Enhancing the solubility of SARS-CoV-2 inhibitors to increase future prospects for clinical development

Kuhn, A. J., Outlaw, V. K., Marcink, T. C., Yu, Z., Mears, M. C., Cajimat, M. N., Kreitler, D. F., Cleven, P. R., Mook, J. C., Bente, D. A., Porotto, M., Gellman, S. H., & Moscona, A. (2025). Enhancing the solubility of SARS-CoV-2 inhibitors to increase future prospects for clinical development. Journal of Virology. https://doi.org/10.1128/jvi.02159-24
Authors:
Ariel J Kuhn
Victor K Outlaw
Tara C Marcink
Zhen Yu
Megan C Mears
Maria N Cajimat
Dale F Kreitler
Payton R Cleven
Jee Ching Mook
Dennis A Bente
Matteo Porotto
Samuel H Gellman
Anne Moscona
Affiliated Authors:
Tara C Marcink
Matteo Porotto
Anne Moscona
Columbia Affiliation:
Subjects:
Coronavirus Disease 2019 Research (OpenAlex Topic)
Influenza Virus Research and Epidemiology (OpenAlex Topic)
Epidemiology and Pathogenesis of Respiratory Viral Infections (OpenAlex Topic)
Author Keywords:
antiviral
crystal structure
heptad repeats
inhibitors
lipopeptide
peptide design
sars-cov-2
solubility
viral fusion
elink
Publication Type:
Article
Unique ID:
10.1128/jvi.02159-24
PMID:
39902960
DOI:
10.1128/jvi.02159-24
Journal:
Journal of Virology
Publication Date:
Data Source:
PubMed
Source Link:
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Record Created: