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Maniatis, T. (2025). Safeguarding the future of biomedical science in the United States. Cell, 188(6), 1457–1459. https://doi.org/10.1016/j.cell.2025.02.024
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Chowdhury, S., Kamatkar, N. G., Wang, W. X., Akerele, C. A., Huang, J., Wu, J., Nwankpa, A., Kane, C. M., Bhave, V. M., Huang, H., Wang, X., & Nectow, A. R. (2025). Brainstem neuropeptidergic neurons link a neurohumoral axis to satiation. Cell. https://doi.org/10.1016/j.cell.2025.01.018
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Bunne, C., Roohani, Y., Rosen, Y., Gupta, A., Zhang, X., Roed, M., Alexandrov, T., AlQuraishi, M., Brennan, P., Burkhardt, D. B., Califano, A., Cool, J., Dernburg, A. F., Ewing, K., Fox, E. B., Haury, M., Herr, A. E., Horvitz, E., Hsu, P. D., … Quake, S. R. (2024). How to build the virtual cell with artificial intelligence: Priorities and opportunities. Cell, 187(25), 7045–7063. https://doi.org/10.1016/j.cell.2024.11.015
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Maniatis, T. (2024). From bacterial operons to gene therapy: 50 years of the journal Cell. Cell, 187(23), 6417–6420. https://doi.org/10.1016/j.cell.2024.10.037
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Wang, H., Cheng, C., Dal Santo, J. L., Shen, C.-H., Bylund, T., Henry, A. R., Howe, C. A., Hwang, J., Morano, N. C., Morris, D. J., Pletnev, S., Roark, R. S., Zhou, T., Hansen, B. T., Hoyt, F. H., Johnston, T. S., Wang, S., Zhang, B., Ambrozak, D. R., … Kwong, P. D. (2024). Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques. Cell. https://doi.org/10.1016/j.cell.2024.10.003
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Gordon, J. A., Dzirasa, K., & Petzschner, F. H. (2024). The neuroscience of mental illness: Building toward the future. Cell, 187(21), 5858–5870. https://doi.org/10.1016/j.cell.2024.09.028
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Yang, H. H., Brezovec, B. E., Serratosa Capdevila, L., Vanderbeck, Q. X., Adachi, A., Mann, R. S., & Wilson, R. I. (2024). Fine-grained descending control of steering in walking Drosophila. Cell, 187(22), 6290-6308.e27. https://doi.org/10.1016/j.cell.2024.08.033
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Yu, J., Zhang, Y., Fang, Y., Paulo, J. A., Yaghoubi, D., Hua, X., Shipkovenska, G., Toda, T., Zhang, Z., Gygi, S. P., Jia, S., Li, Q., & Moazed, D. (2024). A replisome-associated histone H3-H4 chaperone required for epigenetic inheritance. Cell. https://doi.org/10.1016/j.cell.2024.07.006
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Abel, E. D., Gloyn, A. L., Evans-Molina, C., Joseph, J. J., Misra, S., Pajvani, U. B., Simcox, J., Susztak, K., & Drucker, D. J. (2024). Diabetes mellitus—Progress and opportunities in the evolving epidemic. Cell, 187(15), 3789–3820. https://doi.org/10.1016/j.cell.2024.06.029
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Sinha, N. K., McKenney, C., Yeow, Z. Y., Li, J. J., Nam, K. H., Yaron-Barir, T. M., Johnson, J. L., Huntsman, E. M., Cantley, L. C., Ordureau, A., Regot, S., & Green, R. (2024). The ribotoxic stress response drives UV-mediated cell death. Cell, 187(14), 3652-3670.e40. https://doi.org/10.1016/j.cell.2024.05.018
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Malagola, E., Vasciaveo, A., Ochiai, Y., Kim, W., Zheng, B., Zanella, L., Wang, A. L. E., Middelhoff, M., Nienhüser, H., Deng, L., Wu, F., Waterbury, Q. T., Belin, B., LaBella, J., Zamechek, L. B., Wong, M. H., Li, L., Guha, C., Cheng, C.-W., … Wang, T. C. (2024). Isthmus progenitor cells contribute to homeostatic cellular turnover and support regeneration following intestinal injury. Cell, 187(12), 3056-3071.e17. https://doi.org/10.1016/j.cell.2024.05.004
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Department of Systems Biology; Vagelos College of Physicians and Surgeons; Department of Medicine; Division of Digestive and Liver Diseases; Department of Genetics and Development; Columbia Stem Cell Initiative; Department of Biochemistry and Molecular Biophysics; Department of Biomedical Informatics; Division of Hematology/Oncology; Herbert Irving Comprehensive Cancer Center
Capdevila, C., Miller, J., Cheng, L., Kornberg, A., George, J. J., Lee, H., Botella, T., Moon, C. S., Murray, J. W., Lam, S., Calderon, R. I., Malagola, E., Whelan, G., Lin, C.-S., Han, A., Wang, T. C., Sims, P. A., & Yan, K. S. (2024). Time-resolved fate mapping identifies the intestinal upper crypt zone as an origin of Lgr5+ crypt base columnar cells. Cell, 187(12), 3039-3055.e14. https://doi.org/10.1016/j.cell.2024.05.001
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Center for Stem Cell Therapies; Center for Human Development; Vagelos College of Physicians and Surgeons; Department of Medicine; Division of Pulmonary, Allergy, and Critical Care Medicine; Department of Pathology and Cell Biology; Department of Systems Biology; Department of Biochemistry and Molecular Biophysics; Division of Digestive and Liver Diseases; Department of Genetics and Development; Herbert Irving Comprehensive Cancer Center; Department of Pediatrics; Department of Microbiology and Immunology
Gao, L., Lee, H., Goodman, J. H., & Ding, L. (2024). Hematopoietic stem cell niche generation and maintenance are distinguishable by an epitranscriptomic program. Cell, 187(11), 2801-2816.e17. https://doi.org/10.1016/j.cell.2024.03.032
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Throesch, B. T., bin Imtiaz, M. K., Muñoz-Castañeda, R., Sakurai, M., Hartzell, A. L., James, K. N., Rodriguez, A. R., Martin, G., Lippi, G., Kupriyanov, S., Wu, Z., Osten, P., Izpisua Belmonte, J. C., Wu, J., & Baldwin, K. K. (2024). Functional sensory circuits built from neurons of two species. Cell, 187(9), 2143-2157.e15. https://doi.org/10.1016/j.cell.2024.03.042
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Qi, L., Iskols, M., Shi, D., Reddy, P., Walker, C., Lezgiyeva, K., Voisin, T., Pawlak, M., Kuchroo, V. K., Chiu, I. M., Ginty, D. D., & Sharma, N. (2024). A mouse DRG genetic toolkit reveals morphological and physiological diversity of somatosensory neuron subtypes. Cell, 187(6), 1508-1526.e16. https://doi.org/10.1016/j.cell.2024.02.006
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Fogarty, E. C., Schechter, M. S., Lolans, K., Sheahan, M. L., Veseli, I., Moore, R. M., Kiefl, E., Moody, T., Rice, P. A., Yu, M. K., Mimee, M., Chang, E. B., Ruscheweyh, H.-J., Sunagawa, S., Mclellan, S. L., Willis, A. D., Comstock, L. E., & Eren, A. M. (2024). A cryptic plasmid is among the most numerous genetic elements in the human gut. Cell, 187(5), 1206-1222.e16. https://doi.org/10.1016/j.cell.2024.01.039
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Collins, A., Swann, J. W., Proven, M. A., Patel, C. M., Mitchell, C. A., Kasbekar, M., Dellorusso, P. V., & Passegué, E. (2024). Maternal inflammation regulates fetal emergency myelopoiesis. Cell, 187(6), 1402-1421.e21. https://doi.org/10.1016/j.cell.2024.02.002
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Qiu, B., Zandkarimi, F., Bezjian, C. T., Reznik, E., Soni, R. K., Gu, W., Jiang, X., & Stockwell, B. R. (2024). Phospholipids with two polyunsaturated fatty acyl tails promote ferroptosis. Cell, 187(5), 1177-1190.e18. https://doi.org/10.1016/j.cell.2024.01.030
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Petralia, F., Ma, W., Yaron, T. M., Caruso, F. P., Tignor, N., Wang, J. M., Charytonowicz, D., Johnson, J. L., Huntsman, E. M., Marino, G. B., Calinawan, A., Evangelista, J. E., Selvan, M. E., Chowdhury, S., Rykunov, D., Krek, A., Song, X., Turhan, B., Christianson, K. E., … Zhang, Z. (2024). Pan-cancer proteogenomics characterization of tumor immunity. Cell, 187(5), 1255-1277.e27. https://doi.org/10.1016/j.cell.2024.01.027
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Leuzzi, G., Vasciaveo, A., Taglialatela, A., Chen, X., Firestone, T. M., Hickman, A. R., Mao, W., Thakar, T., Vaitsiankova, A., Huang, J.-W., Cuella-Martin, R., Hayward, S. B., Kesner, J. S., Ghasemzadeh, A., Nambiar, T. S., Ho, P., Rialdi, A., Hebrard, M., Li, Y., … Ciccia, A. (2024). SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion. Cell, 187(4), 861-881.e32. https://doi.org/10.1016/j.cell.2024.01.008
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Vagelos College of Physicians and Surgeons; Department of Genetics and Development; Department of Systems Biology; Department of Medicine; Division of Hematology/Oncology; Department of Urology; Department of Biochemistry and Molecular Biophysics; Department of Biomedical Informatics; Herbert Irving Comprehensive Cancer Center; Center for Translational Immunology; Institute for Cancer Genetics
Bhattacharjee, S., Feng, X., Maji, S., Dadhwal, P., Zhang, Z., Brown, Z. P., & Frank, J. (2024). Time resolution in cryo-EM using a PDMS-based microfluidic chip assembly and its application to the study of HflX-mediated ribosome recycling. Cell, 187(3), 782-796.e23. https://doi.org/10.1016/j.cell.2023.12.027
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Verma, S. S., Gudiseva, H. V., Chavali, V. R. M., Salowe, R. J., Bradford, Y., Guare, L., Lucas, A., Collins, D. W., Vrathasha, V., Nair, R. M., Rathi, S., Zhao, B., He, J., Lee, R., Zenebe-Gete, S., Bowman, A. S., McHugh, C. P., Zody, M. C., Pistilli, M., … O’Brien, J. M. (2024). A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma. Cell, 187(2), 464-480.e10. https://doi.org/10.1016/j.cell.2023.12.006
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Tamari, M., Del Bel, K. L., Ver Heul, A. M., Zamidar, L., Orimo, K., Hoshi, M., Trier, A. M., Yano, H., Yang, T.-L., Biggs, C. M., Motomura, K., Shibuya, R., Yu, C. D., Xie, Z., Iriki, H., Wang, Z., Auyeung, K., Damle, G., Demircioglu, D., … Kim, B. S. (2024). Sensory neurons promote immune homeostasis in the lung. Cell, 187(1), 44-61.e17. https://doi.org/10.1016/j.cell.2023.11.027
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Moqri, M., Herzog, C., Poganik, J. R., Justice, J., Belsky, D. W., Higgins-Chen, A., Moskalev, A., Fuellen, G., Cohen, A. A., Bautmans, I., Widschwendter, M., Ding, J., Fleming, A., Mannick, J., Han, J.-D. J., Zhavoronkov, A., Barzilai, N., Kaeberlein, M., Cummings, S., … Gladyshev, V. N. (2023). Biomarkers of aging for the identification and evaluation of longevity interventions. Cell, 186(18), 3758–3775. https://doi.org/10.1016/j.cell.2023.08.003
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Mays, A., Byars-Winston, A., Hinton, A., Marshall, A. G., Kirabo, A., August, A., Marlin, B. J., Riggs, B., Tolbert, B., Wanjalla, C., Womack, C., Evans, C. S., Barnes, C., Starbird, C., Williams, C., Reynolds, C., Taabazuing, C., Cameron, C. E., Murray, D. D., … Clemons, W. M. (2023). Juneteenth in STEMM and the barriers to equitable science. Cell, 186(12), 2510–2517. https://doi.org/10.1016/j.cell.2023.05.016
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Sutton, M. S., Pletnev, S., Callahan, V., Ko, S., Tsybovsky, Y., Bylund, T., Casner, R. G., Cerutti, G., Gardner, C. L., Guirguis, V., Verardi, R., Zhang, B., Ambrozak, D., Beddall, M., Lei, H., Yang, E. S., Liu, T., Henry, A. R., Rawi, R., … Roederer, M. (2023). Vaccine elicitation and structural basis for antibody protection against alphaviruses. Cell, 186(12), 2672-2689.e25. https://doi.org/10.1016/j.cell.2023.05.019
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Liang, D., Feng, Y., Zandkarimi, F., Wang, H., Zhang, Z., Kim, J., Cai, Y., Gu, W., Stockwell, B. R., & Jiang, X. (2023). Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones. Cell, 186(13), 2748-2764.e22. https://doi.org/10.1016/j.cell.2023.05.003
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Winkler, F., Venkatesh, H. S., Amit, M., Batchelor, T., Demir, I. E., Deneen, B., Gutmann, D. H., Hervey-Jumper, S., Kuner, T., Mabbott, D., Platten, M., Rolls, A., Sloan, E. K., Wang, T. C., Wick, W., Venkataramani, V., & Monje, M. (2023). Cancer neuroscience: State of the field, emerging directions. Cell, 186(8), 1689–1707. https://doi.org/10.1016/j.cell.2023.02.002
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Dadonaite, B., Crawford, K. H. D., Radford, C. E., Farrell, A. G., Yu, T. C., Hannon, W. W., Zhou, P., Andrabi, R., Burton, D. R., Liu, L., Ho, D. D., Chu, H. Y., Neher, R. A., & Bloom, J. D. (2023). A pseudovirus system enables deep mutational scanning of the full SARS-CoV-2 spike. Cell, 186(6), 1263-1278.e20. https://doi.org/10.1016/j.cell.2023.02.001
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Khazaei, S., Chen, C. C. L., Andrade, A. F., Kabir, N., Azarafshar, P., Morcos, S. M., França, J. A., Lopes, M., Lund, P. J., Danieau, G., Worme, S., Adnani, L., Nzirorera, N., Chen, X., Yogarajah, G., Russo, C., Zeinieh, M., Wong, C. J., Bryant, L., … Jabado, N. (2023). Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration. Cell, 186(6), 1162-1178.e20. https://doi.org/10.1016/j.cell.2023.02.023
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Reardon, J., Lee, S. S.-J., Goering, S., Fullerton, S. M., Cho, M. K., Panofsky, A., & Hammonds, E. M. (2023). Trustworthiness matters: Building equitable and ethical science. Cell, 186(5), 894–898. https://doi.org/10.1016/j.cell.2023.01.008
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Beenken, A., Cerutti, G., Brasch, J., Guo, Y., Sheng, Z., Erdjument-Bromage, H., Aziz, Z., Robbins-Juarez, S. Y., Chavez, E. Y., Ahlsen, G., Katsamba, P. S., Neubert, T. A., Fitzpatrick, A. W. P., Barasch, J., & Shapiro, L. (2023). Structures of LRP2 reveal a molecular machine for endocytosis. Cell, 186(4), 821-836.e13. https://doi.org/10.1016/j.cell.2023.01.016
