Prenatal Exposure Delayed Effects

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Sourander, A., Silwal, S., Surcel, H.-M., Hinkka-Yli-Salomäki, S., Cheslack-Postava, K., Upadhyaya, S., McKeague, I. W., & Brown, A. S. (2025). Maternal vitamin B12 during pregnancy and schizophrenia in offspring. Psychiatry Research, 344, 116284. https://doi.org/10.1016/j.psychres.2024.116284
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Hu, C.-Y., Gutierrez-Avila, I., He, M. Z., Lavigne, É., Alcala, C. S., Yitshak-Sade, M., Lamadrid-Figueroa, H., Tamayo-Ortiz, M., Mercado-Garcia, A., Just, A. C., Gennings, C., Téllez-Rojo, M. M., Wright, R. O., Wright, R. J., & Rosa, M. J. (2024). Windows of susceptibility and joint effects of prenatal and postnatal ambient air pollution and temperature exposure on asthma and wheeze in Mexican children. Environment International, 193, 109122. https://doi.org/10.1016/j.envint.2024.109122
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Perera, F., Miao, Y., Ross, Z., Rauh, V., Margolis, A., Hoepner, L., Riley, K. W., Herbstman, J., & Wang, S. (2024). Prenatal exposure to air pollution during the early and middle stages of pregnancy is associated with adverse neurodevelopmental outcomes at ages 1 to 3 years. Environmental Health, 23(1). https://doi.org/10.1186/s12940-024-01132-9
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Price, N. F., Lin, P.-I. D., Cardenas, A., Rifas-Shiman, S. L., Zota, A. R., Hivert, M.-F., Oken, E., Aris, I. M., & Sanders, A. P. (2024). Prenatal metal exposures and kidney function in adolescence in Project Viva. Environmental Health, 23(1). https://doi.org/10.1186/s12940-024-01135-6
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Rayport, Y. K., Morales, S., Shuffrey, L. C., Hockett, C. W., Ziegler, K., Rao, S., Fifer, W. P., Elliott, A. J., & Sania, A. (2024). Prenatal risk factors for child executive function at 3–5 years of age: the roles of maternal mood, substance use, and socioeconomic adversity in a prospective cohort study. BMC Pediatrics, 24(1). https://doi.org/10.1186/s12887-024-05113-2
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Peterson, A. K., Alexeeff, S. E., Ames, J. L., Feng, J., Yoshida, C., Avalos, L. A., Barrett, E. S., Bastain, T. M., Bennett, D. H., Buckley, J. P., Croen, L. A., Dunlop, A. L., Hedderson, M. M., Herbstman, J. B., Kannan, K., Karagas, M. R., McEvoy, C. T., O’Connor, T. G., Romano, M. E., … Ferrara, A. (2024). Gestational exposure to organophosphate ester flame retardants and risk of childhood obesity in the environmental influences on child health outcomes consortium. Environment International, 193, 109071. https://doi.org/10.1016/j.envint.2024.109071
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Columbia Affiliation
Abuaish, S., Babineau, V., Lee, S., Tycko, B., Champagne, F. A., Werner, E., & Monk, C. (2025). Maternal high BMI: Sex-dimorphic alterations in maternal and offspring stress indices. Psychoneuroendocrinology, 171, 107196. https://doi.org/10.1016/j.psyneuen.2024.107196
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Firestein, M. R., Manessis, A., Warmingham, J. M., Xu, R., Hu, Y., Finkel, M. A., Kyle, M., Hussain, M., Ahmed, I., Lavallée, A., Solis, A., Chaves, V., Rodriguez, C., Goldman, S., Muhle, R. A., Lee, S., Austin, J., Silver, W. G., O’Reilly, K. C., … Dumitriu, D. (2024). Positive Autism Screening Rates in Toddlers Born During the COVID-19 Pandemic. JAMA Network Open, 7(9), e2435005. https://doi.org/10.1001/jamanetworkopen.2024.35005
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Alcala, C. S., Lamadrid-Figueroa, H., Tamayo-Ortiz, M., Mercado-Garcia, A., Midya, V., Just, A. C., Foppa-Pedretti, N., Colicino, E., Téllez-Rojo, M. M., Wright, R. O., Wright, R. J., Carroll, K. N., & Rosa, M. J. (2024). Prenatal exposure to phthalates and childhood wheeze and asthma in the PROGRESS cohort. Science of The Total Environment, 954, 176311. https://doi.org/10.1016/j.scitotenv.2024.176311
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Rosa, M. J., Gennings, C., Curtin, P., Alcala, C. S., Lamadrid-Figueroa, H., Tamayo-Ortiz, M., Mercado-Garcia, A., Torres-Olascoaga, L., Téllez-Rojo, M. M., Wright, R. O., Arora, M., Austin, C., & Wright, R. J. (2024). Associations between prenatal metal and metalloid mixtures in teeth and reductions in childhood lung function. Science of The Total Environment, 938, 173352. https://doi.org/10.1016/j.scitotenv.2024.173352
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Hu, C.-Y., Alcala, C. S., Lamadrid-Figueroa, H., Tamayo-Ortiz, M., Mercado-Garcia, A., Rivera Rivera, N., Just, A. C., Gennings, C., Téllez-Rojo, M. M., Wright, R. O., Wright, R. J., Carroll, K. N., & Rosa, M. J. (2024). Associations of prenatal exposure to phthalates and their mixture with lung function in Mexican children. Journal of Hazardous Materials, 475, 134863. https://doi.org/10.1016/j.jhazmat.2024.134863
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Lumey, L. H., Li, C., Khalangot, M., Levchuk, N., & Wolowyna, O. (2024). Fetal exposure to the Ukraine famine of 1932–1933 and adult type 2 diabetes mellitus. Science, 385(6709), 667–671. https://doi.org/10.1126/science.adn4614
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Nutor, C., Dickerson, A. S., Hsu, T., Al‐Jadiri, A., Camargo, C. A., Schweitzer, J. B., Shuster, C. L., Karagas, M. R., Madan, J. C., Restrepo, B., Schmidt, R. J., Lugo‐Candelas, C., Neiderhiser, J., Sathyanarayana, S., Dunlop, A. L., & Brennan, P. A. (2024). Examining the association between prenatal cannabis exposure and child autism traits: A multi‐cohort investigation in the environmental influences on child health outcome program. Autism Research, 17(8), 1651–1664. Portico. https://doi.org/10.1002/aur.3185
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Sourander, A., Upadhyaya, S., Surcel, H.-M., Hinkka-Yli-Salomäki, S., Cheslack-Postava, K., Silwal, S., McKeague, I. W., & Brown, A. S. (2024). Maternal vitamin D levels during pregnancy and offspring schizophrenia. Schizophrenia Research, 270, 289–294. https://doi.org/10.1016/j.schres.2024.06.039
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Isik, O. G., Junaid, S., Guo, L., Lackraj, D., Landau, R., Miles, C. H., Pennell, C., von Ungern Sternberg, B. S., Whitehouse, A. J. O., Li, G., & Ing, C. (2024). Behavioural and neuropsychological outcomes in children exposed in utero to maternal labour epidural analgesia. British Journal of Anaesthesia, 133(2), 334–343. https://doi.org/10.1016/j.bja.2024.02.036
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Taeubert, M. J., Kuipers, T. B., Zhou, J., Li, C., Wang, S., Wang, T., Tobi, E. W., Belsky, D. W., Lumey, L. H., & Heijmans, B. T. (2024). Adults prenatally exposed to the Dutch Famine exhibit a metabolic signature associated with a broad spectrum of common diseases. BMC Medicine, 22(1). https://doi.org/10.1186/s12916-024-03529-2
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Curtis, M. A., Saferin, N., Nguyen, J. H., Imami, A. S., Ryan, W. G., Neifer, K. L., Miller, G. W., & Burkett, J. P. (2024). Developmental pyrethroid exposure in mouse leads to disrupted brain metabolism in adulthood. NeuroToxicology, 103, 87–95. https://doi.org/10.1016/j.neuro.2024.06.007
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Cheng, M., Conley, D., Kuipers, T., Li, C., Ryan, C. P., Taeubert, M. J., Wang, S., Wang, T., Zhou, J., Schmitz, L. L., Tobi, E. W., Heijmans, B. T., Lumey, L. H., & Belsky, D. W. (2024). Accelerated biological aging six decades after prenatal famine exposure. Proceedings of the National Academy of Sciences, 121(24). https://doi.org/10.1073/pnas.2319179121
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Lauby, S. C., Lapp, H. E., Salazar, M., Semyrenko, S., Chauhan, D., Margolis, A. E., & Champagne, F. A. (2024). Postnatal maternal care moderates the effects of prenatal bisphenol exposure on offspring neurodevelopmental, behavioral, and transcriptomic outcomes. PLOS ONE, 19(6), e0305256. https://doi.org/10.1371/journal.pone.0305256
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Jones, R. R., Madrigal, J. M., Troisi, R., Surcel, H.-M., Öhman, H., Kivelä, J., Kiviranta, H., Rantakokko, P., Koponen, J., Medgyesi, D. N., McGlynn, K. A., Sampson, J., Albert, P. S., & Ward, M. H. (2023). Maternal serum concentrations of per- and polyfluoroalkyl substances and childhood acute lymphoblastic leukemia. JNCI: Journal of the National Cancer Institute, 116(5), 728–736. https://doi.org/10.1093/jnci/djad261
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Sacchi, C., De Carli, P., Gregorini, C., Monk, C., & Simonelli, A. (2023). In the pandemic from the womb. Prenatal exposure, maternal psychological stress and mental health in association with infant negative affect at 6 months of life. Development and Psychopathology, 36(2), 810–820. https://doi.org/10.1017/s0954579423000093
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Balalian, A. A., Stingone, J. A., Kahn, L. G., Herbstman, J. B., Graeve, R. I., Stellman, S. D., & Factor-Litvak, P. (2024). Perinatal exposure to polychlorinated biphenyls (PCBs) and child neurodevelopment: A comprehensive systematic review of outcomes and methodological approaches. Environmental Research, 252, 118912. https://doi.org/10.1016/j.envres.2024.118912
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Skowronski, A. A., Leibel, R. L., & LeDuc, C. A. (2023). Neurodevelopmental Programming of Adiposity: Contributions to Obesity Risk. Endocrine Reviews, 45(2), 253–280. https://doi.org/10.1210/endrev/bnad031
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Conti, G., Poupakis, S., Ekamper, P., Bijwaard, G. E., & Lumey, L. H. (2024). Severe prenatal shocks and adolescent health: Evidence from the Dutch Hunger Winter. Economics & Human Biology, 53, 101372. https://doi.org/10.1016/j.ehb.2024.101372
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Greenwood, P. B., DeSerisy, M., Koe, E., Rodriguez, E., Salas, L., Perera, F. P., Herbstman, J., Pagliaccio, D., & Margolis, A. E. (2024). Combined and sequential exposure to prenatal second hand smoke and postnatal maternal distress is associated with cingulo-opercular global efficiency and attention problems in school-age children. Neurotoxicology and Teratology, 102, 107338. https://doi.org/10.1016/j.ntt.2024.107338
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Ing, C., Silber, J. H., Lackraj, D., Olfson, M., Miles, C., Reiter, J. G., Jain, S., Chihuri, S., Guo, L., Gyamfi-Bannerman, C., Wall, M., & Li, G. (2024). Behavioural disorders after prenatal exposure to anaesthesia for maternal surgery. British Journal of Anaesthesia, 132(5), 899–910. https://doi.org/10.1016/j.bja.2024.01.025
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Oskar, S., Balalian, A. A., & Stingone, J. A. (2024). Identifying critical windows of prenatal phenol, paraben, and pesticide exposure and child neurodevelopment: Findings from a prospective cohort study. Science of The Total Environment, 920, 170754. https://doi.org/10.1016/j.scitotenv.2024.170754
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McGuinn, L. A., Klein, D. N., Gutiérrez-Avila, I., Keil, A. P., Tamayo-Ortiz, M., Just, A., Coull, B., Torres-Calapiz, M., Kloog, I., Téllez-Rojo, M. M., Wright, R. J., & Wright, R. O. (2024). Individual and joint effects of prenatal PM2.5 and maternal stress on child temperament. Environmental Research, 249, 118432. https://doi.org/10.1016/j.envres.2024.118432
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Deyssenroth, M. A., Williams, R. P., Lesseur, C., Jacobson, S. W., Jacobson, J. L., Cheng, H., Bose, P., Li, Q., Wainwright, H., Meintjes, E. M., Hao, K., Chen, J., & Carter, R. C. (2024). Prenatal alcohol exposure is associated with changes in placental gene co-expression networks. Scientific Reports, 14(1). https://doi.org/10.1038/s41598-024-52737-6
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Correa Pinto Junior, D., Canal Delgado, I., Yang, H., Clemenceau, A., Corvelo, A., Narzisi, G., Musunuri, R., Meyer Berger, J., Hendricks, L. E., Tokumura, K., Luo, N., Li, H., Oury, F., Ducy, P., Yadav, V. K., Li, X., & Karsenty, G. (2024). Osteocalcin of maternal and embryonic origins synergize to establish homeostasis in offspring. EMBO Reports, 25(2), 593–615. https://doi.org/10.1038/s44319-023-00031-3
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Pini, N., Sania, A., Rao, S., Shuffrey, L. C., Nugent, J. D., Lucchini, M., McSweeney, M., Hockett, C., Morales, S., Yoder, L., Ziegler, K., Perzanowski, M. S., Fox, N. A., Elliott, A. J., Myers, M. M., & Fifer, W. P. (2024). In Utero Exposure to Alcohol and Tobacco and Electroencephalogram Power During Childhood. JAMA Network Open, 7(1), e2350528. https://doi.org/10.1001/jamanetworkopen.2023.50528
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Jacobson, M. H., Hamra, G. B., Monk, C., Crum, R. M., Upadhyaya, S., Avalos, L. A., Bastain, T. M., Barrett, E. S., Bush, N. R., Dunlop, A. L., Ferrara, A., Firestein, M. R., Hipwell, A. E., Kannan, K., Lewis, J., Meeker, J. D., Ruden, D. M., Starling, A. P., … Watkins, D. J. (2024). Prenatal Exposure to Nonpersistent Environmental Chemicals and Postpartum Depression. JAMA Psychiatry, 81(1), 67. https://doi.org/10.1001/jamapsychiatry.2023.3542
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Fekom, M., Nguyen, T.-L., Lepeule, J., Nakamura, A., Keyes, K., Martins, S., Strandberg-Larsen, K., & Melchior, M. (2024). Intergenerational transmission of tobacco smoking: The role of the child’s behavioral difficulties. Data from the Danish National Birth cohort (DNBC). Drug and Alcohol Dependence, 255, 111056. https://doi.org/10.1016/j.drugalcdep.2023.111056
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Warmingham, J., Petrenko, C., Rockhold, M., Alto, M., Manly, J. T., & Toth, S. (2024). Investigating the associations between prenatal exposure to substances and intergenerational maltreatment and symptoms of psychopathology for adolescent girls from families with low income. Child Abuse & Neglect, 147, 106594. https://doi.org/10.1016/j.chiabu.2023.106594
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Ji, N., Johnson, M., Eckel, S. P., Gauderman, W. J., Chavez, T. A., Berhane, K., Faham, D., Lurmann, F., Pavlovic, N. R., Grubbs, B. H., Lerner, D., Habre, R., Farzan, S. F., Bastain, T. M., & Breton, C. V. (2023). Prenatal ambient air pollution exposure and child weight trajectories from the 3rd trimester of pregnancy to 2 years of age: a cohort study. BMC Medicine, 21(1). https://doi.org/10.1186/s12916-023-03050-y
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Fage-Larsen, B., Andersen, H. R., Wesselhoeft, R., Larsen, P. V., Dalsager, L., Nielsen, F., Rauh, V., & Bilenberg, N. (2024). Exposure to chlorpyrifos and pyrethroid insecticides and symptoms of Attention Deficit Hyperactivity Disorder (ADHD) in preschool children from the Odense Child Cohort. Environmental Research, 241, 117679. https://doi.org/10.1016/j.envres.2023.117679
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Lewis, J. V., Knapp, E. A., Bakre, S., Dickerson, A. S., Bastain, T. M., Bendixsen, C., Bennett, D. H., Camargo, C. A., Cassidy-Bushrow, A. E., Colicino, E., D’Sa, V., Dabelea, D., Deoni, S., Dunlop, A. L., Elliott, A. J., Farzan, S. F., Ferrara, A., Fry, R. C., Hartert, T., … Kress, A. M. (2023). Associations between area-level arsenic exposure and adverse birth outcomes: An Echo-wide cohort analysis. Environmental Research, 236, 116772. https://doi.org/10.1016/j.envres.2023.116772
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Williams, R. P., Lesseur, C., Cheng, H., Li, Q., Deyssenroth, M., Molteno, C. D., Meintjes, E. M., Jacobson, S. W., Jacobson, J. L., Wainwright, H., Hao, K., Chen, J., & Carter, R. C. (2024). RNA-seq analysis reveals prenatal alcohol exposure is associated with placental inflammatory cells and gene expression. Gene, 894, 147951. https://doi.org/10.1016/j.gene.2023.147951
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Kuhn, L. (2023). Are links between maternal obesity early in pregnancy and child neurodevelopment causal? Developmental Medicine & Child Neurology, 66(4), 411–412. Portico. https://doi.org/10.1111/dmcn.15780
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Masehi-Lano, J. J., Deyssenroth, M., Jacobson, S. W., Jacobson, J. L., Molteno, C. D., Dodge, N. C., Wainwright, H. C., Meintjes, E. M., Lesseur, C., Cheng, H., Li, Q., Hao, K., Chen, J., & Carter, R. C. (2023). Alterations in Placental Inflammation-Related Gene Expression Partially Mediate the Effects of Prenatal Alcohol Consumption on Maternal Iron Homeostasis. Nutrients, 15(19), 4105. https://doi.org/10.3390/nu15194105
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Tan, Y., Taibl, K. R., Dunlop, A. L., Barr, D. B., Panuwet, P., Yakimavets, V., Kannan, K., Corwin, E. J., Ryan, P. B., Eatman, J. A., Liang, D., & Eick, S. M. (2023). Association between a Mixture of Per- and Polyfluoroalkyl Substances (PFAS) and Inflammatory Biomarkers in the Atlanta African American Maternal–Child Cohort. Environmental Science & Technology, 57(36), 13419–13428. https://doi.org/10.1021/acs.est.3c04688
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Columbia Affiliation
Avalos, L. A., Chandran, A., Churchill, M. L., Gao, X., Ames, J. L., Nozadi, S. S., Roubinov, D., Brennan, P. A., Bush, N. R., Camargo, C. A., Carroll, K. N., Cioffi, C. C., Ferrara, A., Goldson, B., Hedderson, M. M., Hipwell, A. E., Kerver, J. M., O’Connor, T. G., … Porucznik, C. A. (2023). Prenatal depression and risk of child autism‐related traits among participants in the Environmental influences on Child Health Outcomes program. Autism Research, 16(9), 1825–1835. Portico. https://doi.org/10.1002/aur.2988
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Yao, X., Wang, Y., Ma, Y., Fu, M., Wang, H., Tang, D., & Nie, J. (2023). Associations between prenatal exposure to polycyclic aromatic hydrocarbons and thyroid hormones in umbilical cord blood. Environmental Science and Pollution Research, 30(31), 77096–77106. https://doi.org/10.1007/s11356-023-27379-2
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Liu, R., Pagliaccio, D., Herbstman, J. B., Fox, N. A., & Margolis, A. E. (2023). Prenatal exposure to air pollution and childhood internalizing problems: roles of shyness and anterior cingulate cortex activity. Journal of Child Psychology and Psychiatry, 64(7), 1037–1044. Portico. https://doi.org/10.1111/jcpp.13768
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Margolis, A. E., Lee, S. H., Liu, R., Goolsby, L., Champagne, F., Herbstman, J., & Beebe, B. (2023). Associations between prenatal exposure to second hand smoke and infant self-regulation in a New York city longitudinal prospective birth cohort. Environmental Research, 227, 115652. https://doi.org/10.1016/j.envres.2023.115652
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Upadhyaya, S., Brown, A., Cheslack-Postava, K., Gissler, M., Gyllenberg, D., Heinonen, E., Laitinen, J., McKeague, I., Hinkka-Yli-Salomäki, S., Sourander, A., Tornio, A., & Malm, H. (2023). Maternal SSRI use during pregnancy and offspring depression or anxiety disorders: A review of the literature and description of a study protocol for a register-based cohort study. Reproductive Toxicology, 118, 108365. https://doi.org/10.1016/j.reprotox.2023.108365
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Edwards, A. C., Jacobson, S. W., Senekal, M., Dodge, N. C., Molteno, C. D., Meintjes, E. M., Jacobson, J. L., & Carter, R. C. (2023). Fetal Alcohol-Related Postnatal Growth Restriction Is Independent of Infant Feeding Practices and Postnatal Alcohol Exposure in a Prospective South African Birth Cohort. Nutrients, 15(9), 2018. https://doi.org/10.3390/nu15092018
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Firestein, M. R., Shuffrey, L. C., Hu, Y., Kyle, M., Hussain, M., Bianco, C., Hott, V., Hyman, S. P., Kyler, M., Rodriguez, C., Tejeda Romero, M., Tzul Lopez, H., Alcántara, C., Amso, D., Austin, J., Bain, J. M., Barbosa, J., Battarbee, A. N., Bruno, A., … Dumitriu, D. (2023). Assessment of Neurodevelopment in Infants With and Without Exposure to Asymptomatic or Mild Maternal SARS-CoV-2 Infection During Pregnancy. JAMA Network Open, 6(4), e237396. https://doi.org/10.1001/jamanetworkopen.2023.7396
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Baker, B. H., Joo, Y. Y., Park, J., Cha, J., Baccarelli, A. A., & Posner, J. (2022). Maternal age at birth and child attention‐deficit hyperactivity disorder: causal association or familial confounding? Journal of Child Psychology and Psychiatry, 64(2), 299–310. Portico. https://doi.org/10.1111/jcpp.13726
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