yilmaz, Ö. H. (2024). Short-term post-fast refeeding enhances intestinal stemness via polyamines. Nature, 633(8031), 895–904. https://doi.org/10.1038/s41586-024-07840-z
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Courellis, H. S., Minxha, J., Cardenas, A. R., Kimmel, D. L., Reed, C. M., Valiante, T. A., Salzman, C. D., Mamelak, A. N., Fusi, S., & Rutishauser, U. (2024). Abstract representations emerge in human hippocampal neurons during inference. Nature, 632(8026), 841–849. https://doi.org/10.1038/s41586-024-07799-x
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Law, C., Wacleche, V. S., Cao, Y., Pillai, A., Sowerby, J., Hancock, B., Horisberger, A., Bracero, S., Skidanova, V., Li, Z., Adejoorin, I., Dillon, E., Benque, I. J., Nunez, D. P., Simmons, D. P., Keegan, J., Chen, L., Baker, T., Brohawn, P. Z., … Rao, D. A. (2024). Interferon subverts an AHR–JUN axis to promote CXCL13+ T cells in lupus. Nature, 631(8022), 857–866. https://doi.org/10.1038/s41586-024-07627-2
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Gong, B., Johnston, J. D., Thiemicke, A., de Marco, A., & Meyer, T. (2024). Endoplasmic reticulum–plasma membrane contact gradients direct cell migration. Nature, 631(8020), 415–423. https://doi.org/10.1038/s41586-024-07527-5
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Wiegand, T., Hoffmann, F. T., Walker, M. W. G., Tang, S., Richard, E., Le, H. C., Meers, C., & Sternberg, S. H. (2024). TnpB homologues exapted from transposons are RNA-guided transcription factors. Nature, 631(8020), 439–448. https://doi.org/10.1038/s41586-024-07598-4
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Jones, C. W., Overbey, E. G., Lacombe, J., Ecker, A. J., Meydan, C., Ryon, K., Tierney, B., Damle, N., MacKay, M., Afshin, E. E., Foox, J., Park, J., Nelson, T. M., Suhail Mohamad, M., Byhaqui, S. G. A., Aslam, B., Tali, U. A., Nisa, L., Menon, P. V., … Mason, C. E. (2024). Molecular and physiological changes in the SpaceX Inspiration4 civilian crew. Nature. https://doi.org/10.1038/s41586-024-07648-x
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Overbey, E. G., Kim, J., Tierney, B. T., Park, J., Houerbi, N., Lucaci, A. G., Garcia Medina, S., Damle, N., Najjar, D., Grigorev, K., Afshin, E. E., Ryon, K. A., Sienkiewicz, K., Patras, L., Klotz, R., Ortiz, V., MacKay, M., Schweickart, A., Chin, C. R., … Mason, C. E. (2024). The Space Omics and Medical Atlas (SOMA) and international astronaut biobank. Nature. https://doi.org/10.1038/s41586-024-07639-y
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Jin, H., Li, M., Jeong, E., Castro-Martinez, F., & Zuker, C. S. (2024). A body–brain circuit that regulates body inflammatory responses. Nature, 630(8017), 695–703. https://doi.org/10.1038/s41586-024-07469-y
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Gangwar, S. P., Yelshanskaya, M. V., Nadezhdin, K. D., Yen, L. Y., Newton, T. P., Aktolun, M., Kurnikova, M. G., & Sobolevsky, A. I. (2024). Kainate receptor channel opening and gating mechanism. Nature, 630(8017), 762–768. https://doi.org/10.1038/s41586-024-07475-0
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Zuo, H., Park, J., Frangaj, A., Ye, J., Lu, G., Manning, J. J., Asher, W. B., Lu, Z., Hu, G., Wang, L., Mendez, J., Eng, E., Zhang, Z., Lin, X., Grassucci, R., Hendrickson, W. A., Clarke, O. B., Javitch, J. A., Conigrave, A. D., & Fan, Q. R. (2024). Promiscuous G-protein activation by the calcium-sensing receptor. Nature, 629(8011), 481–488. https://doi.org/10.1038/s41586-024-07331-1
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Yaron-Barir, T. M., Joughin, B. A., Huntsman, E. M., Kerelsky, A., Cizin, D. M., Cohen, B. M., Regev, A., Song, J., Vasan, N., Lin, T.-Y., Orozco, J. M., Schoenherr, C., Sagum, C., Bedford, M. T., Wynn, R. M., Tso, S.-C., Chuang, D. T., Li, L., Li, S. S.-C., … Johnson, J. L. (2024). The intrinsic substrate specificity of the human tyrosine kinome. Nature, 629(8014), 1174–1181. https://doi.org/10.1038/s41586-024-07407-y
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Cater, R. J., Mukherjee, D., Gil-Iturbe, E., Erramilli, S. K., Chen, T., Koo, K., Santander, N., Reckers, A., Kloss, B., Gawda, T., Choy, B. C., Zhang, Z., Katewa, A., Larpthaveesarp, A., Huang, E. J., Mooney, S. W. J., Clarke, O. B., Yee, S. W., Giacomini, K. M., … Mancia, F. (2024). Structural and molecular basis of choline uptake into the brain by FLVCR2. Nature, 629(8012), 704–709. https://doi.org/10.1038/s41586-024-07326-y
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Wasko, U. N., Jiang, J., Dalton, T. C., Curiel-Garcia, A., Edwards, A. C., Wang, Y., Lee, B., Orlen, M., Tian, S., Stalnecker, C. A., Drizyte-Miller, K., Menard, M., Dilly, J., Sastra, S. A., Palermo, C. F., Hasselluhn, M. C., Decker-Farrell, A. R., Chang, S., Jiang, L., … Olive, K. P. (2024). Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer. Nature, 629(8013), 927–936. https://doi.org/10.1038/s41586-024-07379-z
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Suzuki, K., Hatzikotoulas, K., Southam, L., Taylor, H. J., Yin, X., Lorenz, K. M., Mandla, R., Huerta-Chagoya, A., Melloni, G. E. M., Kanoni, S., Rayner, N. W., Bocher, O., Arruda, A. L., Sonehara, K., Namba, S., Lee, S. S. K., Preuss, M. H., Petty, L. E., … Schroeder, P. (2024). Genetic drivers of heterogeneity in type 2 diabetes pathophysiology. Nature, 627(8003), 347–357. https://doi.org/10.1038/s41586-024-07019-6
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Weng, C., Yu, F., Yang, D., Poeschla, M., Liggett, L. A., Jones, M. G., Qiu, X., Wahlster, L., Caulier, A., Hussmann, J. A., Schnell, A., Yost, K. E., Koblan, L. W., Martin-Rufino, J. D., Min, J., Hammond, A., Ssozi, D., Bueno, R., Mallidi, H., … Sankaran, V. G. (2024). Deciphering cell states and genealogies of human haematopoiesis. Nature, 627(8003), 389–398. https://doi.org/10.1038/s41586-024-07066-z
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Chen, S., Francioli, L. C., Goodrich, J. K., Collins, R. L., Kanai, M., Wang, Q., Alföldi, J., Watts, N. A., Vittal, C., Gauthier, L. D., Poterba, T., Wilson, M. W., Tarasova, Y., Phu, W., Grant, R., Yohannes, M. T., Koenig, Z., Farjoun, Y., … Banks, E. (2023). A genomic mutational constraint map using variation in 76,156 human genomes. Nature, 625(7993), 92–100. https://doi.org/10.1038/s41586-023-06045-0
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Pourmorady, A. D., Bashkirova, E. V., Chiariello, A. M., Belagzhal, H., Kodra, A., Duffié, R., Kahiapo, J., Monahan, K., Pulupa, J., Schieren, I., Osterhoudt, A., Dekker, J., Nicodemi, M., & Lomvardas, S. (2023). RNA-mediated symmetry breaking enables singular olfactory receptor choice. Nature, 625(7993), 181–188. https://doi.org/10.1038/s41586-023-06845-4
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Ruggeri, K., Stock, F., Haslam, S. A., Capraro, V., Boggio, P., Ellemers, N., Cichocka, A., Douglas, K. M., Rand, D. G., van der Linden, S., Cikara, M., Finkel, E. J., Druckman, J. N., Wohl, M. J. A., Petty, R. E., Tucker, J. A., Shariff, A., Gelfand, M., Packer, D., … Willer, R. (2023). A synthesis of evidence for policy from behavioural science during COVID-19. Nature, 625(7993), 134–147. https://doi.org/10.1038/s41586-023-06840-9
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Le Voyer, T., Parent, A. V., Liu, X., Cederholm, A., Gervais, A., Rosain, J., Nguyen, T., Perez Lorenzo, M., Rackaityte, E., Rinchai, D., Zhang, P., Bizien, L., Hancioglu, G., Ghillani-Dalbin, P., Charuel, J.-L., Philippot, Q., Gueye, M. S., Maglorius Renkilaraj, M. R. L., … Ogishi, M. (2023). Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency. Nature, 623(7988), 803–813. https://doi.org/10.1038/s41586-023-06717-x
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Zhang, F., Jonsson, A. H., Nathan, A., Millard, N., Curtis, M., Xiao, Q., Gutierrez-Arcelus, M., Apruzzese, W., Watts, G. F. M., Weisenfeld, D., Nayar, S., Rangel-Moreno, J., Meednu, N., Marks, K. E., Mantel, I., Kang, J. B., Rumker, L., Mears, J., … Slowikowski, K. (2023). Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes. Nature, 623(7987), 616–624. https://doi.org/10.1038/s41586-023-06708-y
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Wang, Q., Guo, Y., Liu, L., Schwanz, L. T., Li, Z., Nair, M. S., Ho, J., Zhang, R. M., Iketani, S., Yu, J., Huang, Y., Qu, Y., Valdez, R., Lauring, A. S., Huang, Y., Gordon, A., Wang, H. H., Liu, L., & Ho, D. D. (2023). Antigenicity and receptor affinity of SARS-CoV-2 BA.2.86 spike. Nature, 624(7992), 639–644. https://doi.org/10.1038/s41586-023-06750-w
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Meers, C., Le, H. C., Pesari, S. R., Hoffmann, F. T., Walker, M. W. G., Gezelle, J., Tang, S., & Sternberg, S. H. (2023). Transposon-encoded nucleases use guide RNAs to promote their selfish spread. Nature, 622(7984), 863–871. https://doi.org/10.1038/s41586-023-06597-1
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Bok, S., Yallowitz, A. R., Sun, J., McCormick, J., Cung, M., Hu, L., Lalani, S., Li, Z., Sosa, B. R., Baumgartner, T., Byrne, P., Zhang, T., Morse, K. W., Mohamed, F. F., Ge, C., Franceschi, R. T., Cowling, R. T., Greenberg, B. H., Pisapia, D. J., … Greenblatt, M. B. (2023). A multi-stem cell basis for craniosynostosis and calvarial mineralization. Nature, 621(7980), 804–812. https://doi.org/10.1038/s41586-023-06526-2
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Duan, Y., Zhou, H., Liu, X., Iketani, S., Lin, M., Zhang, X., Bian, Q., Wang, H., Sun, H., Hong, S. J., Culbertson, B., Mohri, H., Luck, M. I., Zhu, Y., Liu, X., Lu, Y., Yang, X., Yang, K., Sabo, Y., … Yang, H. (2023). Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir. Nature, 622(7982), 376–382. https://doi.org/10.1038/s41586-023-06609-0
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McLaren, P. J., Porreca, I., Iaconis, G., Mok, H. P., Mukhopadhyay, S., Karakoc, E., Cristinelli, S., Pomilla, C., Bartha, I., Thorball, C. W., Tough, R. H., Angelino, P., Kiar, C. S., Carstensen, T., Fatumo, S., Porter, T., Jarvis, I., Skarnes, W. C., Bassett, A., … Fellay, J. (2023). Africa-specific human genetic variation near CHD1L associates with HIV-1 load. Nature, 620(7976), 1025–1030. https://doi.org/10.1038/s41586-023-06370-4
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Columbia Affiliation
Li, J., Hubisz, M. J., Earlie, E. M., Duran, M. A., Hong, C., Varela, A. A., Lettera, E., Deyell, M., Tavora, B., Havel, J. J., Phyu, S. M., Amin, A. D., Budre, K., Kamiya, E., Cavallo, J.-A., Garris, C., Powell, S., Reis-Filho, J. S., Wen, H., … Bakhoum, S. F. (2023). Non-cell-autonomous cancer progression from chromosomal instability. Nature, 620(7976), 1080–1088. https://doi.org/10.1038/s41586-023-06464-z
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Harroud, A., Stridh, P., McCauley, J. L., Saarela, J., van den Bosch, A. M. R., Engelenburg, H. J., Beecham, A. H., Alfredsson, L., Alikhani, K., Amezcua, L., Andlauer, T. F. M., Ban, M., Barcellos, L. F., Barizzone, N., Berge, T., Berthele, A., Bittner, S., Bos, S. D., … Stefánsson, K. (2023). Locus for severity implicates CNS resilience in progression of multiple sclerosis. Nature, 619(7969), 323–331. https://doi.org/10.1038/s41586-023-06250-x
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Watson, J. L., Juergens, D., Bennett, N. R., Trippe, B. L., Yim, J., Eisenach, H. E., Ahern, W., Borst, A. J., Ragotte, R. J., Milles, L. F., Wicky, B. I. M., Hanikel, N., Pellock, S. J., Courbet, A., Sheffler, W., Wang, J., Venkatesh, P., Sappington, I., Torres, S. V., … Baker, D. (2023). De novo design of protein structure and function with RFdiffusion. Nature, 620(7976), 1089–1100. https://doi.org/10.1038/s41586-023-06415-8
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Lake, B. B., Menon, R., Winfree, S., Hu, Q., Melo Ferreira, R., Kalhor, K., Barwinska, D., Otto, E. A., Ferkowicz, M., Diep, D., Plongthongkum, N., Knoten, A., Urata, S., Mariani, L. H., Naik, A. S., Eddy, S., Zhang, B., Wu, Y., Salamon, D., … Jain, S. (2023). An atlas of healthy and injured cell states and niches in the human kidney. Nature, 619(7970), 585–594. https://doi.org/10.1038/s41586-023-05769-3
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