Naomi Berrie Diabetes Center

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Li, J., Cai, C., Teo, W. W., Chin, K. S., Naing, Y. T., Song, S., Nelson, F., Qiang, L., Xu, D., & Sun, L. (2025). Isoform usage as a distinct regulatory layer driving nutrient-responsive metabolic adaptation. Cell Metabolism, 37(3), 772-787.e6. https://doi.org/10.1016/j.cmet.2025.01.009
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Basu, S., Običan, S., Bertaggia, E., Staab, H., Izquierdo, M. C., Gyamfi-Bannerman, C., & Haeusler, R. (2025). Unresolved alterations in bile acid composition and dyslipidemia in maternal and cord blood after UDCA treatment for intrahepatic cholestasis of pregnancy. American Journal of Physiology-Gastrointestinal and Liver Physiology. https://doi.org/10.1152/ajpgi.00266.2024
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Rajamoorthi, A., Zheng, H., Skowronski, A. A., Zork, N., Reddy, U., Tung, P. W., Kupsco, A., Gallagher, D., Salem, R. M., Leibel, R. L., LeDuc, C. A., & Thaker, V. V. (2024). Association of gestational and childhood circulating C-peptide concentrations in the hyperglycemia and adverse pregnancy outcomes follow-up study. Diabetes Research and Clinical Practice, 111967. https://doi.org/10.1016/j.diabres.2024.111967
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Zahr, T., Li, T., Bhansali, D., Wan, Q., Leong, K. W., & Qiang, L. (2024). Targeted delivery of a cationic dendrimer with a plaque-homing peptide for the treatment of atherosclerosis. Life Medicine. https://doi.org/10.1093/lifemedi/lnae039
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Seaquist, E. R., Phillips, L. S., Ghosh, A., Baker, C., Bergenstal, R. M., Crandall, J. P., Goland, R. S., Gramzinski, M. R., Hox, S. H., Hsia, D. S., Johnson, M. L., Lachin, J. M., Raskin, P., Valencia, W. M., Waltje, A. H., & Younes, N. (2024). Glycemia reduction in type 2 diabetes—Hypoglycemia outcomes: A randomized clinical trial. PLOS ONE, 19(11), e0309907. https://doi.org/10.1371/journal.pone.0309907
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Kinreich, S., Bialer-Tsypin, A., Viner-Breuer, R., Keshet, G., Suhler, R., Lim, P. S. L., Golan-Lev, T., Yanuka, O., Turjeman, A., Ram, O., Meshorer, E., Egli, D., Yilmaz, A., & Benvenisty, N. (2024). Genome-wide screening reveals essential roles for HOX genes and imprinted genes during caudal neurogenesis of human embryonic stem cells. Stem Cell Reports, 19(11), 1598–1619. https://doi.org/10.1016/j.stemcr.2024.09.009
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Ziegler, A., Koval-Burt, C., Kay, D. M., Suchy, S. F., Begtrup, A., Langley, K. G., Hernan, R., Amendola, L. M., Boyd, B. M., Bradley, J., Brandt, T., Cohen, L. L., Coffey, A. J., Devaney, J. M., Dygulska, B., Friedman, B., Fuleihan, R. L., Gyimah, A., Hahn, S., … Chung, W. K. (2024). Expanded Newborn Screening Using Genome Sequencing for Early Actionable Conditions. JAMA. https://doi.org/10.1001/jama.2024.19662
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Fernández-Tussy, P., Cardelo, M. P., Zhang, H., Sun, J., Price, N. L., Boutagy, N. E., Goedeke, L., Cadena-Sandoval, M., Xirouchaki, C. E., Brown, W., Yang, X., Pastor-Rojo, O., Haeusler, R. A., Bennett, A. M., Tiganis, T., Suárez, Y., & Fernández-Hernando, C. (2024). miR-33 deletion in hepatocytes attenuates MASLD-MASH-HCC progression. JCI Insight, 9(19). https://doi.org/10.1172/jci.insight.168476
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McKimpson, W. M., Spiegel, S., Mukhanova, M., Kraakman, M., Du, W., Kitamoto, T., Yu, J., Deng, Z., Pajvani, U., & Accili, D. (2024). Calorie restriction activates a gastric Notch-FOXO1 pathway to expand ghrelin cells. Journal of Cell Biology, 223(10). https://doi.org/10.1083/jcb.202305093
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Edwards, M. M., Wang, N., Sagi, I., Kinreich, S., Benvenisty, N., Gerhardt, J., Egli, D., & Koren, A. (2024). Parent-of-origin-specific DNA replication timing is confined to large imprinted regions. Cell Reports, 43(9), 114700. https://doi.org/10.1016/j.celrep.2024.114700
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Guilz, N. C., Ahn, Y.-O., Fatima, H., Pedroza, L. A., Seo, S., Soni, R. K., Wang, N., Egli, D., & Mace, E. M. (2024). Replication Stress in Activated Human NK Cells Induces Sensitivity to Apoptosis. The Journal of Immunology, 213(1), 40–51. https://doi.org/10.4049/jimmunol.2300843
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Firdessa-Fite, R., Johnson, S. N., Bechi Genzano, C., Leon, M. A., Ku, A., Ocampo Gonzalez, F. A., Milner, J. D., Sestak, J. O., Berkland, C., & Creusot, R. J. (2024). Soluble antigen arrays provide increased efficacy and safety over free peptides for tolerogenic immunotherapy. Frontiers in Immunology, 15. https://doi.org/10.3389/fimmu.2024.1258369
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Xu, S., Wang, N., Zuccaro, M. V., Gerhardt, J., Iyyappan, R., Scatolin, G. N., Jiang, Z., Baslan, T., Koren, A., & Egli, D. (2024). DNA replication in early mammalian embryos is patterned, predisposing lamina-associated regions to fragility. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-49565-7
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Petta, S., Targher, G., Romeo, S., Pajvani, U. B., Zheng, M., Aghemo, A., & Valenti, L. V. C. (2024). The first MASH drug therapy on the horizon: Current perspectives of resmetirom. Liver International, 44(7), 1526–1536. Portico. https://doi.org/10.1111/liv.15930
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Georgieva, D., Wang, N., Taglialatela, A., Jerabek, S., Reczek, C. R., Lim, P. X., Sung, J., Du, Q., Horiguchi, M., Jasin, M., Ciccia, A., Baer, R., & Egli, D. (2024). BRCA1 and 53BP1 regulate reprogramming efficiency by mediating DNA repair pathway choice at replication-associated double-strand breaks. Cell Reports, 43(4), 114006. https://doi.org/10.1016/j.celrep.2024.114006
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Skowronski, A. A., Leibel, R. L., & LeDuc, C. A. (2023). Neurodevelopmental Programming of Adiposity: Contributions to Obesity Risk. Endocrine Reviews, 45(2), 253–280. https://doi.org/10.1210/endrev/bnad031
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Accili, D., Talchai, S. C., Bouchi, R., Lee, A. Y., Du, W., Kitamoto, T., McKimpson, W. M., Belvedere, S., & Lin, H. V. (2024). Diabetes treatment by conversion of gut epithelial cells to insulin‐producing cells. Journal of Diabetes Investigation, 15(7), 797–804. Portico. https://doi.org/10.1111/jdi.14175
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Watanabe, H., Asahara, S., Son, J., McKimpson, W. M., de Cabo, R., & Accili, D. (2024). Cyb5r3 activation rescues secondary failure to sulfonylurea but not β-cell dedifferentiation. PLOS ONE, 19(2), e0297555. https://doi.org/10.1371/journal.pone.0297555
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Savage, T. M., Fortson, K. T., de los Santos-Alexis, K., Oliveras-Alsina, A., Rouanne, M., Rae, S. S., Gamarra, J. R., Shayya, H., Kornberg, A., Cavero, R., Li, F., Han, A., Haeusler, R. A., Adam, J., Schwabe, R. F., & Arpaia, N. (2024). Amphiregulin from regulatory T cells promotes liver fibrosis and insulin resistance in non-alcoholic steatohepatitis. Immunity, 57(2), 303-318.e6. https://doi.org/10.1016/j.immuni.2024.01.009
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Cherkaoui, I., Du, Q., Egli, D., Misra, S., & Rutter, G. A. (2024). Optimized Protocol for Generating Functional Pancreatic Insulin-secreting Cells from Human Pluripotent Stem Cells. Journal of Visualized Experiments, 204. https://doi.org/10.3791/65530
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Kwak, S. H., Srinivasan, S., Chen, L., Todd, J., Mercader, J. M., Jensen, E. T., Divers, J., Mottl, A. K., Pihoker, C., Gandica, R. G., Laffel, L. M., Isganaitis, E., Haymond, M. W., Levitsky, L. L., Pollin, T. I., Florez, J. C., & Flannick, J. (2024). Genetic architecture and biology of youth-onset type 2 diabetes. Nature Metabolism, 6(2), 226–237. https://doi.org/10.1038/s42255-023-00970-0
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Columbia Affiliation
Edwards, M. M., Wang, N., Massey, D. J., Bhatele, S., Egli, D., & Koren, A. (2024). Incomplete reprogramming of DNA replication timing in induced pluripotent stem cells. Cell Reports, 43(1), 113664. https://doi.org/10.1016/j.celrep.2023.113664
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Zhang, Y., Sui, L., Du, Q., Haataja, L., Yin, Y., Viola, R., Xu, S., Nielsson, C. U., Leibel, R. L., Barbetti, F., Arvan, P., & Egli, D. (2024). Permanent neonatal diabetes-causing insulin mutations have dominant negative effects on beta cell identity. Molecular Metabolism, 80, 101879. https://doi.org/10.1016/j.molmet.2024.101879
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Chung, W., Ziegler, A., Koval-Burt, C., Kay, D., Suchy, S., Bergtrup, A., Langley, K., Amendola, L., Boyd, B., Bradley, J., Brandt, T., Cohen, L., Coffey, A., Devaney, J., Dygulska, B., Friedman, B., Fuleihan, R., Gyimah, A., Hernan, R., … Caggana, M. (2024). O35: Feasibility of expanded newborn screening using genome sequencing for early actionable conditions in a diverse city. Genetics in Medicine Open, 2, 101369. https://doi.org/10.1016/j.gimo.2024.101369
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Yu, Z., Zou, X., Deng, Z., Zhao, M., Gu, C., Fu, L., Xiao, W., He, M., He, L., Yang, Q., Liang, S., Wen, C., & Lü, M. (2024). Genome analysis of the mpox (formerly monkeypox) virus and characterization of core/variable regions. Genomics, 116(1), 110763. https://doi.org/10.1016/j.ygeno.2023.110763
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Son, J., Du, W., Esposito, M., Shariati, K., Ding, H., Kang, Y., & Accili, D. (2023). Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of β-cell failure. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-36315-4
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Park, J., Hall, C., Hubbard, B., LaMoia, T., Gaspar, R., Nasiri, A., Li, F., Zhang, H., Kim, J., Haeusler, R. A., Accili, D., Shulman, G. I., Yu, H., & Choi, E. (2023). MAD2-Dependent Insulin Receptor Endocytosis Regulates Metabolic Homeostasis. Diabetes, 72(12), 1781–1794. https://doi.org/10.2337/db23-0314
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Herb, B. R., Glover, H. J., Bhaduri, A., Colantuoni, C., Bale, T. L., Siletti, K., Hodge, R., Lein, E., Kriegstein, A. R., Doege, C. A., & Ament, S. A. (2023). Single-cell genomics reveals region-specific developmental trajectories underlying neuronal diversity in the human hypothalamus. Science Advances, 9(45). https://doi.org/10.1126/sciadv.adf6251
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Glover, H. J., Holliday, H., Shparberg, R. A., Winkler, D., Day, M., & Morris, M. B. (2023). Signalling pathway crosstalk stimulated by L-proline drives mouse embryonic stem cells to primitive-ectoderm-like cells. Development, 150(20). https://doi.org/10.1242/dev.201704
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Wang, N., Xu, S., & Egli, D. (2023). Replication stress in mammalian embryo development, differentiation, and reprogramming. Trends in Cell Biology, 33(10), 872–886. https://doi.org/10.1016/j.tcb.2023.03.015
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Rapuano, K. M., Tejavibulya, L., Dinc, E. N., Li, A., Davis, H., Korn, R., Leibel, R. L., Walsh, B. T., Ranzenhofer, L., Rosenbaum, M., Casey, B. J., & Mayer, L. (2023). Heightened sensitivity to high-calorie foods in children at risk for obesity: insights from behavior, neuroimaging, and genetics. Brain Imaging and Behavior, 17(5), 461–470. https://doi.org/10.1007/s11682-023-00773-7
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Kitamoto, T., & Accili, D. (2023). Unraveling the mysteries of hepatic insulin signaling: deconvoluting the nuclear targets of insulin. Endocrine Journal, 70(9), 851–866. https://doi.org/10.1507/endocrj.ej23-0150
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Higuchi, S., Wood, C., Nasiri, R. H., Giddla, L. J., Molina, V., Diarra, R., DiPatrizio, N. V., Kawamura, A., & Haeusler, R. A. (2023). The 16α-hydroxylated Bile Acid, Pythocholic Acid Decreases Food Intake and Increases Oleoylethanolamide in Male Mice. Endocrinology, 164(9). https://doi.org/10.1210/endocr/bqad116
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Son, J., & Accili, D. (2023). Reversing pancreatic β-cell dedifferentiation in the treatment of type 2 diabetes. Experimental & Molecular Medicine, 55(8), 1652–1658. https://doi.org/10.1038/s12276-023-01043-8
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Van Name, M. A., Kanapka, L. G., DiMeglio, L. A., Miller, K. M., Albanese-O’Neill, A., Commissariat, P., Corathers, S. D., Harrington, K. R., Hilliard, M. E., Anderson, B. J., Kelley, J. C., Laffel, L. M., MacLeish, S. A., Nathan, B. M., Tamborlane, W. V., Wadwa, R. P., Willi, S. M., Williams, K. M., Wintergerst, K. A., … DeSalvo, D. J. (2022). Long-term Continuous Glucose Monitor Use in Very Young Children With Type 1 Diabetes: One-Year Results From the SENCE Study. Journal of Diabetes Science and Technology, 17(4), 976–987. https://doi.org/10.1177/19322968221084667
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Neri, D., Ramos-Lobo, A. M., Lee, S., Lafond, A., & Zeltser, L. M. (2023). Rearing mice at 22°C programs increased capacity to respond to chronic exposure to cold but not high fat diet. Molecular Metabolism, 73, 101740. https://doi.org/10.1016/j.molmet.2023.101740
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Gandica, R., Weinstock, R. S., Gunaratne, M., Arslanian, S., Doherty, L., Geffner, M. E., Laffel, L., & Higgins, J. (2022). Long-Term Retention of Young Adult Study Participants with Youth-Onset Type 2 Diabetes: Results from the TODAY2 Study. Hormone Research in Paediatrics, 96(3), 325–331. Portico. https://doi.org/10.1159/000528205
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Columbia Affiliation
Pahl, M. C., Grant, S. F. A., Leibel, R. L., & Stratigopoulos, G. (2023). Technologies, strategies, and cautions when deconvoluting genome‐wide association signals: FTO in focus. Obesity Reviews, 24(5). Portico. https://doi.org/10.1111/obr.13558
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Parra-Vargas, M., Bouret, S. G., Bruning, J. C., de Moura, E. G., Garland, T., Lisboa, P. C., Ozanne, S. E., Patti, M.-E., Plagemann, A., Speakman, J. R., Tena-Sempere, M., Vergely, C., Zeltser, L. M., & Jiménez-Chillarón, J. C. (2023). The long-lasting shadow of litter size in rodents: litter size is an underreported variable that strongly determines adult physiology. Molecular Metabolism, 71, 101707. https://doi.org/10.1016/j.molmet.2023.101707
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