Structural determinants of ivabradine block of the open pore of HCN4

Saponaro, A., Krumbach, J. H., Chaves-Sanjuan, A., Sharifzadeh, A. S., Porro, A., Castelli, R., Hamacher, K., Bolognesi, M., DiFrancesco, D., Clarke, O. B., Thiel, G., & Moroni, A. (2024). Structural determinants of ivabradine block of the open pore of HCN4. Proceedings of the National Academy of Sciences, 121(27). https://doi.org/10.1073/pnas.2402259121
Authors:
Andrea Saponaro
Jan H. Krumbach
Antonio Chaves‐Sanjuan
Atiyeh Sadat Sharifzadeh
Alessandro Porro
Rosario Castelli
Kay Hamacher
Martino Bolognesi
Dario DiFrancesco
Oliver B. Clarke
Gerhard Thiel
Anna Moroni
Affiliated Authors:
Oliver B. Clarke
Columbia Affiliation:
Subjects:
Ivabradine (MeSH)
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels (MeSH)
Molecular Dynamics Simulation (MeSH)
Molecular Mechanisms of Cardiac Arrhythmias (OpenAlex Topic)
Impact of Resting Heart Rate on Cardiovascular Health (OpenAlex Topic)
Nonlinear Optical Materials and Properties (OpenAlex Topic)
Author Keywords:
hcn
ivabradine
structure
elink
Publication Type:
Article
Unique ID:
10.1073/pnas.2402259121
PMID:
38917012
DOI:
10.1073/pnas.2402259121
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Publication Date:
Data Source:
OpenAlex
Source Link:
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