Proceedings of the National Academy of Sciences of the United States of America
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Miotto, M. C., Luna-Figueroa, E., Tchagou, C., Bahlouli, L., Reiken, S., Dridi, H., Liu, Y., Weninger, G., & Marks, A. R. (2025). Targeting ryanodine receptors with allopurinol and xanthine derivatives for the treatment of cardiac and musculoskeletal weakness disorders. Proceedings of the National Academy of Sciences, 122(24). https://doi.org/10.1073/pnas.2422082122
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Suter, T., Friedman, M. J., Tazearslan, C., Merkurjev, D., Ohgi, K., Meluzzi, D., Rosenfeld, M. G., & Suh, Y. (2025). Ligand-specific regulation of a binary enhancer code dictating cellular senescence. Proceedings of the National Academy of Sciences, 122(24). https://doi.org/10.1073/pnas.2506321122
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Pappas, K., Ferrari, M., Smith, P., Nandakumar, S., Khan, Z., Young, S. B., LaClair, J., Russo, M. V., Huang-Hobbs, E., Schultz, N., Abida, W., Karthaus, W., Jasin, M., & L. Sawyers, C. (2025). BRCA2 reversion mutation–independent resistance to PARP inhibition through impaired DNA prereplication complex function. Proceedings of the National Academy of Sciences, 122(23). https://doi.org/10.1073/pnas.2426743122
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Wang, X., & Tabas, I. (2025). Location, location, location: Cholesterol in lipid droplets as a driver of MASH progression. Proceedings of the National Academy of Sciences, 122(23). https://doi.org/10.1073/pnas.2509899122
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Stolyarova, A., Coop, G., & Przeworski, M. (2025). The distribution of highly deleterious variants across human ancestry groups. Proceedings of the National Academy of Sciences, 122(21). https://doi.org/10.1073/pnas.2503857122
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Wang, X., Tsien, S. J., Jin, M., Goldberg, M. E., Zhang, M., & Qian, N. (2025). A circuit model for transsaccadic space updating and mislocalization. Proceedings of the National Academy of Sciences, 122(21). https://doi.org/10.1073/pnas.2422911122
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Duy, P. Q., Kiziltug, E., Greenberg, A. B. W., Mehta, N. H., Hao, L. T., Fortes, C., Mullany, S., Fan, B., Manichaikul, A., Teich, A. F., Chan, D., Alper, S. L., Hyman, B. T., Arnold, S. E., McKhann, G. M., Frosch, M. P., & Kahle, K. T. (2025). Single-cell elderly blood–CSF atlas implicates peripherally influenced immune dysregulation in normal pressure hydrocephalus. Proceedings of the National Academy of Sciences, 122(19). https://doi.org/10.1073/pnas.2412159122
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Miller, B. R., Gonzaga-Jauregui, C., Brigatti, K. W., de Jong, J., Breese, R. S., Ko, S. Y., Puffenberger, E. G., Van Hout, C., Young, M., Luna, V. M., Staples, J., First, M. B., Gregoire, H. J., Dwork, A. J., Pefanis, E., McCarthy, S., Brydges, S., Rojas, J., Ye, B., … Strauss, K. A. (2025). A rare variant in GPR156 associated with depression in a Mennonite pedigree causes habenula hyperactivity and stress sensitivity in mice. Proceedings of the National Academy of Sciences, 122(16). https://doi.org/10.1073/pnas.2404754122
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Vercammen, A., Wray, B., Crider, Y. S., Belkin, G., & Lawrance, E. L. (2025). Psychological impacts of climate change on US youth. Proceedings of the National Academy of Sciences, 122(16). https://doi.org/10.1073/pnas.2311400122
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Ambrogi, M., Hernandez, L. L., Strand, D. W., Kumar, S., Romero, M. F., Barasch, J., Ridlon, M., Keil Stietz, K. P., & Vezina, C. M. (2025). A 5-HT-mediated urethral defense against urinary tract infections. Proceedings of the National Academy of Sciences, 122(16). https://doi.org/10.1073/pnas.2409754122
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Bertulfo, K., Perez-Duran, P., Miller, H., Ma, C., Ambesi-Impiombato, A., Samon, J., Mackey, A., Lin, W.-H. W., Ferrando, A. A., & Palomero, T. (2025). Therapeutic targeting of the NOTCH1 and neddylation pathways in T cell acute lymphoblastic leukemia. Proceedings of the National Academy of Sciences, 122(14). https://doi.org/10.1073/pnas.2426742122
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Qiu, W., Trinh, T. K. H., Catalano, C., Mehta, A., Desai, U. R., Kellogg, G. E., Hendrickson, W. A., & Guo, Y. (2025). Cholesterol-dependent enzyme activity of human TSPO1. Proceedings of the National Academy of Sciences, 122(13). https://doi.org/10.1073/pnas.2323045122
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Sierant, M. C., Jin, S. C., Bilguvar, K., Morton, S. U., Dong, W., Jiang, W., Lu, Z., Li, B., López-Giráldez, F., Tikhonova, I., Zeng, X., Lu, Q., Choi, J., Zhang, J., Nelson-Williams, C., Knight, J. R., Zhao, H., Cao, J., Mane, S., … Lifton, R. P. (2025). Genomic analysis of 11,555 probands identifies 60 dominant congenital heart disease genes. Proceedings of the National Academy of Sciences, 122(13). https://doi.org/10.1073/pnas.2420343122
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Dong, W., Jin, S. C., Sierant, M. C., Lu, Z., Li, B., Lu, Q., Morton, S. U., Zhang, J., López-Giráldez, F., Nelson-Williams, C., Knight, J. R., Zhao, H., Cao, J., Mane, S., Gruber, P. J., Lek, M., Goldmuntz, E., Deanfield, J., Giardini, A., … Brueckner, M. (2025). Recessive genetic contribution to congenital heart disease in 5,424 probands. Proceedings of the National Academy of Sciences, 122(10). https://doi.org/10.1073/pnas.2419992122
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Horne, C. R., Dite, T. A., Young, S. N., Mather, L. J., Dagley, L. F., Johnson, J. L., Yaron-Barir, T. M., Huntsman, E. M., Daly, L. A., Byrne, D. P., Cadell, A. L., Ng, B. H., Yousef, J., Multari, D. H., Shen, L., McAloon, L. M., Manning, G., Febbraio, M. A., Means, A. R., … Murphy, J. M. (2025). PSKH1 kinase activity is differentially modulated via allosteric binding of Ca 2+ sensor proteins. Proceedings of the National Academy of Sciences, 122(8). https://doi.org/10.1073/pnas.2420961122
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Ma, L., Pang, Z., Zhang, H., Yang, X., Zheng, S., Chen, Y., Ding, W., Han, Q., Zhang, X., Cao, L., Fei, T., Wang, Q., Gao, D., He, A., Hu, K.-B., Li, X., & Sheng, R. (2025). Clear cell renal carcinoma essentially requires CDKL3 for oncogenesis. Proceedings of the National Academy of Sciences, 122(7). https://doi.org/10.1073/pnas.2415244122
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Delgado-Chaves, F. M., Jennings, M. J., Atalaia, A., Wolff, J., Horvath, R., Mamdouh, Z. M., Baumbach, J., & Baumbach, L. (2025). Transforming literature screening: The emerging role of large language models in systematic reviews. Proceedings of the National Academy of Sciences, 122(2). https://doi.org/10.1073/pnas.2411962122
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Topper, M. J., Guarnieri, J. W., Haltom, J. A., Chadburn, A., Cope, H., Frere, J., An, J., Borczuk, A., Sinha, S., Kim, J., Park, J., Butler, D., Meydan, C., Foox, J., Bram, Y., Richard, S. A., Epsi, N. J., Agan, B., Chenoweth, J. G., … Baylin, S. B. (2024). Lethal COVID-19 associates with RAAS-induced inflammation for multiple organ damage including mediastinal lymph nodes. Proceedings of the National Academy of Sciences, 121(49). https://doi.org/10.1073/pnas.2401968121
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Buss, E. W., Lofaro, O. M., Barnett, A., Leroy, F., Santoro, B., Siegelbaum, S. A., & Bock, T. (2024). HCN1 hyperpolarization-activated cyclic nucleotide–gated channels enhance evoked GABA release from parvalbumin-positive interneurons. Proceedings of the National Academy of Sciences, 121(42). https://doi.org/10.1073/pnas.2319246121
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Baldassarri, I., Tavakol, D. N., Graney, P. L., Chramiec, A. G., Hibshoosh, H., & Vunjak-Novakovic, G. (2024). An engineered model of metastatic colonization of human bone marrow reveals breast cancer cell remodeling of the hematopoietic niche. Proceedings of the National Academy of Sciences, 121(42). https://doi.org/10.1073/pnas.2405257121
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Wang, W., Williams, D. J., Teoh, J. J., Soundararajan, D., Zuberi, A., Lutz, C. M., Frankel, W. N., & Makinson, C. D. (2024). Impaired axon initial segment structure and function in a model of
ARHGEF9
developmental and epileptic encephalopathy. Proceedings of the National Academy of Sciences, 121(42). https://doi.org/10.1073/pnas.2400709121
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Bratsberg, B., Fjell, A. M., Rogeberg, O. J., Skirbekk, V. F., & Walhovd, K. B. (2024). Differences in cognitive function at 18 y of age explain the association between low education and early dementia risk. Proceedings of the National Academy of Sciences, 121(41). https://doi.org/10.1073/pnas.2412017121
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Abhimanyu, Longlax, S. C., Nishiguchi, T., Ladki, M., Sheikh, D., Martinez, A. L., Mace, E. M., Grimm, S. L., Caldwell, T., Portillo Varela, A., Sekhar, R. V., Mandalakas, A. M., Mlotshwa, M., Ginidza, S., Cirillo, J. D., Wallis, R. S., Netea, M. G., van Crevel, R., Coarfa, C., & DiNardo, A. R. (2024). TCA metabolism regulates DNA hypermethylation in LPS andMycobacterium tuberculosis–induced immune tolerance. Proceedings of the National Academy of Sciences, 121(41). https://doi.org/10.1073/pnas.2404841121
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Alternating access of a bacterial homolog of neurotransmitter: sodium symporters determined from AlphaFold2 ensembles and DEER spectroscopy. (2024). Proceedings of the National Academy of Sciences, 121(40). https://doi.org/10.1073/pnas.2406063121
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Rodriguez, P., Kalia, V., Fenollar-Ferrer, C., Gibson, C. L., Gichi, Z., Rajoo, A., Matier, C. D., Pezacki, A. T., Xiao, T., Carvelli, L., Chang, C. J., Miller, G. W., Khamoui, A. V., Boerner, J., & Blakely, R. D. (2024). Glial swip-10 controls systemic mitochondrial function, oxidative stress, and neuronal viability via copper ion homeostasis. Proceedings of the National Academy of Sciences, 121(39). https://doi.org/10.1073/pnas.2320611121
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Holland, M. A., Maisel, K., Ibberson, C. B., Wiley, L. K., Burnett, D. C., Mace, E. M., & Elting, M. W. (2024). Extended time, elevated expectations: The unappreciated downsides of pausing the tenure clock. Proceedings of the National Academy of Sciences, 121(34). https://doi.org/10.1073/pnas.2403489121
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Qin, L., Deng, Y., Zhang, X., Tang, L., Zhang, C., Xu, S., Wang, K., Wang, M., Zhang, X., Su, M., Xie, Q., Hendrickson, W. A., & Chen, Y. (2024). Mechanistic insights into phosphoactivation of SLAC1 in guard cell signaling. Proceedings of the National Academy of Sciences, 121(29). https://doi.org/10.1073/pnas.2323040121
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Wu, Q., Rafatian, N., Wagner, K. T., Blamer, J., Smith, J., Okhovatian, S., Aggarwal, P., Wang, E. Y., Banerjee, A., Zhao, Y., Nash, T. R., Lu, R. X. Z., Portillo-Esquivel, L. E., Li, C. Y., Kuzmanov, U., Mandla, S., Virlee, E., Landau, S., Lai, B. F., … Radisic, M. (2024). SARS-CoV-2 pathogenesis in an angiotensin II–induced heart-on-a-chip disease model and extracellular vesicle screening. Proceedings of the National Academy of Sciences, 121(28). https://doi.org/10.1073/pnas.2403581121
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Lippl, S., Kay, K., Jensen, G., Ferrera, V. P., & Abbott, L. F. (2024). A mathematical theory of relational generalization in transitive inference. Proceedings of the National Academy of Sciences, 121(28). https://doi.org/10.1073/pnas.2314511121
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Zaidi, S., Park, J., Chan, J. M., Roudier, M. P., Zhao, J. L., Gopalan, A., Wadosky, K. M., Patel, R. A., Sayar, E., Karthaus, W. R., Kates, D. H., Chaudhary, O., Xu, T., Masilionis, I., Mazutis, L., Chaligné, R., Obradovic, A., Linkov, I., Barlas, A., … Sawyers, C. L. (2024). Single-cell analysis of treatment-resistant prostate cancer: Implications of cell state changes for cell surface antigen–targeted therapies. Proceedings of the National Academy of Sciences, 121(28). https://doi.org/10.1073/pnas.2322203121
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Weninger, G., Miotto, M. C., Tchagou, C., Reiken, S., Dridi, H., Brandenburg, S., Riedemann, G. C., Yuan, Q., Liu, Y., Chang, A., Wronska, A., Lehnart, S. E., & Marks, A. R. (2024). Structural insights into the regulation of RyR1 by S100A1. Proceedings of the National Academy of Sciences, 121(27). https://doi.org/10.1073/pnas.2400497121
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Saponaro, A., Krumbach, J. H., Chaves-Sanjuan, A., Sharifzadeh, A. S., Porro, A., Castelli, R., Hamacher, K., Bolognesi, M., DiFrancesco, D., Clarke, O. B., Thiel, G., & Moroni, A. (2024). Structural determinants of ivabradine block of the open pore of HCN4. Proceedings of the National Academy of Sciences, 121(27). https://doi.org/10.1073/pnas.2402259121
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Trumpff, C., Monzel, A. S., Sandi, C., Menon, V., Klein, H.-U., Fujita, M., Lee, A., Petyuk, V. A., Hurst, C., Duong, D. M., Seyfried, N. T., Wingo, A. P., Wingo, T. S., Wang, Y., Thambisetty, M., Ferrucci, L., Bennett, D. A., De Jager, P. L., & Picard, M. (2024). Psychosocial experiences are associated with human brain mitochondrial biology. Proceedings of the National Academy of Sciences, 121(27). https://doi.org/10.1073/pnas.2317673121
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Vagelos College of Physicians and Surgeons; Department of Psychiatry; Division of Behavioral Medicine; Department of Neurology; Center for Translational and Computational Neuroimmunology; Columbia Translational Neuroscience Initiative; Robert N. Butler Columbia Aging Center; Mailman School of Public Health
Cheng, M., Conley, D., Kuipers, T., Li, C., Ryan, C. P., Taeubert, M. J., Wang, S., Wang, T., Zhou, J., Schmitz, L. L., Tobi, E. W., Heijmans, B. T., Lumey, L. H., & Belsky, D. W. (2024). Accelerated biological aging six decades after prenatal famine exposure. Proceedings of the National Academy of Sciences, 121(24). https://doi.org/10.1073/pnas.2319179121
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Nebo, I. D., Frew, J. W., Gudjonsson, J. E., & Petukhova, L. (2024). Tissue comparability and bias in hidradenitis suppurativa transcriptomic studies. Proceedings of the National Academy of Sciences, 121(23). https://doi.org/10.1073/pnas.2404503121
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Zhao, H., Petrey, D., Murray, D., & Honig, B. (2024). ZEPPI: Proteome-scale sequence-based evaluation of protein–protein interaction models. Proceedings of the National Academy of Sciences, 121(21). https://doi.org/10.1073/pnas.2400260121
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Lee, J., Lee, J., Sohn, E. J., Taglialatela, A., O’Sullivan, R. J., Ciccia, A., & Min, J. (2024). Extrachromosomal telomere DNA derived from excessive strand displacements. Proceedings of the National Academy of Sciences, 121(19). https://doi.org/10.1073/pnas.2318438121
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Thomas, M. A., Naik, P., Wang, H., Giles, J. T., Girgis, A. A., Kim, S.-Y., Johnson, T. P., Curran, A. M., Crawford, J. D., Jahanbani, S., Bingham, C. O., Robinson, W. H., Na, C. H., & Darrah, E. (2024). The monocyte cell surface is a unique site of autoantigen generation in rheumatoid arthritis. Proceedings of the National Academy of Sciences, 121(17). https://doi.org/10.1073/pnas.2304199121
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Ryan, C. P., Lee, N. R., Carba, D. B., MacIsaac, J. L., Lin, D. T. S., Atashzay, P., Belsky, D. W., Kobor, M. S., & Kuzawa, C. W. (2024). Pregnancy is linked to faster epigenetic aging in young women. Proceedings of the National Academy of Sciences, 121(16). https://doi.org/10.1073/pnas.2317290121
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Heckmeier, P. J., Ruf, J., Rochereau, C., & Hamm, P. (2024). A billion years of evolution manifest in nanosecond protein dynamics. Proceedings of the National Academy of Sciences, 121(10). https://doi.org/10.1073/pnas.2318743121
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Casey, J. A., Kioumourtzoglou, M.-A., Padula, A., González, D. J. X., Elser, H., Aguilera, R., Northrop, A. J., Tartof, S. Y., Mayeda, E. R., Braun, D., Dominici, F., Eisen, E. A., Morello-Frosch, R., & Benmarhnia, T. (2024). Measuring long-term exposure to wildfire PM 2.5 in California: Time-varying inequities in environmental burden. Proceedings of the National Academy of Sciences, 121(8). https://doi.org/10.1073/pnas.2306729121
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Schönherr, H., Ayaz, P., Taylor, A. M., Casaletto, J. B., Touré, B. B., Moustakas, D. T., Hudson, B. M., Valverde, R., Zhao, S., O’Hearn, P. J., Foster, L., Sharon, D. A., Garfinkle, S., Giordanetto, F., Lescarbeau, A., Kurukulasuriya, R., Gerami-Moayed, N., Maglic, D., Bruderek, K., … Bergstrom, D. A. (2024). Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2. Proceedings of the National Academy of Sciences, 121(6). https://doi.org/10.1073/pnas.2317756121
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Qian, N., Gao, X., Lang, X., Deng, H., Bratu, T. M., Chen, Q., Stapleton, P., Yan, B., & Min, W. (2024). Rapid single-particle chemical imaging of nanoplastics by SRS microscopy. Proceedings of the National Academy of Sciences, 121(3). https://doi.org/10.1073/pnas.2300582121
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Goff, S. P., & Shenk, T. (2023). Paul Berg: Recombinant DNA trailblazer. Proceedings of the National Academy of Sciences, 120(47). https://doi.org/10.1073/pnas.2318196120
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Postler, T. S., Wang, A., Brundu, F. G., Wang, P., Wu, Z., Butler, K. E., Grinberg-Bleyer, Y., Krishnareddy, S., Lagana, S. M., Saqi, A., Oeckinghaus, A., Rabadan, R., & Ghosh, S. (2023). A pan-cancer analysis implicates human NKIRAS1 as a tumor-suppressor gene. Proceedings of the National Academy of Sciences, 120(46). https://doi.org/10.1073/pnas.2312595120
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Hatton, I. A., Galbraith, E. D., Merleau, N. S. C., Miettinen, T. P., Smith, B. M., & Shander, J. A. (2023). The human cell count and size distribution. Proceedings of the National Academy of Sciences, 120(39). https://doi.org/10.1073/pnas.2303077120
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Qin, Y., Mace, E. M., & Barton, J. P. (2023). An inference model gives insights into innate immune adaptation and repertoire diversity. Proceedings of the National Academy of Sciences, 120(38). https://doi.org/10.1073/pnas.2305859120
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Li, A. M., He, B., Karagiannis, D., Li, Y., Jiang, H., Srinivasan, P., Ramirez, Y., Zhou, M.-N., Curtis, C., Gruber, J. J., Lu, C., Rankin, E. B., & Ye, J. (2023). Serine starvation silences estrogen receptor signaling through histone hypoacetylation. Proceedings of the National Academy of Sciences, 120(38). https://doi.org/10.1073/pnas.2302489120
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Le Guen, Y., Luo, G., Ambati, A., Damotte, V., Jansen, I., Yu, E., Nicolas, A., de Rojas, I., Peixoto Leal, T., Miyashita, A., Bellenguez, C., Lian, M. M., Parveen, K., Morizono, T., Park, H., Grenier-Boley, B., Naito, T., Küçükali, F., Talyansky, S. D., … Tan, E.-K. (2023). Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes. Proceedings of the National Academy of Sciences, 120(36). https://doi.org/10.1073/pnas.2302720120
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Lao, Y.-H., Ji, R., Zhou, J. K., Snow, K. J., Kwon, N., Saville, E., He, S., Chauhan, S., Chi, C.-W., Datta, M. S., Zhang, H., Quek, C. H., Cai, S. S., Li, M., Gaitan, Y., Bechtel, L., Wu, S.-Y., Lutz, C. M., Tomer, R., … Leong, K. W. (2023). Focused ultrasound–mediated brain genome editing. Proceedings of the National Academy of Sciences, 120(34). https://doi.org/10.1073/pnas.2302910120
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