Center for Translational Immunology

Displaying 1 - 50 of 149CSV
Tagore, S., Caprio, L., Amin, A. D., Bestak, K., Luthria, K., D’Souza, E., Barrera, I., Melms, J. C., Wu, S., Abuzaid, S., Wang, Y., Jakubikova, V., Koch, P., Brodtman, D. Z., Bawa, B., Deshmukh, S. K., Ebel, L., Ibarra-Arellano, M. A., Jaiswal, A., … Izar, B. (2025). Single-cell and spatial genomic landscape of non-small cell lung cancer brain metastases. Nature Medicine. https://doi.org/10.1038/s41591-025-03530-z
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Gunes, M. E., Patwardhan, S., Hong, J., Manell, E., Jordache, P., Chauhan, I., Almesallmy, A., Fu, J., Sykes, M., & Weiner, J. (2025). Mucosal Mixed Lymphocyte Reaction Assay Using Intestinal Lymphocytes as a Biomarker for Intestinal Transplant Tolerance Development. Transplantation. https://doi.org/10.1097/tp.0000000000005348
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Craig-Schapiro, R., Li, G., Chen, K., Gomez-Salinero, J. M., Nachman, R., Kopacz, A., Schreiner, R., Chen, X., Zhou, Q., Rafii, S., & Redmond, D. (2025). Single-cell atlas of human pancreatic islet and acinar endothelial cells in health and diabetes. Nature Communications, 16(1). https://doi.org/10.1038/s41467-024-55415-3
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Tonsho, M., O, J. M., Ahrens, K., Robinson, K., Sommer, W., Boskovic, S., Patel, P. M., Becerra, D. C., Huh, K. H., Miller, C. L., Dehnadi, A., Hanekamp, I., Rosales, I. A., Colvin, R. B., Sachs, D. H., Alessandrini, A., Cosimi, A., Fairchild, R. L., Cravedi, P., … Madsen, J. C. (2025). Cardiac allograft tolerance can be achieved in nonhuman primates by donor bone marrow and kidney cotransplantation. Science Translational Medicine, 17(782). https://doi.org/10.1126/scitranslmed.ads0255
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Ahn, J., Hwang, I.-S., Park, M.-R., Rosa-Velazquez, M., Cho, I.-C., Relling, A. E., Hwang, S., & Lee, K. (2025). Evolutionary lineage-specific genomic imprinting at the ZNF791 locus. PLOS Genetics, 21(1), e1011532. https://doi.org/10.1371/journal.pgen.1011532
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Stark, H., Ho, Q. Y., Cross, A., Alessandrini, A., Bertaina, A., Brennan, D., Busque, S., Demetris, A., Devey, L., Fruhwirth, G., Fuchs, E., Friend, P., Geissler, E., Guillonneau, C., Hester, J., Isaacs, J., Jaeckel, E., Kawai, T., Lakkis, F., … Issa, F. (2025). Meeting Report: The Sixth International Sam Strober Workshop on Clinical Immune Tolerance. Transplantation. https://doi.org/10.1097/tp.0000000000005311
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Cravedi, P., Maggiore, U., Molinari, P., Levitsky, J., & Zorn, E. (2025). Where Are All the Clinical Trials for Chronic Rejection? Transplantation. https://doi.org/10.1097/tp.0000000000005081
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Furuhashi, K., Kakiuchi, M., Ueda, R., Oda, H., Ummarino, S., Ebralidze, A. K., Bassal, M. A., Meng, C., Sato, T., Lyu, J., Han, M., Maruyama, S., Watanabe, Y., Sawa, Y., Kato, D., Wake, H., Reizis, B., Frangos, J. A., Owens, D. M., … Fujisaki, J. (2025). Bone marrow niches orchestrate stem-cell hierarchy and immune tolerance. Nature. https://doi.org/10.1038/s41586-024-08352-6
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Miller, W. C., Yousefzadeh, M. J., Fisher, J., Sarumi, H., Kirchner, V., Niedernhofer, L. J., & Pruett, T. (2024). A brief report on biomarkers of cellular senescence associated with liver frailty and length of stay in liver transplantation. GeroScience. https://doi.org/10.1007/s11357-024-01482-9
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Batty, L., Park, J., Qin, L., Riaz, M., Lin, Y., Xu, Z., Gao, X., Li, X., Lopez, C., Zhang, W., Hoareau, M., Fallon, M. E., Huang, Y., Luo, H., Luo, J., Ménoret, S., Li, P., Jiang, Z., Smith, P., … Qyang, Y. (2024). Vascular endothelial cells derived from transgene-free pig induced pluripotent stem cells for vascular tissue engineering. Acta Biomaterialia. https://doi.org/10.1016/j.actbio.2024.12.033
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Katsivelos, N., Spyrou, N., Weber, D., Vasova, I., Ayuk, F., Choe, H., Hogan, W., DeFilipp, Z., Qayed, M., Etra, A. M., Sandhu, K., Kraus, S., Olson, T., Hexner, E., Aguayo-Hiraldo, P., Reshef, R., Ullrich, E., Schechter, T., Kitko, C., … Levine, J. E. (2024). Serial Clinical and Biomarker Monitoring during Graft-Versus-Host Disease Treatment Identifies Distinct Risk Strata Including an Ultra-Low Risk Group. Transplantation and Cellular Therapy. https://doi.org/10.1016/j.jtct.2024.10.012
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Gunes, M. E., Fujiwara, S., Wolbrom, D. H., Cadelina, A., Qudus, S., Ekanayake-Alper, D., Hajosi, D., Sachs, D. H., & Nowak, G. (2024). Detailed surgical description of porcine vascularized thymus lobe transplantation. Frontiers in Transplantation, 3. https://doi.org/10.3389/frtra.2024.1499844
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Miller, W. C., Wallace, S., Kamm, W., Reardon, E., Theis-Mahon, N., Yousefzadeh, M. J., Schmidt, E. L., Niedernhofer, L. J., & Puskarich, M. A. (2024). Cellular senescence in acute human infectious disease: a systematic review. Frontiers in Aging, 5. https://doi.org/10.3389/fragi.2024.1500741
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Nordström, J. E. A., Wennberg, L. M., Nowak, G., Larsson, T. E., Thuresson, S. J., & Reusch, M. (2024). Assessing Pharmacokinetics and Safety of Therapeutic Alpha-1-Microglobulin in First-in-Human Kidney Transplantation: A Noncomparative Open-Label Multiple-Dose Phase 1b Study. Transplantation Direct, 10(12), e1727. https://doi.org/10.1097/txd.0000000000001727
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Wrona, M. V., Ghosh, R., Coll, K., Chun, C., & Yousefzadeh, M. J. (2024). The 3 I’s of immunity and aging: immunosenescence, inflammaging, and immune resilience. Frontiers in Aging, 5. https://doi.org/10.3389/fragi.2024.1490302
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Patwardhan, S., Gunes, M. E., Manell, E., Hong, J., Jordache, P., Chauhan, I., Almesallmy, A., Mulder, H., Ekanayake-Alper, D., Hajosi, D., Ko, H. M., Shanmugarajah, K., Cetrulo, C. L., Nowak, G., Sachs, D. H., Sykes, M., & Weiner, J. (2024). Durable mixed chimerism may permit subsequent immunosuppression-free intestinal transplantation—A proof-of-principle study. American Journal of Transplantation. https://doi.org/10.1016/j.ajt.2024.10.014
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Hertel, A., Aguiar, T., Mashiko, S., Núñez, S., Moore, C., Gao, B., Ausmeier, M., Roy, P., & Zorn, E. (2024). Clones reactive to apoptotic cells and specific chemical adducts are prevalent among human thymic B cells. Frontiers in Immunology, 15. https://doi.org/10.3389/fimmu.2024.1462126
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El Jurdi, N., Te, H. S., Cao, Q., Napurski, C., Wang, S., Robinson, A., Arora, M., ElHusseini, H., He, F., Niedernhofer, L. J., Thyagarajan, B., Prizment, A., Holtan, S., Blaes, A. H., & Yousefzadeh, M. J. (2024). Frailty and pre-frailty associated with long-term diminished physical performance and quality of life in breast cancer and hematopoietic cell transplant survivors. Aging, 16(18), 12432–12442. https://doi.org/10.18632/aging.206109
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Hao, L. Y., Lerrer, S., Paiola, M., Moore, E. K., Gartshteyn, Y., Song, R., Goeckeritz, M., Black, M. J., Bukhari, S., Hu, X., & Mor, A. (2024). Exclusion of PD-1 from the immune synapse: A novel strategy to modulate T cell function. Molecular Therapy: Oncology, 32(3), 200839. https://doi.org/10.1016/j.omton.2024.200839
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Gunes, M. E., Wolbrom, D. H., Nygaard, E. D., Manell, E., Jordache, P., Qudus, S., Cadelina, A., Weiner, J., & Nowak, G. (2024). OMIP‐108: 22‐color flow cytometry panel for detection and monitoring of chimerism and immune reconstitution in porcine‐to‐baboon models of operational xenotransplant tolerance studies. Cytometry Part A, 105(11), 800–806. Portico. https://doi.org/10.1002/cyto.a.24899
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Zhong, J., Lerrer, S., & Mor, A. (2024). An Imaging-Based Assay to Measure the Location of PD-1 at the Immune Synapse for Testing the Binding Efficacy of Anti-PD-1 and Anti-PD-L1 Antibodies. BIO-PROTOCOL, 14(1352). https://doi.org/10.21769/bioprotoc.5057
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Grattoni, A., Korbutt, G., Tomei, A. A., García, A. J., Pepper, A. R., Stabler, C., Brehm, M., Papas, K., Citro, A., Shirwan, H., Millman, J. R., Melero-Martin, J., Graham, M., Sefton, M., Ma, M., Kenyon, N., Veiseh, O., Desai, T. A., Nostro, M. C., … de Vos, P. (2024). Harnessing cellular therapeutics for type 1 diabetes mellitus: progress, challenges, and the road ahead. Nature Reviews Endocrinology. https://doi.org/10.1038/s41574-024-01029-0
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Rios, C. A. O., Qayed, M., Etra, A. M., Reshef, R., Newcomb, R., Yuhasz, N., Hexner, E. O., Aguayo-Hiraldo, P., Merli, P., Hogan, W. J., Weber, D., Kitko, C. L., Ayuk, F., Eder, M., Grupp, S. A., Kraus, S., Sandhu, K., Ullrich, E., Vasova, I., … Akahoshi, Y. (2024). Differences in Acute Graft-Versus-Host Disease (GVHD) Severity and Its Outcomes Between Black and White Patients. Transplantation and Cellular Therapy, 30(11), 1061.e1-1061.e10. https://doi.org/10.1016/j.jtct.2024.08.019
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Cordoves, E. M., Ferrari, G., Zorn, E., Bacha, E., Vunjak-Novakovic, G., & Kalfa, D. M. (2024). Storage, preservation, and rehabilitation of living heart valves to treat congenital heart disease. Med, 5(8), 859–862. https://doi.org/10.1016/j.medj.2024.07.004
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David, A. F., Heinzel, A., Kammer, M., Aschauer, C., Reindl-Schwaighofer, R., Hu, K., Chen, H.-S., Muckenhuber, M., Kubetz, A., Weijler, A. M., Worel, N., Edinger, M., Berlakovich, G., Lion, T., Sykes, M., Wekerle, T., & Oberbauer, R. (2024). Combination cell therapy leads to clonal deletion of donor-specific T cells in kidney transplant recipients. EBioMedicine, 106, 105239. https://doi.org/10.1016/j.ebiom.2024.105239
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Schweitzer, L., Miko, B. A., & Pereira, M. R. (2024). Infectious Disease Prophylaxis During and After Immunosuppressive Therapy. Kidney International Reports, 9(8), 2337–2352. https://doi.org/10.1016/j.ekir.2024.04.043
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Fu, J., Hsiao, T., Waffarn, E., Meng, W., Long, K. D., Frangaj, K., Jones, R., Gorur, A., Shtewe, A., Li, M., Muntnich, C. B., Rogers, K., Jiao, W., Velasco, M., Matsumoto, R., Kubota, M., Wells, S., Danzl, N., Ravella, S., … Sykes, M. (2024). Dynamic establishment and maintenance of the human intestinal B cell population and repertoire following transplantation in a pediatric-dominated cohort. Frontiers in Immunology, 15. https://doi.org/10.3389/fimmu.2024.1375486
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Merl, S., Chen, B., Gunes, M. E., Atta, H., Yang, K., Ekanayake-Alper, D., Hajosi, D., Huang, F., Bhola, B., Patwardhan, S., Jordache, P., Nowak, G., Martinez, M., Kato, T., Sykes, M., Yamada, K., & Weiner, J. (2024). Development of a large animal orthotopic intestinal transplantation model with long-term survival for study of immunologic outcomes. Frontiers in Transplantation, 3. https://doi.org/10.3389/frtra.2024.1367486
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Strazza, M., Song, R., Hiner, S., & Mor, A. (2024). Changing the location of proteins on the cell surface is a promising strategy for modulating T cell functions. Immunology. Portico. https://doi.org/10.1111/imm.13828
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Dahlquist, K. J. V., Huggins, M. A., Yousefzadeh, M. J., Soto-Palma, C., Cholensky, S. H., Pierson, M., Smith, D. M., Hamilton, S. E., & Camell, C. D. (2024). PD1 blockade improves survival and CD8+ cytotoxic capacity, without increasing inflammation, during normal microbial experience in old mice. Nature Aging, 4(7), 915–925. https://doi.org/10.1038/s43587-024-00620-4
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Firdessa-Fite, R., Johnson, S. N., Bechi Genzano, C., Leon, M. A., Ku, A., Ocampo Gonzalez, F. A., Milner, J. D., Sestak, J. O., Berkland, C., & Creusot, R. J. (2024). Soluble antigen arrays provide increased efficacy and safety over free peptides for tolerogenic immunotherapy. Frontiers in Immunology, 15. https://doi.org/10.3389/fimmu.2024.1258369
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Durot, E., Roos-Weil, D., Chauchet, A., Decroocq, J., Di Blasi, R., Gastinne, T., Bensaber, H., Cheminant, M., Jacquet, C., Guidez, S., Gros, F.-X., Bachy, E., Coste, A., Cony-Makhoul, P., Treon, S. P., Delmer, A., Reshef, R., Le Gouill, S., Castillo, J. J., & Houot, R. (2024). High efficacy of CD19 CAR T cells in patients with transformed Waldenström macroglobulinemia. Blood, 143(26), 2804–2807. https://doi.org/10.1182/blood.2024024452
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Morcillo, P., Kabra, K., Velasco, K., Cordero, H., Jennings, S., Yun, T. D., Larrea, D., Akman, H. O., & Schon, E. A. (2024). Aberrant ER-mitochondria communication is a common pathomechanism in mitochondrial disease. Cell Death & Disease, 15(6). https://doi.org/10.1038/s41419-024-06781-9
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Abadie, V., Han, A. S., Jabri, B., & Sollid, L. M. (2024). New Insights on Genes, Gluten, and Immunopathogenesis of Celiac Disease. Gastroenterology, 167(1), 4–22. https://doi.org/10.1053/j.gastro.2024.03.042
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Gartshteyn, Y., Geraldino-Pardilla, L., Khalili, L., Bukhari, S., Lerrer, S., Winchester, R. J., Askanase, A. D., & Mor, A. (2024). SAP-expressing T peripheral helper cells identify systemic lupus erythematosus patients with lupus nephritis. Frontiers in Immunology, 15. https://doi.org/10.3389/fimmu.2024.1327437
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Philips, E. A., Liu, J., Kvalvaag, A., Mørch, A. M., Tocheva, A. S., Ng, C., Liang, H., Ahearn, I. M., Pan, R., Luo, C. C., Leithner, A., Qin, Z., Zhou, Y., Garcia-España, A., Mor, A., Littman, D. R., Dustin, M. L., Wang, J., & Kong, X.-P. (2024). Transmembrane domain–driven PD-1 dimers mediate T cell inhibition. Science Immunology, 9(93). https://doi.org/10.1126/sciimmunol.ade6256
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Hu, X., Bukhari, S. M., Tymm, C., Adam, K., Lerrer, S., Henick, B. S., Winchester, R. J., & Mor, A. (2024). Inhibition of IL-25/IL-17RA improves immune-related adverse events of checkpoint inhibitors and reveals antitumor activity. Journal for ImmunoTherapy of Cancer, 12(3), e008482. https://doi.org/10.1136/jitc-2023-008482
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AMANCHERLA, K., SCHLENDORF, K. H., VLASSCHAERT, C., LOWERY, B. D., WELLS, Q. S., SEE, S. B., ZORN, E., COLOMBO, P. C., REILLY, M. P., LINDENFELD, J., URIEL, N., SHAH, R. V., FREEDMAN, J. E., MOSLEHI, J., BICK, A. G., & CLERKIN, K. (2024). Genetic Interleukin-6 Receptor Variant Is Not Associated With Rejection and Mortality After Heart Transplantation. Journal of Cardiac Failure, 30(6), 848–852. https://doi.org/10.1016/j.cardfail.2024.01.009
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Savage, T. M., Fortson, K. T., de los Santos-Alexis, K., Oliveras-Alsina, A., Rouanne, M., Rae, S. S., Gamarra, J. R., Shayya, H., Kornberg, A., Cavero, R., Li, F., Han, A., Haeusler, R. A., Adam, J., Schwabe, R. F., & Arpaia, N. (2024). Amphiregulin from regulatory T cells promotes liver fibrosis and insulin resistance in non-alcoholic steatohepatitis. Immunity, 57(2), 303-318.e6. https://doi.org/10.1016/j.immuni.2024.01.009
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Leuzzi, G., Vasciaveo, A., Taglialatela, A., Chen, X., Firestone, T. M., Hickman, A. R., Mao, W., Thakar, T., Vaitsiankova, A., Huang, J.-W., Cuella-Martin, R., Hayward, S. B., Kesner, J. S., Ghasemzadeh, A., Nambiar, T. S., Ho, P., Rialdi, A., Hebrard, M., Li, Y., … Ciccia, A. (2024). SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion. Cell, 187(4), 861-881.e32. https://doi.org/10.1016/j.cell.2024.01.008
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Rogava, M., Aprati, T. J., Chi, W.-Y., Melms, J. C., Hug, C., Davis, S. H., Earlie, E. M., Chung, C., Deshmukh, S. K., Wu, S., Sledge, G., Tang, S., Ho, P., Amin, A. D., Caprio, L., Gurjao, C., Tagore, S., Ngo, B., Lee, M. J., … Izar, B. (2024). Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation. Nature Cancer, 5(3), 433–447. https://doi.org/10.1038/s43018-023-00704-x
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Straube, J., Bukhari, S., Lerrer, S., Winchester, R. J., Gartshteyn, Y., Henick, B. S., Dragovich, M. A., & Mor, A. (2024). PD-1 signaling uncovers a pathogenic subset of T cells in inflammatory arthritis. Arthritis Research & Therapy, 26(1). https://doi.org/10.1186/s13075-023-03259-5
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