Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum physiology

Hagenah, L. M., Dhingra, S. K., Small-Saunders, J. L., Qahash, T., Willems, A., Schindler, K. A., Rangel, G. W., Gil-Iturbe, E., Kim, J., Akhundova, E., Yeo, T., Okombo, J., Mancia, F., Quick, M., Roepe, P. D., Llinás, M., & Fidock, D. A. (2024). Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum physiology. MBio, 15(1). https://doi.org/10.1128/mbio.01832-23
Authors:
Laura M. Hagenah
Satish K. Dhingra
Jennifer L. Small-Saunders
Tarrick Qahash
Andreas V. Willems
Kyra A. Schindler
Gabriel W. Rangel
Eva Gil‐Iturbe
Jonathan Kim
E. Akhundova
Tomas Yeo
John Okombo
Filippo Mancia
Matthias Quick
Paul D. Roepe
Manuel Llinás
David A. Fidock
Affiliated Authors:
Laura M. Hagenah
Satish K. Dhingra
Jennifer L. Small-Saunders
Kyra A. Schindler
Eva Gil‐Iturbe
Jonathan Kim
E. Akhundova
Tomas Yeo
John Okombo
Filippo Mancia
Matthias Quick
David A. Fidock
Subjects:
Author Keywords:
drug resistance evolution
fitness
malaria
pfcrt
plasmodium falciparum
Publication Type:
Article
Unique ID:
10.1128/mbio.01832-23
PMID:
Journal:
Publication Date:
Data Source:
OpenAlex

Record Created: