Inhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission

Gomez-Gonzalez, P.-J., Gupta, A., Drought, L. G., Patel, A., Okombo, J., van der Watt, M., Walker-Gray, R., Schindler, K. A., Burkhard, A. Y., Yeo, T., Narwal, S. K., Bloxham, T. S., Flueck, C., Walker, E. M., Rey, J. A., Fairhurst, K. J., Reader, J., Park, H., Pollard, H. G., … Baker, D. A. (2024). Inhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission. Science Advances, 10(49). https://doi.org/10.1126/sciadv.adq1383
Authors:
Paula Josefina Gómez
Anumeha Gupta
Laura Drought
Avnish Patel
John Okombo
Mariëtte van der Watt
Ryan Walker-Gray
Kyra A. Schindler
Anna Y. Burkhard
Tomas Yeo
Sunil Kumar Narwal
Talia S. Bloxham
Christian Flueck
Eloise M. Walker
Joshua A. Rey
Kate J. Fairhurst
Janette Reader
Heekuk Park
Harry Pollard
Lindsay B. Stewart
Luke Brandner-Garrod
Mojca Kristan
Geert-Jan Sterk
Youri M. van Nuland
Emilia Mańko
Donelly A. van Schalkwyk
Yang Zheng
Rob Leurs
Koen J. Dechering
Anna Caroline Campos Aguiar
Rafael V. C. Guido
Dhélio B. Pereira
Patrick K. Tumwebaze
Samuel L. Nosbya
Philip J. Rosenthal
Roland A. Cooper
Mark Palmer
Tanya Parkinson
Jeremy N. Burrows
Anne‐Catrin Uhlemann
Lyn‐Marié Birkholtz
Jennifer L. Small-Saunders
James Duffy
David A. Fidock
Alan Brown
Mark Gardner
David A. Baker
Affiliated Authors:
John Okombo
Kyra A. Schindler
Anna Y. Burkhard
Tomas Yeo
Sunil Kumar Narwal
Talia S. Bloxham
Kate J. Fairhurst
Heekuk Park
Anne‐Catrin Uhlemann
Jennifer L. Small-Saunders
David A. Fidock
Columbia Affiliation:
Subjects:
Plasmodium falciparum (MeSH)
Phosphodiesterase Inhibitors (MeSH)
Antimalarials (MeSH)
Malaria (OpenAlex Topic)
Molecular Regulation and Clinical Applications of PDEs (OpenAlex Topic)
Catalytic C-H Amination Reactions (OpenAlex Topic)
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Publication Type:
Article
Unique ID:
10.1126/sciadv.adq1383
PMID:
39642214
DOI:
10.1126/sciadv.adq1383
Journal:
Science Advances
Publication Date:
Data Source:
OpenAlex
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