Analysis of Brain Functional Connectivity Networks

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Lagarde, J., Maiti, P., Schonhaut, D. R., Blazhenets, G., Zhang, J., Eloyan, A., Thangarajah, M., Taurone, A., Allen, I. E., Soleimani‐Meigooni, D. N., Zeltzer, E., Windon, C., Abu Raya, M., Vrillon, A., Smith, K., Shankar, R., Amuiri, A., Rocha, S., … Hammers, D. B. (2025). Amyloid PET in Sporadic Early‐ Versus Late‐Onset Alzheimer’s Disease: Comparison of the LEADS and ADNI Cohorts. Annals of Neurology. Portico. https://doi.org/10.1002/ana.27233
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Katsumi, Y., Touroutoglou, A., Brickhouse, M., Eloyan, A., Eckbo, R., Zaitsev, A., La Joie, R., Lagarde, J., Schonhaut, D., Thangarajah, M., Taurone, A., Vemuri, P., Jack, C. R., Dage, J. L., Nudelman, K. N. H., Foroud, T., Hammers, D. B., Ghetti, B., … Murray, M. E. (2025). Dissociable spatial topography of cortical atrophy in early‐onset and late‐onset Alzheimer’s disease: A head‐to‐head comparison of the LEADS and ADNI cohorts. Alzheimer’s & Dementia, 21(2). Portico. https://doi.org/10.1002/alz.14489
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Hammers, D. B., Musema, J., Eloyan, A., Thangarajah, M., Taurone, A., La Joie, R., Touroutoglou, A., Vemuri, P., Kramer, J., Aisen, P., Dage, J. L., Nudelman, K. N., Kirby, K., Atri, A., Clark, D., Day, G. S., Duara, R., Graff-Radford, N. R., Grant, I., … Apostolova, L. G. (2025). Characterizing and validating 12-month reliable cognitive change in Early-Onset Alzheimer’s Disease for use in clinical trials. The Journal of Prevention of Alzheimer’s Disease, 100075. https://doi.org/10.1016/j.tjpad.2025.100075
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Putcha, D., Katsumi, Y., Touroutoglou, A., Eloyan, A., Taurone, A., Thangarajah, M., Aisen, P., Dage, J. L., Foroud, T., Jack, C. R., Kramer, J. H., Nudelman, K. N. H., Raman, R., Vemuri, P., Atri, A., Day, G. S., Duara, R., Graff-Radford, N. R., Grant, I. M., … Honig, L. S. (2025). Heterogeneous clinical phenotypes of sporadic early-onset Alzheimer’s disease: a neuropsychological data-driven approach. Alzheimer’s Research & Therapy, 17(1). https://doi.org/10.1186/s13195-025-01689-8
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Song, J. Y., Fleysher, R., Ye, K., Kim, M., Zimmerman, M. E., Lipton, R. B., & Lipton, M. L. (2025). Characterizing the microstructural transition at the gray matter-white matter interface: Implementation and demonstration of age-associated differences. NeuroImage, 306, 121019. https://doi.org/10.1016/j.neuroimage.2025.121019
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Shi, T. C., Durham, K., Marsh, R., & Pagliaccio, D. (2025). Differences in Head Motion During Functional Magnetic Resonance Imaging Across Pediatric Neuropsychiatric Disorders. Biological Psychiatry Global Open Science, 5(3), 100446. https://doi.org/10.1016/j.bpsgos.2024.100446
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Hammers, D. B., Eloyan, A., Taurone, A., Thangarajah, M., Gao, S., Beckett, L., Polsinelli, A. J., Kirby, K., Dage, J. L., Nudelman, K., Aisen, P., Reman, R., La Joie, R., Lagarde, J., Atri, A., Clark, D., Day, G. S., Duara, R., … Graff‐Radford, N. R. (2024). Longitudinal cognitive performance of participants with sporadic early onset Alzheimer’s disease from LEADS. Alzheimer’s & Dementia. Portico. https://doi.org/10.1002/alz.14439
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Habeck, C. G., & Stern, Y. (2024). Regional amyloid shows associations with task‐related fMRI activation recorded 5 years earlier. Alzheimer’s & Dementia, 20(S8). Portico. https://doi.org/10.1002/alz.094698
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Hojjati, S. H., Butler, T. A., de Leon, M. J., Gupta, A. H., Nayak, S., Luchsinger, J. A., Chiang, G., & Razlighi, Q. R. (2024). Remote associations between beta‐amyloid and tau are mediated by between‐network connectivity. Alzheimer’s & Dementia, 20(S2). Portico. https://doi.org/10.1002/alz.086460
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Goldberg, T. E., Kim, H., Devanand, D., & Lee, S. (2024). Effects of APOE e4 and Neuropathological Diagnoses on Neuropsychiatric Symptoms: Mediation Analyses and Likely Causation in an Integrated NACC Database. Alzheimer’s & Dementia, 20(S8). Portico. https://doi.org/10.1002/alz.094887
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Neumann, D. L., Tozlu, C., Razlighi, Q. R., Luchsinger, J. A., Stern, Y., Devanand, D., & Kuceyeski, A. (2024). Decreased entropy of functional MRI signals in individuals with mild cognitive impairment compared to cognitively normal controls. Alzheimer’s & Dementia, 20(S2). Portico. https://doi.org/10.1002/alz.087627
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Hasanzadeh, F., Stern, Y., Habeck, C. G., & Gazes, E. (2024). Task‐related brain activation moderates age‐related structural decline in cognitive flexibility: A longitudinal study. Alzheimer’s & Dementia, 20(S3). Portico. https://doi.org/10.1002/alz.092613
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Kim, H., Zhang, Y., Huber, B., Rueppel, E., Goldberg, T. E., & Lee, S. (2024). Age‐related differences in the relationship between sleep quality and cortical thickness. Alzheimer’s & Dementia, 20(S2). Portico. https://doi.org/10.1002/alz.093110
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Argiris, G., Stern, Y., & Habeck, C. G. (2024). Brain Resilience to Targeted Attack of Resting BOLD Networks as a Measure of Cognitive Reserve. Alzheimer’s & Dementia, 20(S2). Portico. https://doi.org/10.1002/alz.087406
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Jones, A. A., Ramos‐Miguel, A., Gicas, K. M., Petyuk, V. A., Leurgans, S. E., De Jager, P. L., Schneider, J. A., Bennett, D. A., Honer, W. G., & Casaletto, K. B. (2024). A multilayer network analysis of Alzheimer’s disease pathogenesis: Roles for p‐tau, synaptic peptides, and physical activity. Alzheimer’s & Dementia, 20(11), 8012–8027. Portico. https://doi.org/10.1002/alz.14286
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Clelland, J. D., Hesson, H., Ramiah, K., Anderson, J., Thengampallil, A., Girgis, R. R., & Clelland, C. L. (2024). The relationship between COMT, proline, and negative symptoms in clinical high risk and recent psychosis onset. Translational Psychiatry, 14(1). https://doi.org/10.1038/s41398-024-03099-0
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Lipton, M. L., Fleysher, R., Song, J. Y., Ye, K., Zimmerman, M. E., Lipton, R. B., & Daily, J. P. (2024). Brain effects of mild COVID-19 in healthy young adults: A pilot study. Heliyon, 10(15), e34764. https://doi.org/10.1016/j.heliyon.2024.e34764
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Libon, D. J., Swenson, R., Price, C. C., Lamar, M., Cosentino, S., Bezdicek, O., Kling, M. A., Tobyne, S., Jannati, A., Banks, R., & Pascual-Leone, A. (2024). Digital assessment of cognition in neurodegenerative disease: a data driven approach leveraging artificial intelligence. Frontiers in Psychology, 15. https://doi.org/10.3389/fpsyg.2024.1415629
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Liu, Y.-H., Lin, Y.-C., Shih, L.-C., Lin, C.-P., & Chang, L.-H. (2024). Dissociation of focal and large-scale inhibitory functions in the older adults: A multimodal MRI study. Archives of Gerontology and Geriatrics, 127, 105583. https://doi.org/10.1016/j.archger.2024.105583
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Laroy, M., Bouckaert, F., Ousdal, O. T., Dols, A., Rhebergen, D., van Exel, E., van Wingen, G., van Waarde, J., Verdijk, J., Kessler, U., Bartsch, H., Jorgensen, M. B., Paulson, O. B., Nordanskog, P., Prudic, J., Sienaert, P., Vandenbulcke, M., Oltedal, L., & Emsell, L. (2024). Characterization of gray matter volume changes from one week to 6 months after termination of electroconvulsive therapy in depressed patients. Brain Stimulation, 17(4), 876–886. https://doi.org/10.1016/j.brs.2024.07.015
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Kim, Y., Ravid, O., Zheng, X., Kim, Y., Neria, Y., Lee, S., He, X., & Zhu, X. (2024). Explaining deep learning-based representations of resting state functional connectivity data: focusing on interpreting nonlinear patterns in autism spectrum disorder. Frontiers in Psychiatry, 15. https://doi.org/10.3389/fpsyt.2024.1397093
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Hansen, M., Simon, K. R., He, X., Steele, N., Thomas, M. L., Noble, K. G., & Merz, E. C. (2024). Socioeconomic factors, sleep timing and duration, and amygdala resting-state functional connectivity in children. Frontiers in Psychiatry, 15. https://doi.org/10.3389/fpsyt.2024.1373546
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Fresán, A., Domínguez, T., Flores, Y., Nieto, L., Sheinbaum, T., Robles, R., & Medalia, A. (2024). Psychometric properties of the Spanish version of the measure of insight into cognition‐self‐report in psychosis‐risk and non‐clinical Mexican young adults. Early Intervention in Psychiatry. Portico. https://doi.org/10.1111/eip.13559
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Luo, K. L., Santos, L., Tokaria, R., Jambawalikar, S., Duong, P. T., Raya, J. G., Mostoufi‐Moab, S., & Jaramillo, D. (2024). Generalizing Diffusion Tensor Imaging of the Physis and Metaphysis. Journal of Magnetic Resonance Imaging. Portico. https://doi.org/10.1002/jmri.29455
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Muratore, A. F., Foerde, K., Lloyd, E. C., Touzeau, C., Uniacke, B., Aw, N., Semanek, D., Wang, Y., Walsh, B. T., Attia, E., Posner, J., & Steinglass, J. E. (2024). Reduced dorsal fronto-striatal connectivity at rest in anorexia nervosa. Psychological Medicine, 1–10. https://doi.org/10.1017/s003329172400031x
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Charney, M., Foster, S., Shukla, V., Zhao, W., Jiang, S. H., Kozlowska, K., & Lin, A. (2024). Neurometabolic alterations in children and adolescents with functional neurological disorder. NeuroImage: Clinical, 41, 103557. https://doi.org/10.1016/j.nicl.2023.103557
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Whittington, A., Porat, L., Christian, B. T., Devanand, D. P., Hostetler, E. D., Johnson, K. A., Johnson, S. C., Klunk, W. E., Lao, P. J., Rowe, C. C., Devanarayan, V., Reilhac, A., Reyderman, L., Irizarry, M. C., Charil, A., & Gunn, R. N. (2023). Estimating Braak stage from [18F]MK6240 PET scans. Alzheimer’s & Dementia, 19(S24). Portico. https://doi.org/10.1002/alz.083004
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Nayak, S., Hojjati, S. H., Feiz, F., Ozoria, S., Shteingart, J., Picha, S. G., Fernández, A., Stern, Y., Devanand, D. P., Luchsinger, J. A., & Razlighi, Q. R. (2023). Functional Connectivity of Entorhinal Cortex Predicts Tau in the Elderly. Alzheimer’s & Dementia, 19(S14). Portico. https://doi.org/10.1002/alz.077407
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Hojjati, S. H., Feiz, F., Nayak, S., Shteingart, J., Ozoria, S., Picha, S. G., Fernández, A., Devanand, D. P., Luchsinger, J. A., Stern, Y., & Razlighi, Q. R. (2023). Hub brain regions for the remote spatial association between tau and Amyloid‐β proteins. Alzheimer’s & Dementia, 19(S16). Portico. https://doi.org/10.1002/alz.076456
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Munkombwe, C., Misiura, M., Igwe, K. C., Likos, K. D. S., Verble, D. D., Zetterberg, H., Brickman, A. M., Hu, W. T., Dotson, V. M., & Wharton, W. (2023). Neuroimaging Correlates of Alzheimer’s Disease biomarkers in a mid‐life, racially diverse high‐risk cohort. Alzheimer’s & Dementia, 19(S16). Portico. https://doi.org/10.1002/alz.080380
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Zhu, X., Kim, Y., Ravid, O., He, X., Suarez-Jimenez, B., Zilcha-Mano, S., Lazarov, A., Lee, S., Abdallah, C. G., Angstadt, M., Averill, C. L., Baird, C. L., Baugh, L. A., Blackford, J. U., Bomyea, J., Bruce, S. E., Bryant, R. A., Cao, Z., Choi, K., … Morey, R. A. (2023). Neuroimaging-based classification of PTSD using data-driven computational approaches: A multisite big data study from the ENIGMA-PGC PTSD consortium. NeuroImage, 283, 120412. https://doi.org/10.1016/j.neuroimage.2023.120412
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Instrella, R., & Juchem, C. (2023). Uncertainty propagation in absolute metabolite quantification for in vivo MRS of the human brain. Magnetic Resonance in Medicine, 91(4), 1284–1300. Portico. https://doi.org/10.1002/mrm.29903
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Rizer, S., Chapman, S., Joyce, J., Delgado, N., McGurn, M., Powell, A., Hernandez, D. I., Gu, Y., Louis, E. D., & Cosentino, S. (2023). 50 Remote Assessment has Minimal Effect on Test-Retest Reliability Among Older Adults with Essential Tremor. Journal of the International Neuropsychological Society, 29(s1), 729–729. https://doi.org/10.1017/s1355617723009086
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George, M. S., Huffman, S., Doose, J., Sun, X., Dancy, M., Faller, J., Li, X., Yuan, H., Goldman, R. I., Sajda, P., & Brown, T. R. (2023). EEG synchronized left prefrontal transcranial magnetic stimulation (TMS) for treatment resistant depression is feasible and produces an entrainment dependent clinical response: A randomized controlled double blind clinical trial. Brain Stimulation, 16(6), 1753–1763. https://doi.org/10.1016/j.brs.2023.11.010
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Bruin, W. B., Abe, Y., Alonso, P., Anticevic, A., Backhausen, L. L., Balachander, S., Bargallo, N., Batistuzzo, M. C., Benedetti, F., Bertolin Triquell, S., Brem, S., Calesella, F., Couto, B., Denys, D. A. J. P., Echevarria, M. A. N., Eng, G. K., Ferreira, S., Feusner, J. D., … Grazioplene, R. G. (2023). The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium. Molecular Psychiatry, 28(10), 4307–4319. https://doi.org/10.1038/s41380-023-02077-0
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Cho, H., Mundada, N. S., Apostolova, L. G., Carrillo, M. C., Shankar, R., Amuiri, A. N., Zeltzer, E., Windon, C. C., Soleimani‐Meigooni, D. N., Tanner, J. A., Heath, C. L., Lesman‐Segev, O. H., Aisen, P., Eloyan, A., Lee, H. S., Hammers, D. B., Kirby, K., Dage, J. L., … Fagan, A. (2023). Amyloid and tau‐PET in early‐onset AD: Baseline data from the Longitudinal Early‐onset Alzheimer’s Disease Study (LEADS). Alzheimer’s & Dementia, 19(S9). Portico. https://doi.org/10.1002/alz.13453
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Argiris, G., Stern, Y., Lee, S., Ryu, H., & Habeck, C. (2023). Simple topological task-based functional connectivity features predict longitudinal behavioral change of fluid reasoning in the RANN cohort. NeuroImage, 277, 120237. https://doi.org/10.1016/j.neuroimage.2023.120237
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McKay, N. S., Gordon, B. A., Hornbeck, R. C., Dincer, A., Flores, S., Keefe, S. J., Joseph-Mathurin, N., Jack, C. R., Koeppe, R., Millar, P. R., Ances, B. M., Chen, C. D., Daniels, A., Hobbs, D. A., Jackson, K., Koudelis, D., Massoumzadeh, P., McCullough, A., Nickels, M. L., … la Fougère, C. (2023). Positron emission tomography and magnetic resonance imaging methods and datasets within the Dominantly Inherited Alzheimer Network (DIAN). Nature Neuroscience, 26(8), 1449–1460. https://doi.org/10.1038/s41593-023-01359-8
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Suarez-Jimenez, B., Lazarov, A., Zhu, X., Pine, D. S., Bar-Haim, Y., & Neria, Y. (2022). Attention allocation to negatively-valenced stimuli in PTSD is associated with reward-related neural pathways. Psychological Medicine, 53(10), 4666–4674. https://doi.org/10.1017/s003329172200157x
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Shahsavarani, S., Thibodeaux, D. N., Xu, W., Kim, S. H., Lodgher, F., Nwokeabia, C., Cambareri, M., Yagielski, A. J., Zhao, H. T., Handwerker, D. A., Gonzalez-Castillo, J., Bandettini, P. A., & Hillman, E. M. C. (2023). Cortex-wide neural dynamics predict behavioral states and provide a neural basis for resting-state dynamic functional connectivity. Cell Reports, 42(6), 112527. https://doi.org/10.1016/j.celrep.2023.112527
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Kim, H., Zhu, X., Zhao, Y., Bell, S. A., Cohen, D. E., Lee, S., & Goldberg, T. E. (2023). Resting‐State Connectivity Changes in Older Adults with Sleep Disturbance. Alzheimer’s & Dementia, 19(S8). Portico. https://doi.org/10.1002/alz.062749
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Misiura, M., Munkombwe, C., Verble, D. D., Likos, K. D. S., Igwe, K. C., Zetterberg, H., Kumar, V., Brickman, A. M., Hu, W. T., Dotson, V. M., & Wharton, W. (2023). Correlates of neuroimaging biomarkers in a middle‐age racially diverse cohort: Updates from the association between cardiovascular risk and preclinical Alzheimer’s Disease pathology (ASCEND) study. Alzheimer’s & Dementia, 19(S3). Portico. https://doi.org/10.1002/alz.066894
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Zhu, X., Lazarov, A., Dolan, S., Bar-Haim, Y., Dillon, D. G., Pizzagalli, D. A., & Schneier, F. (2022). Resting state connectivity predictors of symptom change during gaze-contingent music reward therapy of social anxiety disorder. Psychological Medicine, 53(7), 3115–3123. https://doi.org/10.1017/s0033291721005171
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Pantazatos, S. P., Mclntosh, J. R., Saber, G. T., Sun, X., Doose, J., Faller, J., Lin, Y., Teves, J. B., Blankenship, A., Huffman, S., Goldman, R. I., George, M. S., Sajda, P., & Brown, T. R. (2023). The timing of transcranial magnetic stimulation relative to the phase of prefrontal alpha EEG modulates downstream target engagement. Brain Stimulation, 16(3), 830–839. https://doi.org/10.1016/j.brs.2023.05.007
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Eich, T. S., Langfield, C., Sakhardande, J., Gazes, Y., Habeck, C., & Stern, Y. (2023). Older adults compensate for switch, but not mixing costs, relative to younger adults on an intrinsically cued task switching experiment. Frontiers in Aging Neuroscience, 15. https://doi.org/10.3389/fnagi.2023.1152582
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McSweeney, M., Morales, S., Valadez, E. A., Buzzell, G. A., Yoder, L., Fifer, W. P., Pini, N., Shuffrey, L. C., Elliott, A. J., Isler, J. R., & Fox, N. A. (2023). Age-related trends in aperiodic EEG activity and alpha oscillations during early- to middle-childhood. NeuroImage, 269, 119925. https://doi.org/10.1016/j.neuroimage.2023.119925
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Pouwels, P. J. W., Vriend, C., Liu, F., de Joode, N. T., Otaduy, M. C. G., Pastorello, B., Robertson, F. C., Venkatasubramanian, G., Ipser, J., Lee, S., Batistuzzo, M. C., Hoexter, M. Q., Lochner, C., Miguel, E. C., Narayanaswamy, J. C., Rao, R., Janardhan Reddy, Y. C., Shavitt, R. G., Sheshachala, K., … van den Heuvel, O. A. (2022). Global multi‐center and multi‐modal magnetic resonance imaging study of obsessive‐compulsive disorder: Harmonization and monitoring of protocols in healthy volunteers and phantoms. International Journal of Methods in Psychiatric Research, 32(1). Portico. https://doi.org/10.1002/mpr.1931
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Qi, W., Marx, J., Zingman, M., Li, Y., Petkova, E., Blessing, E., Ardekani, B., Sakalli Kani, A., Cather, C., Freudenreich, O., Holt, D., Zhao, J., Wang, J., & Goff, D. C. (2022). Hippocampal Subfield Volumes Predict Disengagement from Maintenance Treatment in First Episode Schizophrenia. Schizophrenia Bulletin, 49(1), 34–42. https://doi.org/10.1093/schbul/sbac043
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