Mitochondrial dysfunction and increased reactive oxygen species production in MECP2 mutant astrocytes and their impact on neurons

Tomasello, D. L., Barrasa, M. I., Mankus, D., Alarcon, K. I., Lytton-Jean, A. K. R., Liu, X. S., & Jaenisch, R. (2024). Mitochondrial dysfunction and increased reactive oxygen species production in MECP2 mutant astrocytes and their impact on neurons. Scientific Reports, 14(1). https://doi.org/10.1038/s41598-024-71040-y
Authors:
Danielle L. Tomasello
M. Inmaculada Barrasa
David Mankus
Katia I Alarcon
Abigail K. R. Lytton‐Jean
X. Shawn Liu
Rudolf Jaenisch
Affiliated Authors:
X. Shawn Liu
Columbia Affiliation:
Subjects:
Methyl-CpG-Binding Protein 2 (MeSH)
Mitochondria (MeSH)
Astrocytes (MeSH)
Reactive Oxygen Species (MeSH)
Neurons (MeSH)
Rett Syndrome (MeSH)
Mutation (MeSH)
Molecular Basis of Rett Syndrome and Related Disorders (OpenAlex Topic)
Adult Neurogenesis and Brain Development (OpenAlex Topic)
Mitochondrial Dynamics and Reactive Oxygen Species Regulation (OpenAlex Topic)
Author Keywords:
amino acid metabolism
astrocyte
electrophysiology
mecp2
mitochondrial transplantation
neurodevelopment
rett syndrome
single nuclei atac-seq
single nuclei rna-seq
stem cells
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Publication Type:
Article
Unique ID:
10.1038/s41598-024-71040-y
PMID:
39232000
DOI:
10.1038/s41598-024-71040-y
Journal:
Scientific Reports
Publication Date:
Data Source:
OpenAlex
Source Link:
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