A rare variant in GPR156 associated with depression in a Mennonite pedigree causes habenula hyperactivity and stress sensitivity in mice

Miller, B. R., Gonzaga-Jauregui, C., Brigatti, K. W., de Jong, J., Breese, R. S., Ko, S. Y., Puffenberger, E. G., Van Hout, C., Young, M., Luna, V. M., Staples, J., First, M. B., Gregoire, H. J., Dwork, A. J., Pefanis, E., McCarthy, S., Brydges, S., Rojas, J., Ye, B., … Strauss, K. A. (2025). A rare variant in GPR156 associated with depression in a Mennonite pedigree causes habenula hyperactivity and stress sensitivity in mice. Proceedings of the National Academy of Sciences, 122(16). https://doi.org/10.1073/pnas.2404754122
Authors:
Bradley R. Miller
Claudia Gonzaga-Jauregui
Karlla W. Brigatti
Job de Jong
Robert S. Breese
Seung Yeon Ko
Erik G. Puffenberger
Cristopher Van Hout
Millie Young
Victor M. Luna
Jeffrey Staples
Michael B. First
Hilledna J. Gregoire
Andrew J. Dwork
Evangelos Pefanis
Shane McCarthy
Susannah Brydges
Jose Rojas
Bin Ye
Eli Stahl
Silvio Alessandro Di Gioia
René Hen
Kevin Elwood
Gorazd Rosoklija
Dadong Li
Scott Mellis
David Carey
Susan D. Croll
John D. Overton
Lynn E. Macdonald
Aris N. Economides
Alan R. Shuldiner
Nao Chuhma
Stephen Rayport
Najaf Amin
Steven A. Kushner
Nicole Alessandri-Haber
Sander Markx
Kevin A. Strauss
Affiliated Authors:
Bradley R. Miller
Job de Jong
Seung Yeon Ko
Michael B. First
Hilledna J. Gregoire
Andrew J. Dwork
René Hen
Gorazd Rosoklija
Steven A. Kushner
Sander Markx
Columbia Affiliation:
Author Keywords:
major depressive disorder
genetics
orphan g protein-coupled receptor
medial habenula
gpr156
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Publication Type:
Article
Unique ID:
10.1073/pnas.2404754122
PMID:
40228124
DOI:
10.1073/pnas.2404754122
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Publication Date:
Data Source:
Scopus
Source Link:
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