Department of Physiology and Cellular Biophysics

Displaying 1 - 50 of 232CSV
Mosialou, I., Ali, A. M., Labella, R., Bisikirska, B., Cuesta-Dominguez, A., Vgenopoulou, P., Reyes, I., Rao, S. M., Wang, A., Luo, N., Galan-Diez, M., Zhao, J., Chernak, B. J., Bewersdorf, J. P., Fukasawa, K., Su, J., Higa, J., Adams, R. A., Corper, A. L., … Kousteni, S. (2025). A niche driven mechanism determines response and a mutation-independent therapeutic approach for myeloid malignancies. Cancer Cell. https://doi.org/10.1016/j.ccell.2025.03.007
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Qiu, W., Trinh, T. K. H., Catalano, C., Mehta, A., Desai, U. R., Kellogg, G. E., Hendrickson, W. A., & Guo, Y. (2025). Cholesterol-dependent enzyme activity of human TSPO1. Proceedings of the National Academy of Sciences, 122(13). https://doi.org/10.1073/pnas.2323045122
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Godbout, K., Dugas, M., Reiken, S. R., Ramezani, S., Falle, A., Rousseau, J., Wronska, A. E., Lamothe, G., Canet, G., Lu, Y., Planel, E., Marks, A. R., & Tremblay, J. P. (2025). Universal Prime Editing Therapeutic Strategy for RyR1-Related Myopathies: A Protective Mutation Rescues Leaky RyR1 Channel. International Journal of Molecular Sciences, 26(7), 2835. https://doi.org/10.3390/ijms26072835
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Barber, A. G., Quintero, C. M., Hamilton, M., Rajbhandari, N., Sasik, R., Zhang, Y., Kim, C., Husain, H., Sun, X., & Reya, T. (2025). Regulation of lung cancer initiation and progression by the stem cell determinant Musashi. ELife, 13. CLOCKSS. https://doi.org/10.7554/elife.97021
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Zhang, J., Chen, J., Wo, D., Ma, E., Yan, H., Peng, J., Ren, D., & Zhu, W. (2025). Physical and functional interactions between LDLR family members and CXCR4 in breast cancer. The FEBS Journal. Portico. https://doi.org/10.1111/febs.70016
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Rubinelli, L., Manzo, O. L., Sungho, J., Del Gaudio, I., Bareja, R., Marino, A., Palikhe, S., Di Mauro, V., Bucci, M., Falcone, D. J., Elemento, O., Ersoy, B., Diano, S., Sasset, L., & Di Lorenzo, A. (2025). Suppression of endothelial ceramide de novo biosynthesis by Nogo-B contributes to cardiometabolic diseases. Nature Communications, 16(1). https://doi.org/10.1038/s41467-025-56869-9
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Chestnut, C., Johnston, J. D., Velazquez, M., Neselu, K., & Eng, E. T. (2025). Leveraging Virtual Reality for Immersive Segmentation and Analysis of Cryo-Electron Tomography Data. Journal of Visualized Experiments, 215. https://doi.org/10.3791/67849
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Kuhn, A. J., Outlaw, V. K., Marcink, T. C., Yu, Z., Mears, M. C., Cajimat, M. N., Kreitler, D. F., Cleven, P. R., Mook, J. C., Bente, D. A., Porotto, M., Gellman, S. H., & Moscona, A. (2025). Enhancing the solubility of SARS-CoV-2 inhibitors to increase future prospects for clinical development. Journal of Virology. https://doi.org/10.1128/jvi.02159-24
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Reynard, O., Iampietro, M., Dumont, C., Le Guellec, S., Durand, S., Moroso, M., Brisebard, E., Dhondt, K. P., Pelissier, R., Mathieu, C., Cabrera, M., Le Pennec, D., Amurri, L., Alabi, C., Cardinaud, S., Porotto, M., Moscona, A., Vecellio, L., & Horvat, B. (2025). Development of nebulized inhalation delivery for fusion-inhibitory lipopeptides to protect non-human primates against Nipah-Bangladesh infection. Antiviral Research, 235, 106095. https://doi.org/10.1016/j.antiviral.2025.106095
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Hendrickson, W. A., & Gong, Z. (2025). Structural and evolutionary insights into the functioning of glycoprotein hormones and their receptors. Andrology. Portico. https://doi.org/10.1111/andr.70001
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Mougari, S., Favède, V., Predella, C., Reynard, O., Durand, S., Mazelier, M., Pizzioli, E., Decimo, D., Bovier, F. T., Lapsley, L. M., Castagna, C., Lieberman, N. A. P., Noel, G., Mathieu, C., Malissen, B., Briese, T., Greninger, A. L., Alabi, C. A., Dorrello, N. V., … Horvat, B. (2025). Intranasally administrated fusion-inhibitory lipopeptides block SARS-CoV-2 infection in mice and enable long-term protective immunity. Communications Biology, 8(1). https://doi.org/10.1038/s42003-025-07491-4
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Wang, W., Gong, Z., & Hendrickson, W. A. (2025). AlphaFold-guided molecular replacement for solving challenging crystal structures. Acta Crystallographica Section D Structural Biology, 81(1), 4–21. https://doi.org/10.1107/s2059798324011999
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Handrejk, K., Schmitz, K. S., Veldhuis Kroeze, E. J. B., van Dijk, L. L. A., van Run, P., Haagmans, B., Moscona, A., Porotto, M., de Swart, R. L., de Vries, R. D., & Rissmann, M. (2024). Characterization of a SARS-CoV-2 Omicron BA.5 direct-contact transmission model in hamsters. Npj Viruses, 2(1). https://doi.org/10.1038/s44298-024-00061-1
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Cerutti, G., Arias, R., Bahna, F., Mannepalli, S., Katsamba, P. S., Ahlsen, G., Kloss, B., Bruni, R., Tomlinson, A., & Shapiro, L. (2024). Structures and pH-dependent dimerization of the sevenless receptor tyrosine kinase. Molecular Cell, 84(23), 4677-4690.e6. https://doi.org/10.1016/j.molcel.2024.10.017
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del Rivero Morfin, P. J., Chavez, D. S., Jayaraman, S., Yang, L., Geisler, S. M., Kochiss, A. L., Tuluc, P., Colecraft, H. M., Marx, S. O., Liu, X. S., Rajadhyaksha, A. M., & Ben-Johny, M. (2024). A genetically encoded actuator boosts L-type calcium channel function in diverse physiological settings. Science Advances, 10(44). https://doi.org/10.1126/sciadv.adq3374
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Ferreira, L. T., Cassiano, G. C., Alvarez, L. C. S., Okombo, J., Calit, J., Fontinha, D., Gil-Iturbe, E., Coyle, R., Andrade, C. H., Sunnerhagen, P., Bargieri, D. Y., Prudêncio, M., Quick, M., Cravo, P. V., Lee, M. C. S., Fidock, D. A., & Costa, F. T. M. (2024). A novel 4-aminoquinoline chemotype with multistage antimalarial activity and lack of cross-resistance with PfCRT and PfMDR1 mutants. PLOS Pathogens, 20(10), e1012627. https://doi.org/10.1371/journal.ppat.1012627
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Bhansali, D., Tu, N. H., Inoue, K., Teng, S., Li, T., Tran, H. D., Kim, D. H., Dong, J., Peach, C. J., Sokrat, B., Jensen, D. D., Dolan, J. C., Yamano, S., Robinson, V. M., Bunnett, N. W., Albertson, D. G., Leong, K. W., & Schmidt, B. L. (2025). PAR2 on oral cancer cells and nociceptors contributes to oral cancer pain that can be relieved by nanoparticle-encapsulated AZ3451. Biomaterials, 314, 122874. https://doi.org/10.1016/j.biomaterials.2024.122874
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Bisikirska, B., Labella, R., Cuesta-Dominguez, A., Luo, N., De Angelis, J., Mosialou, I., Lin, C.-S., Beck, D., Lata, S., Shyu, P. T., McMahon, D. J., Guo, E., Hagen, J., Chung, W. K., Shane, E., Cohen, A., & Kousteni, S. (2024). Melatonin receptor 1A variants as genetic cause of idiopathic osteoporosis. Science Translational Medicine, 16(769). https://doi.org/10.1126/scitranslmed.adj0085
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Corbin, A., Aromolaran, K. A., & Aromolaran, A. S. (2024). Leukotriene B4 is elevated in diabetes and promotes ventricular arrhythmogenesis in guinea pig. Journal of Cellular Physiology. Portico. https://doi.org/10.1002/jcp.31467
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Marcink, T. C., Zipursky, G., Sobolik, E. B., Golub, K., Herman, E., Stearns, K., Greninger, A. L., Porotto, M., & Moscona, A. (2024). How a paramyxovirus fusion/entry complex adapts to escape a neutralizing antibody. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-53082-y
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Stearns, K., Lampe, G., Hanan, R., Marcink, T., Niewiesk, S., Sternberg, S. H., Greninger, A. L., Porotto, M., & Moscona, A. (2024). Human parainfluenza virus 3 field strains undergo extracellular fusion protein cleavage to activate entry. MBio, 15(11). https://doi.org/10.1128/mbio.02327-24
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Alwine, J., Goodrum, F., Banfield, B., Bloom, D., Britt, W. J., Broadbent, A. J., Campos, S. K., Casadevall, A., Chan, G. C., Cliffe, A. R., Dermody, T., Duprex, P., Enquist, L. W., Frueh, K., Geballe, A. P., Gaglia, M., Goldstein, S., Greninger, A. L., Gronvall, G. K., … Yurochko, A. (2024). The harms of promoting the lab leak hypothesis for SARS-CoV-2 origins without evidence. Journal of Virology, 98(9). https://doi.org/10.1128/jvi.01240-24
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Miotto, M. C., Reiken, S., Wronska, A., Yuan, Q., Dridi, H., Liu, Y., Weninger, G., Tchagou, C., & Marks, A. R. (2024). Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-51791-y
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Krukenberg, S., Möckl, F., Weiß, M., Dekiert, P., Hofmann, M., Gerlach, F., Winterberg, K. J., Kovacevic, D., Khansahib, I., Troost, B., Hinrichs, M., Granato, V., Nawrocki, M., Hub, T., Tsvilovskyy, V., Medert, R., Woelk, L.-M., Förster, F., Li, H., … Guse, A. H. (2024). MASTER-NAADP: a membrane permeable precursor of the Ca2+ mobilizing second messenger NAADP. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-52024-y
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Sukka, S. R., Ampomah, P. B., Darville, L. N. F., Ngai, D., Wang, X., Kuriakose, G., Xiao, Y., Shi, J., Koomen, J. M., McCusker, R. H., & Tabas, I. (2024). Efferocytosis drives a tryptophan metabolism pathway in macrophages to promote tissue resolution. Nature Metabolism, 6(9), 1736–1755. https://doi.org/10.1038/s42255-024-01115-7
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Tomasello, D. L., Barrasa, M. I., Mankus, D., Alarcon, K. I., Lytton-Jean, A. K. R., Liu, X. S., & Jaenisch, R. (2024). Mitochondrial dysfunction and increased reactive oxygen species production in MECP2 mutant astrocytes and their impact on neurons. Scientific Reports, 14(1). https://doi.org/10.1038/s41598-024-71040-y
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Lahiri, S. K., Lu, J., Aguilar-Sanchez, Y., Li, H., Moreira, L. M., Hulsurkar, M. M., Mendoza, A., Turkieltaub Paredes, M. R., Navarro-Garcia, J. A., Munivez, E., Horist, B., Moore, O. M., Weninger, G., Brandenburg, S., Lenz, C., Lehnart, S. E., Sayeed, R., Krasopoulos, G., Srivastava, V., … Wehrens, X. H. T. (2024). Targeting calpain-2-mediated junctophilin-2 cleavage delays heart failure progression following myocardial infarction. Journal of Molecular and Cellular Cardiology, 194, 85–95. https://doi.org/10.1016/j.yjmcc.2024.06.011
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Gusach, A., Lee, Y., Khoshgrudi, A. N., Mukhaleva, E., Ma, N., Koers, E. J., Chen, Q., Edwards, P. C., Huang, F., Kim, J., Mancia, F., Veprintsev, D. B., Vaidehi, N., Weyand, S. N., & Tate, C. G. (2024). Molecular recognition of an odorant by the murine trace amine-associated receptor TAAR7f. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-51793-w
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Suryadevara, N., Otrelo-Cardoso, A. R., Kose, N., Hu, Y.-X., Binshtein, E., Wolters, R. M., Greninger, A. L., Handal, L. S., Carnahan, R. H., Moscona, A., Jardetzky, T. S., & Crowe, J. E. (2024). Functional and structural basis of human parainfluenza virus type 3 neutralization with human monoclonal antibodies. Nature Microbiology, 9(8), 2128–2143. https://doi.org/10.1038/s41564-024-01722-w
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Rangan, R., Feathers, R., Khavnekar, S., Lerer, A., Johnston, J. D., Kelley, R., Obr, M., Kotecha, A., & Zhong, E. D. (2024). CryoDRGN-ET: deep reconstructing generative networks for visualizing dynamic biomolecules inside cells. Nature Methods, 21(8), 1537–1545. https://doi.org/10.1038/s41592-024-02340-4
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Qin, L., Deng, Y., Zhang, X., Tang, L., Zhang, C., Xu, S., Wang, K., Wang, M., Zhang, X., Su, M., Xie, Q., Hendrickson, W. A., & Chen, Y. (2024). Mechanistic insights into phosphoactivation of SLAC1 in guard cell signaling. Proceedings of the National Academy of Sciences, 121(29). https://doi.org/10.1073/pnas.2323040121
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Gong, B., Johnston, J. D., Thiemicke, A., de Marco, A., & Meyer, T. (2024). Endoplasmic reticulum–plasma membrane contact gradients direct cell migration. Nature, 631(8020), 415–423. https://doi.org/10.1038/s41586-024-07527-5
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Jellinger, A. L., Suthard, R. L., Yuan, B., Surets, M., Ruesch, E. A., Caban, A. J., Liu, S., Shpokayte, M., & Ramirez, S. (2024). Chronic activation of a negative engram induces behavioral and cellular abnormalities. ELife, 13. CLOCKSS. https://doi.org/10.7554/elife.96281
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Weninger, G., Miotto, M. C., Tchagou, C., Reiken, S., Dridi, H., Brandenburg, S., Riedemann, G. C., Yuan, Q., Liu, Y., Chang, A., Wronska, A., Lehnart, S. E., & Marks, A. R. (2024). Structural insights into the regulation of RyR1 by S100A1. Proceedings of the National Academy of Sciences, 121(27). https://doi.org/10.1073/pnas.2400497121
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Zyla, D. S., Della Marca, R., Niemeyer, G., Zipursky, G., Stearns, K., Leedale, C., Sobolik, E. B., Callaway, H. M., Hariharan, C., Peng, W., Parekh, D., Marcink, T. C., Diaz Avalos, R., Horvat, B., Mathieu, C., Snijder, J., Greninger, A. L., Hastie, K. M., Niewiesk, S., … Ollmann Saphire, E. (2024). A neutralizing antibody prevents postfusion transition of measles virus fusion protein. Science, 384(6703). https://doi.org/10.1126/science.adm8693
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Trivanović, D., Vujačić, M., Labella, R., Djordjević, I. O., Ćazić, M., Chernak, B., & Jauković, A. (2024). Molecular Deconvolution of Bone Marrow Adipose Tissue Interactions with Malignant Hematopoiesis: Potential for New Therapy Development. Current Osteoporosis Reports. https://doi.org/10.1007/s11914-024-00879-x
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Saponaro, A., Krumbach, J. H., Chaves-Sanjuan, A., Sharifzadeh, A. S., Porro, A., Castelli, R., Hamacher, K., Bolognesi, M., DiFrancesco, D., Clarke, O. B., Thiel, G., & Moroni, A. (2024). Structural determinants of ivabradine block of the open pore of HCN4. Proceedings of the National Academy of Sciences, 121(27). https://doi.org/10.1073/pnas.2402259121
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Kumar, A., Larrea, D., Pero, M. E., Infante, P., Conenna, M., Shin, G. J., Van Elias, V., Grueber, W. B., Di Marcotullio, L., Area-Gomez, E., & Bartolini, F. (2024). MFN2 coordinates mitochondria motility with α-tubulin acetylation and this regulation is disrupted in CMT2A. IScience, 27(6), 109994. https://doi.org/10.1016/j.isci.2024.109994
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Liu, Y., Flamier, A., Bell, G. W., Diao, A. J., Whitfield, T. W., Wang, H.-C., Wu, Y., Schulte, F., Friesen, M., Guo, R., Mitalipova, M., Liu, X. S., Vos, S. M., Young, R. A., & Jaenisch, R. (2024). MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons. Neuron, 112(12), 1943-1958.e10. https://doi.org/10.1016/j.neuron.2024.04.007
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Xu, S., Wang, N., Zuccaro, M. V., Gerhardt, J., Iyyappan, R., Scatolin, G. N., Jiang, Z., Baslan, T., Koren, A., & Egli, D. (2024). DNA replication in early mammalian embryos is patterned, predisposing lamina-associated regions to fragility. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-49565-7
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Parte, S., Pothuraju, R., Kumavath, R., Bhatia, R., Nimmakayala, R. K., & Gautam, S. (2024). Editorial: Altered metabolic traits in gastrointestinal tract cancers. Frontiers in Endocrinology, 15. https://doi.org/10.3389/fendo.2024.1390877
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