Department of Microbiology and Immunology

Displaying 251 - 300 of 329CSV
Laleu, B., Rubiano, K., Yeo, T., Hallyburton, I., Anderson, M., Crespo‐Fernandez, B., Gamo, F., Antonova‐Koch, Y., Orjuela‐Sanchez, P., Wittlin, S., Jana, G. P., Maity, B. C., Chenu, E., Duffy, J., Sjö, P., Waterson, D., Winzeler, E., Guantai, E., Fidock, D. A., & Hansson, T. G. (2022). Exploring a Tetrahydroquinoline Antimalarial Hit from the Medicines for Malaria Pathogen Box and Identification of its Mode of Resistance as PfeEF2. ChemMedChem, 17(22). Portico. https://doi.org/10.1002/cmdc.202200393
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Wang, Q., Iketani, S., Li, Z., Guo, Y., Yeh, A. Y., Liu, M., Yu, J., Sheng, Z., Huang, Y., Liu, L., & Ho, D. D. (2022). Antigenic characterization of the SARS-CoV-2 Omicron subvariant BA.2.75. Cell Host & Microbe, 30(11), 1512-1517.e4. https://doi.org/10.1016/j.chom.2022.09.002
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Okombo, J., Mok, S., Qahash, T., Yeo, T., Bath, J., Orchard, L. M., Owens, E., Koo, I., Albert, I., Llinás, M., & Fidock, D. A. (2022). Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages. PLOS Pathogens, 18(10), e1010926. https://doi.org/10.1371/journal.ppat.1010926
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Gomez-Simmonds, A., Annavajhala, M. K., Nunez, M. P., Macesic, N., Park, H., & Uhlemann, A.-C. (2022). Intestinal Dysbiosis and Risk of Posttransplant Clostridioides difficile Infection in a Longitudinal Cohort of Liver Transplant Recipients. MSphere, 7(5). https://doi.org/10.1128/msphere.00361-22
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Arendse, L. B., Murithi, J. M., Qahash, T., Pasaje, C. F. A., Godoy, L. C., Dey, S., Gibhard, L., Ghidelli-Disse, S., Drewes, G., Bantscheff, M., Lafuente-Monasterio, M. J., Fienberg, S., Wambua, L., Gachuhi, S., Coertzen, D., van der Watt, M., Reader, J., Aswat, A. S., Erlank, E., … Chibale, K. (2022). The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stages. Science Translational Medicine, 14(667). https://doi.org/10.1126/scitranslmed.abo7219
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Filliol, A., Saito, Y., Nair, A., Dapito, D. H., Yu, L.-X., Ravichandra, A., Bhattacharjee, S., Affo, S., Fujiwara, N., Su, H., Sun, Q., Savage, T. M., Wilson-Kanamori, J. R., Caviglia, J. M., Chin, L., Chen, D., Wang, X., Caruso, S., Kang, J. K., … Schwabe, R. F. (2022). Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis. Nature, 610(7931), 356–365. https://doi.org/10.1038/s41586-022-05289-6
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Iketani, S., Hong, S. J., Sheng, J., Bahari, F., Culbertson, B., Atanaki, F. F., Aditham, A. K., Kratz, A. F., Luck, M. I., Tian, R., Goff, S. P., Montazeri, H., Sabo, Y., Ho, D. D., & Chavez, A. (2022). Functional map of SARS-CoV-2 3CL protease reveals tolerant and immutable sites. Cell Host & Microbe, 30(10), 1354-1362.e6. https://doi.org/10.1016/j.chom.2022.08.003
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Lowe, M. A., Cardenas, A., Valentin, J.-P., Zhu, Z., Abendroth, J., Castro, J. L., Class, R., Delaunois, A., Fleurance, R., Gerets, H., Gryshkova, V., King, L., Lorimer, D. D., MacCoss, M., Rowley, J. H., Rosseels, M.-L., Royer, L., Taylor, R. D., Wong, M., … de Haro, T. (2022). Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362. Journal of Medicinal Chemistry, 65(20), 14121–14143. https://doi.org/10.1021/acs.jmedchem.2c01336
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Goubet, A.-G., Lordello, L., Alves Costa Silva, C., Peguillet, I., Gazzano, M., Mbogning-Fonkou, M. D., Thelemaque, C., Lebacle, C., Thibault, C., Audenet, F., Pignot, G., Gravis, G., Helissey, C., Campedel, L., Roupret, M., Xylinas, E., Ouzaid, I., Dubuisson, A., Mazzenga, M., … Loriot, Y. (2022). Escherichia coli–Specific CXCL13-Producing TFH Are Associated with Clinical Efficacy of Neoadjuvant PD-1 Blockade against Muscle-Invasive Bladder Cancer. Cancer Discovery, 12(10), 2280–2307. https://doi.org/10.1158/2159-8290.cd-22-0201
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Ward, K. E., Fidock, D. A., & Bridgford, J. L. (2022). Plasmodium falciparum resistance to artemisinin-based combination therapies. Current Opinion in Microbiology, 69, 102193. https://doi.org/10.1016/j.mib.2022.102193
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Qiu, D., Pei, J. V., Rosling, J. E. O., Thathy, V., Li, D., Xue, Y., Tanner, J. D., Penington, J. S., Aw, Y. T. V., Aw, J. Y. H., Xu, G., Tripathi, A. K., Gnadig, N. F., Yeo, T., Fairhurst, K. J., Stokes, B. H., Murithi, J. M., Kümpornsin, K., Hasemer, H., … Lehane, A. M. (2022). A G358S mutation in the Plasmodium falciparum Na+ pump PfATP4 confers clinically-relevant resistance to cipargamin. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-33403-9
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Kawano, Y., Edwards, M., Huang, Y., Bilate, A. M., Araujo, L. P., Tanoue, T., Atarashi, K., Ladinsky, M. S., Reiner, S. L., Wang, H. H., Mucida, D., Honda, K., & Ivanov, I. I. (2022). Microbiota imbalance induced by dietary sugar disrupts immune-mediated protection from metabolic syndrome. Cell, 185(19), 3501-3519.e20. https://doi.org/10.1016/j.cell.2022.08.005
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Chethikkattuveli Salih, A. R., Asif, A., Samantasinghar, A., Umer Farooqi, H. M., Kim, S., & Choi, K. H. (2022). Renal Hypoxic Reperfusion Injury-on-Chip Model for Studying Combinational Vitamin Therapy. ACS Biomaterials Science & Engineering, 8(9), 3733–3740. https://doi.org/10.1021/acsbiomaterials.2c00180
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Mathema, B., Chen, L., Wang, P., Cunningham, M. H., Mediavilla, J. R., Chow, K. F., Luo, Y., Zhao, Y., Composto, K., Zuckerman, J., Zody, M. C., Wilson, N., Lee, A., Oschwald, D. M., Liu, L., Iketani, S., Germer, S., Fennessey, S., Wang, M., … Kreiswirth, B. N. (2022). Genomic Epidemiology and Serology Associated with a SARS-CoV-2 R.1 Variant Outbreak in New Jersey. MBio, 13(5). https://doi.org/10.1128/mbio.02141-22
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Kanai, M., Hagenah, L. M., Ashley, E. A., Chibale, K., & Fidock, D. A. (2022). Keystone Malaria Symposium 2022: a vibrant discussion of progress made and challenges ahead from drug discovery to treatment. Trends in Parasitology, 38(9), 711–718. https://doi.org/10.1016/j.pt.2022.06.005
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Fu, J., Wang, Z., Martinez, M., Jiao, W., Frangaj, K., Jones, R., Guo, X. V., Zhang, Y., Kuo, W.-I., Obradovic, A., Ma, W., Rogers, K., Kato, T., Shen, Y., & Sykes, M. (2022). 425.3: Single-Cell Immune Profiling of Human Intestinal Allografts Reveals Differential Phenotypes of Alloreactive T-Cell Clones in Quiescent vs Chronically Rejecting Allografts. Transplantation, 106(9S), S485–S485. https://doi.org/10.1097/01.tp.0000888048.23424.42
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Marcink, T. C., Kicmal, T., Armbruster, E., Zhang, Z., Zipursky, G., Golub, K. L., Idris, M., Khao, J., Drew-Bear, J., McGill, G., Gallagher, T., Porotto, M., des Georges, A., & Moscona, A. (2022). Intermediates in SARS-CoV-2 spike–mediated cell entry. Science Advances, 8(33). https://doi.org/10.1126/sciadv.abo3153
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Wang, Q., Guo, Y., Iketani, S., Nair, M. S., Li, Z., Mohri, H., Wang, M., Yu, J., Bowen, A. D., Chang, J. Y., Shah, J. G., Nguyen, N., Chen, Z., Meyers, K., Yin, M. T., Sobieszczyk, M. E., Sheng, Z., Huang, Y., Liu, L., & Ho, D. D. (2022). Antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4 and BA.5. Nature, 608(7923), 603–608. https://doi.org/10.1038/s41586-022-05053-w
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Wang, P. H., Washburn, R., Maniar, R., Mu, M., Ringham, O., Kratchmarov, R., Henick, B. S., & Reiner, S. L. (2022). Cutting Edge: Promoting T Cell Factor 1+ T Cell Self-Renewal to Improve Programmed Cell Death Protein 1 Blockade. The Journal of Immunology, 209(4), 660–664. https://doi.org/10.4049/jimmunol.2200317
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Christensen, P., Racklyeft, A., Ward, K. E., Matheson, J., Suwanarusk, R., Chua, A. C. Y., Kaneko, O., Aung, H. L., Rénia, L., Amanzougaghene, N., Magneron, V., Lemaitre, J., Le Grand, R., Kyle, D., Bifani, P., Cook, G. M., Snounou, G., & Russell, B. (2022). Improving in vitro continuous cultivation of Plasmodium cynomolgi, a model for P. vivax. Parasitology International, 89, 102589. https://doi.org/10.1016/j.parint.2022.102589
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Harimoto, T., Hahn, J., Chen, Y.-Y., Im, J., Zhang, J., Hou, N., Li, F., Coker, C., Gray, K., Harr, N., Chowdhury, S., Pu, K., Nimura, C., Arpaia, N., Leong, K. W., & Danino, T. (2022). A programmable encapsulation system improves delivery of therapeutic bacteria in mice. Nature Biotechnology, 40(8), 1259–1269. https://doi.org/10.1038/s41587-022-01244-y
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Bal, E., Kumar, R., Hadigol, M., Holmes, A. B., Hilton, L. K., Loh, J. W., Dreval, K., Wong, J. C. H., Vlasevska, S., Corinaldesi, C., Soni, R. K., Basso, K., Morin, R. D., Khiabanian, H., Pasqualucci, L., & Dalla-Favera, R. (2022). Super-enhancer hypermutation alters oncogene expression in B cell lymphoma. Nature, 607(7920), 808–815. https://doi.org/10.1038/s41586-022-04906-8
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Reis, B. S., Darcy, P. W., Khan, I. Z., Moon, C. S., Kornberg, A. E., Schneider, V. S., Alvarez, Y., Eleso, O., Zhu, C., Schernthanner, M., Lockhart, A., Reed, A., Bortolatto, J., Castro, T. B. R., Bilate, A. M., Grivennikov, S., Han, A. S., & Mucida, D. (2022). TCR-Vγδ usage distinguishes protumor from antitumor intestinal γδ T cell subsets. Science, 377(6603), 276–284. https://doi.org/10.1126/science.abj8695
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Wu, H., Qiu, W., Zhu, X., Li, X., Xie, Z., Carreras, I., Dedeoglu, A., Van Dyke, T., Han, Y. W., Karimbux, N., Tu, Q., Cheng, L., & Chen, J. (2022). The Periodontal Pathogen Fusobacterium nucleatum Exacerbates Alzheimer’s Pathogenesis via Specific Pathways. Frontiers in Aging Neuroscience, 14. https://doi.org/10.3389/fnagi.2022.912709
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Vecchione, A., Madley, R., Danzl, N., Borsotti, C., Marharlooei, M. K., Li, H.-W., Nauman, G., Ding, X., Ho, S.-H., Fousteri, G., & Sykes, M. (2022). T1D patient-derived hematopoietic stem cells are programmed to generate Tph, Tfh, and autoimmunity-associated B cell subsets in human immune system mice. Clinical Immunology, 240, 109048. https://doi.org/10.1016/j.clim.2022.109048
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Schmitz, K. S., Lange, M. V., Gommers, L., Handrejk, K., Porter, D. P., Alabi, C. A., Moscona, A., Porotto, M., de Vries, R. D., & de Swart, R. L. (2022). Repurposing an In Vitro Measles Virus Dissemination Assay for Screening of Antiviral Compounds. Viruses, 14(6), 1186. https://doi.org/10.3390/v14061186
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Lim, J., Laffleur, B., Basu, U., & Yu, K. (2022). Identification of RNA–DNA Hybrids Associated with R-Loops at the IgH Switch Sequence in Activated B Cells. R-Loops, 55–66. https://doi.org/10.1007/978-1-0716-2477-7_5
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Rouanne, M., Adam, J., Radulescu, C., Letourneur, D., Bredel, D., Mouraud, S., Goubet, A.-G., Leduc, M., Chen, N., Tan, T. Z., Signolle, N., Bigorgne, A., Dussiot, M., Tselikas, L., Susini, S., Danlos, F.-X., Schneider, A. K., Chabanon, R., Vacher, S., … Marabelle, A. (2022). BCG therapy downregulates HLA-I on malignant cells to subvert antitumor immune responses in bladder cancer. Journal of Clinical Investigation, 132(12). https://doi.org/10.1172/jci145666
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Schmitz, K. S., Geers, D., de Vries, R. D., Bovier, T. F., Mykytyn, A. Z., Geurts van Kessel, C. H., Haagmans, B. L., Porotto, M., de Swart, R. L., & Moscona, A. (2022). Potency of Fusion-Inhibitory Lipopeptides against SARS-CoV-2 Variants of Concern. MBio, 13(3). https://doi.org/10.1128/mbio.01249-22
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Chait, M., Yilmaz, M. M., Shakil, S., Ku, A. W., Dogra, P., Connors, T. J., Szabo, P. A., Gray, J. I., Wells, S. B., Kubota, M., Matsumoto, R., Poon, M. M. L., Snyder, M. E., Baldwin, M. R., Sims, P. A., Saqi, A., Farber, D. L., & Weisberg, S. P. (2022). Immune and epithelial determinants of age-related risk and alveolar injury in fatal COVID-19. JCI Insight, 7(11). https://doi.org/10.1172/jci.insight.157608
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Laffleur, B., Batista, C. R., Zhang, W., Lim, J., Yang, B., Rossille, D., Wu, L., Estrella, J., Rothschild, G., Pefanis, E., & Basu, U. (2022). RNA exosome drives early B cell development via noncoding RNA processing mechanisms. Science Immunology, 7(72). https://doi.org/10.1126/sciimmunol.abn2738
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Barber, B. E., Fernandez, M., Patel, H. B., Barcelo, C., Woolley, S. D., Patel, H., Llewellyn, S., Abd-Rahman, A. N., Sharma, S., Jain, M., Ghoghari, A., Di Resta, I., Fuchs, A., Deni, I., Yeo, T., Mok, S., Fidock, D. A., Chalon, S., Möhrle, J. J., … Kansagra, K. (2022). Safety, pharmacokinetics, and antimalarial activity of the novel triaminopyrimidine ZY-19489: a first-in-human, randomised, placebo-controlled, double-blind, single ascending dose study, pilot food-effect study, and volunteer infection study. The Lancet Infectious Diseases, 22(6), 879–890. https://doi.org/10.1016/s1473-3099(21)00679-4
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Liu, L., Iketani, S., Guo, Y., Reddem, E. R., Casner, R. G., Nair, M. S., Yu, J., Chan, J. F.-W., Wang, M., Cerutti, G., Li, Z., Morano, N. C., Castagna, C. D., Corredor, L., Chu, H., Yuan, S., Poon, V. K.-M., Chan, C. C.-S., Chen, Z., … Ho, D. D. (2022). An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses. Science Translational Medicine, 14(646). https://doi.org/10.1126/scitranslmed.abn6859
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Diez, S., Hydorn, M., Whalen, A., & Dworkin, J. (2022). Crosstalk between guanosine nucleotides regulates cellular heterogeneity in protein synthesis during nutrient limitation. PLOS Genetics, 18(5), e1009957. https://doi.org/10.1371/journal.pgen.1009957
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Murithi, J. M., Deni, I., Pasaje, C. F. A., Okombo, J., Bridgford, J. L., Gnädig, N. F., Edwards, R. L., Yeo, T., Mok, S., Burkhard, A. Y., Coburn-Flynn, O., Istvan, E. S., Sakata-Kato, T., Gomez-Lorenzo, M. G., Cowell, A. N., Wicht, K. J., Le Manach, C., Kalantarov, G. F., Dey, S., … Fidock, D. A. (2022). The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance. Cell Chemical Biology, 29(5), 824-839.e6. https://doi.org/10.1016/j.chembiol.2021.06.006
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Domínguez Conde, C., Xu, C., Jarvis, L. B., Rainbow, D. B., Wells, S. B., Gomes, T., Howlett, S. K., Suchanek, O., Polanski, K., King, H. W., Mamanova, L., Huang, N., Szabo, P. A., Richardson, L., Bolt, L., Fasouli, E. S., Mahbubani, K. T., Prete, M., Tuck, L., … Teichmann, S. A. (2022). Cross-tissue immune cell analysis reveals tissue-specific features in humans. Science, 376(6594). https://doi.org/10.1126/science.abl5197
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Gras-Peña, R., Danzl, N. M., Khosravi-Maharlooei, M., Campbell, S. R., Ruiz, A. E., Parks, C. A., Suen Savage, W. M., Holzl, M. A., Chatterjee, D., & Sykes, M. (2022). Human stem cell-derived thymic epithelial cells enhance human T-cell development in a xenogeneic thymus. Journal of Allergy and Clinical Immunology, 149(5), 1755–1771. https://doi.org/10.1016/j.jaci.2021.09.038
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Reed, E. F., Chong, A. S., Levings, M. K., Mutrie, C., Laufer, T. M., Roncarolo, M. G., & Sykes, M. (2022). The Women of FOCIS: Promoting Equality and Inclusiveness in a Professional Federation of Clinical Immunology Societies. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.816535
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Iketani, S., Liu, L., Guo, Y., Liu, L., Chan, J. F.-W., Huang, Y., Wang, M., Luo, Y., Yu, J., Chu, H., Chik, K. K.-H., Yuen, T. T.-T., Yin, M. T., Sobieszczyk, M. E., Huang, Y., Yuen, K.-Y., Wang, H. H., Sheng, Z., & Ho, D. D. (2022). Antibody evasion properties of SARS-CoV-2 Omicron sublineages. Nature, 604(7906), 553–556. https://doi.org/10.1038/s41586-022-04594-4
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Chang, A., Xiang, X., Wang, J., Lee, C., Arakhamia, T., Simjanoska, M., Wang, C., Carlomagno, Y., Zhang, G., Dhingra, S., Thierry, M., Perneel, J., Heeman, B., Forgrave, L. M., DeTure, M., DeMarco, M. L., Cook, C. N., Rademakers, R., Dickson, D. W., … Fitzpatrick, A. W. P. (2022). Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases. Cell, 185(8), 1346-1355.e15. https://doi.org/10.1016/j.cell.2022.02.026
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Papa (Άννα Παπά), A., Marklewitz, M., Paraskevopoulou (Σοφία Παρασκευοπούλου), S., Garrison, A. R., Alkhovsky (Альховский Сергей Владимирович), S. V., Avšič-Županc, T., Bente, D. A., Bergeron, É., Burt, F., Di Paola, N., Ergünay, K., Hewson, R., Mirazimi, A., Sall, A. A., Spengler, J. R., Postler, T. S., Palacios, G., & Kuhn, J. H. (2022). History and classification of Aigai virus (formerly Crimean–Congo haemorrhagic fever virus genotype VI). Journal of General Virology, 103(4). https://doi.org/10.1099/jgv.0.001734
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