Department of Physiology and Cellular Biophysics

Displaying 1 - 50 of 316CSV
Jin, S., Yoon, N. A., Liu, Z.-W., Menale, C., Kim, J. D., Diano, N., & Diano, S. (2025). UCP2 mediates mitochondrial dynamics to induce AgRP neuronal activity. Molecular Metabolism, 99, 102215. https://doi.org/10.1016/j.molmet.2025.102215
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Shanmugam, S. K., Kanner, S. A., Zou, X., Amarh, E., Choudhury, P., Soni, R., Kass, R. S., & Colecraft, H. M. (2025). Decoding polyubiquitin regulation of KV7. 1 (KCNQ1) surface expression with engineered linkage-selective deubiquitinases. Nature Communications, 16(1). https://doi.org/10.1038/s41467-025-60893-0
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Stoiljkovic, M., Song, J. E., Hong, H., Endle, H., Varela, L., Catarino, J., Gao, X.-B., Liu, Z.-W., Sotonyi, P., Diano, S., Cedernaes, J., Bass, J. T., & Horvath, T. L. (2025). Mitofusin 2 controls mitochondrial and synaptic dynamics of suprachiasmatic VIP neurons and related circadian rhythms. Journal of Clinical Investigation, 135(13). https://doi.org/10.1172/jci185000
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Levy, A., Raghu, R., Feathers, J. R., Grzadkowski, M., Poitevin, F., Johnston, J. D., Vallese, F., Clarke, O. B., Wetzstein, G., & Zhong, E. D. (2025). CryoDRGN-AI: neural ab initio reconstruction of challenging cryo-EM and cryo-ET datasets. Nature Methods. https://doi.org/10.1038/s41592-025-02720-4
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Sarchi, M., Clough, C. A., Gallì, A., Picone, C., Ferrari, B., Crosse, E. I., Baquero Galvis, L. D., Fiducioso, C., Aydinyan, N., Creamer, J. P., Pozzi, S., Molteni, E., Elena, C., Bradley, R. K., Malcovati, L., & Doulatov, S. (2025). Distinct routes of clonal progression in SF3B1-mutant myelodysplastic syndromes. Blood Advances, 9(12), 3044–3055. https://doi.org/10.1182/bloodadvances.2024014965
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Miotto, M. C., Luna-Figueroa, E., Tchagou, C., Bahlouli, L., Reiken, S., Dridi, H., Liu, Y., Weninger, G., & Marks, A. R. (2025). Targeting ryanodine receptors with allopurinol and xanthine derivatives for the treatment of cardiac and musculoskeletal weakness disorders. Proceedings of the National Academy of Sciences, 122(24). https://doi.org/10.1073/pnas.2422082122
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Wang, X., & Tabas, I. (2025). Location, location, location: Cholesterol in lipid droplets as a driver of MASH progression. Proceedings of the National Academy of Sciences, 122(23). https://doi.org/10.1073/pnas.2509899122
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Yamagata, S., Copperi, F., White, G. T., Kim, J. D., & Diano, S. (2025). Dorsal raphe nucleus MC4R-GABAergic neurons regulate feeding and anxiety. Molecular Metabolism, 99, 102199. https://doi.org/10.1016/j.molmet.2025.102199
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Thakur, P., Lackinger, M., Diamantopoulou, A., Rao, S., Chen, Y., Khalizova, K., Ferng, A., Mazur, C., Kordasiewicz, H., Shprintzen, R. J., Markx, S., Xu, B., & Gogos, J. A. (2025). An antisense oligonucleotide-based strategy to ameliorate cognitive dysfunction in the 22q11.2 Deletion Syndrome. ELife, 13. CLOCKSS. https://doi.org/10.7554/elife.103328
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Wang, X., Tsien, S. J., Jin, M., Goldberg, M. E., Zhang, M., & Qian, N. (2025). A circuit model for transsaccadic space updating and mislocalization. Proceedings of the National Academy of Sciences, 122(21). https://doi.org/10.1073/pnas.2422911122
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Lansky, S., Wang, Z., Clarke, O. B., Chipot, C., & Scheuring, S. (2025). Structural dynamics and permeability of the TRPV3 pentamer. Nature Communications, 16(1). https://doi.org/10.1038/s41467-025-59798-9
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Bankaitis, V. A., Khan, D., Chen, X.-R., Wang, Y., & Igumenova, T. I. (2025). A brief history of phosphatidylinositol transfer proteins: from the backwaters of cell biology to prime time in lipid signaling. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1870(5), 159625. https://doi.org/10.1016/j.bbalip.2025.159625
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Jin, S., Yoon, N. A., Wei, M., Worgall, T., Rubinelli, L., Horvath, T. L., Min, W., Diano, N., di Lorenzo, A., & Diano, S. (2025). Endoplasmic reticulum Nogo drives AgRP neuronal activation and feeding behavior. Cell Metabolism. https://doi.org/10.1016/j.cmet.2025.04.005
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Somnay, Y. R., Wang, A., Lim, H., Griffiths, K. K., Zandkarimi, F., Chen, K., Yang, G., Wasilczuk, A. Z., Kelz, M. B., Larr, D., Yang, M., Gil-Iturbe, E., Moon, A., Quick, M., & Levy, R. J. (2025). Effects of the quinone analog, ubiquinone-5, on murine mitochondria and hypnosis. Anesthesiology. https://doi.org/10.1097/aln.0000000000005549
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Liu, Y., Brown, C. M., Borges, N., Nobre, R. N., Erramilli, S., Belcher Dufrisne, M., Kloss, B., Giacometti, S., Esteves, A. M., Timóteo, C. G., Tokarz, P., Cater, R. J., Lowary, T. L., Morita, Y. S., Kossiakoff, A. A., Santos, H., Stansfeld, P. J., Nygaard, R., & Mancia, F. (2025). Mechanistic studies of mycobacterial glycolipid biosynthesis by the mannosyltransferase PimE. Nature Communications, 16(1). https://doi.org/10.1038/s41467-025-57843-1
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Liu, Y., Brown, C. M., Erramilli, S., Su, Y.-C., Guu, S.-Y., Tseng, P.-S., Wang, Y.-J., Duong, N. H., Tokarz, P., Kloss, B., Han, C.-R., Chen, H.-Y., Rodrigues, J., Khoo, K.-H., Archer, M., Kossiakoff, A. A., Lowary, T. L., Stansfeld, P. J., Nygaard, R., & Mancia, F. (2025). Structural insights into terminal arabinosylation of mycobacterial cell wall arabinan. Nature Communications, 16(1). https://doi.org/10.1038/s41467-025-58196-5
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Ford, C., de Sena-Tomás, C., Wun, T. T. R., Aleman, A. G., Rangaswamy, U., Leyhr, J., Nuñez, M. I., Gao, C. Z., Nim, H. T., See, M., Coppola, U., Waxman, J. S., Ramialison, M., Haitina, T., Smeeton, J., Sanges, R., & Targoff, K. L. (2025). Nkx2.7 is a conserved regulator of craniofacial development. Nature Communications, 16(1). https://doi.org/10.1038/s41467-025-58821-3
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Jayaraman, S., Kochiss, A., Alcalay, T.-L., del Rivero Morfin, P. J., & Ben-Johny, M. (2025). Engineered depalmitoylases enable selective manipulation of protein localization and function. Nature Communications, 16(1). https://doi.org/10.1038/s41467-025-58908-x
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Mosialou, I., Ali, A. M., Labella, R., Bisikirska, B., Cuesta-Dominguez, A., Vgenopoulou, P., Reyes, I., Rao, S. M., Wang, A., Luo, N., Galan-Diez, M., Zhao, J., Chernak, B. J., Bewersdorf, J. P., Fukasawa, K., Su, J., Higa, J., Adams, R. A., Corper, A. L., … Kousteni, S. (2025). A niche driven mechanism determines response and a mutation-independent therapeutic approach for myeloid malignancies. Cancer Cell. https://doi.org/10.1016/j.ccell.2025.03.007
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Qiu, W., Trinh, T. K. H., Catalano, C., Mehta, A., Desai, U. R., Kellogg, G. E., Hendrickson, W. A., & Guo, Y. (2025). Cholesterol-dependent enzyme activity of human TSPO1. Proceedings of the National Academy of Sciences, 122(13). https://doi.org/10.1073/pnas.2323045122
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Godbout, K., Dugas, M., Reiken, S. R., Ramezani, S., Falle, A., Rousseau, J., Wronska, A. E., Lamothe, G., Canet, G., Lu, Y., Planel, E., Marks, A. R., & Tremblay, J. P. (2025). Universal Prime Editing Therapeutic Strategy for RyR1-Related Myopathies: A Protective Mutation Rescues Leaky RyR1 Channel. International Journal of Molecular Sciences, 26(7), 2835. https://doi.org/10.3390/ijms26072835
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Barber, A. G., Quintero, C. M., Hamilton, M., Rajbhandari, N., Sasik, R., Zhang, Y., Kim, C., Husain, H., Sun, X., & Reya, T. (2025). Regulation of lung cancer initiation and progression by the stem cell determinant Musashi. ELife, 13. CLOCKSS. https://doi.org/10.7554/elife.97021
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Zhang, J., Chen, J., Wo, D., Ma, E., Yan, H., Peng, J., Ren, D., & Zhu, W. (2025). Physical and functional interactions between LDLR family members and CXCR4 in breast cancer. The FEBS Journal. Portico. https://doi.org/10.1111/febs.70016
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Rubinelli, L., Manzo, O. L., Sungho, J., Del Gaudio, I., Bareja, R., Marino, A., Palikhe, S., Di Mauro, V., Bucci, M., Falcone, D. J., Elemento, O., Ersoy, B., Diano, S., Sasset, L., & Di Lorenzo, A. (2025). Suppression of endothelial ceramide de novo biosynthesis by Nogo-B contributes to cardiometabolic diseases. Nature Communications, 16(1). https://doi.org/10.1038/s41467-025-56869-9
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Chestnut, C., Johnston, J. D., Velazquez, M., Neselu, K., & Eng, E. T. (2025). Leveraging Virtual Reality for Immersive Segmentation and Analysis of Cryo-Electron Tomography Data. Journal of Visualized Experiments, 215. https://doi.org/10.3791/67849
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Kuhn, A. J., Outlaw, V. K., Marcink, T. C., Yu, Z., Mears, M. C., Cajimat, M. N., Kreitler, D. F., Cleven, P. R., Mook, J. C., Bente, D. A., Porotto, M., Gellman, S. H., & Moscona, A. (2025). Enhancing the solubility of SARS-CoV-2 inhibitors to increase future prospects for clinical development. Journal of Virology. https://doi.org/10.1128/jvi.02159-24
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Reynard, O., Iampietro, M., Dumont, C., Le Guellec, S., Durand, S., Moroso, M., Brisebard, E., Dhondt, K. P., Pelissier, R., Mathieu, C., Cabrera, M., Le Pennec, D., Amurri, L., Alabi, C., Cardinaud, S., Porotto, M., Moscona, A., Vecellio, L., & Horvat, B. (2025). Development of nebulized inhalation delivery for fusion-inhibitory lipopeptides to protect non-human primates against Nipah-Bangladesh infection. Antiviral Research, 235, 106095. https://doi.org/10.1016/j.antiviral.2025.106095
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Hendrickson, W. A., & Gong, Z. (2025). Structural and evolutionary insights into the functioning of glycoprotein hormones and their receptors. Andrology. Portico. https://doi.org/10.1111/andr.70001
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Mougari, S., Favède, V., Predella, C., Reynard, O., Durand, S., Mazelier, M., Pizzioli, E., Decimo, D., Bovier, F. T., Lapsley, L. M., Castagna, C., Lieberman, N. A. P., Noel, G., Mathieu, C., Malissen, B., Briese, T., Greninger, A. L., Alabi, C. A., Dorrello, N. V., … Horvat, B. (2025). Intranasally administrated fusion-inhibitory lipopeptides block SARS-CoV-2 infection in mice and enable long-term protective immunity. Communications Biology, 8(1). https://doi.org/10.1038/s42003-025-07491-4
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Wang, W., Gong, Z., & Hendrickson, W. A. (2025). AlphaFold-guided molecular replacement for solving challenging crystal structures. Acta Crystallographica Section D Structural Biology, 81(1), 4–21. https://doi.org/10.1107/s2059798324011999
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Cerutti, G., Arias, R., Bahna, F., Mannepalli, S., Katsamba, P. S., Ahlsen, G., Kloss, B., Bruni, R., Tomlinson, A., & Shapiro, L. (2024). Structures and pH-dependent dimerization of the sevenless receptor tyrosine kinase. Molecular Cell, 84(23), 4677-4690.e6. https://doi.org/10.1016/j.molcel.2024.10.017
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Handrejk, K., Schmitz, K. S., Veldhuis Kroeze, E. J. B., van Dijk, L. L. A., van Run, P., Haagmans, B., Moscona, A., Porotto, M., de Swart, R. L., de Vries, R. D., & Rissmann, M. (2024). Characterization of a SARS-CoV-2 Omicron BA.5 direct-contact transmission model in hamsters. Npj Viruses, 2(1). https://doi.org/10.1038/s44298-024-00061-1
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del Rivero Morfin, P. J., Chavez, D. S., Jayaraman, S., Yang, L., Geisler, S. M., Kochiss, A. L., Tuluc, P., Colecraft, H. M., Marx, S. O., Liu, X. S., Rajadhyaksha, A. M., & Ben-Johny, M. (2024). A genetically encoded actuator boosts L-type calcium channel function in diverse physiological settings. Science Advances, 10(44). https://doi.org/10.1126/sciadv.adq3374
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Ferreira, L. T., Cassiano, G. C., Alvarez, L. C. S., Okombo, J., Calit, J., Fontinha, D., Gil-Iturbe, E., Coyle, R., Andrade, C. H., Sunnerhagen, P., Bargieri, D. Y., Prudêncio, M., Quick, M., Cravo, P. V., Lee, M. C. S., Fidock, D. A., & Costa, F. T. M. (2024). A novel 4-aminoquinoline chemotype with multistage antimalarial activity and lack of cross-resistance with PfCRT and PfMDR1 mutants. PLOS Pathogens, 20(10), e1012627. https://doi.org/10.1371/journal.ppat.1012627
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Bhansali, D., Tu, N. H., Inoue, K., Teng, S., Li, T., Tran, H. D., Kim, D. H., Dong, J., Peach, C. J., Sokrat, B., Jensen, D. D., Dolan, J. C., Yamano, S., Robinson, V. M., Bunnett, N. W., Albertson, D. G., Leong, K. W., & Schmidt, B. L. (2025). PAR2 on oral cancer cells and nociceptors contributes to oral cancer pain that can be relieved by nanoparticle-encapsulated AZ3451. Biomaterials, 314, 122874. https://doi.org/10.1016/j.biomaterials.2024.122874
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Bisikirska, B., Labella, R., Cuesta-Dominguez, A., Luo, N., De Angelis, J., Mosialou, I., Lin, C.-S., Beck, D., Lata, S., Shyu, P. T., McMahon, D. J., Guo, E., Hagen, J., Chung, W. K., Shane, E., Cohen, A., & Kousteni, S. (2024). Melatonin receptor 1A variants as genetic cause of idiopathic osteoporosis. Science Translational Medicine, 16(769). https://doi.org/10.1126/scitranslmed.adj0085
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Corbin, A., Aromolaran, K. A., & Aromolaran, A. S. (2024). Leukotriene B4 is elevated in diabetes and promotes ventricular arrhythmogenesis in guinea pig. Journal of Cellular Physiology. Portico. https://doi.org/10.1002/jcp.31467
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Marcink, T. C., Zipursky, G., Sobolik, E. B., Golub, K., Herman, E., Stearns, K., Greninger, A. L., Porotto, M., & Moscona, A. (2024). How a paramyxovirus fusion/entry complex adapts to escape a neutralizing antibody. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-53082-y
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Stearns, K., Lampe, G., Hanan, R., Marcink, T., Niewiesk, S., Sternberg, S. H., Greninger, A. L., Porotto, M., & Moscona, A. (2024). Human parainfluenza virus 3 field strains undergo extracellular fusion protein cleavage to activate entry. MBio, 15(11). https://doi.org/10.1128/mbio.02327-24
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Alwine, J., Goodrum, F., Banfield, B., Bloom, D., Britt, W. J., Broadbent, A. J., Campos, S. K., Casadevall, A., Chan, G. C., Cliffe, A. R., Dermody, T., Duprex, P., Enquist, L. W., Frueh, K., Geballe, A. P., Gaglia, M., Goldstein, S., Greninger, A. L., Gronvall, G. K., … Yurochko, A. (2024). The harms of promoting the lab leak hypothesis for SARS-CoV-2 origins without evidence. Journal of Virology, 98(9). https://doi.org/10.1128/jvi.01240-24
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Miotto, M. C., Reiken, S., Wronska, A., Yuan, Q., Dridi, H., Liu, Y., Weninger, G., Tchagou, C., & Marks, A. R. (2024). Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-51791-y
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