Aging reshapes the adaptive immune system from healer to saboteur

Delgado-Pulido, S., Yousefzadeh, M. J., & Mittelbrunn, M. (2025). Aging reshapes the adaptive immune system from healer to saboteur. Nature aging, 5(8), 1393–1403. https://doi.org/10.1038/s43587-025-00906-1

Authors:
Sandra Delgado-Pulido
Matthew J Yousefzadeh
Maria Mittelbrunn
Affiliated Authors:
Matthew J Yousefzadeh
Maria Mittelbrunn
Columbia Affiliation:
Subjects:
Aging (MeSH)
Adaptive Immunity (MeSH)
Author Keywords:
gamma interferon
immunoglobulin
toll like receptor
interleukin 10
transcription factor foxp3
tumor necrosis factor
adaptive immunity
aging
alzheimer disease
article
autoimmunity
cancer epidemiology
cd4+ t lymphocyte
cd8+ t lymphocyte
cell aging
chronic inflammation
cytotoxic t lymphocyte
degenerative disease
dysbiosis
healthy aging
human
immunocompetent cell
immunological monitoring
immunological tolerance
immunomodulation
immunoregulation
immunosuppressive treatment
immunosurveillance
inflammaging
lymphocyte
major histocompatibility complex
natural killer cell
phenotype
senescence
single cell rna seq
tfh cell
tissue injury
tissue regeneration
tissue repair
elink
Publication Type:
Article
Unique ID:
10.1038/s43587-025-00906-1
PMID:
40813808
DOI:
10.1038/s43587-025-00906-1
Journal:
Nature Aging
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
View Scopus Record

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