Inactive Parp2 causes Tp53-dependent lethal anemia by blocking replication-associated nick ligation in erythroblasts

Lin, X., Gupta, D., Vaitsiankova, A., Bhandari, S. K., Leung, K. S. K., Menolfi, D., Lee, B. J., Russell, H. R., Gershik, S., Huang, X., Gu, W., McKinnon, P. J., Dantzer, F., Rothenberg, E., Tomkinson, A. E., & Zha, S. (2024). Inactive Parp2 causes Tp53-dependent lethal anemia by blocking replication-associated nick ligation in erythroblasts. Molecular Cell, 84(20), 3916-3931.e7. https://doi.org/10.1016/j.molcel.2024.09.020
Authors:
Xiaohui Lin
Dipika Gupta
Alina Vaitsiankova
Seema Khattri Bhandari
Kay Sze Karina Leung
Demis Menolfi
Brian J Lee
Helen R Russell
Steven Gershik
Xiaoyu Huang
Wei Gu
Peter J McKinnon
Françoise Dantzer
Eli Rothenberg
Alan E Tomkinson
Shan Zha
Affiliated Authors:
Xiaohui Lin
Kay Sze Karina Leung
Demis Menolfi
Brian J Lee
Steven Gershik
Xiaoyu Huang
Wei Gu
Shan Zha
Columbia Affiliation:
Subjects:
Tumor Suppressor Protein p53 (MeSH)
Erythroblasts (MeSH)
DNA Replication (MeSH)
Anemia (MeSH)
Poly(ADP-ribose) Polymerases (MeSH)
Checkpoint Kinase 2 (MeSH)
Author Keywords:
5′p-nicks
anemia
erythropoiesis
hematological toxicity
lig1
parp inhibition
parp inhibitor
parp2
elink
Publication Type:
Article
Unique ID:
10.1016/j.molcel.2024.09.020
PMID:
39383878
DOI:
10.1016/j.molcel.2024.09.020
Journal:
Molecular Cell
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
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Record Created: