A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo

Xie, S. C., Tai, C.-W., Morton, C. J., Ma, L., Huang, S.-C., Wittlin, S., Du, Y., Hu, Y., Dogovski, C., Salimimarand, M., Griffin, R., England, D., de la Cruz, E., Deni, I., Yeo, T., Burkhard, A. Y., Striepen, J., Schindler, K. A., Crespo, B., … Tilley, L. (2024). A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo. PLOS Pathogens, 20(12), e1012429. https://doi.org/10.1371/journal.ppat.1012429
Authors:
Stanley C. Xie
C.-Y. Tai
Craig J. Morton
Li‐Ting Ma
Shih‐Chung Huang
Sergio Wittlin
Yawei Du
Yongbo Hu
Con Dogovski
Mina Salimimarand
Robert Griffin
Dylan B. England
Elisa De La Cruz
Ioanna Deni
Tomas Yeo
Anna Y. Burkhard
Josefine Striepen
Kyra A. Schindler
Benigno Crespo
Francisco‐Javier Gamo
Yogesh Khandokar
Craig A. Hutton
Tayla Rabie
Lyn-Marié Birkholtz
Mufuliat Toyin Famodimu
Michael J. Delves
Judith Bolsher
Karin M. J. Koolen
Rianne van der Laak
Anna Caroline Campos Aguiar
Dhélio B. Pereira
Rafael V. C. Guido
Darren J. Creek
David A. Fidock
Lawrence R. Dick
Stephen Brand
Alexandra E. Gould
Steven Langston
Michael D. W. Griffin
Leann Tilley
Affiliated Authors:
Ioanna Deni
Tomas Yeo
Anna Y. Burkhard
Josefine Striepen
Kyra A. Schindler
David A. Fidock
Columbia Affiliation:
Subjects:
Plasmodium falciparum (MeSH)
Malaria, Falciparum (MeSH)
Antimalarials (MeSH)
Tyrosine-tRNA Ligase (MeSH)
Mice, SCID (MeSH)
Ribosome Structure and Translation Mechanisms (OpenAlex Topic)
Innate Immunity to Viral Infection (OpenAlex Topic)
Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (OpenAlex Topic)
elink
Publication Type:
Article
Unique ID:
10.1371/journal.ppat.1012429
PMID:
39652589
DOI:
10.1371/journal.ppat.1012429
Journal:
PLOS Pathogens
Publication Date:
Data Source:
OpenAlex
Source Link:
View OpenAlex Record
View PubMed Record
View Scopus Record
View Web of Science Record

Record Created: