Safety, pharmacokinetics, and antimalarial activity of the novel triaminopyrimidine ZY-19489: a first-in-human, randomised, placebo-controlled, double-blind, single ascending dose study, pilot food-effect study, and volunteer infection study

Barber, B. E., Fernandez, M., Patel, H. B., Barcelo, C., Woolley, S. D., Patel, H., Llewellyn, S., Abd-Rahman, A. N., Sharma, S., Jain, M., Ghoghari, A., Di Resta, I., Fuchs, A., Deni, I., Yeo, T., Mok, S., Fidock, D. A., Chalon, S., Möhrle, J. J., … Kansagra, K. (2022). Safety, pharmacokinetics, and antimalarial activity of the novel triaminopyrimidine ZY-19489: a first-in-human, randomised, placebo-controlled, double-blind, single ascending dose study, pilot food-effect study, and volunteer infection study. The Lancet Infectious Diseases, 22(6), 879–890. https://doi.org/10.1016/s1473-3099(21)00679-4
Authors:
Bridget E Barber
Melissa Fernandez
Hardik Babubhai Patel
Catalina Barcelo
Stephen D Woolley
Harilal Patel
Stacey Llewellyn
Azrin N Abd-Rahman
Sunil Sharma
Mukul Jain
Ashok Ghoghari
Ilaria Di Resta
Aline Fuchs
Ioanna Deni
Tomas Yeo
Sachel Mok
David A Fidock
Stephan Chalon
Jörg J Möhrle
Deven Parmar
James S McCarthy
Kevinkumar Kansagra
Affiliated Authors:
Ioanna Deni
Tomas Yeo
Sachel Mok
David A Fidock
Subjects:
Publication Type:
Article
Unique ID:
10.1016/S1473-3099(21)00679-4
PMID:
Publication Date:
Data Source:
Scopus

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