A G358S mutation in the Plasmodium falciparum Na+ pump PfATP4 confers clinically-relevant resistance to cipargamin

Qiu, D., Pei, J. V., Rosling, J. E. O., Thathy, V., Li, D., Xue, Y., Tanner, J. D., Penington, J. S., Aw, Y. T. V., Aw, J. Y. H., Xu, G., Tripathi, A. K., Gnadig, N. F., Yeo, T., Fairhurst, K. J., Stokes, B. H., Murithi, J. M., Kümpornsin, K., Hasemer, H., … Lehane, A. M. (2022). A G358S mutation in the Plasmodium falciparum Na+ pump PfATP4 confers clinically-relevant resistance to cipargamin. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-33403-9
Authors:
Deyun Qiu
Jinxin V. Pei
James E. O. Rosling
Vandana Thathy
Dongdi Li
Yi Xue
John D. Tanner
Jocelyn Sietsma Penington
Yi Tong Vincent Aw
Jessica Yi Han Aw
Guoyue Xu
Abhai K. Tripathi
Nina F. Gnädig
Tomas Yeo
Kate J. Fairhurst
Barbara H. Stokes
James M. Murithi
Krittikorn Kümpornsin
Heath Hasemer
Adelaide S. M. Dennis
Melanie C. Ridgway
E. Schmitt
Judith Straimer
Anthony T. Papenfuss
Lee M
Ben Corry
Photini Sinnis
David A. Fidock
Giel G. van Dooren
Kiaran Kirk
Adele M. Lehane
Affiliated Authors:
Vandana Thathy
Nina F. Gnädig
Tomas Yeo
Kate J. Fairhurst
Barbara H. Stokes
James M. Murithi
David A. Fidock
Columbia Affiliation:
Subjects:
Antimalarials (MeSH)
Malaria, Falciparum (MeSH)
Malaria (OpenAlex Topic)
Toxoplasmosis and Neosporosis Research (OpenAlex Topic)
Efficacy and Safety of Antiretroviral Therapy for HIV (OpenAlex Topic)
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Publication Type:
Article
Unique ID:
10.1038/s41467-022-33403-9
PMID:
36180431
DOI:
10.1038/s41467-022-33403-9
Journal:
Nature Communications
Publication Date:
Data Source:
OpenAlex
Source Link:
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