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Vagelos College of Physicians and Surgeons; Department of Medicine; Division of Nephrology; Zuckerman Mind, Brain, and Behavior Institute; Division of Infectious Diseases; Department of Pathology and Cell Biology; Aaron Diamond AIDS Research Center; Department of Pediatrics; Department of Biochemistry and Molecular Biophysics; Taub Institute for Research on Alzheimer’s Disease and the Aging Brain; O’Brien Center for Benign Urology
Wang, Q., Iketani, S., Li, Z., Liu, L., Guo, Y., Huang, Y., Bowen, A. D., Liu, M., Wang, M., Yu, J., Valdez, R., Lauring, A. S., Sheng, Z., Wang, H. H., Gordon, A., Liu, L., & Ho, D. D. (2023). Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants. Cell, 186(2), 279-286.e8. https://doi.org/10.1016/j.cell.2022.12.018
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Shayya, H. J., Kahiapo, J. K., Duffié, R., Lehmann, K. S., Bashkirova, L., Monahan, K., Dalton, R. P., Gao, J., Jiao, S., Schieren, I., Belluscio, L., & Lomvardas, S. (2022). ER stress transforms random olfactory receptor choice into axon targeting precision. Cell, 185(21), 3896-3912.e22. https://doi.org/10.1016/j.cell.2022.08.025
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Kawano, Y., Edwards, M., Huang, Y., Bilate, A. M., Araujo, L. P., Tanoue, T., Atarashi, K., Ladinsky, M. S., Reiner, S. L., Wang, H. H., Mucida, D., Honda, K., & Ivanov, I. I. (2022). Microbiota imbalance induced by dietary sugar disrupts immune-mediated protection from metabolic syndrome. Cell, 185(19), 3501-3519.e20. https://doi.org/10.1016/j.cell.2022.08.005
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Palmerola, K. L., Amrane, S., De Los Angeles, A., Xu, S., Wang, N., de Pinho, J., Zuccaro, M. V., Taglialatela, A., Massey, D. J., Turocy, J., Robles, A., Subbiah, A., Prosser, B., Lobo, R., Ciccia, A., Koren, A., Baslan, T., & Egli, D. (2022). Replication stress impairs chromosome segregation and preimplantation development in human embryos. Cell, 185(16), 2988-3007.e20. https://doi.org/10.1016/j.cell.2022.06.028
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Venkataramani, V., Yang, Y., Schubert, M. C., Reyhan, E., Tetzlaff, S. K., Wißmann, N., Botz, M., Soyka, S. J., Beretta, C. A., Pramatarov, R. L., Fankhauser, L., Garofano, L., Freudenberg, A., Wagner, J., Tanev, D. I., Ratliff, M., Xie, R., Kessler, T., Hoffmann, D. C., … Winkler, F. (2022). Glioblastoma hijacks neuronal mechanisms for brain invasion. Cell, 185(16), 2899-2917.e31. https://doi.org/10.1016/j.cell.2022.06.054
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Biermann, J., Melms, J. C., Amin, A. D., Wang, Y., Caprio, L. A., Karz, A., Tagore, S., Barrera, I., Ibarra-Arellano, M. A., Andreatta, M., Fullerton, B. T., Gretarsson, K. H., Sahu, V., Mangipudy, V. S., Nguyen, T. T. T., Nair, A., Rogava, M., Ho, P., Koch, P. D., … Izar, B. (2022). Dissecting the treatment-naive ecosystem of human melanoma brain metastasis. Cell, 185(14), 2591-2608.e30. https://doi.org/10.1016/j.cell.2022.06.007
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Vagelos College of Physicians and Surgeons; Department of Medicine; Division of Hematology/Oncology; Department of Genetics and Development; Department of Pathology and Cell Biology; Department of Neurosurgery; Department of Radiology; Herbert Irving Comprehensive Cancer Center; Department of Systems Biology; Center for Translational Immunology; Irving Institute for Cancer Dynamics
