Perry-Hauser, N. A., Du Rand, J. R., Lee, K. H., Shi, L., & Javitch, J. A. (2025). N-terminal fragment shedding contributes to signaling of the full-length adhesion receptor ADGRL3. Journal of Biological Chemistry, 108174. https://doi.org/10.1016/j.jbc.2025.108174

Boumhaouad, S., Makowicz, E. A., Choi, S., Bouhaddou, N., Balla, J., Taghzouti, K., Sulzer, D., & Mosharov, E. V. (2025). Regulation of Dopamine Release by Tonic Activity Patterns in the Striatal Brain Slice. ACS Chemical Neuroscience. https://doi.org/10.1021/acschemneuro.4c00323

Cataldi, S., Lacefield, C., Shashaank, N., & Sulzer, D. (2024). Direct Pathway Neurons in the Mouse Ventral Striatum Are Active During Goal-Directed Action but Not Reward Consumption During Operant Conditioning. Biomedicines, 12(12), 2755. https://doi.org/10.3390/biomedicines12122755

Ferreira, L. T., Cassiano, G. C., Alvarez, L. C. S., Okombo, J., Calit, J., Fontinha, D., Gil-Iturbe, E., Coyle, R., Andrade, C. H., Sunnerhagen, P., Bargieri, D. Y., Prudêncio, M., Quick, M., Cravo, P. V., Lee, M. C. S., Fidock, D. A., & Costa, F. T. M. (2024). A novel 4-aminoquinoline chemotype with multistage antimalarial activity and lack of cross-resistance with PfCRT and PfMDR1 mutants. PLOS Pathogens, 20(10), e1012627. https://doi.org/10.1371/journal.ppat.1012627

Lin, X., Provasi, D., Niswender, C. M., Asher, W. B., & Javitch, J. A. (2024). Elucidating the molecular logic of a metabotropic glutamate receptor heterodimer. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-52822-4

Olivetti, P. R., Torres-Herraez, A., Gallo, M. E., Raudales, R., Sumerau, M., Moyles, S., Balsam, P. D., & Kellendonk, C. (2024). Inhibition of striatal indirect pathway during second postnatal week leads to long-lasting deficits in motivated behavior. Neuropsychopharmacology. https://doi.org/10.1038/s41386-024-01997-x

Havel, V., Kruegel, A. C., Bechand, B., McIntosh, S., Stallings, L., Hodges, A., Wulf, M. G., Nelson, M., Hunkele, A., Ansonoff, M., Pintar, J. E., Hwu, C., Ople, R. S., Abi-Gerges, N., Zaidi, S. A., Katritch, V., Yang, M., Javitch, J. A., Majumdar, S., … Sames, D. (2024). Oxa-Iboga alkaloids lack cardiac risk and disrupt opioid use in animal models. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-51856-y

Alternating access of a bacterial homolog of neurotransmitter: sodium symporters determined from AlphaFold2 ensembles and DEER spectroscopy. (2024). Proceedings of the National Academy of Sciences, 121(40). https://doi.org/10.1073/pnas.2406063121

Taxier, L. R., Pillerová, M., Branyan, T. E., Sohrabji, F., & Frick, K. M. (2024). Astrocytic glutamate transport is essential for the memory-enhancing effects of 17β-estradiol in ovariectomized mice. Hormones and Behavior, 165, 105618. https://doi.org/10.1016/j.yhbeh.2024.105618

Courellis, H. S., Minxha, J., Cardenas, A. R., Kimmel, D. L., Reed, C. M., Valiante, T. A., Salzman, C. D., Mamelak, A. N., Fusi, S., & Rutishauser, U. (2024). Abstract representations emerge in human hippocampal neurons during inference. Nature, 632(8026), 841–849. https://doi.org/10.1038/s41586-024-07799-x

Petersen, D., Raudales, R., Silva, A. K., Kellendonk, C., & Canetta, S. (2024). Adolescent Thalamoprefrontal Inhibition Leads to Changes in Intrinsic Prefrontal Network Connectivity. Eneuro, 11(8), ENEURO.0284-24.2024. https://doi.org/10.1523/eneuro.0284-24.2024

Raudales, R., Kim, G., Kelly, S. M., Hatfield, J., Guan, W., Zhao, S., Paul, A., Qian, Y., Li, B., & Huang, Z. J. (2024). Specific and comprehensive genetic targeting reveals brain-wide distribution and synaptic input patterns of GABAergic axo-axonic interneurons. ELife, 13. CLOCKSS. https://doi.org/10.7554/elife.93481

Zuo, H., Park, J., Frangaj, A., Ye, J., Lu, G., Manning, J. J., Asher, W. B., Lu, Z., Hu, G., Wang, L., Mendez, J., Eng, E., Zhang, Z., Lin, X., Grassucci, R., Hendrickson, W. A., Clarke, O. B., Javitch, J. A., Conigrave, A. D., & Fan, Q. R. (2024). Promiscuous G-protein activation by the calcium-sensing receptor. Nature, 629(8011), 481–488. https://doi.org/10.1038/s41586-024-07331-1

Cater, R. J., Mukherjee, D., Gil-Iturbe, E., Erramilli, S. K., Chen, T., Koo, K., Santander, N., Reckers, A., Kloss, B., Gawda, T., Choy, B. C., Zhang, Z., Katewa, A., Larpthaveesarp, A., Huang, E. J., Mooney, S. W. J., Clarke, O. B., Yee, S. W., Giacomini, K. M., … Mancia, F. (2024). Structural and molecular basis of choline uptake into the brain by FLVCR2. Nature, 629(8012), 704–709. https://doi.org/10.1038/s41586-024-07326-y

Kim, H. S., Xiao, Y., Chen, X., He, S., Im, J., Willner, M. J., Finlayson, M. O., Xu, C., Zhu, H., Choi, S. J., Mosharov, E. V., Kim, H., Xu, B., & Leong, K. W. (2024). Chronic Opioid Treatment Arrests Neurodevelopment and Alters Synaptic Activity in Human Midbrain Organoids. Advanced Science, 11(21). Portico. https://doi.org/10.1002/advs.202400847

Hagenah, L. M., Dhingra, S. K., Small-Saunders, J. L., Qahash, T., Willems, A., Schindler, K. A., Rangel, G. W., Gil-Iturbe, E., Kim, J., Akhundova, E., Yeo, T., Okombo, J., Mancia, F., Quick, M., Roepe, P. D., Llinás, M., & Fidock, D. A. (2024). Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum physiology. MBio, 15(1). https://doi.org/10.1128/mbio.01832-23

Wang, L., Hoang, A., Gil-Iturbe, E., Laganowsky, A., Quick, M., & Zhou, M. (2024). Mechanism of anion exchange and small-molecule inhibition of pendrin. Nature Communications, 15(1). https://doi.org/10.1038/s41467-023-44612-1

Hill, R., Sanchez, J., Lemel, L., Antonijevic, M., Hosking, Y., Mistry, S. N., Kruegel, A. C., Javitch, J. A., Lane, J. R., & Canals, M. (2023). Assessment of the potential of novel and classical opioids to induce respiratory depression in mice. British Journal of Pharmacology, 180(24), 3160–3174. Portico. https://doi.org/10.1111/bph.16199

Ramalingam, N., Jin, S.-X., Moors, T. E., Fonseca-Ornelas, L., Shimanaka, K., Lei, S., Cam, H. P., Watson, A. H., Brontesi, L., Ding, L., Hacibaloglu, D. Y., Jiang, H., Choi, S. J., Kanter, E., Liu, L., Bartels, T., Nuber, S., Sulzer, D., Mosharov, E. V., … Dettmer, U. (2023). Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity. Npj Parkinson’s Disease, 9(1). https://doi.org/10.1038/s41531-023-00444-w

Stanley, A. T., Post, M. R., Lacefield, C., Sulzer, D., & Miniaci, M. C. (2023). Norepinephrine release in the cerebellum contributes to aversive learning. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-40548-8

Labouesse, M. A., Torres-Herraez, A., Chohan, M. O., Villarin, J. M., Greenwald, J., Sun, X., Zahran, M., Tang, A., Lam, S., Veenstra-VanderWeele, J., Lacefield, C. O., Bonaventura, J., Michaelides, M., Chan, C. S., Yizhar, O., & Kellendonk, C. (2023). A non-canonical striatopallidal Go pathway that supports motor control. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-42288-1

Rosenberg, A. M., Saggar, M., Monzel, A. S., Devine, J., Rogu, P., Limoges, A., Junker, A., Sandi, C., Mosharov, E. V., Dumitriu, D., Anacker, C., & Picard, M. (2023). Brain mitochondrial diversity and network organization predict anxiety-like behavior in male mice. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-39941-0

Mok, S., Yeo, T., Hong, D., Shears, M. J., Ross, L. S., Ward, K. E., Dhingra, S. K., Kanai, M., Bridgford, J. L., Tripathi, A. K., Mlambo, G., Burkhard, A. Y., Ansbro, M. R., Fairhurst, K. J., Gil-Iturbe, E., Park, H., Rozenberg, F. D., Kim, J., Mancia, F., … Fidock, D. A. (2023). Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness. Science Advances, 9(45). https://doi.org/10.1126/sciadv.adi2364

Garretti, F., Monahan, C., Sloan, N., Bergen, J., Shahriar, S., Kim, S. W., Sette, A., Cutforth, T., Kanter, E., Agalliu, D., & Sulzer, D. (2023). Interaction of an α-synuclein epitope with HLA-DRB1∗15:01 triggers enteric features in mice reminiscent of prodromal Parkinson’s disease. Neuron, 111(21), 3397-3413.e5. https://doi.org/10.1016/j.neuron.2023.07.015

Serafini, R. A., Estill, M., Pekarskaya, E. A., Sakloth, F., Shen, L., Javitch, J. A., & Zachariou, V. (2023). Tianeptine promotes lasting antiallodynic effects in a mouse model of neuropathic pain. Neuropsychopharmacology, 48(11), 1680–1689. https://doi.org/10.1038/s41386-023-01645-w

Meszaros, J., Geggier, P., Manning, J. J., Asher, W. B., & Javitch, J. A. (2023). Methods for automating the analysis of live-cell single-molecule FRET data. Frontiers in Cell and Developmental Biology, 11. https://doi.org/10.3389/fcell.2023.1184077

Di Maio, A., Nuzzo, T., Gilio, L., Serra, M., Buttari, F., Errico, F., De Rosa, A., Bassi, M. S., Morelli, M., Sasabe, J., Sulzer, D., Carta, M., Centonze, D., & Usiello, A. (2023). Homeostasis of serine enantiomers is disrupted in the post-mortem caudate putamen and cerebrospinal fluid of living Parkinson’s disease patients. Neurobiology of Disease, 184, 106203. https://doi.org/10.1016/j.nbd.2023.106203

Suri, D., Zanni, G., Mahadevia, D., Chuhma, N., Saha, R., Spivack, S., Pini, N., Stevens, G. S., Ziolkowski-Blake, A., Simpson, E. H., Balsam, P., Rayport, S., & Ansorge, M. S. (2023). Dopamine transporter blockade during adolescence increases adult dopamine function, impulsivity, and aggression. Molecular Psychiatry, 28(8), 3512–3523. https://doi.org/10.1038/s41380-023-02194-w

Serra, M., Di Maio, A., Bassareo, V., Nuzzo, T., Errico, F., Servillo, F., Capasso, M., Parekh, P., Li, Q., Thiolat, M.-L., Bezard, E., Calabresi, P., Sulzer, D., Carta, M., Morelli, M., & Usiello, A. (2023). Perturbation of serine enantiomers homeostasis in the striatum of MPTP-lesioned monkeys and mice reflects the extent of dopaminergic midbrain degeneration. Neurobiology of Disease, 184, 106226. https://doi.org/10.1016/j.nbd.2023.106226

Vidyadhara, D. J., Somayaji, M., Wade, N., Yücel, B., Zhao, H., Shashaank, N., Ribaudo, J., Gupta, J., Lam, T. T., Sames, D., Greene, L. E., Sulzer, D. L., & Chandra, S. S. (2023). Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson’s disease. Cell Reports, 42(3), 112231. https://doi.org/10.1016/j.celrep.2023.112231

Shashaank, N., Somayaji, M., Miotto, M., Mosharov, E. V., Makowicz, E. A., Knowles, D. A., Ruocco, G., & Sulzer, D. L. (2023). Computational models of dopamine release measured by fast scan cyclic voltammetry in vivo. PNAS Nexus, 2(3). https://doi.org/10.1093/pnasnexus/pgad044

Karasawa, A., Liu, H., Quick, M., Hendrickson, W. A., & Liu, Q. (2023). Crystallographic Characterization of Sodium Ions in a Bacterial Leucine/Sodium Symporter. Crystals, 13(2), 183. https://doi.org/10.3390/cryst13020183

Keen, A. C., Pedersen, M. H., Lemel, L., Scott, D. J., Canals, M., Littler, D. R., Beddoe, T., Ono, Y., Shi, L., Inoue, A., Javitch, J. A., & Lane, J. R. (2022). OZITX, a pertussis toxin-like protein for occluding inhibitory G protein signalling including Gαz. Communications Biology, 5(1). https://doi.org/10.1038/s42003-022-03191-5

Dhanwani, R., Lima-Junior, J. R., Sethi, A., Pham, J., Williams, G., Frazier, A., Xu, Y., Amara, A. W., Standaert, D. G., Goldman, J. G., Litvan, I., Alcalay, R. N., Peters, B., Sulzer, D., Arlehamn, C. S. L., & Sette, A. (2022). Transcriptional analysis of peripheral memory T cells reveals Parkinson’s disease-specific gene signatures. Npj Parkinson’s Disease, 8(1). https://doi.org/10.1038/s41531-022-00282-2

Wise, R. M., Wagener, A., Fietzek, U. M., Klopstock, T., Mosharov, E. V., Zucca, F. A., Sulzer, D., Zecca, L., & Burbulla, L. F. (2022). Interactions of dopamine, iron, and alpha-synuclein linked to dopaminergic neuron vulnerability in Parkinson’s disease and Neurodegeneration with Brain Iron Accumulation disorders. Neurobiology of Disease, 175, 105920. https://doi.org/10.1016/j.nbd.2022.105920

McGuirt, A., Pigulevskiy, I., & Sulzer, D. (2022). Developmental regulation of thalamus-driven pauses in striatal cholinergic interneurons. IScience, 25(11), 105332. https://doi.org/10.1016/j.isci.2022.105332

Lin, X., Fisher, N. M., Dogra, S., Senter, R. K., Reed, C. W., Kalbfleisch, J. J., Lindsley, C. W., Asher, W. B., Xiang, Z., Niswender, C. M., & Javitch, J. A. (2022). Differential activity of mGlu7 allosteric modulators provides evidence for mGlu7/8 heterodimers at hippocampal Schaffer collateral-CA1 synapses. Journal of Biological Chemistry, 298(10), 102458. https://doi.org/10.1016/j.jbc.2022.102458

Hill, R., Kruegel, A. C., Javitch, J. A., Lane, J. R., & Canals, M. (2022). The respiratory depressant effects of mitragynine are limited by its conversion to 7‐OH mitragynine. British Journal of Pharmacology, 179(14), 3875–3885. Portico. https://doi.org/10.1111/bph.15832

Martyniuk, K. M., Torres-Herraez, A., Lowes, D. C., Rubinstein, M., Labouesse, M. A., & Kellendonk, C. (2022). Dopamine D2Rs coordinate cue-evoked changes in striatal acetylcholine levels. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.76111

Benoit, L. J., Holt, E. S., Posani, L., Fusi, S., Harris, A. Z., Canetta, S., & Kellendonk, C. (2022). Adolescent thalamic inhibition leads to long-lasting impairments in prefrontal cortex function. Nature Neuroscience, 25(6), 714–725. https://doi.org/10.1038/s41593-022-01072-y

Asher, W. B., Terry, D. S., Gregorio, G. G. A., Kahsai, A. W., Borgia, A., Xie, B., Modak, A., Zhu, Y., Jang, W., Govindaraju, A., Huang, L.-Y., Inoue, A., Lambert, N. A., Gurevich, V. V., Shi, L., Lefkowitz, R. J., Blanchard, S. C., & Javitch, J. A. (2022). GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision. Cell, 185(10), 1661-1675.e16. https://doi.org/10.1016/j.cell.2022.03.042

Patel, M., Matti, C., Grimsey, N. L., Legler, D. F., Javitch, J. A., Finlay, D. B., & Glass, M. (2022). Delineating the interactions between the cannabinoid CB2 receptor and its regulatory effectors; β‐arrestins and GPCR kinases. British Journal of Pharmacology, 179(10), 2223–2239. Portico. https://doi.org/10.1111/bph.15748

Chalazonitis, A., Rao, M., & Sulzer, D. (2022). Similarities and differences between nigral and enteric dopaminergic neurons unravel distinctive involvement in Parkinson’s disease. Npj Parkinson’s Disease, 8(1). https://doi.org/10.1038/s41531-022-00308-9

Fiala, T., Mosharov, E. V., Wang, J., Mendieta, A. M., Choi, S. J., Fialova, E., Hwu, C., Sulzer, D., & Sames, D. (2022). Chemical Targeting of Rhodol Voltage-Sensitive Dyes to Dopaminergic Neurons. ACS Chemical Neuroscience, 13(8), 1251–1262. https://doi.org/10.1021/acschemneuro.1c00862

Galán-Díez, M., Borot, F., Ali, A. M., Zhao, J., Gil-Iturbe, E., Shan, X., Luo, N., Liu, Y., Huang, X.-P., Bisikirska, B., Labella, R., Kurland, I., Roth, B. L., Quick, M., Mukherjee, S., Rabadán, R., Carroll, M., Raza, A., & Kousteni, S. (2022). Subversion of Serotonin Receptor Signaling in Osteoblasts by Kynurenine Drives Acute Myeloid Leukemia. Cancer Discovery, 12(4), 1106–1127. https://doi.org/10.1158/2159-8290.cd-21-0692

Rolotti, S. V., Ahmed, M. S., Szoboszlay, M., Geiller, T., Negrean, A., Blockus, H., Gonzalez, K. C., Sparks, F. T., Solis Canales, A. S., Tuttman, A. L., Peterka, D. S., Zemelman, B. V., Polleux, F., & Losonczy, A. (2022). Local feedback inhibition tightly controls rapid formation of hippocampal place fields. Neuron, 110(5), 783-794.e6. https://doi.org/10.1016/j.neuron.2021.12.003

Gallo, E. F., Greenwald, J., Yeisley, J., Teboul, E., Martyniuk, K. M., Villarin, J. M., Li, Y., Javitch, J. A., Balsam, P. D., & Kellendonk, C. (2021). Dopamine D2 receptors modulate the cholinergic pause and inhibitory learning. Molecular Psychiatry, 27(3), 1502–1514. https://doi.org/10.1038/s41380-021-01364-y

Small-Saunders, J. L., Hagenah, L. M., Wicht, K. J., Dhingra, S. K., Deni, I., Kim, J., Vendome, J., Gil-Iturbe, E., Roepe, P. D., Mehta, M., Mancia, F., Quick, M., Eppstein, M. J., & Fidock, D. A. (2022). Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance. PLOS Pathogens, 18(2), e1010278. https://doi.org/10.1371/journal.ppat.1010278

Garretti, F., Monahan, C., Sette, A., Agalliu, D., & Sulzer, D. (2022). T cells, α-synuclein and Parkinson disease. Neuroplasticity - From Bench to Bedside, 439–455. https://doi.org/10.1016/b978-0-12-819410-2.00023-0

Ayari, S., Gil-Iturbe, E., le Gléau, L., Osinski, C., Kapel, N., Soula, H. A., Leturque, A., Andreelli, F., Clément, K., Serradas, P., & Ribeiro, A. (2022). Hnf4g invalidation prevents diet-induced obesity via intestinal lipid malabsorption. Journal of Endocrinology, 252(1), 31–44. https://doi.org/10.1530/joe-21-0092