Department of Microbiology and Immunology

Displaying 1 - 50 of 329CSV
Pezet, M. G., Torres, J. A., Thimraj, T. A., Matkovic, I., Schrode, N., Murray, J. W., Saqi, A., Beaumont, K. G., & Snoeck, H.-W. (2025). Human respiratory airway progenitors derived from pluripotent cells generate alveolar epithelial cells and model pulmonary fibrosis. Nature Biotechnology. https://doi.org/10.1038/s41587-025-02569-0
Publication Date
Sharan, K., Brandt, C., Yusuf, M. A., Singh, P., Halder, N., Edwards, M. E., Mangu, S. R., Das, A., Mishra, A., Kumar, S. S., Sharma, A., Gupta, A., Liu, X. S., Guo, E. X., Monani, U. R., Ponnalagu, D., Ivanov, I. I., Lal, G., Clare, S., … Yadav, V. K. (2025). Rapid and relaying deleterious effects of a gastrointestinal pathogen, Citrobacter rodentium, on bone, an extra-intestinal organ. IScience, 28(2), 111802. https://doi.org/10.1016/j.isci.2025.111802
Publication Date
Lin, X., Leung, K. S. K., Wolfe, K. F., Call, N., Bhandari, S. K., Huang, X., Lee, B. J., Tomkinson, A. E., & Zha, S. (2025). XRCC1 mediates PARP1- and PAR-dependent recruitment of PARP2 to DNA damage sites. Nucleic Acids Research, 53(4). https://doi.org/10.1093/nar/gkaf086
Publication Date
Gunes, M. E., Patwardhan, S., Hong, J., Manell, E., Jordache, P., Chauhan, I., Almesallmy, A., Fu, J., Sykes, M., & Weiner, J. (2025). Mucosal Mixed Lymphocyte Reaction Assay Using Intestinal Lymphocytes as a Biomarker for Intestinal Transplant Tolerance Development. Transplantation. https://doi.org/10.1097/tp.0000000000005348
Publication Date
Fang, Y., Chung, S. S. W., Xu, L., Xue, C., Liu, X., Jiang, D., Li, R., Korogi, Y., Yuan, K., Saqi, A., Hibshoosh, H., Huang, Y., Lin, C.-S., Tsukui, T., Sheppard, D., Sun, X., & Que, J. (2025). RUNX2 promotes fibrosis via an alveolar-to-pathological fibroblast transition. Nature. https://doi.org/10.1038/s41586-024-08542-2
Publication Date
Kuhn, A. J., Outlaw, V. K., Marcink, T. C., Yu, Z., Mears, M. C., Cajimat, M. N., Kreitler, D. F., Cleven, P. R., Mook, J. C., Bente, D. A., Porotto, M., Gellman, S. H., & Moscona, A. (2025). Enhancing the solubility of SARS-CoV-2 inhibitors to increase future prospects for clinical development. Journal of Virology. https://doi.org/10.1128/jvi.02159-24
Publication Date
Rawat, M., Padalino, G., Adika, E., Okombo, J., Yeo, T., Brancale, A., Fidock, D. A., Hoffmann, K. F., & Lee, M. C. S. (2025). Quinoxaline-based anti-schistosomal compounds have potent anti-plasmodial activity. PLOS Pathogens, 21(2), e1012216. https://doi.org/10.1371/journal.ppat.1012216
Publication Date
Reynard, O., Iampietro, M., Dumont, C., Le Guellec, S., Durand, S., Moroso, M., Brisebard, E., Dhondt, K. P., Pelissier, R., Mathieu, C., Cabrera, M., Le Pennec, D., Amurri, L., Alabi, C., Cardinaud, S., Porotto, M., Moscona, A., Vecellio, L., & Horvat, B. (2025). Development of nebulized inhalation delivery for fusion-inhibitory lipopeptides to protect non-human primates against Nipah-Bangladesh infection. Antiviral Research, 235, 106095. https://doi.org/10.1016/j.antiviral.2025.106095
Publication Date
Elyaman, W., Stern, L. J., Jiang, N., Dressman, D., Bradley, P., Klatzmann, D., Bradshaw, E. M., Farber, D. L., Kent, S. C., Chizari, S., Funk, K., Devanand, D., Thakur, K. T., Raj, T., Dalahmah, O. A., Sarkis, R. A., Weiner, H. L., Shneider, N. A., & Przedborski, S. (2025). Exploring the role of T cells in Alzheimer’s and other neurodegenerative diseases: Emerging therapeutic insights from the T Cells in the Brain symposium. Alzheimer’s & Dementia. Portico. https://doi.org/10.1002/alz.14548
Publication Date
Riemann, L., Gutierrez, R., Odak, I., Barros-Martins, J., Roesner, L. M., Leon Lara, X., Falk, C., Schulz, T. F., Hansen, G., Werfel, T., Förster, R., Bošnjak, B., Jenniches, F., Klopp, N., Lesker, T. R., & Stangel, M. (2025). Integrative deep immune profiling of the elderly reveals systems-level signatures of aging, sex, smoking, and clinical traits. EBioMedicine, 112, 105558. https://doi.org/10.1016/j.ebiom.2025.105558
Publication Date
Wang, X., Zhao, D., Bi, D., Li, L., Tian, H., Yin, F., Zuo, T., Ianiro, G., Han, Y. W., Li, N., Chen, Q., & Qin, H. (2025). Fecal microbiota transplantation: transitioning from chaos and controversial realm to scientific precision era. Science Bulletin. https://doi.org/10.1016/j.scib.2025.01.029
Publication Date
Mougari, S., Favède, V., Predella, C., Reynard, O., Durand, S., Mazelier, M., Pizzioli, E., Decimo, D., Bovier, F. T., Lapsley, L. M., Castagna, C., Lieberman, N. A. P., Noel, G., Mathieu, C., Malissen, B., Briese, T., Greninger, A. L., Alabi, C. A., Dorrello, N. V., … Horvat, B. (2025). Intranasally administrated fusion-inhibitory lipopeptides block SARS-CoV-2 infection in mice and enable long-term protective immunity. Communications Biology, 8(1). https://doi.org/10.1038/s42003-025-07491-4
Publication Date
Stark, H., Ho, Q. Y., Cross, A., Alessandrini, A., Bertaina, A., Brennan, D., Busque, S., Demetris, A., Devey, L., Fruhwirth, G., Fuchs, E., Friend, P., Geissler, E., Guillonneau, C., Hester, J., Isaacs, J., Jaeckel, E., Kawai, T., Lakkis, F., … Issa, F. (2025). Meeting Report: The Sixth International Sam Strober Workshop on Clinical Immune Tolerance. Transplantation. https://doi.org/10.1097/tp.0000000000005311
Publication Date
Varanasi, S. K., Chen, D., Liu, Y., Johnson, M. A., Miller, C. M., Ganguly, S., Lande, K., LaPorta, M. A., Hoffmann, F. A., Mann, T. H., Teneche, M. G., Casillas, E., Mangalhara, K. C., Mathew, V., Sun, M., Jensen, I. J., Farsakoglu, Y., Chen, T., Parisi, B., … Kaech, S. M. (2025). Bile acid synthesis impedes tumor-specific T cell responses during liver cancer. Science, 387(6730), 192–201. https://doi.org/10.1126/science.adl4100
Publication Date
Hong, S. J., Resnick, S. J., Iketani, S., Cha, J. W., Albert, B. A., Fazekas, C. T., Chang, C.-W., Liu, H., Dagan, S., Abagyan, M. R., Fajtová, P., Culbertson, B., Brace, B., Reddem, E. R., Forouhar, F., Glickman, J. F., Balkovec, J. M., Stockwell, B. R., Shapiro, L., … Chavez, A. (2025). A multiplex method for rapidly identifying viral protease inhibitors. Molecular Systems Biology, 21(2), 158–172. https://doi.org/10.1038/s44320-024-00082-1
Publication Date
Liu, H., Zask, A., Forouhar, F., Iketani, S., Williams, A., Vaz, D. R., Habashi, D., Choi, K., Resnick, S. J., Hong, S. J., Lovett, D. H., Bai, T., Chavez, A., Ho, D. D., & Stockwell, B. R. (2025). Development of small molecule non-covalent coronavirus 3CL protease inhibitors from DNA-encoded chemical library screening. Nature Communications, 16(1). https://doi.org/10.1038/s41467-024-55421-5
Publication Date
Caron, D. P., Specht, W. L., Chen, D., Wells, S. B., Szabo, P. A., Jensen, I. J., Farber, D. L., & Sims, P. A. (2025). Multimodal hierarchical classification of CITE-seq data delineates immune cell states across lineages and tissues. Cell Reports Methods, 5(1), 100938. https://doi.org/10.1016/j.crmeth.2024.100938
Publication Date
Knaab, T. C., Moritz, A., Pessanha de Carvalho, L., Klein, S., Lungerich, B., Lohse, K., Kruse, L., Mombo-Ngoma, G., Orta, L., Thibaud, J. L., de Villiers, K. A., Fidock, D. A., Burckhardt, B. B., Held, J., Wittlin, S., & Kurz, T. (2024). TKK130 is a 3-Hydroxy-Propanamidine (HPA) with Potent Antimalarial In Vivo Activity and a High Barrier to Resistance. Journal of Medicinal Chemistry. https://doi.org/10.1021/acs.jmedchem.4c01465
Publication Date
Martinez-Vega, R., Ishengoma, D. S., Gosling, R., Rosenthal, P. J., Dondorp, A., Barnes, K. I., Nsanzabana, C., Djimde, A. A., Ochola-Oyier, L. I., Tibenderana, J., Chimumbwa, J., Golassa, L., Kapologwe, N. A., Mbacham, W. F., Kamya, M. R., Fidock, D. A., Komatsu, R., von Seidlein, L., & Dhorda, M. (2025). Regional action needed to halt antimalarial drug resistance in Africa. The Lancet, 405(10472), 7–10. https://doi.org/10.1016/s0140-6736(24)02706-5
Publication Date
Hagenah, L. M., Yeo, T., Schindler, K. A., Jeon, J. H., Bloxham, T. S., Small-Saunders, J. L., Mok, S., & Fidock, D. A. (2024). Plasmodium falciparum African PfCRT Mutant Isoforms Conducive to Piperaquine Resistance Are Infrequent and Impart a Major Fitness Cost. The Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jiae617
Publication Date
Xie, S. C., Tai, C.-W., Morton, C. J., Ma, L., Huang, S.-C., Wittlin, S., Du, Y., Hu, Y., Dogovski, C., Salimimarand, M., Griffin, R., England, D., de la Cruz, E., Deni, I., Yeo, T., Burkhard, A. Y., Striepen, J., Schindler, K. A., Crespo, B., … Tilley, L. (2024). A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo. PLOS Pathogens, 20(12), e1012429. https://doi.org/10.1371/journal.ppat.1012429
Publication Date
Gomez-Gonzalez, P.-J., Gupta, A., Drought, L. G., Patel, A., Okombo, J., van der Watt, M., Walker-Gray, R., Schindler, K. A., Burkhard, A. Y., Yeo, T., Narwal, S. K., Bloxham, T. S., Flueck, C., Walker, E. M., Rey, J. A., Fairhurst, K. J., Reader, J., Park, H., Pollard, H. G., … Baker, D. A. (2024). Inhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission. Science Advances, 10(49). https://doi.org/10.1126/sciadv.adq1383
Publication Date
Kimble, M. T., Sane, A., Reid, R. J. D., Johnson, M. J., Rothstein, R., & Symington, L. S. (2025). Repair of replication-dependent double-strand breaks differs between the leading and lagging strands. Molecular Cell, 85(1), 61-77.e6. https://doi.org/10.1016/j.molcel.2024.10.032
Publication Date
Bestgen, B., Jones, S., Thathy, V., Kuemmerle, A., Barcelo, C., Haouala, A., Gossen, D., Marx, M. W., Di Resta, I., Szramowska, M., Webster, R. A., Llewellyn, S., Ritacco, D. A., Yeo, T., Leroy, D., Barber, B. E., Fidock, D. A., Griffin, P., Lickliter, J., & Chalon, S. (2024). Safety, tolerability, pharmacokinetics, and antimalarial activity of MMV533: a phase 1a first-in-human, randomised, ascending dose and food effect study, and a phase 1b Plasmodium falciparum volunteer infection study. The Lancet Infectious Diseases. https://doi.org/10.1016/s1473-3099(24)00664-9
Publication Date
Wang, Q., Guo, Y., Schwanz, L. T., Mellis, I. A., Sun, Y., Qu, Y., Urtecho, G., Valdez, R., Stoneman, E., Gordon, A., Wang, H. H., Ho, D. D., & Liu, L. (2024). SARS-CoV-2 omicron BA.2.87.1 exhibits higher susceptibility to serum neutralization than EG.5.1 and JN.1. Emerging Microbes & Infections, 13(1). https://doi.org/10.1080/22221751.2024.2359004
Publication Date
Luth, M. R., Godinez-Macias, K. P., Chen, D., Okombo, J., Thathy, V., Cheng, X., Daggupati, S., Davies, H., Dhingra, S. K., Economy, J. M., Edgar, R. C. S., Gomez-Lorenzo, M. G., Istvan, E. S., Jado, J. C., LaMonte, G. M., Melillo, B., Mok, S., Narwal, S. K., Ndiaye, T., … Winzeler, E. A. (2024). Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance. Science, 386(6725). https://doi.org/10.1126/science.adk9893
Publication Date
Davis-Porada, J., George, A. B., Lam, N., Caron, D. P., Gray, J. I., Huang, J., Hwu, J., Wells, S. B., Matsumoto, R., Kubota, M., Lee, Y., Morrison-Colvin, R., Jensen, I. J., Ural, B. B., Shaabani, N., Weiskopf, D., Grifoni, A., Sette, A., Szabo, P. A., … Farber, D. L. (2024). Maintenance and functional regulation of immune memory to COVID-19 vaccines in tissues. Immunity, 57(12), 2895-2913.e8. https://doi.org/10.1016/j.immuni.2024.10.003
Publication Date
Cummings, M. J., Lutwama, J. J., Owor, N., Tomoiaga, A. S., Ross, J. E., Muwanga, M., Nsereko, C., Nayiga, I., Kyebambe, S., Shinyale, J., Ochar, T., Kiwubeyi, M., Nankwanga, R., Nie, K., Xie, H., Miake-Lye, S., Villagomez, B., Qi, J., Reynolds, S. J., … O’Donnell, M. R. (2024). Unsupervised Classification of the Host Response Identifies Dominant Pathobiological Signatures of Sepsis in Sub-Saharan Africa. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.202407-1394oc
Publication Date
Handrejk, K., Schmitz, K. S., Veldhuis Kroeze, E. J. B., van Dijk, L. L. A., van Run, P., Haagmans, B., Moscona, A., Porotto, M., de Swart, R. L., de Vries, R. D., & Rissmann, M. (2024). Characterization of a SARS-CoV-2 Omicron BA.5 direct-contact transmission model in hamsters. Npj Viruses, 2(1). https://doi.org/10.1038/s44298-024-00061-1
Publication Date
FNU, T., Shi, P., Zhang, W., Chung, S. S. W., Damoci, C. B., Fang, Y., Chen, Q.-Y., Saqi, A., Huang, Y., Wu, X., Lu, C., Yang, D., Wang, T. C., & Que, J. (2024). Sympathetic Neurons Promote Small Cell Lung Cancer Through the Beta-2 Adrenergic Receptor. Cancer Discovery. https://doi.org/10.1158/2159-8290.cd-24-0718
Publication Date
Ferreira, L. T., Cassiano, G. C., Alvarez, L. C. S., Okombo, J., Calit, J., Fontinha, D., Gil-Iturbe, E., Coyle, R., Andrade, C. H., Sunnerhagen, P., Bargieri, D. Y., Prudêncio, M., Quick, M., Cravo, P. V., Lee, M. C. S., Fidock, D. A., & Costa, F. T. M. (2024). A novel 4-aminoquinoline chemotype with multistage antimalarial activity and lack of cross-resistance with PfCRT and PfMDR1 mutants. PLOS Pathogens, 20(10), e1012627. https://doi.org/10.1371/journal.ppat.1012627
Publication Date
Rijo-Ferreira, F., Ho, C.-M., & Rosenberg, A. (2024). Young investigators in parasitology meeting: building foundations and supporting early-career researchers. Trends in Parasitology, 40(12), 1063–1065. https://doi.org/10.1016/j.pt.2024.10.004
Publication Date
Patwardhan, S., Gunes, M. E., Manell, E., Hong, J., Jordache, P., Chauhan, I., Almesallmy, A., Mulder, H., Ekanayake-Alper, D., Hajosi, D., Ko, H. M., Shanmugarajah, K., Cetrulo, C. L., Nowak, G., Sachs, D. H., Sykes, M., & Weiner, J. (2024). Durable mixed chimerism may permit subsequent immunosuppression-free intestinal transplantation—A proof-of-principle study. American Journal of Transplantation. https://doi.org/10.1016/j.ajt.2024.10.014
Publication Date
Brettell, S. B., Janha, O., Begen, A., Cann, G., Sharma, S., Olaniyan, N., Yelland, T., Hole, A. J., Alam, B., Mayville, E., Gillespie, R., Capper, M., Fidock, D. A., Milligan, G., Clarke, D. J., Tobin, A. B., & Jamieson, A. G. (2024). Targeting PfCLK3 with Covalent Inhibitors: A Novel Strategy for Malaria Treatment. Journal of Medicinal Chemistry, 67(21), 18895–18910. https://doi.org/10.1021/acs.jmedchem.4c01300
Publication Date
Li, F., Yang, Z., Savage, T. M., Vincent, R. L., de los Santos-Alexis, K., Ahn, A., Rouanne, M., Mariuzza, D. L., Danino, T., & Arpaia, N. (2024). Programmable bacteria synergize with PD-1 blockade to overcome cancer cell–intrinsic immune resistance mechanisms. Science Immunology, 9(100). https://doi.org/10.1126/sciimmunol.adn9879
Publication Date
Redenti, A., Im, J., Redenti, B., Li, F., Rouanne, M., Sheng, Z., Sun, W., Gurbatri, C. R., Huang, S., Komaranchath, M., Jang, Y., Hahn, J., Ballister, E. R., Vincent, R. L., Vardoshivilli, A., Danino, T., & Arpaia, N. (2024). Probiotic neoantigen delivery vectors for precision cancer immunotherapy. Nature, 635(8038), 453–461. https://doi.org/10.1038/s41586-024-08033-4
Publication Date
Marcink, T. C., Zipursky, G., Sobolik, E. B., Golub, K., Herman, E., Stearns, K., Greninger, A. L., Porotto, M., & Moscona, A. (2024). How a paramyxovirus fusion/entry complex adapts to escape a neutralizing antibody. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-53082-y
Publication Date
Awalt, J. K., Su, W., Nguyen, W., Loi, K., Jarman, K. E., Penington, J. S., Ramesh, S., Fairhurst, K. J., Yeo, T., Park, H., Uhlemann, A.-C., Chandra Maity, B., De, N., Mukherjee, P., Chakraborty, A., Churchyard, A., Famodimu, M. T., Delves, M. J., Baum, J., … Sleebs, B. E. (2024). Exploration and characterization of the antimalarial activity of cyclopropyl carboxamides that target the mitochondrial protein, cytochrome b. European Journal of Medicinal Chemistry, 280, 116921. https://doi.org/10.1016/j.ejmech.2024.116921
Publication Date
Lin, X., Gupta, D., Vaitsiankova, A., Bhandari, S. K., Leung, K. S. K., Menolfi, D., Lee, B. J., Russell, H. R., Gershik, S., Huang, X., Gu, W., McKinnon, P. J., Dantzer, F., Rothenberg, E., Tomkinson, A. E., & Zha, S. (2024). Inactive Parp2 causes Tp53-dependent lethal anemia by blocking replication-associated nick ligation in erythroblasts. Molecular Cell, 84(20), 3916-3931.e7. https://doi.org/10.1016/j.molcel.2024.09.020
Publication Date
Stearns, K., Lampe, G., Hanan, R., Marcink, T., Niewiesk, S., Sternberg, S. H., Greninger, A. L., Porotto, M., & Moscona, A. (2024). Human parainfluenza virus 3 field strains undergo extracellular fusion protein cleavage to activate entry. MBio, 15(11). https://doi.org/10.1128/mbio.02327-24
Publication Date
Gu, J., Iyer, A., Wesley, B., Taglialatela, A., Leuzzi, G., Hangai, S., Decker, A., Gu, R., Klickstein, N., Shuai, Y., Jankovic, K., Parker-Burns, L., Jin, Y., Zhang, J. Y., Hong, J., Niu, X., Costa, J. A., Pezet, M. G., Chou, J., … Gaublomme, J. T. (2024). Mapping multimodal phenotypes to perturbations in cells and tissue with CRISPRmap. Nature Biotechnology. https://doi.org/10.1038/s41587-024-02386-x
Publication Date
Calic, P. P. S., Ashton, T. D., Mansouri, M., Loi, K., Jarman, K. E., Qiu, D., Lehane, A. M., Roy, S., Rao, G. P., Maity, B., Wittlin, S., Crespo, B., Gamo, F.-J., Deni, I., Fidock, D. A., Chowdury, M., de Koning-Ward, T. F., Cowman, A. F., Jackson, P. F., … Sleebs, B. E. (2024). Optimization of pyrazolopyridine 4-carboxamides with potent antimalarial activity for which resistance is associated with the P. falciparum transporter ABCI3. European Journal of Medicinal Chemistry, 276, 116677. https://doi.org/10.1016/j.ejmech.2024.116677
Publication Date
Triplett, M. K., Johnson, M. J., & Symington, L. S. (2024). Induction of homologous recombination by site-specific replication stress. DNA Repair, 142, 103753. https://doi.org/10.1016/j.dnarep.2024.103753
Publication Date
Hargrave, K. E., Worrell, J. C., Pirillo, C., Brennan, E., Masdefiol Garriga, A., Gray, J. I., Purnell, T., Roberts, E. W., & MacLeod, M. K. L. (2024). Lung influenza virus-specific memory CD4 T cell location and optimal cytokine production are dependent on interactions with lung antigen-presenting cells. Mucosal Immunology, 17(5), 843–857. https://doi.org/10.1016/j.mucimm.2024.06.001
Publication Date
Hwang, Y., Shimamura, Y., Tanaka, J., Miura, A., Sawada, A., Sarmah, H., Shimizu, D., Kondo, Y., Lee, H., Martini, F., Ninish, Z., Yan, K. S., Yamada, K., & Mori, M. (2024). FGF2 promotes the expansion of parietal mesothelial progenitor pools and inhibits BMP4-mediated smooth muscle cell differentiation. Frontiers in Cell and Developmental Biology, 12. https://doi.org/10.3389/fcell.2024.1387237
Publication Date
Bennett, J. M., Narwal, S. K., Kabeche, S., Abegg, D., Thathy, V., Hackett, F., Yeo, T., Li, V. L., Muir, R., Faucher, F., Lovell, S., Blackman, M. J., Adibekian, A., Yeh, E., Fidock, D. A., & Bogyo, M. (2024). Mixed alkyl/aryl phosphonates identify metabolic serine hydrolases as antimalarial targets. Cell Chemical Biology, 31(9), 1714-1728.e10. https://doi.org/10.1016/j.chembiol.2024.07.006
Publication Date
Wang, Q., Mellis, I. A., Guo, Y., Gherasim, C., Valdez, R., Gordon, A., Ho, D. D., & Liu, L. (2024). Robust SARS-CoV-2-neutralizing antibodies sustained through 6 months post XBB.1.5 mRNA vaccine booster. Cell Reports Medicine, 5(9), 101701. https://doi.org/10.1016/j.xcrm.2024.101701
Publication Date