The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stages

Arendse, L. B., Murithi, J. M., Qahash, T., Pasaje, C. F. A., Godoy, L. C., Dey, S., Gibhard, L., Ghidelli-Disse, S., Drewes, G., Bantscheff, M., Lafuente-Monasterio, M. J., Fienberg, S., Wambua, L., Gachuhi, S., Coertzen, D., van der Watt, M., Reader, J., Aswat, A. S., Erlank, E., … Chibale, K. (2022). The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stages. Science Translational Medicine, 14(667). https://doi.org/10.1126/scitranslmed.abo7219
Authors:
Lauren B. Arendse
James M. Murithi
Tarrick Qahash
Charisse Flerida A. Pasaje
Luiz C. Godoy
Sumanta Dey
Liezl Gibhard
Sonja Ghidelli-Disse
Gerard Drewes
Marcus Bantscheff
Maria J. Lafuente-Monasterio
Stephen Fienberg
Lynn Wambua
Samuel Gachuhi
Dina Coertzen
Mariëtte van der Watt
Janette Reader
Ayesha S. Aswat
Erica Erlank
Nelius Venter
Nimisha Mittal
Madeline R. Luth
Sabine Ottilie
Elizabeth A. Winzeler
Lizette L. Koekemoer
Lyn-Marie Birkholtz
Jacquin C. Niles
Manuel Llinás
David A. Fidock
Kelly Chibale
Affiliated Authors:
James M. Murithi
David A. Fidock
Columbia Affiliation:
Subjects:
Antimalarials (MeSH)
Plasmodium (MeSH)
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Publication Type:
Article
Unique ID:
10.1126/scitranslmed.abo7219
PMID:
36260689
DOI:
10.1126/scitranslmed.abo7219
Journal:
Science Translational Medicine
Publication Date:
Data Source:
Scopus
Source Link:
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