Functional map of SARS-CoV-2 3CL protease reveals tolerant and immutable sites

Iketani, S., Hong, S. J., Sheng, J., Bahari, F., Culbertson, B., Atanaki, F. F., Aditham, A. K., Kratz, A. F., Luck, M. I., Tian, R., Goff, S. P., Montazeri, H., Sabo, Y., Ho, D. D., & Chavez, A. (2022). Functional map of SARS-CoV-2 3CL protease reveals tolerant and immutable sites. Cell Host & Microbe, 30(10), 1354-1362.e6. https://doi.org/10.1016/j.chom.2022.08.003
Authors:
Sho Iketani
Seo Jung Hong
Jenny Sheng
Farideh Bahari
Bruce Culbertson
Fereshteh Fallah Atanaki
Arjun K. Aditham
Alexander F. Kratz
Maria I. Luck
Ruxiao Tian
Stephen P. Goff
Hesam Montazeri
Yosef Sabo
David D. Ho
Alejandro Chavez
Affiliated Authors:
Sho Iketani
Seo Jung Hong
Jenny Sheng
Bruce Culbertson
Alexander F. Kratz
Maria I. Luck
Ruxiao Tian
Stephen P. Goff
Yosef Sabo
David D. Ho
Alejandro Chavez
Columbia Affiliation:
Subjects:
Coronavirus Disease 2019 Research (OpenAlex Topic)
Gastrointestinal Viral Infections and Vaccines Development (OpenAlex Topic)
Prediction of Peptide-MHC Binding Affinity (OpenAlex Topic)
COVID-19 (MeSH)
SARS-CoV-2 (MeSH)
Author Keywords:
3cl protease
covid-19
sars-cov-2
deep mutational scanning
drug resistance
nirmatrelvir
protease inhibitors
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Publication Type:
Article
Unique ID:
10.1016/j.chom.2022.08.003
PMID:
36029764
DOI:
10.1016/j.chom.2022.08.003
Journal:
Cell Host and Microbe
Publication Date:
Data Source:
Scopus
Source Link:
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Record Created: