Center for Human Development

Displaying 1 - 50 of 77CSV
Pinezich, M. R., O’Neill, J. D., Guenthart, B. A., Kim, J., Vila, O. F., Ma, S. P., Chen, Y.-W., Hozain, A. E., Krishnan, A., Fawad, M., Cunningham, K. M., Wobma, H. M., Van Hassel, J., Snoeck, H.-W., Bacchetta, M., & Vunjak-Novakovic, G. (2025). Theranostic methodology for ex vivo donor lung rehabilitation. Med, 100644. https://doi.org/10.1016/j.medj.2025.100644
Publication Date
Vann, K. R., Sharma, R., Hsu, C.-C., Devoucoux, M., Tencer, A. H., Zeng, L., Lin, K., Zhu, L., Li, Q., Lachance, C., Ospina, R. R., Tong, Q., Cheung, K. L., Yang, S., Biswas, S., Xuan, H., Gatchalian, J., Alamillo, L., Wang, J., … Kutateladze, T. G. (2025). Structure-function relationship of ASH1L and histone H3K36 and H3K4 methylation. Nature Communications, 16(1). https://doi.org/10.1038/s41467-025-57556-5
Publication Date
Wei, X., Qian, W., Narasimhan, H., Chan, T., Liu, X., Arish, M., Young, S., Li, C., Cheon, I. S., Yu, Q., Almeida-Santos, G., Zhao, X.-Y., Yeatts, E. V., Spear, O. J., Yi, M., Parimon, T., Fang, Y., Hahn, Y. S., Bullock, T. N. J., … Sun, J. (2025). Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae. Science, 387(6738). https://doi.org/10.1126/science.adq2509
Publication Date
Ma, F., Longo, M., Meroni, M., Bhattacharya, D., Paolini, E., Mughal, S., Hussain, S., Anand, S. K., Gupta, N., Zhu, Y., Navarro-Corcuera, A., Li, K., Prakash, S., Cogliati, B., Wang, S., Huang, X., Wang, X., Yurdagul, A., Rom, O., … Cai, B. (2025). EHBP1 suppresses liver fibrosis in metabolic dysfunction-associated steatohepatitis. Cell Metabolism. https://doi.org/10.1016/j.cmet.2025.01.020
Publication Date
Pezet, M. G., Torres, J. A., Thimraj, T. A., Matkovic, I., Schrode, N., Murray, J. W., Saqi, A., Beaumont, K. G., & Snoeck, H.-W. (2025). Human respiratory airway progenitors derived from pluripotent cells generate alveolar epithelial cells and model pulmonary fibrosis. Nature Biotechnology. https://doi.org/10.1038/s41587-025-02569-0
Publication Date
Yuan, F., Yang, J., Ma, F., Hu, Z., Malik, V., Zang, R., Li, D., Shi, X., Huang, X., Zhou, H., & Wang, J. (2025). Pluripotency factor Tex10 finetunes Wnt signaling for spermatogenesis and primordial germ cell development. Nature Communications, 16(1). https://doi.org/10.1038/s41467-025-57165-2
Publication Date
Hong, J., Sui, P., Li, Y., Xu, K. Y., Lee, J.-H., Wang, J., Chen, S., Zhang, P., Wingate, N., Noor, A., Yuan, Y., Hromas, R., Zhou, H., Hamamoto, K., Su, R., Yin, C. C., Ye, F., Quesada, A. E., Chen, J., … Xu, M. (2025). PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1. Cell Stem Cell. https://doi.org/10.1016/j.stem.2025.01.010
Publication Date
Fang, Y., Chung, S. S. W., Xu, L., Xue, C., Liu, X., Jiang, D., Li, R., Korogi, Y., Yuan, K., Saqi, A., Hibshoosh, H., Huang, Y., Lin, C.-S., Tsukui, T., Sheppard, D., Sun, X., & Que, J. (2025). RUNX2 promotes fibrosis via an alveolar-to-pathological fibroblast transition. Nature. https://doi.org/10.1038/s41586-024-08542-2
Publication Date
Wang, Z., Liu, Z., Fang, Y., Zhang, H. H., Sun, X., Hao, N., Que, J., & Ding, H. (2025). Training data diversity enhances the basecalling of novel RNA modification-induced nanopore sequencing readouts. Nature Communications, 16(1). https://doi.org/10.1038/s41467-025-55974-z
Publication Date
Yan, X.-Z., Peng, J., Liu, Y.-Q., Fan, R.-N., Ni, X.-Y., Gong, L., Zhang, D.-N., Huang, X., Tan, S.-H., & Wang, H.-L. (2025). Mixed exposure to PFOA and PFOS induces oocyte apoptosis and subfertility in mice by activating the Hippo signaling pathway. Reproductive Toxicology, 132, 108829. https://doi.org/10.1016/j.reprotox.2024.108829
Publication Date
Shi, X., Li, Y., Zhou, H., Hou, X., Yang, J., Malik, V., Faiola, F., Ding, J., Bao, X., Modic, M., Zhang, W., Chen, L., Mahmood, S. R., Apostolou, E., Yang, F.-C., Xu, M., Xie, W., Huang, X., Chen, Y., & Wang, J. (2024). DDX18 coordinates nucleolus phase separation and nuclear organization to control the pluripotency of human embryonic stem cells. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-55054-8
Publication Date
Flury, A., Aljayousi, L., Park, H.-J., Khakpour, M., Mechler, J., Aziz, S., McGrath, J. D., Deme, P., Sandberg, C., González Ibáñez, F., Braniff, O., Ngo, T., Smith, S., Velez, M., Ramirez, D. M., Avnon-Klein, D., Murray, J. W., Liu, J., Parent, M., … Ayata, P. (2024). A neurodegenerative cellular stress response linked to dark microglia and toxic lipid secretion. Neuron. https://doi.org/10.1016/j.neuron.2024.11.018
Publication Date
Zhang, J.-S., Dhlamini, Q., Guo, Q., Quan, M., Wu, J., Lyu, H., Chong, L., Lv, Y., Lin, Y., Zhou, B., Liu, Y., Ji, H., Lin, X., Ning, W., Sui, P., Chen, H., Gao, P., Chen, W., Peter Di, Y., … Jiang, D. (2024). Progress and Gaps in Respiratory Disease Research and Treatment: Highlights of the IRM 2024 in Shanghai. Journal of Respiratory Biology and Translational Medicine, 1(4), 10021–10021. https://doi.org/10.70322/jrbtm.2024.10021
Publication Date
Zhang, Y., Karagiannis, D., Liu, H., Lin, M., Fang, Y., Jiang, M., Chen, X., Suresh, S., Huang, H., She, J., Shi, F., Liu, J., Luo, D., Angel, J. C., Lin, G., Yang, P., El-Rifai, W., Zaika, A., Oro, A. E., … Que, J. (2024). Epigenetic regulation of p63 blocks squamous-to-neuroendocrine transdifferentiation in esophageal development and malignancy. Science Advances, 10(41). https://doi.org/10.1126/sciadv.adq0479
Publication Date
Lian, G., Malagola, E., Wei, C., Shi, Q., Zhao, J., Hata, M., Kobayashi, H., Ochiai, Y., Zheng, B., Zhi, X., Wu, F., Tu, R., Nápoles, O. C., Su, W., Li, L., Jing, C., Chen, M., Zamechek, L., Friedman, R., … Wang, T. C. (2024). p53 mutation biases squamocolumnar junction progenitor cells towards dysplasia rather than metaplasia in Barrett’s oesophagus. Gut, gutjnl-2024-332095. https://doi.org/10.1136/gutjnl-2024-332095
Publication Date
Hwang, Y., Shimamura, Y., Tanaka, J., Miura, A., Sawada, A., Sarmah, H., Shimizu, D., Kondo, Y., Lee, H., Martini, F., Ninish, Z., Yan, K. S., Yamada, K., & Mori, M. (2024). FGF2 promotes the expansion of parietal mesothelial progenitor pools and inhibits BMP4-mediated smooth muscle cell differentiation. Frontiers in Cell and Developmental Biology, 12. https://doi.org/10.3389/fcell.2024.1387237
Publication Date
Ngule, C., Shi, R., Ren, X., Jia, H., Oyelami, F., Li, D., Park, Y., Kim, J., Hemati, H., Zhang, Y., Xiong, X., Shinkle, A., Vanderford, N. L., Bachert, S., Zhou, B. P., Wang, J., Song, J., Liu, X., & Yang, J.-M. (2024). NAC1 promotes stemness and regulates myeloid-derived cell status in triple-negative breast cancer. Molecular Cancer, 23(1). https://doi.org/10.1186/s12943-024-02102-y
Publication Date
Yang, L., Han, Y., Zhang, T., Dong, X., Ge, J., Roy, A., Zhu, J., Lu, T., Jeya Vandana, J., de Silva, N., Robertson, C. C., Xiang, J. Z., Pan, C., Sun, Y., Que, J., Evans, T., Liu, C., Wang, W., Naji, A., … Chen, S. (2024). Human vascularized macrophage-islet organoids to model immune-mediated pancreatic β cell pyroptosis upon viral infection. Cell Stem Cell. https://doi.org/10.1016/j.stem.2024.08.007
Publication Date
Wang, Z., Fang, Y., Liu, Z., Hao, N., Zhang, H. H., Sun, X., Que, J., & Ding, H. (2024). Adapting nanopore sequencing basecalling models for modification detection via incremental learning and anomaly detection. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-51639-5
Publication Date
Shimizu, D., Miura, A., & Mori, M. (2024). The perspective for next-generation lung replacement therapies: functional whole lung generation by blastocyst complementation. Current Opinion in Organ Transplantation. https://doi.org/10.1097/mot.0000000000001169
Publication Date
Huang, X.-B., Huang, Q., Jiang, M.-C., Zhong, Q., Zheng, H.-L., Wang, J.-B., Huang, Z.-N., Wang, H.-G., Liu, Z.-Y., Li, Y.-F., Xu, K.-X., Lin, M., Li, P., Huang, Z.-H., Xie, J.-W., Lin, J.-X., Lu, J., Que, J.-W., Zheng, C.-H., … Huang, C.-M. (2024). KLHL21 suppresses gastric tumourigenesis via maintaining STAT3 signalling equilibrium in stomach homoeostasis. Gut, gutjnl-2023-331111. https://doi.org/10.1136/gutjnl-2023-331111
Publication Date
Hassan, N., Yi, H., Malik, B., Gaspard-Boulinc, L., Samaraweera, S. E., Casolari, D. A., Seneviratne, J., Balachandran, A., Chew, T., Duly, A., Carter, D. R., Cheung, B. B., Norris, M., Haber, M., Kavallaris, M., Marshall, G. M., Zhang, X. D., Liu, T., Wang, J., … Wang, J. Y. (2024). Loss of the stress sensor GADD45A promotes stem cell activity and ferroptosis resistance in LGR4/HOXA9-dependent AML. Blood, 144(1), 84–98. https://doi.org/10.1182/blood.2024024072
Publication Date
Tanaka, J., Miura, A., Shimamura, Y., Hwang, Y., Shimizu, D., Kondo, Y., Sawada, A., Sarmah, H., Ninish, Z., Mishima, K., & Mori, M. (2024). Generation of salivary glands derived from pluripotent stem cells via conditional blastocyst complementation. Cell Reports, 43(6), 114340. https://doi.org/10.1016/j.celrep.2024.114340
Publication Date
Sarmah, H., Sawada, A., Hwang, Y., Miura, A., Shimamura, Y., Tanaka, J., Yamada, K., & Mori, M. (2023). Towards human organ generation using interspecies blastocyst complementation: Challenges and perspectives for therapy. Frontiers in Cell and Developmental Biology, 11. https://doi.org/10.3389/fcell.2023.1070560
Publication Date
Huang, X., Balmer, S., Lyu, C., Xiang, Y., Malik, V., Wang, H., Zhang, Y., Cai, B., Xie, W., Hadjantonakis, A.-K., Zhou, H., & Wang, J. (2024). ZFP281 controls transcriptional and epigenetic changes promoting mouse pluripotent state transitions via DNMT3 and TET1. Developmental Cell, 59(4), 465-481.e6. https://doi.org/10.1016/j.devcel.2023.12.018
Publication Date
A. Whitsett, J., & Que, J. (2024). The Journal of Respiratory Biology and Translational Medicine, a Versatile Platform for Basic and Clinical Science. Journal of Respiratory Biology and Translational Medicine, 1(1), 10001–10001. https://doi.org/10.35534/jrbtm.2024.10001
Publication Date
MacCarthy, C. M., Wu, G., Malik, V., Menuchin-Lasowski, Y., Velychko, T., Keshet, G., Fan, R., Bedzhov, I., Church, G. M., Jauch, R., Cojocaru, V., Schöler, H. R., & Velychko, S. (2024). Highly cooperative chimeric super-SOX induces naive pluripotency across species. Cell Stem Cell, 31(1), 127-147.e9. https://doi.org/10.1016/j.stem.2023.11.010
Publication Date
Bankoti, K., Wang, W., Amonkar, G. M., Xiong, L., Shui, J. E., Zhao, C., Van, E., Mwase, C., Park, J.-A., Mou, H., Fang, Y., Que, J., Bai, Y., Lerou, P. H., & Ai, X. (2024). Airway Basal Stem Cells in COVID-19 Exhibit a Proinflammatory Signature and Impaired Mucocililary Differentiation. American Journal of Respiratory Cell and Molecular Biology, 70(1), 26–38. https://doi.org/10.1165/rcmb.2023-0104oc
Publication Date
Jiang, Z., Waterbury, Q. T., Malagola, E., Fu, N., Kim, W., Ochiai, Y., Wu, F., Guha, C., Shawber, C. J., Yan, K. S., & Wang, T. C. (2024). Microbial-Dependent Recruitment of Immature Myeloid Cells Promotes Intestinal Regeneration. Cellular and Molecular Gastroenterology and Hepatology, 17(3), 321–346. https://doi.org/10.1016/j.jcmgh.2023.10.007
Publication Date
Tsuji, M., Nair, M. S., Masuda, K., Castagna, C., Chong, Z., Darling, T. L., Seehra, K., Hwang, Y., Ribeiro, Á. L., Ferreira, G. M., Corredor, L., Coelho-dos-Reis, J. G. A., Tsuji, Y., Mori, M., Boon, A. C. M., Diamond, M. S., Huang, Y., & Ho, D. D. (2023). An immunostimulatory glycolipid that blocks SARS-CoV-2, RSV, and influenza infections in vivo. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-39738-1
Publication Date
Liu, H., Li, H., Jiang, Z., Jin, S., Song, R., Yang, Y., Li, J., Huang, J., Zhang, X., Dong, X., Mori, M., Fritzler, M. J., He, L., Cardoso, W. V., & Lu, J. (2023). A local translation program regulates centriole amplification in the airway epithelium. Scientific Reports, 13(1). https://doi.org/10.1038/s41598-023-34365-8
Publication Date
van Soldt, B. J., Metscher, B. D., Richardson, M. K., & Cardoso, W. V. (2024). Sox9 is associated with two distinct patterning events during snake lung morphogenesis. Developmental Biology, 506, 7–19. https://doi.org/10.1016/j.ydbio.2023.11.006
Publication Date
Miura, A., Sarmah, H., Tanaka, J., Hwang, Y., Sawada, A., Shimamura, Y., Otoshi, T., Kondo, Y., Fang, Y., Shimizu, D., Ninish, Z., Suer, J. L., Dubois, N. C., Davis, J., Toyooka, S., Wu, J., Que, J., Hawkins, F. J., Lin, C.-S., & Mori, M. (2023). Conditional blastocyst complementation of a defective Foxa2 lineage efficiently promotes the generation of the whole lung. ELife, 12. CLOCKSS. https://doi.org/10.7554/elife.86105
Publication Date
Daniel, J. A., Elizarova, S., Shaib, A. H., Chouaib, A. A., Magnussen, H. M., Wang, J., Brose, N., Rhee, J., & Tirard, M. (2023). An intellectual-disability-associated mutation of the transcriptional regulator NACC1 impairs glutamatergic neurotransmission. Frontiers in Molecular Neuroscience, 16. https://doi.org/10.3389/fnmol.2023.1115880
Publication Date
Zhang, Y., Zhang, W., Zhao, J., Ito, T., Jin, J., Aparicio, A. O., Zhou, J., Guichard, V., Fang, Y., Que, J., Urban, J. F., Hanna, J. H., Ghosh, S., Wu, X., Ding, L., Basu, U., & Huang, Y. (2023). m6A RNA modification regulates innate lymphoid cell responses in a lineage-specific manner. Nature Immunology, 24(8), 1256–1264. https://doi.org/10.1038/s41590-023-01548-4
Publication Date
Kornberg, A., Botella, T., Moon, C. S., Rao, S., Gelbs, J., Cheng, L., Miller, J., Bacarella, A. M., García-Vilas, J. A., Vargas, J., Yu, X., Krupska, I., Bush, E., Garcia-Carrasquillo, R., Lebwohl, B., Krishnareddy, S., Lewis, S., Green, P. H. R., Bhagat, G., … Han, A. (2023). Gluten induces rapid reprogramming of natural memory αβ and γδ intraepithelial T cells to induce cytotoxicity in celiac disease. Science Immunology, 8(85). https://doi.org/10.1126/sciimmunol.adf4312
Publication Date
Gwon, K., Lee, S., Kim, Y., Choi, J., Kim, S., Kim, S.-J., Hong, H. J., Hwang, Y., Mori, M., & Lee, D. N. (2023). Construction of a bioactive copper-based metal organic framework-embedded dual-crosslinked alginate hydrogel for antimicrobial applications. International Journal of Biological Macromolecules, 242, 124840. https://doi.org/10.1016/j.ijbiomac.2023.124840
Publication Date
Matkovic Leko, I., Schneider, R. T., Thimraj, T. A., Schrode, N., Beitler, D., Liu, H.-Y., Beaumont, K., Chen, Y.-W., & Snoeck, H.-W. (2023). A distal lung organoid model to study interstitial lung disease, viral infection and human lung development. Nature Protocols, 18(7), 2283–2312. https://doi.org/10.1038/s41596-023-00827-6
Publication Date
Chen, Q., Weng, K., Lin, M., Jiang, M., Fang, Y., Chung, S. S. W., Huang, X., Zhong, Q., Liu, Z., Huang, Z., Lin, J., Li, P., El-Rifai, W., Zaika, A., Li, H., Rustgi, A. K., Nakagawa, H., Abrams, J. A., Wang, T. C., … Que, J. (2023). SOX9 Modulates the Transformation of Gastric Stem Cells Through Biased Symmetric Cell Division. Gastroenterology, 164(7), 1119-1136.e12. https://doi.org/10.1053/j.gastro.2023.01.037
Publication Date
Huang, C.-Y., Huang, H.-C., Chen, M.-H., Lai, T.-T., Chou, H.-C., Chen, C.-Y., Yen, T.-A., Cardoso, W. V., & Tsao, P.-N. (2022). Intravitreal Bevacizumab Is Associated With Prolonged Ventilatory Support in Preterm Infants With Bronchopulmonary Dysplasia. Chest, 162(6), 1328–1337. https://doi.org/10.1016/j.chest.2022.06.017
Publication Date
Kim, M., Singh, M., Lee, B.-K., Hibbs, M., Richardson, K., Ellies, L., Wintle, L., Stuart, L. M., Wang, J. Y., Voon, D. C., Blancafort, P., Wang, J., Kim, J., Leedman, P. J., & Woo, A. J. (2022). A MYC-ZNF148-ID1/3 regulatory axis modulating cancer stem cell traits in aggressive breast cancer. Oncogenesis, 11(1). https://doi.org/10.1038/s41389-022-00435-1
Publication Date