Lee, S. S.-J., Appelbaum, P. S., & Chung, W. K. (2022). Challenges and potential solutions to health disparities in genomic medicine. Cell, 185(12), 2007–2010. https://doi.org/10.1016/j.cell.2022.05.010
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Hallacli, E., Kayatekin, C., Nazeen, S., Wang, X. H., Sheinkopf, Z., Sathyakumar, S., Sarkar, S., Jiang, X., Dong, X., Di Maio, R., Wang, W., Keeney, M. T., Felsky, D., Sandoe, J., Vahdatshoar, A., Udeshi, N. D., Mani, D. R., Carr, S. A., Lindquist, S., … Khurana, V. (2022). The Parkinson’s disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability. Cell, 185(12), 2035-2056.e33. https://doi.org/10.1016/j.cell.2022.05.008
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Varn, F. S., Johnson, K. C., Martinek, J., Huse, J. T., Nasrallah, M. P., Wesseling, P., Cooper, L. A. D., Malta, T. M., Wade, T. E., Sabedot, T. S., Brat, D., Gould, P. V., Wöehrer, A., Aldape, K., Ismail, A., Sivajothi, S. K., Barthel, F. P., Kim, H., Kocakavuk, E., … Verhaak, R. GW. (2022). Glioma progression is shaped by genetic evolution and microenvironment interactions. Cell, 185(12), 2184-2199.e16. https://doi.org/10.1016/j.cell.2022.04.038
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Asher, W. B., Terry, D. S., Gregorio, G. G. A., Kahsai, A. W., Borgia, A., Xie, B., Modak, A., Zhu, Y., Jang, W., Govindaraju, A., Huang, L.-Y., Inoue, A., Lambert, N. A., Gurevich, V. V., Shi, L., Lefkowitz, R. J., Blanchard, S. C., & Javitch, J. A. (2022). GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision. Cell, 185(10), 1661-1675.e16. https://doi.org/10.1016/j.cell.2022.03.042
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Chang, A., Xiang, X., Wang, J., Lee, C., Arakhamia, T., Simjanoska, M., Wang, C., Carlomagno, Y., Zhang, G., Dhingra, S., Thierry, M., Perneel, J., Heeman, B., Forgrave, L. M., DeTure, M., DeMarco, M. L., Cook, C. N., Rademakers, R., Dickson, D. W., … Fitzpatrick, A. W. P. (2022). Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases. Cell, 185(8), 1346-1355.e15. https://doi.org/10.1016/j.cell.2022.02.026
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Zazhytska, M., Kodra, A., Hoagland, D. A., Frere, J., Fullard, J. F., Shayya, H., McArthur, N. G., Moeller, R., Uhl, S., Omer, A. D., Gottesman, M. E., Firestein, S., Gong, Q., Canoll, P. D., Goldman, J. E., Roussos, P., tenOever, B. R., Jonathan B. Overdevest, & Lomvardas, S. (2022). Non-cell-autonomous disruption of nuclear architecture as a potential cause of COVID-19-induced anosmia. Cell, 185(6), 1052-1064.e12. https://doi.org/10.1016/j.cell.2022.01.024
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Zuckerman Mind, Brain, and Behavior Institute; Vagelos College of Physicians and Surgeons; Department of Pathology and Cell Biology; Department of Otolaryngology—Head and Neck Surgery; Department of Biochemistry and Molecular Biophysics; Department of Neuroscience; Department of Genetics and Development
Sinnis, P., & Fidock, D. A. (2022). The RTS,S vaccine—a chance to regain the upper hand against malaria? Cell, 185(5), 750–754. https://doi.org/10.1016/j.cell.2022.01.028
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Chalif, J. I., Martínez-Silva, M. de L., Pagiazitis, J. G., Murray, A. J., & Mentis, G. Z. (2022). Control of mammalian locomotion by ventral spinocerebellar tract neurons. Cell, 185(2), 328-344.e26. https://doi.org/10.1016/j.cell.2021.12.014
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