Taub Institute for Research on Alzheimer’s Disease and the Aging Brain

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Herline-Killian, K., Pauers, M. M., Lipponen, J. E., Zrzavy, M. A., Gouveia Roque, C., McCurdy, E. P., Chung, K. M., & Hengst, U. (2025). Modulation of CREB3L2-ATF4 heterodimerization via proteasome inhibition and HRI activation in Alzheimer’s disease pathology. Cell Death & Disease, 16(1). https://doi.org/10.1038/s41419-025-07586-0
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Roy, S. M., Acquarone, E., Argyrousi, E. K., Zhang, H., Staniszewski, A., Inoue, A., Ziarek, J. J., Arancio, O., & Watterson, D. M. (2025). Optimized 5‐HT2b inhibitors for neuropsychiatric syndromes with cognitive dysfunction. Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 11(1). Portico. https://doi.org/10.1002/trc2.70073
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Miner, A. E., Groh, J. R., Farris, C., Hattiangadi, S., Cui, A., Brickman, A. M., Alshikho, M., Rabinovici, G. D., Rosen, H. J., Cobigo, Y., Asken, B., Nowinski, C. J., Bureau, S., Shahrokhi, F., Tripodis, Y., Ly, M., Altaras, C., Lenio, S., Stern, R. A., … Alosco, M. L. (2025). Does white matter and vascular injury from repetitive head impacts lead to a novel pattern on T2 FLAIR MRI? A hypothesis proposal and call for research. Alzheimer’s & Dementia, 21(3). Portico. https://doi.org/10.1002/alz.70085
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Melgarejo, J. D., Patil, D., Charisis, S., Vatcheva, K. P., Mejia-Arango, S., Mena, L. J., Satizabal, C. L., Gaona, C., Silva, E., Manusov, E., Lee, J. H., Terwilliger, J. D., Gutierrez, J., Seshadri, S., & Maestre, G. E. (2025). Baseline associations of office and ambulatory blood pressure monitoring with cognitive function and dementia prevalence. Journal of Alzheimer’s Disease. https://doi.org/10.1177/13872877251322400
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Zhao, J., Gu, T., Gao, C., Miao, G., Palma-Gudiel, H., Yu, L., Yang, J., Wang, Y., Li, Y., Lim, J., Li, R., Yao, B., Wu, H., Schneider, J. A., Seyfried, N., Grodstein, F., De Jager, P. L., Jin, P., & Bennett, D. A. (2025). Brain 5-hydroxymethylcytosine alterations are associated with Alzheimer’s disease neuropathology. Nature Communications, 16(1). https://doi.org/10.1038/s41467-025-58159-w
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Nixon-Abell, J., Ruggeri, F. S., Qamar, S., Herling, T. W., Czekalska, M. A., Shen, Y., Wang, G., King, C., Fernandopulle, M. S., Sneideris, T., Watson, J. L., Pillai, V. V. S., Meadows, W., Henderson, J. W., Chambers, J. E., Wagstaff, J. L., Williams, S. H., Coyle, H., Šneiderienė, G., … St George-Hyslop, P. (2025). ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes. Nature Communications, 16(1). https://doi.org/10.1038/s41467-025-58142-5
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Hoost, S. S., Honig, L. S., Kang, M. S., Bahl, A., Lee, A. J., Sanchez, D., Reyes-Dumeyer, D., Lantigua, R. A., Dage, J. L., Brickman, A. M., Manly, J. J., Mayeux, R., & Gu, Y. (2025). Association of dietary fatty acids with longitudinal change in plasma-based biomarkers of Alzheimer’s disease. The Journal of Prevention of Alzheimer’s Disease, 100117. https://doi.org/10.1016/j.tjpad.2025.100117
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Phillips, J. M., Dumitrescu, L. C., Archer, D. B., Regelson, A. N., Mukherjee, S., Lee, M. L., Choi, S.-E., Scollard, P., Trittschuh, E. H., Kukull, W. A., Biber, S., Mez, J., Mahoney, E. R., Clifton, M., Libby, J. B., Walters, S., Bush, W. S., Engelman, C. D., Lu, Q., … Hohman, T. J. (2025). Novel modelling approaches to elucidate the genetic architecture of resilience to Alzheimer’s disease. Brain. https://doi.org/10.1093/brain/awaf106
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Lagarde, J., Maiti, P., Schonhaut, D. R., Blazhenets, G., Zhang, J., Eloyan, A., Thangarajah, M., Taurone, A., Allen, I. E., Soleimani‐Meigooni, D. N., Zeltzer, E., Windon, C., Abu Raya, M., Vrillon, A., Smith, K., Shankar, R., Amuiri, A., Rocha, S., … Hammers, D. B. (2025). Amyloid PET in Sporadic Early‐ Versus Late‐Onset Alzheimer’s Disease: Comparison of the LEADS and ADNI Cohorts. Annals of Neurology. Portico. https://doi.org/10.1002/ana.27233
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Winford, E. D., & Bachstetter, A. D. (2024). Alzheimer’s disease and the immune system: the emerging role of TEMRA cells. Neural Regeneration Research, 20(12), 3529–3530. https://doi.org/10.4103/nrr.nrr-d-24-00793
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Ray, N. R., Bradley, J., Yilmaz, E., Kizil, C., Kurup, J. T., Martin, E. R., Klein, H.-U., Kunkle, B. W., Bennett, D. A., De Jager, P. L., Beecham, G. W., Cruchaga, C., & Reitz, C. (2025). Local genetic covariance analysis with lipid traits identifies novel loci for early-onset Alzheimer’s Disease. PLOS Genetics, 21(3), e1011631. https://doi.org/10.1371/journal.pgen.1011631
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Wang, D., Scalici, A., Wang, Y., Lin, H., Pitsillides, A., Heard-Costa, N., Cruchaga, C., Ziegemeier, E., Bis, J. C., Fornage, M., Boerwinkle, E., De Jager, P. L., Wijsman, E., Dupuis, J., Renton, A. E., Seshadri, S., Goate, A. M., DeStefano, A. L., & Peloso, G. M. (2025). Frequency of variants in Mendelian Alzheimer’s disease genes within the Alzheimer’s Disease Sequencing Project. Journal of Alzheimer’s Disease. https://doi.org/10.1177/13872877251320375
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Petrosyan, S., Strangmann, I. M., Nichols, E., Meijer, E., Briceño, E. M., Narayanan, S., Lee, J., & Arce Rentería, M. (2025). The association of multilingualism with diverse language families and cognition among adults with and without education in India. Neuropsychology, 39(3), 223–234. https://doi.org/10.1037/neu0000988
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Cornejo-Sanchez, D. M., Bharadwaj, T., Dong, R., Wang, G. T., Schrauwen, I., DeWan, A. T., & Leal, S. M. (2025). Mendelian non-syndromic and syndromic hearing loss genes contribute to presbycusis. European Journal of Human Genetics. https://doi.org/10.1038/s41431-025-01789-x
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Thomas, H. B., Demain, L. A. M., Cabrera-Orefice, A., Schrauwen, I., Shamseldin, H. E., Rea, A., Bharadwaj, T., Smith, T. B., Oláhová, M., Thompson, K., He, L., Kaur, N., Shukla, A., Abukhalid, M., Ansar, M., Rehman, S., Riazuddin, S., Abdulwahab, F., Smith, J. M., … Newman, W. G. (2025). Bi-allelic variants in MRPL49 cause variable clinical presentations, including sensorineural hearing loss, leukodystrophy, and ovarian insufficiency. The American Journal of Human Genetics. https://doi.org/10.1016/j.ajhg.2025.02.005
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Fioriti, L., Wijesekara, N., Argyrousi, E. K., Matsuzaki, S., Takamura, H., Satoh, K., Han, K., Yamauchi, H., Staniszewski, A., Acquarone, E., Orsini, F., Martucci, A., Katayama, T., Arancio, O., & Fraser, P. E. (2025). Genetic and pharmacologic enhancement of SUMO2 conjugation prevents and reverses cognitive impairment and synaptotoxicity in a preclinical model of Alzheimer’s disease. Alzheimer’s & Dementia, 21(3). Portico. https://doi.org/10.1002/alz.70030
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Reho, P., Kalia, V., Jackson, G. L., Wang, F., Eiten, E., Brennan, K., Brickman, A. M., Mayeux, R., Miller, G. W., Vardarajan, B. N., Baccarelli, A., & Wu, H. (2025). Preclinical Alzheimer’s disease shows alterations in circulating neuronal‐derived extracellular vesicle microRNAs in a multiethnic cohort. Alzheimer’s & Dementia, 21(3). Portico. https://doi.org/10.1002/alz.70050
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Sokol, L. L., Ashner, M. C., Bega, D., Kluger, B. M., Smith, A. K., Marder, K. S., & Garcia, T. P. (2025). Spiritual Well-Being and Phenoconversion in Huntington’s Disease: Analysis from the Prospective Huntington at Risk Observational Study. Journal of Palliative Medicine, 000–000. https://doi.org/10.1089/jpm.2024.0227
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Leuzy, A., Bollack, A., Pellegrino, D., Teunissen, C. E., La Joie, R., Rabinovici, G. D., Franzmeier, N., Johnson, K., Barkhof, F., Shaw, L. M., Arkhipenko, A., Schindler, S. E., Honig, L. S., Moscoso Rial, A., Schöll, M., Zetterberg, H., Blennow, K., Hansson, O., & Farrar, G. (2025). Considerations in the clinical use of amyloid PET and CSF biomarkers for Alzheimer’s disease. Alzheimer’s & Dementia, 21(3). Portico. https://doi.org/10.1002/alz.14528
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Wang, S., Lenzini, P., Thyagarajan, B., Lee, J. H., Vardarajan, B. N., Yashin, A., Miljkovic, I., Daw, E. W., Lin, S. J., Patti, G. J., Brent, M. R., Zmuda, J. M., Perls, T. T., Christensen, K., Province, M. A., & An, P. (2025). Evidence of a novel gene locus ARHGAP44 for longitudinal change in hemoglobin A1c levels among subjects without diabetes from the Long Life Family Study. Physiological Genomics, 57(5), 293–298. https://doi.org/10.1152/physiolgenomics.00137.2024
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Muller, C., Grodsky, E., Brickman, A. M., Manly, J. J., Hung, K., Culbertson, M. J., & Warren, J. R. (2025). Education and midlife cognitive functioning: Evidence from the High School and Beyond cohort. Alzheimer's & dementia : the journal of the Alzheimer's Association, 21(2), e70015. https://doi.org/10.1002/alz.70015

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Arnold, M., Buyukozkan, M., Doraiswamy, P. M., Nho, K., Wu, T., Gudnason, V., Launer, L. J., Wang-Sattler, R., Adamski, J., De Jager, P. L., Ertekin-Taner, N., Bennett, D. A., Saykin, A. J., Peters, A., Suhre, K., Kaddurah-Daouk, R., Kastenmüller, G., & Krumsiek, J. (2025). Individual bioenergetic capacity as a potential source of resilience to Alzheimer’s disease. Nature Communications, 16(1). https://doi.org/10.1038/s41467-025-57032-0
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Katsumi, Y., Touroutoglou, A., Brickhouse, M., Eloyan, A., Eckbo, R., Zaitsev, A., La Joie, R., Lagarde, J., Schonhaut, D., Thangarajah, M., Taurone, A., Vemuri, P., Jack, C. R., Dage, J. L., Nudelman, K. N. H., Foroud, T., Hammers, D. B., Ghetti, B., … Murray, M. E. (2025). Dissociable spatial topography of cortical atrophy in early‐onset and late‐onset Alzheimer’s disease: A head‐to‐head comparison of the LEADS and ADNI cohorts. Alzheimer’s & Dementia, 21(2). Portico. https://doi.org/10.1002/alz.14489
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Hammers, D. B., Musema, J., Eloyan, A., Thangarajah, M., Taurone, A., La Joie, R., Touroutoglou, A., Vemuri, P., Kramer, J., Aisen, P., Dage, J. L., Nudelman, K. N., Kirby, K., Atri, A., Clark, D., Day, G. S., Duara, R., Graff-Radford, N. R., Grant, I., … Apostolova, L. G. (2025). Characterizing and validating 12-month reliable cognitive change in Early-Onset Alzheimer’s Disease for use in clinical trials. The Journal of Prevention of Alzheimer’s Disease, 100075. https://doi.org/10.1016/j.tjpad.2025.100075
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Lado, W., Wu, X., Choi, S., Dong, Y., Yang, G., Arancio, O., Tempia, F., Miniaci, M. C., Sulzer, D., Mosharov, E., & Tang, G. (2025). Synaptic plasticity deficits in a mouse model of Timothy syndrome: LTP saturation and its pharmacological rescue by nifedipine. Biomedicine & Pharmacotherapy, 184, 117896. https://doi.org/10.1016/j.biopha.2025.117896
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Putcha, D., Katsumi, Y., Touroutoglou, A., Eloyan, A., Taurone, A., Thangarajah, M., Aisen, P., Dage, J. L., Foroud, T., Jack, C. R., Kramer, J. H., Nudelman, K. N. H., Raman, R., Vemuri, P., Atri, A., Day, G. S., Duara, R., Graff-Radford, N. R., Grant, I. M., … Honig, L. S. (2025). Heterogeneous clinical phenotypes of sporadic early-onset Alzheimer’s disease: a neuropsychological data-driven approach. Alzheimer’s Research & Therapy, 17(1). https://doi.org/10.1186/s13195-025-01689-8
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Sattar, S., Bharadwaj, T., Kalsoom, U.-, Acharya, A., Khan, S., Leal, S. M., & Schrauwen, I. (2025). A pathogenic COL7A1 variant highlights semi-dominant inheritance in dystrophic epidermolysis bullosa. BMC Medical Genomics, 18(1). https://doi.org/10.1186/s12920-024-02077-1
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Lee, H., Pearse, R. V., Lish, A. M., Pan, C., Augur, Z. M., Terzioglu, G., Gaur, P., Liao, M., Fujita, M., Tio, E. S., Duong, D. M., Felsky, D., Seyfried, N. T., Menon, V., Bennett, D. A., De Jager, P. L., & Young‐Pearse, T. L. (2025). Contributions of Genetic Variation in Astrocytes to Cell and Molecular Mechanisms of Risk and Resilience to Late‐Onset Alzheimer’s Disease. Glia. Portico. https://doi.org/10.1002/glia.24677
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Liu, H., Marsh, T. W., Shi, X., Renton, A. E., Bowling, K. M., Ziegemeier, E., Wang, G., Cao, Y., Aristel, A., Li, J., Dickson, A., Perrin, R. J., Goate, A. M., Fernández, V., Day, G. S., Doering, M., Daniels, A., Gordon, B. A., Benzinger, T. L. S., … Llibre-Guerra, J. J. (2025). The landscape of autosomal-dominant Alzheimer’s disease: global distribution and age of onset. Brain. https://doi.org/10.1093/brain/awaf038
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Carter, E. D., Berry, D. S., Cosentino, S., & Louis, E. D. (2025). Predictors of mortality in a large cohort of elders with essential tremor. Neuroepidemiology, 1–20. Portico. https://doi.org/10.1159/000543879
