Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation

Rogava, M., Aprati, T. J., Chi, W.-Y., Melms, J. C., Hug, C., Davis, S. H., Earlie, E. M., Chung, C., Deshmukh, S. K., Wu, S., Sledge, G., Tang, S., Ho, P., Amin, A. D., Caprio, L., Gurjao, C., Tagore, S., Ngo, B., Lee, M. J., … Izar, B. (2024). Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation. Nature Cancer, 5(3), 433–447. https://doi.org/10.1038/s43018-023-00704-x
Authors:
Meri Rogava
Tyler J Aprati
Wei-Yu Chi
Johannes C Melms
Clemens Hug
Stephanie H Davis
Ethan M Earlie
Charlie Chung
Sachin K Deshmukh
Sharon Wu
George Sledge
Stephen Tang
Patricia Ho
Amit Dipak Amin
Lindsay Caprio
Carino Gurjao
Somnath Tagore
Bryan Ngo
Michael J Lee
Giorgia Zanetti
Yiping Wang
Sean Chen
William Ge
Luiza Martins Nascentes Melo
Gabriele Allies
Jonas Rösler
Goeffrey T Gibney
Oliver J Schmitz
Megan Sykes
Rémi J Creusot
Thomas Tüting
Dirk Schadendorf
Martin Röcken
Thomas K Eigentler
Andrei Molotkov
Akiva Mintz
Samuel F Bakhoum
Semir Beyaz
Lewis C Cantley
Peter K Sorger
Sven W Meckelmann
Alpaslan Tasdogan
David Liu
Ashley M Laughney
Benjamin Izar
Affiliated Authors:
Meri Rogava
Johannes C Melms
Stephen Tang
Patricia Ho
Amit Dipak Amin
Lindsay Caprio
Carino Gurjao
Somnath Tagore
Michael J Lee
Giorgia Zanetti
Yiping Wang
Sean Chen
Megan Sykes
Rémi J Creusot
Andrei Molotkov
Akiva Mintz
Benjamin Izar
Columbia Affiliation:
Subjects:
Proto-Oncogene Proteins c-akt (MeSH)
Liver Neoplasms (MeSH)
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Publication Type:
Article
Unique ID:
10.1038/s43018-023-00704-x
PMID:
38286827
DOI:
10.1038/s43018-023-00704-x
Journal:
Nature Cancer
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
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Record Created: