Miotto, M. C., Luna-Figueroa, E., Tchagou, C., Bahlouli, L., Reiken, S., Dridi, H., Liu, Y., Weninger, G., & Marks, A. R. (2025). Targeting ryanodine receptors with allopurinol and xanthine derivatives for the treatment of cardiac and musculoskeletal weakness disorders. Proceedings of the National Academy of Sciences, 122(24). https://doi.org/10.1073/pnas.2422082122

Suter, T., Friedman, M. J., Tazearslan, C., Merkurjev, D., Ohgi, K., Meluzzi, D., Rosenfeld, M. G., & Suh, Y. (2025). Ligand-specific regulation of a binary enhancer code dictating cellular senescence. Proceedings of the National Academy of Sciences, 122(24). https://doi.org/10.1073/pnas.2506321122

Pappas, K., Ferrari, M., Smith, P., Nandakumar, S., Khan, Z., Young, S. B., LaClair, J., Russo, M. V., Huang-Hobbs, E., Schultz, N., Abida, W., Karthaus, W., Jasin, M., & L. Sawyers, C. (2025). BRCA2 reversion mutation–independent resistance to PARP inhibition through impaired DNA prereplication complex function. Proceedings of the National Academy of Sciences, 122(23). https://doi.org/10.1073/pnas.2426743122

Wang, X., & Tabas, I. (2025). Location, location, location: Cholesterol in lipid droplets as a driver of MASH progression. Proceedings of the National Academy of Sciences, 122(23). https://doi.org/10.1073/pnas.2509899122

Stolyarova, A., Coop, G., & Przeworski, M. (2025). The distribution of highly deleterious variants across human ancestry groups. Proceedings of the National Academy of Sciences, 122(21). https://doi.org/10.1073/pnas.2503857122

Wang, X., Tsien, S. J., Jin, M., Goldberg, M. E., Zhang, M., & Qian, N. (2025). A circuit model for transsaccadic space updating and mislocalization. Proceedings of the National Academy of Sciences, 122(21). https://doi.org/10.1073/pnas.2422911122

Duy, P. Q., Kiziltug, E., Greenberg, A. B. W., Mehta, N. H., Hao, L. T., Fortes, C., Mullany, S., Fan, B., Manichaikul, A., Teich, A. F., Chan, D., Alper, S. L., Hyman, B. T., Arnold, S. E., McKhann, G. M., Frosch, M. P., & Kahle, K. T. (2025). Single-cell elderly blood–CSF atlas implicates peripherally influenced immune dysregulation in normal pressure hydrocephalus. Proceedings of the National Academy of Sciences, 122(19). https://doi.org/10.1073/pnas.2412159122

Miller, B. R., Gonzaga-Jauregui, C., Brigatti, K. W., de Jong, J., Breese, R. S., Ko, S. Y., Puffenberger, E. G., Van Hout, C., Young, M., Luna, V. M., Staples, J., First, M. B., Gregoire, H. J., Dwork, A. J., Pefanis, E., McCarthy, S., Brydges, S., Rojas, J., Ye, B., … Strauss, K. A. (2025). A rare variant in GPR156 associated with depression in a Mennonite pedigree causes habenula hyperactivity and stress sensitivity in mice. Proceedings of the National Academy of Sciences, 122(16). https://doi.org/10.1073/pnas.2404754122

Vercammen, A., Wray, B., Crider, Y. S., Belkin, G., & Lawrance, E. L. (2025). Psychological impacts of climate change on US youth. Proceedings of the National Academy of Sciences, 122(16). https://doi.org/10.1073/pnas.2311400122

Ambrogi, M., Hernandez, L. L., Strand, D. W., Kumar, S., Romero, M. F., Barasch, J., Ridlon, M., Keil Stietz, K. P., & Vezina, C. M. (2025). A 5-HT-mediated urethral defense against urinary tract infections. Proceedings of the National Academy of Sciences, 122(16). https://doi.org/10.1073/pnas.2409754122

Bertulfo, K., Perez-Duran, P., Miller, H., Ma, C., Ambesi-Impiombato, A., Samon, J., Mackey, A., Lin, W.-H. W., Ferrando, A. A., & Palomero, T. (2025). Therapeutic targeting of the NOTCH1 and neddylation pathways in T cell acute lymphoblastic leukemia. Proceedings of the National Academy of Sciences, 122(14). https://doi.org/10.1073/pnas.2426742122

Qiu, W., Trinh, T. K. H., Catalano, C., Mehta, A., Desai, U. R., Kellogg, G. E., Hendrickson, W. A., & Guo, Y. (2025). Cholesterol-dependent enzyme activity of human TSPO1. Proceedings of the National Academy of Sciences, 122(13). https://doi.org/10.1073/pnas.2323045122

Sierant, M. C., Jin, S. C., Bilguvar, K., Morton, S. U., Dong, W., Jiang, W., Lu, Z., Li, B., López-Giráldez, F., Tikhonova, I., Zeng, X., Lu, Q., Choi, J., Zhang, J., Nelson-Williams, C., Knight, J. R., Zhao, H., Cao, J., Mane, S., … Lifton, R. P. (2025). Genomic analysis of 11,555 probands identifies 60 dominant congenital heart disease genes. Proceedings of the National Academy of Sciences, 122(13). https://doi.org/10.1073/pnas.2420343122

Dong, W., Jin, S. C., Sierant, M. C., Lu, Z., Li, B., Lu, Q., Morton, S. U., Zhang, J., López-Giráldez, F., Nelson-Williams, C., Knight, J. R., Zhao, H., Cao, J., Mane, S., Gruber, P. J., Lek, M., Goldmuntz, E., Deanfield, J., Giardini, A., … Brueckner, M. (2025). Recessive genetic contribution to congenital heart disease in 5,424 probands. Proceedings of the National Academy of Sciences, 122(10). https://doi.org/10.1073/pnas.2419992122

Horne, C. R., Dite, T. A., Young, S. N., Mather, L. J., Dagley, L. F., Johnson, J. L., Yaron-Barir, T. M., Huntsman, E. M., Daly, L. A., Byrne, D. P., Cadell, A. L., Ng, B. H., Yousef, J., Multari, D. H., Shen, L., McAloon, L. M., Manning, G., Febbraio, M. A., Means, A. R., … Murphy, J. M. (2025). PSKH1 kinase activity is differentially modulated via allosteric binding of Ca 2+ sensor proteins. Proceedings of the National Academy of Sciences, 122(8). https://doi.org/10.1073/pnas.2420961122

Ma, L., Pang, Z., Zhang, H., Yang, X., Zheng, S., Chen, Y., Ding, W., Han, Q., Zhang, X., Cao, L., Fei, T., Wang, Q., Gao, D., He, A., Hu, K.-B., Li, X., & Sheng, R. (2025). Clear cell renal carcinoma essentially requires CDKL3 for oncogenesis. Proceedings of the National Academy of Sciences, 122(7). https://doi.org/10.1073/pnas.2415244122

Delgado-Chaves, F. M., Jennings, M. J., Atalaia, A., Wolff, J., Horvath, R., Mamdouh, Z. M., Baumbach, J., & Baumbach, L. (2025). Transforming literature screening: The emerging role of large language models in systematic reviews. Proceedings of the National Academy of Sciences, 122(2). https://doi.org/10.1073/pnas.2411962122

Topper, M. J., Guarnieri, J. W., Haltom, J. A., Chadburn, A., Cope, H., Frere, J., An, J., Borczuk, A., Sinha, S., Kim, J., Park, J., Butler, D., Meydan, C., Foox, J., Bram, Y., Richard, S. A., Epsi, N. J., Agan, B., Chenoweth, J. G., … Baylin, S. B. (2024). Lethal COVID-19 associates with RAAS-induced inflammation for multiple organ damage including mediastinal lymph nodes. Proceedings of the National Academy of Sciences, 121(49). https://doi.org/10.1073/pnas.2401968121

Buss, E. W., Lofaro, O. M., Barnett, A., Leroy, F., Santoro, B., Siegelbaum, S. A., & Bock, T. (2024). HCN1 hyperpolarization-activated cyclic nucleotide–gated channels enhance evoked GABA release from parvalbumin-positive interneurons. Proceedings of the National Academy of Sciences, 121(42). https://doi.org/10.1073/pnas.2319246121

Baldassarri, I., Tavakol, D. N., Graney, P. L., Chramiec, A. G., Hibshoosh, H., & Vunjak-Novakovic, G. (2024). An engineered model of metastatic colonization of human bone marrow reveals breast cancer cell remodeling of the hematopoietic niche. Proceedings of the National Academy of Sciences, 121(42). https://doi.org/10.1073/pnas.2405257121

Wang, W., Williams, D. J., Teoh, J. J., Soundararajan, D., Zuberi, A., Lutz, C. M., Frankel, W. N., & Makinson, C. D. (2024). Impaired axon initial segment structure and function in a model of ARHGEF9 developmental and epileptic encephalopathy. Proceedings of the National Academy of Sciences, 121(42). https://doi.org/10.1073/pnas.2400709121

Bratsberg, B., Fjell, A. M., Rogeberg, O. J., Skirbekk, V. F., & Walhovd, K. B. (2024). Differences in cognitive function at 18 y of age explain the association between low education and early dementia risk. Proceedings of the National Academy of Sciences, 121(41). https://doi.org/10.1073/pnas.2412017121

Abhimanyu, Longlax, S. C., Nishiguchi, T., Ladki, M., Sheikh, D., Martinez, A. L., Mace, E. M., Grimm, S. L., Caldwell, T., Portillo Varela, A., Sekhar, R. V., Mandalakas, A. M., Mlotshwa, M., Ginidza, S., Cirillo, J. D., Wallis, R. S., Netea, M. G., van Crevel, R., Coarfa, C., & DiNardo, A. R. (2024). TCA metabolism regulates DNA hypermethylation in LPS andMycobacterium tuberculosis–induced immune tolerance. Proceedings of the National Academy of Sciences, 121(41). https://doi.org/10.1073/pnas.2404841121

Alternating access of a bacterial homolog of neurotransmitter: sodium symporters determined from AlphaFold2 ensembles and DEER spectroscopy. (2024). Proceedings of the National Academy of Sciences, 121(40). https://doi.org/10.1073/pnas.2406063121

Rodriguez, P., Kalia, V., Fenollar-Ferrer, C., Gibson, C. L., Gichi, Z., Rajoo, A., Matier, C. D., Pezacki, A. T., Xiao, T., Carvelli, L., Chang, C. J., Miller, G. W., Khamoui, A. V., Boerner, J., & Blakely, R. D. (2024). Glial swip-10 controls systemic mitochondrial function, oxidative stress, and neuronal viability via copper ion homeostasis. Proceedings of the National Academy of Sciences, 121(39). https://doi.org/10.1073/pnas.2320611121

Holland, M. A., Maisel, K., Ibberson, C. B., Wiley, L. K., Burnett, D. C., Mace, E. M., & Elting, M. W. (2024). Extended time, elevated expectations: The unappreciated downsides of pausing the tenure clock. Proceedings of the National Academy of Sciences, 121(34). https://doi.org/10.1073/pnas.2403489121

Qin, L., Deng, Y., Zhang, X., Tang, L., Zhang, C., Xu, S., Wang, K., Wang, M., Zhang, X., Su, M., Xie, Q., Hendrickson, W. A., & Chen, Y. (2024). Mechanistic insights into phosphoactivation of SLAC1 in guard cell signaling. Proceedings of the National Academy of Sciences, 121(29). https://doi.org/10.1073/pnas.2323040121

Wu, Q., Rafatian, N., Wagner, K. T., Blamer, J., Smith, J., Okhovatian, S., Aggarwal, P., Wang, E. Y., Banerjee, A., Zhao, Y., Nash, T. R., Lu, R. X. Z., Portillo-Esquivel, L. E., Li, C. Y., Kuzmanov, U., Mandla, S., Virlee, E., Landau, S., Lai, B. F., … Radisic, M. (2024). SARS-CoV-2 pathogenesis in an angiotensin II–induced heart-on-a-chip disease model and extracellular vesicle screening. Proceedings of the National Academy of Sciences, 121(28). https://doi.org/10.1073/pnas.2403581121

Lippl, S., Kay, K., Jensen, G., Ferrera, V. P., & Abbott, L. F. (2024). A mathematical theory of relational generalization in transitive inference. Proceedings of the National Academy of Sciences, 121(28). https://doi.org/10.1073/pnas.2314511121

Zaidi, S., Park, J., Chan, J. M., Roudier, M. P., Zhao, J. L., Gopalan, A., Wadosky, K. M., Patel, R. A., Sayar, E., Karthaus, W. R., Kates, D. H., Chaudhary, O., Xu, T., Masilionis, I., Mazutis, L., Chaligné, R., Obradovic, A., Linkov, I., Barlas, A., … Sawyers, C. L. (2024). Single-cell analysis of treatment-resistant prostate cancer: Implications of cell state changes for cell surface antigen–targeted therapies. Proceedings of the National Academy of Sciences, 121(28). https://doi.org/10.1073/pnas.2322203121

Weninger, G., Miotto, M. C., Tchagou, C., Reiken, S., Dridi, H., Brandenburg, S., Riedemann, G. C., Yuan, Q., Liu, Y., Chang, A., Wronska, A., Lehnart, S. E., & Marks, A. R. (2024). Structural insights into the regulation of RyR1 by S100A1. Proceedings of the National Academy of Sciences, 121(27). https://doi.org/10.1073/pnas.2400497121

Saponaro, A., Krumbach, J. H., Chaves-Sanjuan, A., Sharifzadeh, A. S., Porro, A., Castelli, R., Hamacher, K., Bolognesi, M., DiFrancesco, D., Clarke, O. B., Thiel, G., & Moroni, A. (2024). Structural determinants of ivabradine block of the open pore of HCN4. Proceedings of the National Academy of Sciences, 121(27). https://doi.org/10.1073/pnas.2402259121

Trumpff, C., Monzel, A. S., Sandi, C., Menon, V., Klein, H.-U., Fujita, M., Lee, A., Petyuk, V. A., Hurst, C., Duong, D. M., Seyfried, N. T., Wingo, A. P., Wingo, T. S., Wang, Y., Thambisetty, M., Ferrucci, L., Bennett, D. A., De Jager, P. L., & Picard, M. (2024). Psychosocial experiences are associated with human brain mitochondrial biology. Proceedings of the National Academy of Sciences, 121(27). https://doi.org/10.1073/pnas.2317673121

Cheng, M., Conley, D., Kuipers, T., Li, C., Ryan, C. P., Taeubert, M. J., Wang, S., Wang, T., Zhou, J., Schmitz, L. L., Tobi, E. W., Heijmans, B. T., Lumey, L. H., & Belsky, D. W. (2024). Accelerated biological aging six decades after prenatal famine exposure. Proceedings of the National Academy of Sciences, 121(24). https://doi.org/10.1073/pnas.2319179121

Nebo, I. D., Frew, J. W., Gudjonsson, J. E., & Petukhova, L. (2024). Tissue comparability and bias in hidradenitis suppurativa transcriptomic studies. Proceedings of the National Academy of Sciences, 121(23). https://doi.org/10.1073/pnas.2404503121

Zhao, H., Petrey, D., Murray, D., & Honig, B. (2024). ZEPPI: Proteome-scale sequence-based evaluation of protein–protein interaction models. Proceedings of the National Academy of Sciences, 121(21). https://doi.org/10.1073/pnas.2400260121

Lee, J., Lee, J., Sohn, E. J., Taglialatela, A., O’Sullivan, R. J., Ciccia, A., & Min, J. (2024). Extrachromosomal telomere DNA derived from excessive strand displacements. Proceedings of the National Academy of Sciences, 121(19). https://doi.org/10.1073/pnas.2318438121

Thomas, M. A., Naik, P., Wang, H., Giles, J. T., Girgis, A. A., Kim, S.-Y., Johnson, T. P., Curran, A. M., Crawford, J. D., Jahanbani, S., Bingham, C. O., Robinson, W. H., Na, C. H., & Darrah, E. (2024). The monocyte cell surface is a unique site of autoantigen generation in rheumatoid arthritis. Proceedings of the National Academy of Sciences, 121(17). https://doi.org/10.1073/pnas.2304199121

Ryan, C. P., Lee, N. R., Carba, D. B., MacIsaac, J. L., Lin, D. T. S., Atashzay, P., Belsky, D. W., Kobor, M. S., & Kuzawa, C. W. (2024). Pregnancy is linked to faster epigenetic aging in young women. Proceedings of the National Academy of Sciences, 121(16). https://doi.org/10.1073/pnas.2317290121

Heckmeier, P. J., Ruf, J., Rochereau, C., & Hamm, P. (2024). A billion years of evolution manifest in nanosecond protein dynamics. Proceedings of the National Academy of Sciences, 121(10). https://doi.org/10.1073/pnas.2318743121

Casey, J. A., Kioumourtzoglou, M.-A., Padula, A., González, D. J. X., Elser, H., Aguilera, R., Northrop, A. J., Tartof, S. Y., Mayeda, E. R., Braun, D., Dominici, F., Eisen, E. A., Morello-Frosch, R., & Benmarhnia, T. (2024). Measuring long-term exposure to wildfire PM 2.5 in California: Time-varying inequities in environmental burden. Proceedings of the National Academy of Sciences, 121(8). https://doi.org/10.1073/pnas.2306729121

Schönherr, H., Ayaz, P., Taylor, A. M., Casaletto, J. B., Touré, B. B., Moustakas, D. T., Hudson, B. M., Valverde, R., Zhao, S., O’Hearn, P. J., Foster, L., Sharon, D. A., Garfinkle, S., Giordanetto, F., Lescarbeau, A., Kurukulasuriya, R., Gerami-Moayed, N., Maglic, D., Bruderek, K., … Bergstrom, D. A. (2024). Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2. Proceedings of the National Academy of Sciences, 121(6). https://doi.org/10.1073/pnas.2317756121

Qian, N., Gao, X., Lang, X., Deng, H., Bratu, T. M., Chen, Q., Stapleton, P., Yan, B., & Min, W. (2024). Rapid single-particle chemical imaging of nanoplastics by SRS microscopy. Proceedings of the National Academy of Sciences, 121(3). https://doi.org/10.1073/pnas.2300582121

Goff, S. P., & Shenk, T. (2023). Paul Berg: Recombinant DNA trailblazer. Proceedings of the National Academy of Sciences, 120(47). https://doi.org/10.1073/pnas.2318196120

Postler, T. S., Wang, A., Brundu, F. G., Wang, P., Wu, Z., Butler, K. E., Grinberg-Bleyer, Y., Krishnareddy, S., Lagana, S. M., Saqi, A., Oeckinghaus, A., Rabadan, R., & Ghosh, S. (2023). A pan-cancer analysis implicates human NKIRAS1 as a tumor-suppressor gene. Proceedings of the National Academy of Sciences, 120(46). https://doi.org/10.1073/pnas.2312595120

Hatton, I. A., Galbraith, E. D., Merleau, N. S. C., Miettinen, T. P., Smith, B. M., & Shander, J. A. (2023). The human cell count and size distribution. Proceedings of the National Academy of Sciences, 120(39). https://doi.org/10.1073/pnas.2303077120

Qin, Y., Mace, E. M., & Barton, J. P. (2023). An inference model gives insights into innate immune adaptation and repertoire diversity. Proceedings of the National Academy of Sciences, 120(38). https://doi.org/10.1073/pnas.2305859120

Li, A. M., He, B., Karagiannis, D., Li, Y., Jiang, H., Srinivasan, P., Ramirez, Y., Zhou, M.-N., Curtis, C., Gruber, J. J., Lu, C., Rankin, E. B., & Ye, J. (2023). Serine starvation silences estrogen receptor signaling through histone hypoacetylation. Proceedings of the National Academy of Sciences, 120(38). https://doi.org/10.1073/pnas.2302489120

Le Guen, Y., Luo, G., Ambati, A., Damotte, V., Jansen, I., Yu, E., Nicolas, A., de Rojas, I., Peixoto Leal, T., Miyashita, A., Bellenguez, C., Lian, M. M., Parveen, K., Morizono, T., Park, H., Grenier-Boley, B., Naito, T., Küçükali, F., Talyansky, S. D., … Tan, E.-K. (2023). Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes. Proceedings of the National Academy of Sciences, 120(36). https://doi.org/10.1073/pnas.2302720120

Lao, Y.-H., Ji, R., Zhou, J. K., Snow, K. J., Kwon, N., Saville, E., He, S., Chauhan, S., Chi, C.-W., Datta, M. S., Zhang, H., Quek, C. H., Cai, S. S., Li, M., Gaitan, Y., Bechtel, L., Wu, S.-Y., Lutz, C. M., Tomer, R., … Leong, K. W. (2023). Focused ultrasound–mediated brain genome editing. Proceedings of the National Academy of Sciences, 120(34). https://doi.org/10.1073/pnas.2302910120