A niche driven mechanism determines response and a mutation-independent therapeutic approach for myeloid malignancies

Mosialou, I., Ali, A. M., Labella, R., Bisikirska, B., Cuesta-Dominguez, A., Vgenopoulou, P., Reyes, I., Rao, S. M., Wang, A., Luo, N., Galan-Diez, M., Zhao, J., Chernak, B. J., Bewersdorf, J. P., Fukasawa, K., Su, J., Higa, J., Adams, R. A., Corper, A. L., … Kousteni, S. (2025). A niche driven mechanism determines response and a mutation-independent therapeutic approach for myeloid malignancies. Cancer Cell. https://doi.org/10.1016/j.ccell.2025.03.007
Authors:
Ioanna Mosialou
Abdullah M Ali
Rossella Labella
Brygida Bisikirska
Alvaro Cuesta-Dominguez
Paraskevi Vgenopoulou
Ismarc Reyes
Sanjana M Rao
Anqi Wang
Na Luo
Marta Galan-Diez
Junfei Zhao
Brian J Chernak
Jan Philipp Bewersdorf
Kazuya Fukasawa
Jiayu Su
Jason Higa
Rachel A Adams
Adam L Corper
Sergey Pampou
Catherine M Woods
Xiaomin Fan
Roshan P Shah
Julie Feldstein
Na Liu
Cui Liang
Maël Heiblig
Steven Kornblau
Guillermo Garcia-Manero
Ellin Berman
Joseph G Jurcic
Raul Rabadan
Azra Raza
Stavroula Kousteni
Affiliated Authors:
Ioanna Mosialou
Abdullah M Ali
Rossella Labella
Brygida Bisikirska
Alvaro Cuesta-Dominguez
Paraskevi Vgenopoulou
Ismarc Reyes
Sanjana M Rao
Anqi Wang
Na Luo
Marta Galan-Diez
Junfei Zhao
Brian J Chernak
Kazuya Fukasawa
Jiayu Su
Sergey Pampou
Roshan P Shah
Joseph G Jurcic
Raul Rabadan
Azra Raza
Stavroula Kousteni
Columbia Affiliation:
Author Keywords:
aml
atra
mds
anti-jagged1
b-catenin
bone marrow microenvironment
humanized antibody
myeloid malignancies
therapy
elink
Publication Type:
Article
Unique ID:
10.1016/j.ccell.2025.03.007
PMID:
40154481
DOI:
10.1016/j.ccell.2025.03.007
Journal:
Cancer Cell
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record

Record Created: