Bile acid synthesis impedes tumor-specific T cell responses during liver cancer

Varanasi, S. K., Chen, D., Liu, Y., Johnson, M. A., Miller, C. M., Ganguly, S., Lande, K., LaPorta, M. A., Hoffmann, F. A., Mann, T. H., Teneche, M. G., Casillas, E., Mangalhara, K. C., Mathew, V., Sun, M., Jensen, I. J., Farsakoglu, Y., Chen, T., Parisi, B., … Kaech, S. M. (2025). Bile acid synthesis impedes tumor-specific T cell responses during liver cancer. Science, 387(6730), 192–201. https://doi.org/10.1126/science.adl4100
Authors:
Siva Karthik Varanasi
Dan Chen
Yingluo Liu
Melissa A Johnson
Cayla M Miller
Souradipta Ganguly
Kathryn Lande
Michael A LaPorta
Filipe Araujo Hoffmann
Thomas H Mann
Marcos G Teneche
Eduardo Casillas
Kailash C Mangalhara
Varsha Mathew
Ming Sun
Isaac J Jensen
Yagmur Farsakoglu
Timothy Chen
Bianca Parisi
Shaunak Deota
Aaron Havas
Jin Lee
H Kay Chung
Andrea Schietinger
Satchidananda Panda
April E Williams
Donna L Farber
Debanjan Dhar
Peter D Adams
Gen-Sheng Feng
Gerald S Shadel
Mark S Sundrud
Susan M Kaech
Affiliated Authors:
Isaac J Jensen
Donna L Farber
Columbia Affiliation:
Subjects:
Bile Acids and Salts (MeSH)
Carcinoma, Hepatocellular (MeSH)
CD8-Positive T-Lymphocytes (MeSH)
Endoplasmic Reticulum Stress (MeSH)
Immune Checkpoint Inhibitors (MeSH)
Liver Neoplasms (MeSH)
Ursodeoxycholic Acid (MeSH)
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Publication Type:
Article
Unique ID:
10.1126/science.adl4100
PMID:
39787217
DOI:
10.1126/science.adl4100
Journal:
Science
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
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Record Created: