BRCA2 reversion mutation-independent resistance to PARP inhibition through impaired DNA prereplication complex function

Pappas, K., Ferrari, M., Smith, P., Nandakumar, S., Khan, Z., Young, S. B., LaClair, J., Russo, M. V., Huang-Hobbs, E., Schultz, N., Abida, W., Karthaus, W., Jasin, M., & L. Sawyers, C. (2025). BRCA2 reversion mutation–independent resistance to PARP inhibition through impaired DNA prereplication complex function. Proceedings of the National Academy of Sciences, 122(23). https://doi.org/10.1073/pnas.2426743122
Authors:
Kyrie Pappas
Matteo Ferrari
Perianne Smith
Subhiksha Nandakumar
Zahra Khan
Serina B Young
Justin LaClair
Marco Vincenzo Russo
Emmet Huang-Hobbs
Nikolaus Schultz
Wassim Abida
Wouter Karthaus
Maria Jasin
Charles L Sawyers
Affiliated Authors:
Serina B Young
Columbia Affiliation:
Subjects:
Poly(ADP-ribose) Polymerase Inhibition in Cancer Therapy (OpenAlex Topic)
Molecular Mechanisms of DNA Damage Response (OpenAlex Topic)
Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated proteins (OpenAlex Topic)
Poly(ADP-ribose) Polymerase Inhibitors (MeSH)
Drug Resistance, Neoplasm (MeSH)
BRCA2 Protein (MeSH)
Author Keywords:
cdt1
geminin
homologous recombination
parp
prostate
elink
Publication Type:
Article
Unique ID:
10.1073/pnas.2426743122
PMID:
40460119
DOI:
10.1073/pnas.2426743122
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Publication Date:
Data Source:
PubMed
Source Link:
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Record Created: