Department of Microbiology and Immunology

Displaying 101 - 150 of 329CSV
Wang, Q., Guo, Y., Bowen, A., Mellis, I. A., Valdez, R., Gherasim, C., Gordon, A., Liu, L., & Ho, D. D. (2024). XBB.1.5 monovalent mRNA vaccine booster elicits robust neutralizing antibodies against XBB subvariants and JN.1. Cell Host & Microbe, 32(3), 315-321.e3. https://doi.org/10.1016/j.chom.2024.01.014
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Cummings, M. J., Bakamutumaho, B., Lutwama, J. J., Owor, N., Che, X., Astorkia, M., Postler, T. S., Kayiwa, J., Kiconco, J., Muwanga, M., Nsereko, C., Rwamutwe, E., Nayiga, I., Kyebambe, S., Haumba, M., Bosa, H. K., Ocom, F., Watyaba, B., … Kikaire, B. (2024). COVID-19 immune signatures in Uganda persist in HIV co-infection and diverge by pandemic phase. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-45204-3
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Hasselluhn, M. C., Decker-Farrell, A. R., Vlahos, L., Thomas, D. H., Curiel-Garcia, A., Maurer, H. C., Wasko, U. N., Tomassoni, L., Sastra, S. A., Palermo, C. F., Dalton, T. C., Ma, A., Li, F., Tolosa, E. J., Hibshoosh, H., Fernandez-Zapico, M. E., Muir, A., Califano, A., & Olive, K. P. (2023). Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression. Cancer Discovery, 14(2), 348–361. https://doi.org/10.1158/2159-8290.cd-23-0240
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Vincent, R. L., Li, F., Ballister, E. R., Arpaia, N., & Danino, T. (2024). Efficient Generation of Murine Chimeric Antigen Receptor (CAR)-T Cells. Journal of Visualized Experiments, 204. https://doi.org/10.3791/65887
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Savage, T. M., Fortson, K. T., de los Santos-Alexis, K., Oliveras-Alsina, A., Rouanne, M., Rae, S. S., Gamarra, J. R., Shayya, H., Kornberg, A., Cavero, R., Li, F., Han, A., Haeusler, R. A., Adam, J., Schwabe, R. F., & Arpaia, N. (2024). Amphiregulin from regulatory T cells promotes liver fibrosis and insulin resistance in non-alcoholic steatohepatitis. Immunity, 57(2), 303-318.e6. https://doi.org/10.1016/j.immuni.2024.01.009
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El Sayyed, H., Pambos, O. J., Stracy, M., Gottesman, M. E., & Kapanidis, A. N. (2024). Single-molecule tracking reveals the functional allocation, in vivo interactions, and spatial organization of universal transcription factor NusG. Molecular Cell, 84(5), 926-937.e4. https://doi.org/10.1016/j.molcel.2024.01.025
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Xie, S. C., Wang, Y., Morton, C. J., Metcalfe, R. D., Dogovski, C., Pasaje, C. F. A., Dunn, E., Luth, M. R., Kumpornsin, K., Istvan, E. S., Park, J. S., Fairhurst, K. J., Ketprasit, N., Yeo, T., Yildirim, O., Bhebhe, M. N., Klug, D. M., Rutledge, P. J., Godoy, L. C., … Tilley, L. (2024). Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-45224-z
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Rogava, M., Aprati, T. J., Chi, W.-Y., Melms, J. C., Hug, C., Davis, S. H., Earlie, E. M., Chung, C., Deshmukh, S. K., Wu, S., Sledge, G., Tang, S., Ho, P., Amin, A. D., Caprio, L., Gurjao, C., Tagore, S., Ngo, B., Lee, M. J., … Izar, B. (2024). Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation. Nature Cancer, 5(3), 433–447. https://doi.org/10.1038/s43018-023-00704-x
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Gurbatri, C. R., Radford, G. A., Vrbanac, L., Im, J., Thomas, E. M., Coker, C., Taylor, S. R., Jang, Y., Sivan, A., Rhee, K., Saleh, A. A., Chien, T., Zandkarimi, F., Lia, I., Lannagan, T. R. M., Wang, T., Wright, J. A., Kobayashi, H., Ng, J. Q., … Danino, T. (2024). Engineering tumor-colonizing E. coli Nissle 1917 for detection and treatment of colorectal neoplasia. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-44776-4
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Lee, L. W., Shafiani, S., Crossley, B., Emerson, R. O., Williamson, D., Bunin, A., Vargas, J., Han, A. S., Kaplan, I. M., Green, P. H. R., Kirsch, I., & Bhagat, G. (2022). Characterisation of T cell receptor repertoires in coeliac disease. Journal of Clinical Pathology, 77(2), 116–124. https://doi.org/10.1136/jcp-2022-208541
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Hagenah, L. M., Dhingra, S. K., Small-Saunders, J. L., Qahash, T., Willems, A., Schindler, K. A., Rangel, G. W., Gil-Iturbe, E., Kim, J., Akhundova, E., Yeo, T., Okombo, J., Mancia, F., Quick, M., Roepe, P. D., Llinás, M., & Fidock, D. A. (2024). Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum physiology. MBio, 15(1). https://doi.org/10.1128/mbio.01832-23
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Wang, L., Bohmer, M. J., Wang, J., Nardella, F., Calla, J., Laureano De Souza, M., Schindler, K. A., Montejo, L., Mittal, N., Rocamora, F., Treat, M., Charlton, J. T., Tumwebaze, P. K., Rosenthal, P. J., Cooper, R. A., Chakrabarti, R., Winzeler, E. A., Chakrabarti, D., & Gray, N. S. (2024). Discovery of Potent Antimalarial Type II Kinase Inhibitors with Selectivity over Human Kinases. Journal of Medicinal Chemistry, 67(2), 1460–1480. https://doi.org/10.1021/acs.jmedchem.3c02046
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Abdel Hamid, M. M., Abdelraheem, M. H., Acheampong, D. O., Ahouidi, A., Ali, M., Almagro-Garcia, J., Amambua-Ngwa, A., Amaratunga, C., Amenga-Etego, L., Andagalu, B., Anderson, T., Andrianaranjaka, V., Aniebo, I., Aninagyei, E., Ansah, F., Ansah, P. O., Apinjoh, T., Arnaldo, P., … van der Pluijm, R. W. (2023). Pf7: an open dataset of Plasmodium falciparum genome variation in 20,000 worldwide samples. Wellcome Open Research, 8, 22. https://doi.org/10.12688/wellcomeopenres.18681.1
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Rasmussen, A. L., Gronvall, G. K., Lowen, A. C., Goodrum, F., Alwine, J., Andersen, K. G., Anthony, S. J., Baines, J., Banerjee, A., Broadbent, A. J., Brooke, C. B., Campos, S. K., Caposio, P., Casadevall, A., Chan, G. C., Cliffe, A. R., Collins-McMillen, D., Connell, N., Damania, B., … Yurochko, A. (2024). Virology—the path forward. Journal of Virology, 98(1). https://doi.org/10.1128/jvi.01791-23
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Li, Y., Shah, R. B., Sarti, S., Belcher, A. L., Lee, B. J., Gorbatenko, A., Nemati, F., Yu, H., Stanley, Z., Rahman, M., Shao, Z., Silva, J. M., Zha, S., & Sidi, S. (2023). A noncanonical IRAK4-IRAK1 pathway counters DNA damage–induced apoptosis independently of TLR/IL-1R signaling. Science Signaling, 16(816). https://doi.org/10.1126/scisignal.adh3449
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Hong, J. S., Shamim, A., Atta, H., Nonnecke, E. B., Merl, S., Patwardhan, S., Manell, E., Gunes, E., Jordache, P., Chen, B., Lu, W., Shen, B., Dionigi, B., Kiran, R. P., Sykes, M., Zorn, E., Bevins, C. L., & Weiner, J. (2024). Application of enzyme-linked immunosorbent assay to detect antimicrobial peptides in human intestinal lumen. Journal of Immunological Methods, 525, 113599. https://doi.org/10.1016/j.jim.2023.113599
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Meir, A., Raina, V. B., Rivera, C. E., Marie, L., Symington, L. S., & Greene, E. C. (2023). The separation pin distinguishes the pro– and anti–recombinogenic functions of Saccharomyces cerevisiae Srs2. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-43918-4
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Bredel, D., Tihic, E., Mouraud, S., Danlos, F.-X., Susini, S., Aglave, M., Alfaro, A., Mohamed-Djalim, C., Rouanne, M., Halse, H., Bigorgne, A., Tselikas, L., Dalle, S., Hartl, D. M., Baudin, E., Guettier, C., Vibert, E., Rosmorduc, O., Robert, C., … Bonvalet, M. (2023). Immune checkpoints are predominantly co-expressed by clonally expanded CD4+FoxP3+ intratumoral T-cells in primary human cancers. Journal of Experimental & Clinical Cancer Research, 42(1). https://doi.org/10.1186/s13046-023-02897-6
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Leeman-Neill, R. J., Song, D., Bizarro, J., Wacheul, L., Rothschild, G., Singh, S., Yang, Y., Sarode, A. Y., Gollapalli, K., Wu, L., Zhang, W., Chen, Y., Lauring, M. C., Whisenant, D. E., Bhavsar, S., Lim, J., Swerdlow, S. H., Bhagat, G., Zhao, Q., … Basu, U. (2023). Noncoding mutations cause super-enhancer retargeting resulting in protein synthesis dysregulation during B cell lymphoma progression. Nature Genetics, 55(12), 2160–2174. https://doi.org/10.1038/s41588-023-01561-1
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Al-Zain, A. M., Nester, M. R., Ahmed, I., & Symington, L. S. (2023). Double-strand breaks induce inverted duplication chromosome rearrangements by a DNA polymerase δ-dependent mechanism. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-42640-5
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Tsuji, M., Nair, M. S., Masuda, K., Castagna, C., Chong, Z., Darling, T. L., Seehra, K., Hwang, Y., Ribeiro, Á. L., Ferreira, G. M., Corredor, L., Coelho-dos-Reis, J. G. A., Tsuji, Y., Mori, M., Boon, A. C. M., Diamond, M. S., Huang, Y., & Ho, D. D. (2023). An immunostimulatory glycolipid that blocks SARS-CoV-2, RSV, and influenza infections in vivo. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-39738-1
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Bopp, S., Pasaje, C. F. A., Summers, R. L., Magistrado-Coxen, P., Schindler, K. A., Corpas-Lopez, V., Yeo, T., Mok, S., Dey, S., Smick, S., Nasamu, A. S., Demas, A. R., Milne, R., Wiedemar, N., Corey, V., Gomez-Lorenzo, M. D. G., Franco, V., Early, A. M., Lukens, A. K., … Wirth, D. F. (2023). Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-36921-2
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Rodgers, J., Wright, P., Ballister, E. R., Hughes, R. B., Storchi, R., Wynne, J., Martial, F. P., & Lucas, R. J. (2023). Modulating signalling lifetime to optimise a prototypical animal opsin for optogenetic applications. Pflügers Archiv - European Journal of Physiology, 475(12), 1387–1407. https://doi.org/10.1007/s00424-023-02879-9
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Stadler, E., Maiga, M., Friedrich, L., Thathy, V., Demarta-Gatsi, C., Dara, A., Sogore, F., Striepen, J., Oeuvray, C., Djimdé, A. A., Lee, M. C. S., Dembélé, L., Fidock, D. A., Khoury, D. S., & Spangenberg, T. (2023). Propensity of selecting mutant parasites for the antimalarial drug cabamiquine. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-40974-8
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Wang, Q., Yeh, A. Y., Guo, Y., Mohri, H., Yu, J., Ho, D. D., & Liu, L. (2023). Impaired potency of neutralizing antibodies against cell–cell fusion mediated by SARS-CoV-2. Emerging Microbes & Infections, 12(1). https://doi.org/10.1080/22221751.2023.2210237
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Decker-Farrell, A. R., Ma, A., Li, F., Muir, A., & Olive, K. P. (2023). Generation and ex vivo culture of murine and human pancreatic ductal adenocarcinoma tissue slice explants. STAR Protocols, 4(4), 102711. https://doi.org/10.1016/j.xpro.2023.102711
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Fernandes, H. B., de Oliveira, I. M., Postler, T. S., Lima, S. Q., Santos, C. A. C., Oliveira, M. S., Leão, F. B., Ghosh, S., Souza, M. C., Andrade, W., & Silva, A. M. (2023). Transcriptomic analysis reveals that RasGEF1b deletion alters basal and LPS-induced expression of genes involved in chemotaxis and cytokine responses in macrophages. Scientific Reports, 13(1). https://doi.org/10.1038/s41598-023-47040-9
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Nygaard, R., Graham, C. L. B., Belcher Dufrisne, M., Colburn, J. D., Pepe, J., Hydorn, M. A., Corradi, S., Brown, C. M., Ashraf, K. U., Vickery, O. N., Briggs, N. S., Deering, J. J., Kloss, B., Botta, B., Clarke, O. B., Columbus, L., Dworkin, J., Stansfeld, P. J., Roper, D. I., & Mancia, F. (2023). Structural basis of peptidoglycan synthesis by E. coli RodA-PBP2 complex. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-40483-8
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Kümpornsin, K., Kochakarn, T., Yeo, T., Okombo, J., Luth, M. R., Hoshizaki, J., Rawat, M., Pearson, R. D., Schindler, K. A., Mok, S., Park, H., Uhlemann, A.-C., Jana, G. P., Maity, B. C., Laleu, B., Chenu, E., Duffy, J., Moliner Cubel, S., Franco, V., … Lee, M. C. S. (2023). Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-38774-1
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Brockmann, L., Tran, A., Huang, Y., Edwards, M., Ronda, C., Wang, H. H., & Ivanov, I. I. (2023). Intestinal microbiota-specific Th17 cells possess regulatory properties and suppress effector T cells via c-MAF and IL-10. Immunity, 56(12), 2719-2735.e7. https://doi.org/10.1016/j.immuni.2023.11.003
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Torre, D., Fstkchyan, Y. S., Ho, J. S. Y., Cheon, Y., Patel, R. S., Degrace, E. J., Mzoughi, S., Schwarz, M., Mohammed, K., Seo, J.-S., Romero-Bueno, R., Demircioglu, D., Hasson, D., Tang, W., Mahajani, S. U., Campisi, L., Zheng, S., Song, W.-S., Wang, Y., … Marazzi, I. (2023). Nuclear RNA catabolism controls endogenous retroviruses, gene expression asymmetry, and dedifferentiation. Molecular Cell, 83(23), 4255-4271.e9. https://doi.org/10.1016/j.molcel.2023.10.036
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Mok, S., Yeo, T., Hong, D., Shears, M. J., Ross, L. S., Ward, K. E., Dhingra, S. K., Kanai, M., Bridgford, J. L., Tripathi, A. K., Mlambo, G., Burkhard, A. Y., Ansbro, M. R., Fairhurst, K. J., Gil-Iturbe, E., Park, H., Rozenberg, F. D., Kim, J., Mancia, F., … Fidock, D. A. (2023). Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness. Science Advances, 9(45). https://doi.org/10.1126/sciadv.adi2364
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Postler, T. S., Wang, A., Brundu, F. G., Wang, P., Wu, Z., Butler, K. E., Grinberg-Bleyer, Y., Krishnareddy, S., Lagana, S. M., Saqi, A., Oeckinghaus, A., Rabadan, R., & Ghosh, S. (2023). A pan-cancer analysis implicates human NKIRAS1 as a tumor-suppressor gene. Proceedings of the National Academy of Sciences, 120(46). https://doi.org/10.1073/pnas.2312595120
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De Simone, P., Bal, E., Holmes, A., Hilton, L., Basso, K., Soni, R. K., Morin, R., Dalla-Favera, R., & Pasqualucci, L. (2023). BTG2 Super-Enhancer Mutations Disrupt TFAP4 Binding and Deregulate BTG2 Expression in Diffuse Large B-Cell Lymphoma. Blood, 142(Supplement 1), 523–523. https://doi.org/10.1182/blood-2023-190230
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Wang, Q., Guo, Y., Tam, A. R., Valdez, R., Gordon, A., Liu, L., & Ho, D. D. (2023). Deep immunological imprinting due to the ancestral spike in the current bivalent COVID-19 vaccine. Cell Reports Medicine, 4(11), 101258. https://doi.org/10.1016/j.xcrm.2023.101258
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Detomasi, T. C., Batka, A. E., Valastyan, J. S., Hydorn, M. A., Craik, C. S., Bassler, B. L., & Marletta, M. A. (2023). Proteases influence colony aggregation behavior in Vibrio cholerae. Journal of Biological Chemistry, 299(12), 105386. https://doi.org/10.1016/j.jbc.2023.105386
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Wang, Q., Guo, Y., Liu, L., Schwanz, L. T., Li, Z., Nair, M. S., Ho, J., Zhang, R. M., Iketani, S., Yu, J., Huang, Y., Qu, Y., Valdez, R., Lauring, A. S., Huang, Y., Gordon, A., Wang, H. H., Liu, L., & Ho, D. D. (2023). Antigenicity and receptor affinity of SARS-CoV-2 BA.2.86 spike. Nature, 624(7992), 639–644. https://doi.org/10.1038/s41586-023-06750-w
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Dorrity, T. J., Shin, H., Wiegand, K. A., Aruda, J., Closser, M., Jung, E., Gertie, J. A., Leone, A., Polfer, R., Culbertson, B., Yu, L., Wu, C., Ito, T., Huang, Y., Steckelberg, A.-L., Wichterle, H., & Chung, H. (2023). Long 3′UTRs predispose neurons to inflammation by promoting immunostimulatory double-stranded RNA formation. Science Immunology, 8(88). https://doi.org/10.1126/sciimmunol.adg2979
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Hirakawa, H., Gao, L., Tavakol, D. N., Vunjak-Novakovic, G., & Ding, L. (2023). Cellular plasticity of the bone marrow niche promotes hematopoietic stem cell regeneration. Nature Genetics, 55(11), 1941–1952. https://doi.org/10.1038/s41588-023-01528-2
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