The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance

Murithi, J. M., Deni, I., Pasaje, C. F. A., Okombo, J., Bridgford, J. L., Gnädig, N. F., Edwards, R. L., Yeo, T., Mok, S., Burkhard, A. Y., Coburn-Flynn, O., Istvan, E. S., Sakata-Kato, T., Gomez-Lorenzo, M. G., Cowell, A. N., Wicht, K. J., Le Manach, C., Kalantarov, G. F., Dey, S., … Fidock, D. A. (2022). The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance. Cell Chemical Biology, 29(5), 824-839.e6. https://doi.org/10.1016/j.chembiol.2021.06.006
Authors:
James M. Murithi
Ioanna Deni
Charisse Flerida A. Pasaje
John Okombo
Jessica L. Bridgford
Nina F. Gnädig
Rachel L. Edwards
Tomas Yeo
Sachel Mok
Anna Y. Burkhard
Olivia Coburn-Flynn
Eva S. Istvan
Tomoyo Sakata-Kato
Maria G. Gomez-Lorenzo
Annie N. Cowell
Kathryn J. Wicht
Claire Le Manach
Gavreel F. Kalantarov
Sumanta Dey
Maëlle Duffey
Benoît Laleu
Amanda K. Lukens
Sabine Ottilie
Manu Vanaerschot
Ilya N. Trakht
Francisco-Javier Gamo
Dyann F. Wirth
Daniel E. Goldberg
Audrey R. Odom John
Kelly Chibale
Elizabeth A. Winzeler
Jacquin C. Niles
David A. Fidock
Affiliated Authors:
James M. Murithi
Ioanna Deni
John Okombo
Jessica L. Bridgford
Nina F. Gnädig
Tomas Yeo
Sachel Mok
Anna Y. Burkhard
Olivia Coburn-Flynn
Kathryn J. Wicht
Gavreel F. Kalantarov
Manu Vanaerschot
Ilya N. Trakht
David A. Fidock
Columbia Affiliation:
Author Keywords:
abci3
biphasic dose-response curves
cellular accumulation assays
conditional knockdowns
copy-number variations
crispr/cas9
heme fractionation
pfcrt
plasmodium falciparum malaria
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Publication Type:
Article
Unique ID:
10.1016/j.chembiol.2021.06.006
PMID:
34233174
DOI:
10.1016/j.chembiol.2021.06.006
Journal:
Cell Chemical Biology
Publication Date:
Data Source:
Scopus
Source Link:
View Scopus Record
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Record Created: