SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion

Leuzzi, G., Vasciaveo, A., Taglialatela, A., Chen, X., Firestone, T. M., Hickman, A. R., Mao, W., Thakar, T., Vaitsiankova, A., Huang, J.-W., Cuella-Martin, R., Hayward, S. B., Kesner, J. S., Ghasemzadeh, A., Nambiar, T. S., Ho, P., Rialdi, A., Hebrard, M., Li, Y., … Ciccia, A. (2024). SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion. Cell, 187(4), 861-881.e32. https://doi.org/10.1016/j.cell.2024.01.008
Authors:
Giuseppe Leuzzi
Alessandro Vasciaveo
Angelo Taglialatela
Xiao Chen
Tessa M Firestone
Allison R Hickman
Wendy Mao
Tanay Thakar
Alina Vaitsiankova
Jen-Wei Huang
Raquel Cuella-Martin
Samuel B Hayward
Jordan S Kesner
Ali Ghasemzadeh
Tarun S Nambiar
Patricia Ho
Alexander Rialdi
Maxime Hebrard
Yinglu Li
Jinmei Gao
Saarang Gopinath
Oluwatobi A Adeleke
Bryan J Venters
Charles G Drake
Richard Baer
Benjamin Izar
Ernesto Guccione
Michael-Christopher Keogh
Raphael Guerois
Lu Sun
Chao Lu
Andrea Califano
Alberto Ciccia
Affiliated Authors:
Giuseppe Leuzzi
Alessandro Vasciaveo
Angelo Taglialatela
Xiao Chen
Wendy Mao
Tanay Thakar
Alina Vaitsiankova
Jen-Wei Huang
Raquel Cuella-Martin
Samuel B Hayward
Jordan S Kesner
Ali Ghasemzadeh
Tarun S Nambiar
Patricia Ho
Yinglu Li
Charles G Drake
Richard Baer
Benjamin Izar
Chao Lu
Andrea Califano
Alberto Ciccia
Columbia Affiliation:
Subjects:
B7-H1 Antigen (MeSH)
Immunity, Innate (MeSH)
Melanoma (MeSH)
Tumor Escape (MeSH)
DNA Helicases (MeSH)
Author Keywords:
ap-1
cancer immunotherapy
cancer-intrinsic innate immunity
cgas-sting pathway
crispr-cas9 screens
dna damage response
jun
pd-l1 regulation
smarcal1
elink
Publication Type:
Article
Unique ID:
10.1016/j.cell.2024.01.008
PMID:
38301646
DOI:
10.1016/j.cell.2024.01.008
Journal:
Cell
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
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Record Created: