Clyde and Helen Wu Center for Molecular Cardiology

Displaying 1 - 18 of 18CSV
Godbout, K., Dugas, M., Reiken, S. R., Ramezani, S., Falle, A., Rousseau, J., Wronska, A. E., Lamothe, G., Canet, G., Lu, Y., Planel, E., Marks, A. R., & Tremblay, J. P. (2025). Universal Prime Editing Therapeutic Strategy for RyR1-Related Myopathies: A Protective Mutation Rescues Leaky RyR1 Channel. International Journal of Molecular Sciences, 26(7), 2835. https://doi.org/10.3390/ijms26072835
Publication Date
Miotto, M. C., Reiken, S., Wronska, A., Yuan, Q., Dridi, H., Liu, Y., Weninger, G., Tchagou, C., & Marks, A. R. (2024). Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-51791-y
Publication Date
Dai, Z., Liang, L., Wang, W., Zuo, P., Yu, S., Liu, Y., Zhao, X., Lu, Y., Jin, Y., Zhang, F., Ding, D., Deng, W., & Yin, Y. (2024). Structural insights into the ubiquitylation strategy of the oligomeric CRL2FEM1B E3 ubiquitin ligase. The EMBO Journal, 43(6), 1089–1109. https://doi.org/10.1038/s44318-024-00047-y
Publication Date
Souidi, M., Resta, J., Dridi, H., Sleiman, Y., Reiken, S., Formoso, K., Colombani, S., Amédro, P., Meyer, P., Charrabi, A., Vincenti, M., Liu, Y., Soni, R. K., Lezoualc’h, F., Stéphane Blot, D. V. M., Rivier, F., Cazorla, O., Parini, A., Marks, A. R., … Meli, A. C. (2024). Ryanodine receptor dysfunction causes senescence and fibrosis in Duchenne dilated cardiomyopathy. Journal of Cachexia, Sarcopenia and Muscle, 15(2), 536–551. Portico. https://doi.org/10.1002/jcsm.13411
Publication Date
Sleiman, Y., Reiken, S., Charrabi, A., Jaffré, F., Sittenfeld, L. R., Pasquié, J.-L., Colombani, S., Lerman, B. B., Chen, S., Marks, A. R., Cheung, J. W., Evans, T., Lacampagne, A., & Meli, A. C. (2023). Personalized medicine in the dish to prevent calcium leak associated with short-coupled polymorphic ventricular tachycardia in patient-derived cardiomyocytes. Stem Cell Research & Therapy, 14(1). https://doi.org/10.1186/s13287-023-03502-5
Publication Date
Liu, Y., Reiken, S., Dridi, H., Yuan, Q., Mohammad, K. S., Trivedi, T., Miotto, M. C., Wedderburn-Pugh, K., Sittenfeld, L., Kerley, Y., Meyer, J. A., Peters, J. S., Persohn, S. C., Bedwell, A. A., Figueiredo, L. L., Suresh, S., She, Y., Soni, R. K., Territo, P. R., … Guise, T. A. (2023). Targeting ryanodine receptor type 2 to mitigate chemotherapy-induced neurocognitive impairments in mice. Science Translational Medicine, 15(715). https://doi.org/10.1126/scitranslmed.adf8977
Publication Date
Dridi, H., Santulli, G., Bahlouli, L., Miotto, M. C., Weninger, G., & Marks, A. R. (2023). Mitochondrial Calcium Overload Plays a Causal Role in Oxidative Stress in the Failing Heart. Biomolecules, 13(9), 1409. https://doi.org/10.3390/biom13091409
Publication Date
Dridi, H., Liu, Y., Reiken, S., Liu, X., Argyrousi, E. K., Yuan, Q., Miotto, M. C., Sittenfeld, L., Meddar, A., Soni, R. K., Arancio, O., Lacampagne, A., & Marks, A. R. (2023). Heart failure-induced cognitive dysfunction is mediated by intracellular Ca2+ leak through ryanodine receptor type 2. Nature Neuroscience, 26(8), 1365–1378. https://doi.org/10.1038/s41593-023-01377-6
Publication Date
Wronska, A. (2022). The Role of microRNA in the Development, Diagnosis, and Treatment of Cardiovascular Disease: Recent Developments. Journal of Pharmacology and Experimental Therapeutics, 384(1), 123–132. https://doi.org/10.1124/jpet.121.001152
Publication Date
Miotto, M. C., Weninger, G., Dridi, H., Yuan, Q., Liu, Y., Wronska, A., Melville, Z., Sittenfeld, L., Reiken, S., & Marks, A. R. (2022). Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment. Science Advances, 8(29). https://doi.org/10.1126/sciadv.abo1272
Publication Date
Melville, Z., Dridi, H., Yuan, Q., Reiken, S., Wronska, A., Liu, Y., Clarke, O. B., & Marks, A. R. (2022). A drug and ATP binding site in type 1 ryanodine receptor. Structure, 30(7), 1025-1034.e4. https://doi.org/10.1016/j.str.2022.04.010
Publication Date
Miotto, M. C., & Marks, A. R. (2022). Catching the next wave of recombinant RyR2 cryo-EM structures. Commentary on “Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations.” Cell Calcium, 105, 102614. https://doi.org/10.1016/j.ceca.2022.102614
Publication Date
Reiken, S., Sittenfeld, L., Dridi, H., Liu, Y., Liu, X., & Marks, A. R. (2022). Alzheimer’s‐like signaling in brains of COVID‐19 patients. Alzheimer’s & Dementia, 18(5), 955–965. Portico. https://doi.org/10.1002/alz.12558
Publication Date
Dridi, H., Santulli, G., Gambardella, J., Jankauskas, S. S., Yuan, Q., Yang, J., Reiken, S., Wang, X., Wronska, A., Liu, X., Lacampagne, A., & Marks, A. R. (2022). IP3 receptor orchestrates maladaptive vascular responses in heart failure. Journal of Clinical Investigation, 132(4). https://doi.org/10.1172/jci152859
Publication Date
Zanou, N., Dridi, H., Reiken, S., Imamura de Lima, T., Donnelly, C., De Marchi, U., Ferrini, M., Vidal, J., Sittenfeld, L., Feige, J. N., Garcia-Roves, P. M., Lopez-Mejia, I. C., Marks, A. R., Auwerx, J., Kayser, B., & Place, N. (2021). Acute RyR1 Ca2+ leak enhances NADH-linked mitochondrial respiratory capacity. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-27422-1
Publication Date
Avula, U. M. R., Dridi, H., Chen, B., Yuan, Q., Katchman, A. N., Reiken, S. R., Desai, A. D., Parsons, S., Baksh, H., Ma, E., Dasrat, P., Ji, R., Lin, Y., Sison, C., Lederer, W. J., Joca, H. C., Ward, C. W., Greiser, M., Marks, A. R., … Wan, E. Y. (2021). Attenuating persistent sodium current–induced atrial myopathy and fibrillation by preventing mitochondrial oxidative stress. JCI Insight, 6(23). https://doi.org/10.1172/jci.insight.147371
Publication Date
Yuan, Q., Dridi, H., Clarke, O. B., Reiken, S., Melville, Z., Wronska, A., Kushnir, A., Zalk, R., Sittenfeld, L., & Marks, A. R. (2021). RyR1-related myopathy mutations in ATP and calcium binding sites impair channel regulation. Acta Neuropathologica Communications, 9(1). https://doi.org/10.1186/s40478-021-01287-3
Publication Date