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Sampatakakis, S. N., Mourtzi, N., Hatzimanolis, A., Koutsis, G., Charisis, S., Gkelmpesi, I., Mamalaki, E., Ntanasi, E., Ramirez, A., Yannakoulia, M., Kosmidis, M. H., Dardiotis, E., Hadjigeorgiou, G., Sakka, P., & Scarmeas, N. (2025). Genetic Prοpensity for Different Aspects of Dementia Pathology and Cognitive Decline in a Community Elderly Population. International Journal of Molecular Sciences, 26(3), 910. https://doi.org/10.3390/ijms26030910
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Kennedy, J. T., Wisch, J. K., Dincer, A., Roman, J., Gordon, B. A., Handen, B., Benzinger, T. L. S., Head, E., Mapstone, M., Christian, B. T., Tudorascu, D. L., Laymon, C. L., Hartley, S. L., Lao, P., Brickman, A. M., Zaman, S. H., & Ances, B. M. (2025). Decoding brain structure to stage Alzheimer’s disease pathology in Down syndrome. Alzheimer’s & Dementia, 21(2). Portico. https://doi.org/10.1002/alz.14519
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Liampas, I., Siokas, V., Mourtzi, N., Charisis, S., Sampatakakis, S. N., Foukarakis, I., Hatzimanolis, A., Ramirez, A., Lambert, J.-C., Yannakoulia, M., Kosmidis, M. H., Dardiotis, E., Hadjigeorgiou, G. M., Sakka, P., Rouskas, K., & Scarmeas, N. (2025). Genetic Predisposition to Hippocampal Atrophy and Risk of Amnestic Mild Cognitive Impairment and Alzheimer’s Dementia. Geriatrics, 10(1), 14. https://doi.org/10.3390/geriatrics10010014
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Vinogradova, E., Jarmukhanov, Z., Nurgaziyev, M., Kossumov, A., Nurgozhina, A., Mukhanbetzhanov, N., Sergazy, S., Chulenabyeva, L., Issilbayeva, A., Askarova, S., Kaiyrlykyzy, A., Rakhimova, S., Kozhamkulov, U., Kairov, U., Khassenbekova, Z., Tarzhanova, D., Akilzhanova, A., Lee, J. H., Terwilliger, J., … Kushugulova, A. (2025). Enterococcus dysbiosis as a mediator of vitamin D deficiency-associated memory impairments. Heliyon, 11(2), e41969. https://doi.org/10.1016/j.heliyon.2025.e41969
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Mekonnen, T., Skirbekk, V., Zotcheva, E., Engdahl, B., Bratsberg, B., Jugessur, A., Bowen, C., Selbæk, G., Kohler, H.-P., Harris, J. R., Tom, S. E., Krokstad, S., Edwin, T. H., Wedatilake, Y., Wolfova, K., Kristjansson, D., Stern, Y., Håberg, A. K., & Strand, B. H. (2025). Number of children and dementia risk: a causal mediation analysis using data from the HUNT study linked with national registries in Norway. BMC Neurology, 25(1). https://doi.org/10.1186/s12883-025-04044-4
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Elyaman, W., Stern, L. J., Jiang, N., Dressman, D., Bradley, P., Klatzmann, D., Bradshaw, E. M., Farber, D. L., Kent, S. C., Chizari, S., Funk, K., Devanand, D., Thakur, K. T., Raj, T., Dalahmah, O. A., Sarkis, R. A., Weiner, H. L., Shneider, N. A., & Przedborski, S. (2025). Exploring the role of T cells in Alzheimer’s and other neurodegenerative diseases: Emerging therapeutic insights from the T Cells in the Brain symposium. Alzheimer’s & Dementia. Portico. https://doi.org/10.1002/alz.14548
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Dai, Y., Wang, J., Zhang, J., Liu, X., Sun, G., Lu, J., & Li, Y. (2025). Protocol for identifying Dicer as dsRNA binding and cleaving reagent in response to transfected dsRNA. STAR Protocols, 6(1), 103591. https://doi.org/10.1016/j.xpro.2024.103591
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Nejati, V., Estaji, R., Balanzá-Martínez, V., Balota, D. A., Barker-Collo, S., Bell, M., Berry, J. H., Borhani, K., Cullum, M., Feinstein, A., Golden, C. J., Gonzalez, R., Grafman, J. H., Hollon, S. D., Jansen, P., Kochan, N. A., Van Patten, R., Piguet, O., Raskin, S. A., … Posner, M. I. (2025). Development of a checklist for cognitive assessment requirements (CARE) based on a Delphi consensus study. Scientific Reports, 15(1). https://doi.org/10.1038/s41598-025-87380-2
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Bairami, S., Scarmeas, N., Yannakoulia, M., Dardiotis, E., Sakka, P., Hadjigeorgiou, G., Tsapanou, A., & Kosmidis, M. H. (2025). Can Sleep Predict Conversion to Mild Cognitive Impairment and Dementia? Results From the Hellenic Longitudinal Investigation of Aging and Diet Study. Alzheimer Disease & Associated Disorders. https://doi.org/10.1097/wad.0000000000000661
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Thomas, A., Guo, J., Reyes-Dumeyer, D., Sanchez, D., Scarmeas, N., Manly, J. J., Brickman, A. M., Lantigua, R. A., Mayeux, R., & Gu, Y. (2025). Inflammatory biomarkers profiles and cognition among older adults. Scientific Reports, 15(1). https://doi.org/10.1038/s41598-025-86309-z
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Kost, R. G., Andrews, J., Chatterjee, R., Cheng, A. C., Connally, L., Dozier, A., Dykes, C., Ford, D., Green, N. S., Jiang, C., Khoury-Shakour, S., Lindo, S., Marder, K., Martinez, L., Qureshi, A., Roberts, J., & Schlesinger, N. (2025). What research participants say about their research experiences in Empowering the Participant Voice: Outcomes and actionable data. Journal of Clinical and Translational Science, 9(1). https://doi.org/10.1017/cts.2025.3
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Saez-Calveras, N., Vaquer-Alicea, J., White, C. L., Tak, Y., Cosentino, S., Faust, P. L., Louis, E. D., & Diamond, M. I. (2025). Essential tremor with tau pathology features seeds indistinguishable in conformation from Alzheimer’s disease and primary age-related tauopathy. Acta Neuropathologica, 149(1). https://doi.org/10.1007/s00401-024-02843-6
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Pandey, N., Yang, Z., Cieza, B., Reyes-Dumeyer, D., Kang, M. S., Montesinos, R., Soto-Añari, M., Custodio, N., Honig, L. S., & Tosto, G. (2025). Plasma phospho-tau217 as a predictive biomarker for Alzheimer’s disease in a large south American cohort. Alzheimer’s Research & Therapy, 17(1). https://doi.org/10.1186/s13195-024-01655-w
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Mares, J., Kumar, G., Sharma, A., Emrani, S., McIntire, L. B., Guo, J., Menon, V., & Nuriel, T. (2024). APOE ε4–associated heterogeneity of neuroimaging biomarkers across the Alzheimer’s disease continuum. Alzheimer’s & Dementia, 21(1). Portico. https://doi.org/10.1002/alz.14392
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Lessel, I., Baresic, A., Chinn, I. K., May, J., Goenka, A., Chandler, K. E., Posey, J. E., Afenjar, A., Averdunk, L., Bedeschi, M. F., Besnard, T., Brager, R., Brick, L., Brugger, M., Brunet, T., Byrne, S., Calle-Martín, O. de la, Capra, V., Cardenas, P., … Lessel, D. (2025). DNA-binding affinity and specificity determine the phenotypic diversity in BCL11B-related disorders. The American Journal of Human Genetics. https://doi.org/10.1016/j.ajhg.2024.12.012
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