Gupta, A., Madhavan, M. V., Poterucha, T. J., DeFilippis, E. M., Hennessey, J. A., Redfors, B., Eckhardt, C., Bikdeli, B., Platt, J., Nalbandian, A., Elias, P., Cummings, M. J., Nouri, S. N., Lawlor, M., Ranard, L. S., Li, J., Boyle, C., Givens, R., Brodie, D., … Parikh, S. A. (2021). Association between antecedent statin use and decreased mortality in hospitalized patients with COVID-19. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-21553-1

Nguyen, T. T. T., Shang, E., Shu, C., Kim, S., Mela, A., Humala, N., Mahajan, A., Yang, H. W., Akman, H. O., Quinzii, C. M., Zhang, G., Westhoff, M.-A., Karpel-Massler, G., Bruce, J. N., Canoll, P., & Siegelin, M. D. (2021). Aurora kinase A inhibition reverses the Warburg effect and elicits unique metabolic vulnerabilities in glioblastoma. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-25501-x

Pahl, M. C., Doege, C. A., Hodge, K. M., Littleton, S. H., Leonard, M. E., Lu, S., Rausch, R., Pippin, J. A., De Rosa, M. C., Basak, A., Bradfield, J. P., Hammond, R. K., Boehm, K., Berkowitz, R. I., Lasconi, C., Su, C., Chesi, A., Johnson, M. E., Wells, A. D., … Grant, S. F. A. (2021). Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-27001-4

de Jong, J. O., Llapashtica, C., Genestine, M., Strauss, K., Provenzano, F., Sun, Y., Zhu, H., Cortese, G. P., Brundu, F., Brigatti, K. W., Corneo, B., Migliori, B., Tomer, R., Kushner, S. A., Kellendonk, C., Javitch, J. A., Xu, B., & Markx, S. (2021). Cortical overgrowth in a preclinical forebrain organoid model of CNTNAP2-associated autism spectrum disorder. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-24358-4

Lu, L., Dercle, L., Zhao, B., & Schwartz, L. H. (2021). Deep learning for the prediction of early on-treatment response in metastatic colorectal cancer from serial medical imaging. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-26990-6

Yang, W., & Shaman, J. (2021). Development of a model-inference system for estimating epidemiological characteristics of SARS-CoV-2 variants of concern. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-25913-9

Grapotte, M., Saraswat, M., Bessière, C., Menichelli, C., Ramilowski, J. A., Severin, J., Hayashizaki, Y., Itoh, M., Tagami, M., Murata, M., Kojima-Ishiyama, M., Noma, S., Noguchi, S., Kasukawa, T., Hasegawa, A., Suzuki, H., Nishiyori-Sueki, H., Frith, M. C., … Lecellier, C.-H. (2021). Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-23143-7

Kragel, J. E., Ezzyat, Y., Lega, B. C., Sperling, M. R., Worrell, G. A., Gross, R. E., Jobst, B. C., Sheth, S. A., Zaghloul, K. A., Stein, J. M., & Kahana, M. J. (2021). Distinct cortical systems reinstate the content and context of episodic memories. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-24393-1

Kennedy, A. L., Myers, K. C., Bowman, J., Gibson, C. J., Camarda, N. D., Furutani, E., Muscato, G. M., Klein, R. H., Ballotti, K., Liu, S., Harris, C. E., Galvin, A., Malsch, M., Dale, D., Gansner, J. M., Nakano, T. A., Bertuch, A., Vlachos, A., Lipton, J. M., … Lindsley, R. C. (2021). Distinct genetic pathways define pre-malignant versus compensatory clonal hematopoiesis in Shwachman-Diamond syndrome. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-21588-4

Prakash, R., Sandoval, T., Morati, F., Zagelbaum, J. A., Lim, P.-X., White, T., Taylor, B., Wang, R., Desclos, E. C. B., Sullivan, M. R., Rein, H. L., Bernstein, K. A., Krawczyk, P. M., Gautier, J., Modesti, M., Vanoli, F., & Jasin, M. (2021). Distinct pathways of homologous recombination controlled by the SWS1–SWSAP1–SPIDR complex. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-24205-6

Mahadevia, D., Saha, R., Manganaro, A., Chuhma, N., Ziolkowski-Blake, A., Morgan, A. A., Dumitriu, D., Rayport, S., & Ansorge, M. S. (2021). Dopamine promotes aggression in mice via ventral tegmental area to lateral septum projections. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-27092-z

Schastnaya, E., Raguz Nakic, Z., Gruber, C. H., Doubleday, P. F., Krishnan, A., Johns, N. I., Park, J., Wang, H. H., & Sauer, U. (2021). Extensive regulation of enzyme activity by phosphorylation in Escherichia coli. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-25988-4

Jones, G., Trajanoska, K., Santanasto, A. J., Stringa, N., Kuo, C.-L., Atkins, J. L., Lewis, J. R., Duong, T., Hong, S., Biggs, M. L., Luan, J., Sarnowski, C., Lunetta, K. L., Tanaka, T., Wojczynski, M. K., Cvejkus, R., Nethander, M., Ghasemi, S., Yang, J., … Pilling, L. C. (2021). Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-20918-w

Kremer, D. M., Nelson, B. S., Lin, L., Yarosz, E. L., Halbrook, C. J., Kerk, S. A., Sajjakulnukit, P., Myers, A., Thurston, G., Hou, S. W., Carpenter, E. S., Andren, A. C., Nwosu, Z. C., Cusmano, N., Wisner, S., Mbah, N. E., Shan, M., Das, N. K., Magnuson, B., … Lyssiotis, C. A. (2021). GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-24859-2

Ferren, M., Favède, V., Decimo, D., Iampietro, M., Lieberman, N. A. P., Weickert, J.-L., Pelissier, R., Mazelier, M., Terrier, O., Moscona, A., Porotto, M., Greninger, A. L., Messaddeq, N., Horvat, B., & Mathieu, C. (2021). Hamster organotypic modeling of SARS-CoV-2 lung and brainstem infection. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-26096-z

Hu, W. T., Ozturk, T., Kollhoff, A., Wharton, W., Christina Howell, J., Weiner, M., Aisen, P., Petersen, R., Jack, C. R., Jagust, W., Trojanowki, J. Q., Toga, A. W., Beckett, L., Green, R. C., Saykin, A. J., Morris, J., Perrin, R. J., Shaw, L. M., … Chiang, G. (2021). Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer’s disease. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-24220-7

Chen, Z., Zhang, D., Reynolds, R. H., Gustavsson, E. K., García-Ruiz, S., D’Sa, K., Fairbrother-Browne, A., Vandrovcova, J., Noyce, A. J., Kaiyrzhanov, R., Middlehurst, B., Kia, D. A., Tan, M., Morris, H. R., Plun-Favreau, H., Holmans, P., Trabzuni, D., Bras, J., … Ryten, M. (2021). Human-lineage-specific genomic elements are associated with neurodegenerative disease and APOE transcript usage. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-22262-5

He, Z., Liu, L., Wang, C., Le Guen, Y., Lee, J., Gogarten, S., Lu, F., Montgomery, S., Tang, H., Silverman, E. K., Cho, M. H., Greicius, M., & Ionita-Laza, I. (2021). Identification of putative causal loci in whole-genome sequencing data via knockoff statistics. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-22889-4

Yao, Y., Taub, A. B., LeSauter, J., & Silver, R. (2021). Identification of the suprachiasmatic nucleus venous portal system in the mammalian brain. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-25793-z

Cordero, H., King, R. G., Dogra, P., Dufeu, C., See, S. B., Chong, A. M., Uhlemann, A.-C., Ho, S.-H., Kalfa, D. M., Bacha, E. A., Kearney, J. F., & Zorn, E. (2021). Intrathymic differentiation of natural antibody-producing plasma cells in human neonates. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-26069-2

Chen, D., Chu, B., Yang, X., Liu, Z., Jin, Y., Kon, N., Rabadan, R., Jiang, X., Stockwell, B. R., & Gu, W. (2021). iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-23902-6

Neitzel, J., Franzmeier, N., Rubinski, A., Dichgans, M., Brendel, M., Weiner, M., Aisen, P., Petersen, R., Jack, C. R., Jagust, W., Trojanowki, J. Q., Toga, A. W., Beckett, L., Green, R. C., Saykin, A. J., Morris, J., Shaw, L. M., Liu, E., … Ewers, M. (2021). KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer’s disease. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-23755-z

Liu, K. H., Lee, C. M., Singer, G., Bais, P., Castellanos, F., Woodworth, M. H., Ziegler, T. R., Kraft, C. S., Miller, G. W., Li, S., Go, Y.-M., Morgan, E. T., & Jones, D. P. (2021). Large scale enzyme based xenobiotic identification for exposomics. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-25698-x

Iketani, S., Forouhar, F., Liu, H., Hong, S. J., Lin, F.-Y., Nair, M. S., Zask, A., Huang, Y., Xing, L., Stockwell, B. R., Chavez, A., & Ho, D. D. (2021). Lead compounds for the development of SARS-CoV-2 3CL protease inhibitors. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-22362-2

Chang, W., Pedroni, A., Bertuzzi, M., Kizil, C., Simon, A., & Ampatzis, K. (2021). Locomotion dependent neuron-glia interactions control neurogenesis and regeneration in the adult zebrafish spinal cord. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-25052-1

Sendhilnathan, N., Ipata, A., & Goldberg, M. E. (2021). Mid-lateral cerebellar complex spikes encode multiple independent reward-related signals during reinforcement learning. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-26338-0

Giddings, E. L., Champagne, D. P., Wu, M.-H., Laffin, J. M., Thornton, T. M., Valenca-Pereira, F., Culp-Hill, R., Fortner, K. A., Romero, N., East, J., Cao, P., Arias-Pulido, H., Sidhu, K. S., Silverstrim, B., Kam, Y., Kelley, S., Pereira, M., Bates, S. E., Bunn, J. Y., … Rincon, M. (2021). Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-23071-6

Oliver, K. M., Florez-Paz, D. M., Badea, T. C., Mentis, G. Z., Menon, V., & de Nooij, J. C. (2021). Molecular correlates of muscle spindle and Golgi tendon organ afferents. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-21880-3

Lee, S., Islam, M. N., Boostanpour, K., Aran, D., Jin, G., Christenson, S., Matthay, M. A., Eckalbar, W. L., DePianto, D. J., Arron, J. R., Magee, L., Bhattacharya, S., Matsumoto, R., Kubota, M., Farber, D. L., Bhattacharya, J., Wolters, P. J., & Bhattacharya, M. (2021). Molecular programs of fibrotic change in aging human lung. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-26603-2

Qi, H., Zhang, H., Zhao, Y., Chen, C., Long, J. J., Chung, W. K., Guan, Y., & Shen, Y. (2021). MVP predicts the pathogenicity of missense variants by deep learning. Nature Communications, 12(1). https://doi.org/10.1038/s41467-020-20847-0

Huang, X., Park, K., Gontarz, P., Zhang, B., Pan, J., McKenzie, Z., Fischer, L. A., Dong, C., Dietmann, S., Xing, X., Shliaha, P. V., Yang, J., Li, D., Ding, J., Lungjangwa, T., Mitalipova, M., Khan, S. A., Imsoonthornruksa, S., Jensen, N., … Theunissen, T. W. (2021). OCT4 cooperates with distinct ATP-dependent chromatin remodelers in naïve and primed pluripotent states in human. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-25107-3

Pei, S., Teng, X., Lewis, P., & Shaman, J. (2021). Optimizing respiratory virus surveillance networks using uncertainty propagation. Nature Communications, 12(1). https://doi.org/10.1038/s41467-020-20399-3

Mi, X., Zou, B., Zou, F., & Hu, J. (2021). Permutation-based identification of important biomarkers for complex diseases via machine learning models. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-22756-2

Tate, T., Xiang, T., Wobker, S. E., Zhou, M., Chen, X., Kim, H., Batourina, E., Lin, C.-S., Kim, W. Y., Lu, C., Mckiernan, J. M., & Mendelsohn, C. L. (2021). Pparg signaling controls bladder cancer subtype and immune exclusion. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-26421-6

Elleman, A. V., Devienne, G., Makinson, C. D., Haynes, A. L., Huguenard, J. R., & Du Bois, J. (2021). Precise spatiotemporal control of voltage-gated sodium channels by photocaged saxitoxin. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-24392-2

Lee, M.-L., Matsunaga, H., Sugiura, Y., Hayasaka, T., Yamamoto, I., Ishimoto, T., Imoto, D., Suematsu, M., Iijima, N., Kimura, K., Diano, S., & Toda, C. (2021). Prostaglandin in the ventromedial hypothalamus regulates peripheral glucose metabolism. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-22431-6

Lang-Ouellette, D., Gruver, K. M., Smith-Dijak, A., Blot, F. G. C., Stewart, C. A., de Vanssay de Blavous, P., Li, C. H., Van Eitrem, C., Rosen, C., Faust, P. L., Schonewille, M., & Watt, A. J. (2021). Purkinje cell axonal swellings enhance action potential fidelity and cerebellar function. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-24390-4

Bhowmik, S., Galeta, J., Havel, V., Nelson, M., Faouzi, A., Bechand, B., Ansonoff, M., Fiala, T., Hunkele, A., Kruegel, A. C., Pintar, John. E., Majumdar, S., Javitch, J. A., & Sames, D. (2021). Site selective C–H functionalization of Mitragyna alkaloids reveals a molecular switch for tuning opioid receptor signaling efficacy. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-23736-2

Riboldi, G. M., Faravelli, I., Kuwajima, T., Delestrée, N., Dermentzaki, G., De Planell-Saguer, M., Rinchetti, P., Hao, L. T., Beattie, C. C., Corti, S., Przedborski, S., Mentis, G. Z., & Lotti, F. (2021). Sumoylation regulates the assembly and activity of the SMN complex. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-25272-5

Ding, Q., Edwards, M. M., Wang, N., Zhu, X., Bracci, A. N., Hulke, M. L., Hu, Y., Tong, Y., Hsiao, J., Charvet, C. J., Ghosh, S., Handsaker, R. E., Eggan, K., Merkle, F. T., Gerhardt, J., Egli, D., Clark, A. G., & Koren, A. (2021). The genetic architecture of DNA replication timing in human pluripotent stem cells. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-27115-9

Parks, R. M., Anderson, G. B., Nethery, R. C., Navas-Acien, A., Dominici, F., & Kioumourtzoglou, M.-A. (2021). Tropical cyclone exposure is associated with increased hospitalization rates in older adults. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-21777-1

Beebe-Wang, N., Celik, S., Weinberger, E., Sturmfels, P., De Jager, P. L., Mostafavi, S., & Lee, S.-I. (2021). Unified AI framework to uncover deep interrelationships between gene expression and Alzheimer’s disease neuropathologies. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-25680-7