Role of Microglia in Neurological Disorders

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Gholampour, M., Basu, M. K., Swerdlow, R. H., Zhuo, X., & Haeri, M. (2025). Cell‐specific protein expression in Alzheimer’s disease prefrontal cortex. Alzheimer’s & Dementia, 21(6). Portico. https://doi.org/10.1002/alz.70339
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Johansson, E., Freuchet, A., Williams, G. P., Michealis, T., Frazier, A., Litvan, I., Goldman, J. G., Alcalay, R. N., Standaert, D. G., Amara, A. W., Stover, N., Fon, E. A., Postuma, R. B., Sidney, J., Sulzer, D., Lindestam Arlehamn, C. S., & Sette, A. (2025). T cell responses towards PINK1 and α-synuclein are elevated in prodromal Parkinson’s disease. Npj Parkinson’s Disease, 11(1). https://doi.org/10.1038/s41531-025-01001-3
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Freuchet, A., Johansson, E., Frazier, A., Litvan, I., Goldman, J. G., Alcalay, R. N., Sulzer, D., Lindestam Arlehamn, C. S., & Sette, A. (2025). Differential memory enrichment of cytotoxic CD4 T cells in Parkinson’s disease patients reactive to α-synuclein. Npj Parkinson’s Disease, 11(1). https://doi.org/10.1038/s41531-025-00981-6
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Elyaman, W., Stern, L. J., Jiang, N., Dressman, D., Bradley, P., Klatzmann, D., Bradshaw, E. M., Farber, D. L., Kent, S. C., Chizari, S., Funk, K., Devanand, D., Thakur, K. T., Raj, T., Dalahmah, O. A., Sarkis, R. A., Weiner, H. L., Shneider, N. A., & Przedborski, S. (2025). Exploring the role of T cells in Alzheimer’s and other neurodegenerative diseases: Emerging therapeutic insights from the T Cells in the Brain symposium. Alzheimer’s & Dementia. Portico. https://doi.org/10.1002/alz.14548
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Williams, G. P., Freuchet, A., Michaelis, T., Frazier, A., Tran, N. K., Rodrigues Lima-Junior, J., Phillips, E. J., Mallal, S. A., Litvan, I., Goldman, J. G., Alcalay, R. N., Sidney, J., Sulzer, D., Sette, A., & Lindestam Arlehamn, C. S. (2024). PINK1 is a target of T cell responses in Parkinson’s disease. Journal of Clinical Investigation. https://doi.org/10.1172/jci180478
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Wu, Y., Libby, J. B., Dumitrescu, L., De Jager, P. L., Menon, V., Schneider, J. A., Bennett, D. A., & Hohman, T. J. (2024). Association of ten VEGF family genes with Alzheimer’s disease endophenotypes at single cell resolution. Alzheimer’s & Dementia. Portico. https://doi.org/10.1002/alz.14419
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Ifediora, N. E., Nimmagadda, N., Lee, E., Canoll, P. D., Schneider, J. A., Bennett, D. A., Menon, V., Barnes, L. L., & Olah, M. (2024). Mapping the neuroimmune landscape of Alzheimer’s disease in African Americans. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.091633
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Shani, S., Gana-Weisz, M., Bar-Shira, A., Thaler, A., Gurevich, T., Mirelman, A., Giladi, N., Alcalay, R. N., Orr-Urtreger, A., & Goldstein, O. (2024). P2RX7, an adaptive immune response gene, is associated with Parkinson’s disease risk and age at onset. Journal of Parkinson’s Disease. https://doi.org/10.1177/1877718x241296015
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Tayran, H., Yilmaz, E., Bhattarai, P., Min, Y., Wang, X., Ma, Y., Nelson, N., Kassara, N., Cosacak, M. I., Dogru, R. M., Reyes‐Dumeyer, D., Reddy, J. S., Qiao, M. N., Flaherty, D., Yang, Z., Gunasekaran, T. I., Teich, A. F., Vardarajan, B. N., Tosto, G., … Kizil, C. (2024). ABCA7‐dependent Neuropeptide‐Y signalling is a resilience mechanism required for synaptic integrity in Alzheimer’s disease. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.089273
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Taga, M., Fujita, M., Parghi, N., & De Jager, P. L. (2024). Automated image segmentation uncovers the association of a microglial subtype defined by High CD74 Expression with cognitive decline. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.092664
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Chatila, Z. K., Mares, J., Vardarajan, B. N., Elyaman, W., Menon, V., & Bradshaw, E. M. (2024). Microglial Activation Alters Chromatin Accessibility of AD‐Associated Transcription Factors. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.085990
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Karaahmet, B., Duquesne, L., Sigalov, A., Yung, C. J., Kroshilina, A., Zhang, Y., Taga, M., & Klein, H. (2024). Spatial Transcriptomics Analysis Identifies Glial Signatures Spatially Associated with Neuritic Plaques in Human Post‐Mortem Brains. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.087498
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Houlihan, H. M., Johnson, A. S., Smith, A. C., Guzmán, D. S., Okafor, A., Heuer, L. B., Talmasov, D., Chikwem, N., Dass, D. S., Noble, J. M., Kreisl, W. C., Small, S. A., & Lao, P. J. (2024). Microglia density measured by TSPO PET across amyloid positivity and clinical variants. Alzheimer’s & Dementia, 20(S8). Portico. https://doi.org/10.1002/alz.095057
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Fowler, S. L., Behr, T. S., Turkes, E., O’Brien, D. P., Cauhy, P. M., Rawlinson, I., Edmonds, M., Foiani, M. S., Schaler, A., Crowley, G., Bez, S., Ficulle, E., Tsefou, E., Fischer, R., Geary, B., Gaur, P., Miller, C., D’Acunzo, P., Levy, E., … Ryskeldi-Falcon, B. (2024). Tau filaments are tethered within brain extracellular vesicles in Alzheimer’s disease. Nature Neuroscience. https://doi.org/10.1038/s41593-024-01801-5
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Bullock, M. E., Hogan, T., Williams, C., Morris, S., Nowicka, M., Sharjeel, M., van Dorp, C., Yates, A. J., & Seddon, B. (2024). The dynamics and longevity of circulating CD4+ memory T cells depend on cell age and not the chronological age of the host. PLOS Biology, 22(8), e3002380. https://doi.org/10.1371/journal.pbio.3002380
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Wang, Q., Antone, J., Alsop, E., Reiman, R., Funk, C., Bendl, J., Dudley, J. T., Liang, W. S., Karr, T. L., Roussos, P., Bennett, D. A., De Jager, P. L., Serrano, G. E., Beach, T. G., Van Keuren-Jensen, K., Mastroeni, D., Reiman, E. M., & Readhead, B. P. (2024). Single cell transcriptomes and multiscale networks from persons with and without Alzheimer’s disease. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-49790-0
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Haq, I., Ngo, J. C., Roy, N., Pan, R. L., Nawsheen, N., Chiu, R., Zhang, Y., Fujita, M., Soni, R. K., Wu, X., Bennett, D. A., Menon, V., Olah, M., & Sher, F. (2024). An integrated toolkit for human microglia functional genomics. Stem Cell Research & Therapy, 15(1). https://doi.org/10.1186/s13287-024-03700-9
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Jiang, S., Sydney, E. J., Runyan, A. M., Serpe, R., Srikanth, M., Figueroa, H. Y., Yang, M., & Myeku, N. (2024). 5-HT4 receptor agonists treatment reduces tau pathology and behavioral deficit in the PS19 mouse model of tauopathy. Frontiers in Cellular Neuroscience, 18. https://doi.org/10.3389/fncel.2024.1338502
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Weber, S., Menees, K. B., Park, J., Agin-Liebes, J., Lin, C.-C., Alcalay, R. N., & Lee, J.-K. (2024). Distinctive CD56dim NK subset profiles and increased NKG2D expression in blood NK cells of Parkinson’s disease patients. Npj Parkinson’s Disease, 10(1). https://doi.org/10.1038/s41531-024-00652-y
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Rossano, S. M., Johnson, A. S., Smith, A., Ziaggi, G., Roetman, A., Guzman, D., Okafor, A., Klein, J., Tomljanovic, Z., Stern, Y., Brickman, A. M., Lee, S., Kreisl, W. C., & Lao, P. (2024). Microglia measured by TSPO PET are associated with Alzheimer’s disease pathology and mediate key steps in a disease progression model. Alzheimer’s & Dementia, 20(4), 2397–2407. Portico. https://doi.org/10.1002/alz.13699
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Patel, R., Cosentino, S., Zheng, E. Z., Schupf, N., Barral, S., Feitosa, M., Andersen, S. L., Sebastiani, P., Ukraintseva, S., Christensen, K., Zmuda, J., Thyagarajan, B., & Gu, Y. (2024). Systemic inflammation in relation to exceptional memory in the Long Life Family Study (LLFS). Brain, Behavior, & Immunity - Health, 37, 100746. https://doi.org/10.1016/j.bbih.2024.100746
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Yu, Q., Du, F., Belli, I., Gomes, P. A., Sotiropoulos, I., & Waites, C. L. (2024). Glucocorticoid stress hormones stimulate vesicle-free Tau secretion and spreading in the brain. Cell Death & Disease, 15(1). https://doi.org/10.1038/s41419-024-06458-3
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Aoun, A., Shetler, O., Raghuraman, R., Rodriguez, G. A., & Hussaini, S. A. (2024). Beyond correlation: optimal transport metrics for characterizing representational stability and remapping in neurons encoding spatial memory. Frontiers in Cellular Neuroscience, 17. https://doi.org/10.3389/fncel.2023.1273283
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Al-Dalahmah, O., Sosunov, A. A., Sun, Y., Liu, Y., Madden, N., Connolly, E. S., Troy, C. M., McKhann, G. M., & Goldman, J. E. (2024). The Matrix Receptor CD44 Is Present in Astrocytes throughout the Human Central Nervous System and Accumulates in Hypoxia and Seizures. Cells, 13(2), 129. https://doi.org/10.3390/cells13020129
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Wu, Y., Dumitrescu, L. C., De Jager, P. L., Menon, V., Schneider, J. A., Bennett, D. A. A., Petyuk, V. A., & Hohman, T. J. (2023). Single‐cell Transcriptomes Reveal Cell‐type Specific Roles of VEGF Family Genes in the Pathogenesis of Alzheimer’s Disease. Alzheimer’s & Dementia, 19(S12). Portico. https://doi.org/10.1002/alz.078447
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Mehta, N. H., Zhou, L., Li, Y., McIntire, L. B., Nordvig, A., Butler, T., de Leon, M., & Chiang, G. C. (2023). Peripheral immune cell imbalance is associated with cortical beta-amyloid deposition and longitudinal cognitive decline. Scientific Reports, 13(1). https://doi.org/10.1038/s41598-023-34012-2
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Seblova, D., Higgins, C., Mazen, J., Starks, T. M., Kraal, A. Z., Turney, I. C., Adkins‐Jackson, P. A., Elyaman, W., Bradshaw, E. M., Brickman, A. M., & Manly, J. J. (2023). Relationship of peripheral inflammation and discrimination with memory: a study of Black and Latinx middle‐aged adults. Alzheimer’s & Dementia, 19(S22). Portico. https://doi.org/10.1002/alz.079910
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Bhattarai, P., Cosacak, M. I., Lee, A. J., Yilmaz, E., Is, O., Wang, X., Vardarajan, B. N., Ertekin‐Taner, N., Mayeux, R., & Kizil, C. (2023). Functional investigation of the gliovascular niche‐related genes and their relevance to Alzheimer’s disease pathomechanisms in zebrafish. Alzheimer’s & Dementia, 19(S13). Portico. https://doi.org/10.1002/alz.073812
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Siddiqui, T., Cosacak, M. I., Popova, S., Bhattarai, P., Yilmaz, E., Lee, A. J., Min, Y., Wang, X., Allen, M., İş, Ö., Atasavum, Z. T., Rodriguez-Muela, N., Vardarajan, B. N., Flaherty, D., Teich, A. F., Santa-Maria, I., Freudenberg, U., Werner, C., Tosto, G., … Kizil, C. (2023). Nerve growth factor receptor (Ngfr) induces neurogenic plasticity by suppressing reactive astroglial Lcn2/Slc22a17 signaling in Alzheimer’s disease. Npj Regenerative Medicine, 8(1). https://doi.org/10.1038/s41536-023-00311-5
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Green, G. S., Yang, H., Fujita, M., Taga, M., Regev, A., Menon, V., Bennett, D. A. A., Habib, N., & De Jager, P. L. (2023). Cellular dynamics across aged human brains uncover a multicellular cascade leading to Alzheimer’s disease. Alzheimer’s & Dementia, 19(S24). Portico. https://doi.org/10.1002/alz.083212
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Is, O., Wang, X., Reddy, J. S., Patel, T., Min, Y., Quicksall, Z., Heckman, M. G., Gao, J., Bergman, J., Da Mesquita, S. G. (Sandro D. M. F., Kizil, C., Bhattarai, P., Cosacak, M. I., Lee, A. J., Vardarajan, B. N., Mayeux, R., Koga, S., Kanekiyo, T., White, L. J., … Ertekin‐Taner, N. (2023). Gliovascular molecular alterations in Alzheimer’s disease: a cross‐tissue, cross‐species study. Alzheimer’s & Dementia, 19(S13). Portico. https://doi.org/10.1002/alz.073806
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Ma, Y., Chen, K. W., Fujita, M., Yu, L., Menon, V., Schneider, J. A., Bennett, D. A. A., & De Jager, P. L. (2023). Cataloging the role of brain cell types on suppressing the effect of APOE ε4 on Alzheimer’s disease risk. Alzheimer’s & Dementia, 19(S12). Portico. https://doi.org/10.1002/alz.077046
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Yang, H.-S., Teng, L., Kang, D., Menon, V., Ge, T., Finucane, H. K., Schultz, A. P., Properzi, M., Klein, H.-U., Chibnik, L. B., Schneider, J. A., Bennett, D. A., Hohman, T. J., Mayeux, R. P., Johnson, K. A., De Jager, P. L., & Sperling, R. A. (2023). Cell-type-specific Alzheimer’s disease polygenic risk scores are associated with distinct disease processes in Alzheimer’s disease. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-43132-2
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Solé-Guardia, G., Custers, E., de Lange, A., Clijncke, E., Geenen, B., Gutierrez, J., Küsters, B., Claassen, J. A. H. R., de Leeuw, F.-E., Wiesmann, M., & Kiliaan, A. J. (2023). Association between hypertension and neurovascular inflammation in both normal-appearing white matter and white matter hyperintensities. Acta Neuropathologica Communications, 11(1). https://doi.org/10.1186/s40478-022-01497-3
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Lopes, K. de P., Vialle, R. A., Green, G. S., Fujita, M., Wang, Y., Gaiteri, C., Menon, V., De Jager, P. L., Habib, N., Tasaki, S., & Bennett, D. A. A. (2023). Chasing the cell type‐specific molecular networks involved in Alzheimer’s Disease. Alzheimer’s & Dementia, 19(S12). Portico. https://doi.org/10.1002/alz.073444
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Nashman, Z., Runyan, A., Sydney, E., & Myeku, N. (2023). Modulation of the Immunoproteasome Affects Pathological Tau Aggregation in Alzheimer’s Disease. Alzheimer’s & Dementia, 19(S13). Portico. https://doi.org/10.1002/alz.071413
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Sanchini, C., Rosito, M., Comincini, A., De Panfilis, S., Bartolini, F., & Di Angelantonio, S. (2023). Protocol for observing microtubules and microtubule ends in both fixed and live primary microglia cells. STAR Protocols, 4(3), 102499. https://doi.org/10.1016/j.xpro.2023.102499
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Athanassi, A., Breton, M., Chalençon, L., Brunelin, J., Didier, A., Bath, K., & Mandairon, N. (2023). Chronic unpredictable mild stress alters odor hedonics and adult olfactory neurogenesis in mice. Frontiers in Neuroscience, 17. https://doi.org/10.3389/fnins.2023.1224941
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Imitola, J., Hollingsworth, E. W., Watanabe, F., Olah, M., Elyaman, W., Starossom, S., Kivisäkk, P., & Khoury, S. J. (2023). Stat1 is an inducible transcriptional repressor of neural stem cells self-renewal program during neuroinflammation. Frontiers in Cellular Neuroscience, 17. https://doi.org/10.3389/fncel.2023.1156802
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Connors, T. J., Matsumoto, R., Verma, S., Szabo, P. A., Guyer, R., Gray, J., Wang, Z., Thapa, P., Dogra, P., Poon, M. M. L., Rybkina, K., Bradley, M. C., Idzikowski, E., McNichols, J., Kubota, M., Pethe, K., Shen, Y., Atkinson, M. A., Brusko, M., … Farber, D. L. (2023). Site-specific development and progressive maturation of human tissue-resident memory T cells over infancy and childhood. Immunity, 56(8), 1894-1909.e5. https://doi.org/10.1016/j.immuni.2023.06.008
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Hobson, B. D., Stanley, A. T., De Los Santos, M. B., Culbertson, B., Mosharov, E. V., Sims, P. A., & Sulzer, D. (2023). Conserved and cell type-specific transcriptional responses to IFN-γ in the ventral midbrain. Brain, Behavior, and Immunity, 111, 277–291. https://doi.org/10.1016/j.bbi.2023.04.008
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Touil, H., Roostaei, T., Calini, D., Diaconu, C., Epstein, S., Raposo, C., Onomichi, K., Thakur, K. T., Craveiro, L., Callegari, I., Bryois, J., Riley, C. S., Menon, V., Derfuss, T., De Jager, P. L., & Malhotra, D. (2023). A structured evaluation of cryopreservation in generating single-cell transcriptomes from cerebrospinal fluid. Cell Reports Methods, 3(7), 100533. https://doi.org/10.1016/j.crmeth.2023.100533
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Seto, M., Dumitrescu, L., Mahoney, E. R., Sclafani, A. M., De Jager, P. L., Menon, V., Koran, M. E. I., Robinson, R. A., Ruderfer, D. M., Cox, N. J., Seyfried, N. T., Jefferson, A. L., Schneider, J. A., Bennett, D. A., Petyuk, V. A., & Hohman, T. J. (2023). Multi-omic characterization of brain changes in the vascular endothelial growth factor family during aging and Alzheimer’s disease. Neurobiology of Aging, 126, 25–33. https://doi.org/10.1016/j.neurobiolaging.2023.01.010
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Laternser, S., Petrovic, A., Eze, A., Dettwiler, S., Prutek, F., Contini, P. A., Morinigo, D., Bornhorst, M., Rushing, E. J., McDonough, E., Surrette, C., Ginty, F., Minnis, H., Gartrell, R., Müller, S., Packer, R., & Nazarian, J. (2023). DIPG-25. MAPPING TUMOR MICROENVIRONMENT USING EMERGING TECHNOLOGIES FOR PEDIATRIC BRAIN CANCERS. Neuro-Oncology, 25(Supplement_1), i18–i18. https://doi.org/10.1093/neuonc/noad073.072
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Winfree, R. L., Seto, M., Dumitrescu, L., Menon, V., De Jager, P., Wang, Y., Schneider, J., Bennett, D. A., Jefferson, A. L., & Hohman, T. J. (2023). TREM2 gene expression associations with Alzheimer’s disease neuropathology are region-specific: implications for cortical versus subcortical microglia. Acta Neuropathologica, 145(6), 733–747. https://doi.org/10.1007/s00401-023-02564-2
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Rosito, M., Sanchini, C., Gosti, G., Moreno, M., De Panfilis, S., Giubettini, M., Debellis, D., Catalano, F., Peruzzi, G., Marotta, R., Indrieri, A., De Leonibus, E., De Stefano, M. E., Ragozzino, D., Ruocco, G., Di Angelantonio, S., & Bartolini, F. (2023). Microglia reactivity entails microtubule remodeling from acentrosomal to centrosomal arrays. Cell Reports, 42(2), 112104. https://doi.org/10.1016/j.celrep.2023.112104
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Moioffer, S. J., Berton, R. R., McGonagill, P. W., Jensen, I. J., Griffith, T. S., & Badovinac, V. P. (2023). Inefficient Recovery of Repeatedly Stimulated Memory CD8 T Cells after Polymicrobial Sepsis Induction Leads to Changes in Memory CD8 T Cell Pool Composition. The Journal of Immunology, 210(2), 168–179. https://doi.org/10.4049/jimmunol.2200676
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Williams, G. P., Muskat, K., Frazier, A., Xu, Y., Mateus, J., Grifoni, A., da Silva Antunes, R., Weiskopf, D., Amara, A. W., Standaert, D. G., Goldman, J. G., Litvan, I., Alcalay, R. N., Sulzer, D., Lindestam Arlehamn, C. S., & Sette, A. (2023). Unaltered T cell responses to common antigens in individuals with Parkinson’s disease. Journal of the Neurological Sciences, 444, 120510. https://doi.org/10.1016/j.jns.2022.120510
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Reese, J. T., Blau, H., Casiraghi, E., Bergquist, T., Loomba, J. J., Callahan, T. J., Laraway, B., Antonescu, C., Coleman, B., Gargano, M., Wilkins, K. J., Cappelletti, L., Fontana, T., Ammar, N., Antony, B., Murali, T. M., Caufield, J. H., Karlebach, G., McMurry, J. A., … Divers, J. (2023). Generalisable long COVID subtypes: findings from the NIH N3C and RECOVER programmes. EBioMedicine, 87, 104413. https://doi.org/10.1016/j.ebiom.2022.104413
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