Multiancestry analysis of the HLA locus in Alzheimer's and Parkinson's diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Le Guen, Y., Luo, G., Ambati, A., Damotte, V., Jansen, I., Yu, E., Nicolas, A., de Rojas, I., Peixoto Leal, T., Miyashita, A., Bellenguez, C., Lian, M. M., Parveen, K., Morizono, T., Park, H., Grenier-Boley, B., Naito, T., Küçükali, F., Talyansky, S. D., … Tan, E.-K. (2023). Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes. Proceedings of the National Academy of Sciences, 120(36). https://doi.org/10.1073/pnas.2302720120
Authors:
Yann Le Guen
Guo Luo
Aditya Ambati
Vincent Damotte
Iris Jansen
Eric Yu
Aude Nicolas
Itziar de Rojas
Thiago Peixoto Leal
Akinori Miyashita
Céline Bellenguez
Michelle Mulan Lian
Kayenat Parveen
Takashi Morizono
Hyeonseul Park
Benjamin Grenier-Boley
Tatsuhiko Naito
Fahri Küçükali
Seth D Talyansky
Selina Maria Yogeshwar
Vicente Sempere
Wataru Satake
Victoria Alvarez
Beatrice Arosio
Michael E Belloy
Luisa Benussi
Anne Boland
Barbara Borroni
María J Bullido
Paolo Caffarra
Jordi Clarimon
Antonio Daniele
Daniel Darling
Stéphanie Debette
Jean-François Deleuze
Martin Dichgans
Carole Dufouil
Emmanuel During
Emrah Düzel
Daniela Galimberti
Guillermo Garcia-Ribas
José María García-Alberca
Pablo García-González
Vilmantas Giedraitis
Oliver Goldhardt
Caroline Graff
Edna Grünblatt
Olivier Hanon
Lucrezia Hausner
Stefanie Heilmann-Heimbach
Henne Holstege
Jakub Hort
Yoo Jin Jung
Deckert Jürgen
Silke Kern
Teemu Kuulasmaa
Kun Ho Lee
Ling Lin
Carlo Masullo
Patrizia Mecocci
Shima Mehrabian
Alexandre de Mendonça
Mercè Boada
Pablo Mir
Susanne Moebus
Fermin Moreno
Benedetta Nacmias
Gael Nicolas
Shumpei Niida
Børge G Nordestgaard
Goran Papenberg
Janne Papma
Lucilla Parnetti
Florence Pasquier
Pau Pastor
Oliver Peters
Yolande A L Pijnenburg
Gerard Piñol-Ripoll
Julius Popp
Laura Molina Porcel
Raquel Puerta
Jordi Pérez-Tur
Innocenzo Rainero
Inez Ramakers
Luis M Real
Steffi Riedel-Heller
Eloy Rodriguez-Rodriguez
Owen A Ross
Luis Jose Royo
Dan Rujescu
Nikolaos Scarmeas
Philip Scheltens
Norbert Scherbaum
Anja Schneider
Davide Seripa
Ingmar Skoog
Vincenzo Solfrizzi
Gianfranco Spalletta
Alessio Squassina
John van Swieten
Raquel Sánchez-Valle
Eng-King Tan
Thomas Tegos
Charlotte Teunissen
Jesper Qvist Thomassen
Lucio Tremolizzo
Martin Vyhnalek
Frans Verhey
Margda Waern
Jens Wiltfang
Jing Zhang
Henrik Zetterberg
Kaj Blennow
Zihuai He
Julie Williams
Philippe Amouyel
Frank Jessen
Patrick G Kehoe
Ole A Andreassen
Cornelia Van Duin
Magda Tsolaki
Pascual Sánchez-Juan
Ruth Frikke-Schmidt
Kristel Sleegers
Tatsushi Toda
Anna Zettergren
Martin Ingelsson
Yukinori Okada
Giacomina Rossi
Mikko Hiltunen
Jungsoo Gim
Kouichi Ozaki
Rebecca Sims
Jia Nee Foo
Wiesje van der Flier
Takeshi Ikeuchi
Alfredo Ramirez
Ignacio Mata
Agustín Ruiz
Ziv Gan-Or
Jean-Charles Lambert
Michael D Greicius
Emmanuel Mignot
Affiliated Authors:
Nikolaos Scarmeas
Columbia Affiliation:
Subjects:
Alzheimer Disease (MeSH)
HLA-DRB1 Chains (MeSH)
Parkinson Disease (MeSH)
Author Keywords:
alzheimer’s dementia
hla
parkinson’s disease
autoimmunity
neurodegeneration
elink
Publication Type:
Article
Unique ID:
10.1073/pnas.2302720120
PMID:
37643212
DOI:
10.1073/pnas.2302720120
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record

Record Created: