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Wei, X., Qian, W., Narasimhan, H., Chan, T., Liu, X., Arish, M., Young, S., Li, C., Cheon, I. S., Yu, Q., Almeida-Santos, G., Zhao, X.-Y., Yeatts, E. V., Spear, O. J., Yi, M., Parimon, T., Fang, Y., Hahn, Y. S., Bullock, T. N. J., … Sun, J. (2025). Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae. Science, 387(6738). https://doi.org/10.1126/science.adq2509

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Varanasi, S. K., Chen, D., Liu, Y., Johnson, M. A., Miller, C. M., Ganguly, S., Lande, K., LaPorta, M. A., Hoffmann, F. A., Mann, T. H., Teneche, M. G., Casillas, E., Mangalhara, K. C., Mathew, V., Sun, M., Jensen, I. J., Farsakoglu, Y., Chen, T., Parisi, B., … Kaech, S. M. (2025). Bile acid synthesis impedes tumor-specific T cell responses during liver cancer. Science, 387(6730), 192–201. https://doi.org/10.1126/science.adl4100

Luth, M. R., Godinez-Macias, K. P., Chen, D., Okombo, J., Thathy, V., Cheng, X., Daggupati, S., Davies, H., Dhingra, S. K., Economy, J. M., Edgar, R. C. S., Gomez-Lorenzo, M. G., Istvan, E. S., Jado, J. C., LaMonte, G. M., Melillo, B., Mok, S., Narwal, S. K., Ndiaye, T., … Winzeler, E. A. (2024). Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance. Science, 386(6725). https://doi.org/10.1126/science.adk9893

Brown, A. R., Hirschhorn, T., & Stockwell, B. R. (2024). Ferroptosis—disease perils and therapeutic promise. Science, 386(6724), 848–849. https://doi.org/10.1126/science.adn7030

Munshi-South, J., Garcia, J. A., Orton, D., & Phifer-Rixey, M. (2024). The evolutionary history of wild and domestic brown rats (Rattus norvegicus). Science, 385(6715), 1292–1297. https://doi.org/10.1126/science.adp1166

Yang, Y., Tilman, D., Jin, Z., Smith, P., Barrett, C. B., Zhu, Y.-G., Burney, J., D’Odorico, P., Fantke, P., Fargione, J., Finlay, J. C., Rulli, M. C., Sloat, L., Jan van Groenigen, K., West, P. C., Ziska, L., Michalak, A. M., Lobell, D. B., … Zhuang, M. (2024). Climate change exacerbates the environmental impacts of agriculture. Science, 385(6713). https://doi.org/10.1126/science.adn3747

Di Bona, M., Chen, Y., Agustinus, A. S., Mazzagatti, A., Duran, M. A., Deyell, M., Bronder, D., Hickling, J., Hong, C., Scipioni, L., Tedeschi, G., Martin, S., Li, J., Ruzgaitė, A., Riaz, N., Shah, P., D’Souza, E. K., Brodtman, D. Z., Sidoli, S., … Bakhoum, S. F. (2024). Micronuclear collapse from oxidative damage. Science, 385(6712). https://doi.org/10.1126/science.adj8691

Lumey, L. H., Li, C., Khalangot, M., Levchuk, N., & Wolowyna, O. (2024). Fetal exposure to the Ukraine famine of 1932–1933 and adult type 2 diabetes mellitus. Science, 385(6709), 667–671. https://doi.org/10.1126/science.adn4614

Tang, S., Conte, V., Zhang, D. J., Žedaveinytė, R., Lampe, G. D., Wiegand, T., Tang, L. C., Wang, M., Walker, M. W. G., George, J. T., Berchowitz, L. E., Jovanovic, M., & Sternberg, S. H. (2024). De novo gene synthesis by an antiviral reverse transcriptase. Science, 386(6717). https://doi.org/10.1126/science.adq0876

Kawaoka, J., & Lomvardas, S. (2024). Barcoding distinct neurons. Science, 385(6707), 370–371. https://doi.org/10.1126/science.adq5225

Verma, A., Huffman, J. E., Rodriguez, A., Conery, M., Liu, M., Ho, Y.-L., Kim, Y., Heise, D. A., Guare, L., Panickan, V. A., Garcon, H., Linares, F., Costa, L., Goethert, I., Tipton, R., Honerlaw, J., Davies, L., Whitbourne, S., Cohen, J., … Liao, K. P. (2024). Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. Science, 385(6706). https://doi.org/10.1126/science.adj1182

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Zyla, D. S., Della Marca, R., Niemeyer, G., Zipursky, G., Stearns, K., Leedale, C., Sobolik, E. B., Callaway, H. M., Hariharan, C., Peng, W., Parekh, D., Marcink, T. C., Diaz Avalos, R., Horvat, B., Mathieu, C., Snijder, J., Greninger, A. L., Hastie, K. M., Niewiesk, S., … Ollmann Saphire, E. (2024). A neutralizing antibody prevents postfusion transition of measles virus fusion protein. Science, 384(6703). https://doi.org/10.1126/science.adm8693

Klomp, J. E., Diehl, J. N., Klomp, J. A., Edwards, A. C., Yang, R., Morales, A. J., Taylor, K. E., Drizyte-Miller, K., Bryant, K. L., Schaefer, A., Johnson, J. L., Huntsman, E. M., Yaron, T. M., Pierobon, M., Baldelli, E., Prevatte, A. W., Barker, N. K., Herring, L. E., Petricoin, E. F., … Stalnecker, C. A. (2024). Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer. Science, 384(6700). https://doi.org/10.1126/science.adk0850

Vong, K. I., Lee, S., Au, K. S., Crowley, T. B., Capra, V., Martino, J., Haller, M., Araújo, C., Machado, H. R., George, R., Gerding, B., James, K. N., Stanley, V., Jiang, N., Alu, K., Meave, N., Nidhiry, A. S., Jiwani, F., Tang, I., … Gleeson, J. G. (2024). Risk of meningomyelocele mediated by the common 22q11.2 deletion. Science, 384(6695), 584–590. https://doi.org/10.1126/science.adl1624

Lim, S.-Y., Lee, J., Osuna, C. E., Vikhe, P., Schalk, D. R., Chen, E., Fray, E., Kumar, M., Schultz-Darken, N., Rakasz, E., Capuano, S., Ladd, R. A., Gil, H. M., Evans, D. T., Jeng, E. K., Seaman, M., Martin, M., Van Dorp, C., Perelson, A. S., … Whitney, J. B. (2024). Induction of durable remission by dual immunotherapy in SHIV-infected ART-suppressed macaques. Science, 383(6687), 1104–1111. https://doi.org/10.1126/science.adf7966

Hoge, C., de Manuel, M., Mahgoub, M., Okami, N., Fuller, Z., Banerjee, S., Baker, Z., McNulty, M., Andolfatto, P., Macfarlan, T. S., Schumer, M., Tzika, A. C., & Przeworski, M. (2024). Patterns of recombination in snakes reveal a tug-of-war between PRDM9 and promoter-like features. Science, 383(6685). https://doi.org/10.1126/science.adj7026

Montoya, S., Bourcier, J., Noviski, M., Lu, H., Thompson, M. C., Chirino, A., Jahn, J., Sondhi, A. K., Gajewski, S., Tan, Y. S. (May), Yung, S., Urban, A., Wang, E., Han, C., Mi, X., Kim, W. J., Sievers, Q., Auger, P., Bousquet, H., … Taylor, J. (2024). Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127. Science, 383(6682). https://doi.org/10.1126/science.adi5798

Filizola, M., & Javitch, J. A. (2023). Deciphering downstream receptor signaling. Science, 382(6677), 1357–1358. https://doi.org/10.1126/science.adm8393

Yang, S., Palmquist, K. H., Nathan, L., Pfeifer, C. R., Schultheiss, P. J., Sharma, A., Kam, L. C., Miller, P. W., Shyer, A. E., & Rodrigues, A. R. (2023). Morphogens enable interacting supracellular phases that generate organ architecture. Science, 382(6673). https://doi.org/10.1126/science.adg5579

George, J. T., Acree, C., Park, J.-U., Kong, M., Wiegand, T., Pignot, Y. L., Kellogg, E. H., Greene, E. C., & Sternberg, S. H. (2023). Mechanism of target site selection by type V-K CRISPR-associated transposases. Science, 382(6672). https://doi.org/10.1126/science.adj8543

Tang, S., & Sternberg, S. H. (2023). Genome editing with retroelements. Science, 382(6669), 370–371. https://doi.org/10.1126/science.adi3183

Vincent, R. L., Gurbatri, C. R., Li, F., Vardoshvili, A., Coker, C., Im, J., Ballister, E. R., Rouanne, M., Savage, T., de los Santos-Alexis, K., Redenti, A., Brockmann, L., Komaranchath, M., Arpaia, N., & Danino, T. (2023). Probiotic-guided CAR-T cells for solid tumor targeting. Science, 382(6667), 211–218. https://doi.org/10.1126/science.add7034

Wilks, S. H., Mühlemann, B., Shen, X., Türeli, S., LeGresley, E. B., Netzl, A., Caniza, M. A., Chacaltana-Huarcaya, J. N., Corman, V. M., Daniell, X., Datto, M. B., Dawood, F. S., Denny, T. N., Drosten, C., Fouchier, R. A. M., Garcia, P. J., Halfmann, P. J., Jassem, A., Jeworowski, L. M., … Smith, D. J. (2023). Mapping SARS-CoV-2 antigenic relationships and serological responses. Science, 382(6666). https://doi.org/10.1126/science.adj0070

Dai, W., Zhang, H., Lund, H., Zhang, Z., Castleberry, M., Rodriguez, M., Kuriakose, G., Gupta, S., Lewandowska, M., Powers, H. R., Valmiki, S., Zhu, J., Shapiro, A. D., Hussain, M. M., López, J. A., Sorci-Thomas, M. G., Silverstein, R. L., Ginsberg, H. N., Sahoo, D., … Zheng, Z. (2023). Intracellular tPA–PAI-1 interaction determines VLDL assembly in hepatocytes. Science, 381(6661). https://doi.org/10.1126/science.adh5207

Girish, V., Lakhani, A. A., Thompson, S. L., Scaduto, C. M., Brown, L. M., Hagenson, R. A., Sausville, E. L., Mendelson, B. E., Kandikuppa, P. K., Lukow, D. A., Yuan, M. L., Stevens, E. C., Lee, S. N., Schukken, K. M., Akalu, S. M., Vasudevan, A., Zou, C., Salovska, B., Li, W., … Sheltzer, J. M. (2023). Oncogene-like addiction to aneuploidy in human cancers. Science, 381(6660). https://doi.org/10.1126/science.adg4521

Liu, C.-P., Yu, Z., Xiong, J., Hu, J., Song, A., Ding, D., Yu, C., Yang, N., Wang, M., Yu, J., Hou, P., Zeng, K., Li, Z., Zhang, Z., Zhang, X., Li, W., Zhang, Z., Zhu, B., Li, G., & Xu, R.-M. (2023). Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1. Science, 381(6660). https://doi.org/10.1126/science.add8673

Kun, E., Javan, E. M., Smith, O., Gulamali, F., de la Fuente, J., Flynn, B. I., Vajrala, K., Trutner, Z., Jayakumar, P., Tucker-Drob, E. M., Sohail, M., Singh, T., & Narasimhan, V. M. (2023). The genetic architecture and evolution of the human skeletal form. Science, 381(6655). https://doi.org/10.1126/science.adf8009

Sugarman, J., Wenner, D. M., Rid, A., Henry, L. M., Luna, F., Klitzman, R., MacQueen, K. M., Rennie, S., Singh, J. A., & Gostin, L. O. (2023). Ethical research when abortion access is legally restricted. Science, 380(6651), 1224–1226. https://doi.org/10.1126/science.adh3104

Singh, P., Gollapalli, K., Mangiola, S., Schranner, D., Yusuf, M. A., Chamoli, M., Shi, S. L., Lopes Bastos, B., Nair, T., Riermeier, A., Vayndorf, E. M., Wu, J. Z., Nilakhe, A., Nguyen, C. Q., Muir, M., Kiflezghi, M. G., Foulger, A., Junker, A., Devine, J., … Yadav, V. K. (2023). Taurine deficiency as a driver of aging. Science, 380(6649). https://doi.org/10.1126/science.abn9257

Yang, K., Mitchell, N. M., Banerjee, S., Cheng, Z., Taylor, S., Kostic, A. M., Wong, I., Sajjath, S., Zhang, Y., Stevens, J., Mohan, S., Landry, D. W., Worgall, T. S., Andrews, A. M., & Stojanovic, M. N. (2023). A functional group–guided approach to aptamers for small molecules. Science, 380(6648), 942–948. https://doi.org/10.1126/science.abn9859

Obradovic, A. (2023). Precision immunotherapy. Science, 379(6633), 654–655. https://doi.org/10.1126/science.adg5585

Gurbatri, C. R., Arpaia, N., & Danino, T. (2022). Engineering bacteria as interactive cancer therapies. Science, 378(6622), 858–864. https://doi.org/10.1126/science.add9667

Sabatello, M., Martschenko, D. O., Cho, M. K., & Brothers, K. B. (2022). Data sharing and community-engaged research. Science, 378(6616), 141–143. https://doi.org/10.1126/science.abq6851

Sykes, M. (2022). Developing pig-to-human organ transplants. Science, 378(6616), 135–136. https://doi.org/10.1126/science.abo7935

Reis, B. S., Darcy, P. W., Khan, I. Z., Moon, C. S., Kornberg, A. E., Schneider, V. S., Alvarez, Y., Eleso, O., Zhu, C., Schernthanner, M., Lockhart, A., Reed, A., Bortolatto, J., Castro, T. B. R., Bilate, A. M., Grivennikov, S., Han, A. S., & Mucida, D. (2022). TCR-Vγδ usage distinguishes protumor from antitumor intestinal γδ T cell subsets. Science, 377(6603), 276–284. https://doi.org/10.1126/science.abj8695

Domínguez Conde, C., Xu, C., Jarvis, L. B., Rainbow, D. B., Wells, S. B., Gomes, T., Howlett, S. K., Suchanek, O., Polanski, K., King, H. W., Mamanova, L., Huang, N., Szabo, P. A., Richardson, L., Bolt, L., Fasouli, E. S., Mahbubani, K. T., Prete, M., Tuck, L., … Teichmann, S. A. (2022). Cross-tissue immune cell analysis reveals tissue-specific features in humans. Science, 376(6594). https://doi.org/10.1126/science.abl5197

Ginsberg, H. N., & Mani, A. (2022). Complex regulation of fatty liver disease. Science, 376(6590), 247–248. https://doi.org/10.1126/science.abp8276

Spencer, C. N., McQuade, J. L., Gopalakrishnan, V., McCulloch, J. A., Vetizou, M., Cogdill, A. P., Khan, M. A. W., Zhang, X., White, M. G., Peterson, C. B., Wong, M. C., Morad, G., Rodgers, T., Badger, J. H., Helmink, B. A., Andrews, M. C., Rodrigues, R. R., Morgun, A., Kim, Y. S., … Wargo, J. A. (2021). Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response. Science, 374(6575), 1632–1640. https://doi.org/10.1126/science.aaz7015

Hastie, K. M., Li, H., Bedinger, D., Schendel, S. L., Dennison, S. M., Li, K., Rayaprolu, V., Yu, X., Mann, C., Zandonatti, M., Diaz Avalos, R., Zyla, D., Buck, T., Hui, S., Shaffer, K., Hariharan, C., Yin, J., Olmedillas, E., Enriquez, A., … Saphire, E. O. (2021). Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study. Science, 374(6566), 472–478. https://doi.org/10.1126/science.abh2315

Wagner, C. E., Saad-Roy, C. M., Morris, S. E., Baker, R. E., Mina, M. J., Farrar, J., Holmes, E. C., Pybus, O. G., Graham, A. L., Emanuel, E. J., Levin, S. A., Metcalf, C. J. E., & Grenfell, B. T. (2021). Vaccine nationalism and the dynamics and control of SARS-CoV-2. Science, 373(6562). https://doi.org/10.1126/science.abj7364

Del Poggetto, E., Ho, I.-L., Balestrieri, C., Yen, E.-Y., Zhang, S., Citron, F., Shah, R., Corti, D., Diaferia, G. R., Li, C.-Y., Loponte, S., Carbone, F., Hayakawa, Y., Valenti, G., Jiang, S., Sapio, L., Jiang, H., Dey, P., Gao, S., … Viale, A. (2021). Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis. Science, 373(6561). https://doi.org/10.1126/science.abj0486

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