Exploration and characterization of the antimalarial activity of cyclopropyl carboxamides that target the mitochondrial protein, cytochrome b

Awalt, J. K., Su, W., Nguyen, W., Loi, K., Jarman, K. E., Penington, J. S., Ramesh, S., Fairhurst, K. J., Yeo, T., Park, H., Uhlemann, A.-C., Chandra Maity, B., De, N., Mukherjee, P., Chakraborty, A., Churchyard, A., Famodimu, M. T., Delves, M. J., Baum, J., … Sleebs, B. E. (2024). Exploration and characterization of the antimalarial activity of cyclopropyl carboxamides that target the mitochondrial protein, cytochrome b. European Journal of Medicinal Chemistry, 280, 116921. https://doi.org/10.1016/j.ejmech.2024.116921
Authors:
Jon Kyle Awalt
Wenyin Su
William Nguyen
Katie Loi
Kate E Jarman
Jocelyn S Penington
Saishyam Ramesh
Kate J Fairhurst
Tomas Yeo
Heekuk Park
Anne-Catrin Uhlemann
Bikash Chandra Maity
Nirupam De
Partha Mukherjee
Arnish Chakraborty
Alisje Churchyard
Mufuliat T Famodimu
Michael J Delves
Jake Baum
Nimisha Mittal
Elizabeth A Winzeler
Anthony T Papenfuss
Mrittika Chowdury
Tania F de Koning-Ward
Alexander G Maier
Giel G van Dooren
Delphine Baud
Stephen Brand
David A Fidock
Paul F Jackson
Alan F Cowman
Madeline G Dans
Brad E Sleebs
Affiliated Authors:
Kate J Fairhurst
Tomas Yeo
Heekuk Park
Anne-Catrin Uhlemann
David A Fidock
Columbia Affiliation:
Subjects:
Malaria (OpenAlex Topic)
Computational Methods in Drug Discovery (OpenAlex Topic)
Efficacy and Safety of Antiretroviral Therapy for HIV (OpenAlex Topic)
Antimalarials (MeSH)
Plasmodium falciparum (MeSH)
Cytochromes b (MeSH)
Author Keywords:
antimalarial
cytochrome b
malaria
mitochondria
plasmodium
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Publication Type:
Article
Unique ID:
10.1016/j.ejmech.2024.116921
PMID:
39388903
DOI:
10.1016/j.ejmech.2024.116921
Journal:
European Journal of Medicinal Chemistry
Publication Date:
Data Source:
PubMed
Source Link:
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Record Created: