Department of Physiology and Cellular Biophysics

Displaying 151 - 200 of 232CSV
Morgenstern, T. J., Nirwan, N., Hernández-Ochoa, E. O., Bibollet, H., Choudhury, P., Laloudakis, Y. D., Ben Johny, M., Bannister, R. A., Schneider, M. F., Minor, D. L., & Colecraft, H. M. (2022). Selective posttranslational inhibition of CaVβ1-associated voltage-dependent calcium channels with a functionalized nanobody. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-35025-7
Publication Date
Kameda-Smith, M. M., Zhu, H., Luo, E.-C., Suk, Y., Xella, A., Yee, B., Chokshi, C., Xing, S., Tan, F., Fox, R. G., Adile, A. A., Bakhshinyan, D., Brown, K., Gwynne, W. D., Subapanditha, M., Miletic, P., Picard, D., Burns, I., Moffat, J., … Singh, S. K. (2022). Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-35118-3
Publication Date
Reynard, O., Gonzalez, C., Dumont, C., Iampietro, M., Ferren, M., Le Guellec, S., Laurie, L., Mathieu, C., Carpentier, G., Roseau, G., Bovier, F. T., Zhu, Y., Le Pennec, D., Montharu, J., Addetia, A., Greninger, A. L., Alabi, C. A., Brisebard, E., Moscona, A., … Horvat, B. (2022). Nebulized fusion inhibitory peptide protects cynomolgus macaques from measles virus infection. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-33832-6
Publication Date
González, B. J., Zhao, H., Niu, J., Williams, D. J., Lee, J., Goulbourne, C. N., Xing, Y., Wang, Y., Oberholzer, J., Blumenkrantz, M. H., Chen, X., LeDuc, C. A., Chung, W. K., Colecraft, H. M., Gromada, J., Shen, Y., Goland, R. S., Leibel, R. L., & Egli, D. (2022). Reduced calcium levels and accumulation of abnormal insulin granules in stem cell models of HNF1A deficiency. Communications Biology, 5(1). https://doi.org/10.1038/s42003-022-03696-z
Publication Date
Yoon, N. A., Jin, S., Kim, J. D., Liu, Z. W., Sun, Q., Cardone, R., Kibbey, R., & Diano, S. (2022). UCP2-dependent redox sensing in POMC neurons regulates feeding. Cell Reports, 41(13), 111894. https://doi.org/10.1016/j.celrep.2022.111894
Publication Date
Islam, M. N., Gusarova, G. A., Das, S. R., Li, L., Monma, E., Anjaneyulu, M., Mthunzi, L., Quadri, S. K., Owusu-Ansah, E., Bhattacharya, S., & Bhattacharya, J. (2022). The mitochondrial calcium uniporter of pulmonary type 2 cells determines severity of acute lung injury. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-33543-y
Publication Date
de Sena-Tomás, C., Aleman, A. G., Ford, C., Varshney, A., Yao, D., Harrington, J. K., Saúde, L., Ramialison, M., & Targoff, K. L. (2022). Activation of Nkx2.5 transcriptional program is required for adult myocardial repair. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-30468-4
Publication Date
Luo, N., Mosialou, I., Capulli, M., Bisikirska, B., Lin, C.-S., Huang, Y., Shyu, P. T., Guo, X. E., Economides, A., Mann, J. J., & Kousteni, S. (2022). A neuronal action of sirtuin 1 suppresses bone mass in young and aging mice. Journal of Clinical Investigation, 132(23). https://doi.org/10.1172/jci152868
Publication Date
Rai, N., & D’Armiento, J. (2022). Wingless/integrase-1 signaling in allergic asthma and pediatric lung diseases. Current Opinion in Pediatrics, 34(6), 572–579. https://doi.org/10.1097/mop.0000000000001173
Publication Date
Shpokayte, M., McKissick, O., Guan, X., Yuan, B., Rahsepar, B., Fernandez, F. R., Ruesch, E., Grella, S. L., White, J. A., Liu, X. S., & Ramirez, S. (2022). Hippocampal cells segregate positive and negative engrams. Communications Biology, 5(1). https://doi.org/10.1038/s42003-022-03906-8
Publication Date
Weninger, G., Pochechueva, T., El Chami, D., Luo, X., Kohl, T., Brandenburg, S., Urlaub, H., Guan, K., Lenz, C., & Lehnart, S. E. (2022). Calpain cleavage of Junctophilin-2 generates a spectrum of calcium-dependent cleavage products and DNA-rich NT1-fragment domains in cardiomyocytes. Scientific Reports, 12(1). https://doi.org/10.1038/s41598-022-14320-9
Publication Date
Shi, H., Wang, X., Li, F., Gerlach, B. D., Yurdagul, A., Moore, M. P., Zeldin, S., Zhang, H., Cai, B., Zheng, Z., Valenti, L., & Tabas, I. (2022). CD47-SIRPα axis blockade in NASH promotes necroptotic hepatocyte clearance by liver macrophages and decreases hepatic fibrosis. Science Translational Medicine, 14(672). https://doi.org/10.1126/scitranslmed.abp8309
Publication Date
Mosialou, I., Ali, A. M., Adams, R., Corper, A., Woods, C. M., Fan, X., Raza, A., & Kousteni, S. (2022). Therapeutic Anti-Jagged1 Antibody Targeting Osteoblast-Related Myeloid Dysplasia to Overcome Standard of Care Resistance. Blood, 140(Supplement 1), 2902–2902. https://doi.org/10.1182/blood-2022-167042
Publication Date
Klykov, O., Bobe, D., Paraan, M., Johnston, J., Potter, C., Carragher, B., Kopylov, M., & Noble, A. (2022). In situ cryo-FIB/SEM Specimen Preparation Using the Waffle Method. BIO-PROTOCOL, 12(21). https://doi.org/10.21769/bioprotoc.4544
Publication Date
Qian, N., Lipkin, R. M., Kaszowska, A., Silipo, G., Dias, E. C., Butler, P. D., & Javitt, D. C. (2022). Computational modeling of excitatory/inhibitory balance impairments in schizophrenia. Schizophrenia Research, 249, 47–55. https://doi.org/10.1016/j.schres.2020.03.027
Publication Date
Papa, A., Zakharov, S. I., Katchman, A. N., Kushner, J. S., Chen, B., Yang, L., Liu, G., Jimenez, A. S., Eisert, R. J., Bradshaw, G. A., Dun, W., Ali, S. R., Rodriques, A., Zhou, K., Topkara, V., Yang, M., Morrow, J. P., Tsai, E. J., Karlin, A., … Marx, S. O. (2022). Rad regulation of CaV1.2 channels controls cardiac fight-or-flight response. Nature Cardiovascular Research, 1(11), 1022–1038. https://doi.org/10.1038/s44161-022-00157-y
Publication Date
Marshall, N. J., Glaser, J. I., Trautmann, E. M., Amematsro, E. A., Perkins, S. M., Shadlen, M. N., Abbott, L. F., Cunningham, J. P., & Churchland, M. M. (2022). Flexible neural control of motor units. Nature Neuroscience, 25(11), 1492–1504. https://doi.org/10.1038/s41593-022-01165-8
Publication Date
Karasawa, A., Andi, B., Fuchs, M. R., Shi, W., McSweeney, S., Hendrickson, W. A., & Liu, Q. (2022). Multi-crystal native-SAD phasing at 5 keV with a helium environment. IUCrJ, 9(6), 768–777. https://doi.org/10.1107/s205225252200971x
Publication Date
Filliol, A., Saito, Y., Nair, A., Dapito, D. H., Yu, L.-X., Ravichandra, A., Bhattacharjee, S., Affo, S., Fujiwara, N., Su, H., Sun, Q., Savage, T. M., Wilson-Kanamori, J. R., Caviglia, J. M., Chin, L., Chen, D., Wang, X., Caruso, S., Kang, J. K., … Schwabe, R. F. (2022). Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis. Nature, 610(7931), 356–365. https://doi.org/10.1038/s41586-022-05289-6
Publication Date
Bamgboye, M. A., Herold, K. G., Vieira, D. C. O., Traficante, M. K., Rogers, P. J., Ben-Johny, M., & Dick, I. E. (2022). CaV1.2 channelopathic mutations evoke diverse pathophysiological mechanisms. Journal of General Physiology, 154(11). https://doi.org/10.1085/jgp.202213209
Publication Date
Saponaro, A., Vallese, F., Porro, A., & Clarke, O. B. (2022). Validation of the binding stoichiometry between HCN channels and their neuronal regulator TRIP8b by single molecule measurements. Frontiers in Physiology, 13. https://doi.org/10.3389/fphys.2022.998176
Publication Date
Stutzman, M. J., Kim, C. S. J., Tester, D. J., Hamrick, S. K., Dotzler, S. M., Giudicessi, J. R., Miotto, M. C., GC, J. B., Frank, J., Marks, A. R., & Ackerman, M. J. (2022). Characterization of N-terminal RYR2 variants outside CPVT1 hotspot regions using patient iPSCs reveal pathogenesis and therapeutic potential. Stem Cell Reports, 17(9), 2023–2036. https://doi.org/10.1016/j.stemcr.2022.07.002
Publication Date
Li, Y., Zhang, R., Wang, C., Forouhar, F., Clarke, O. B., Vorobiev, S., Singh, S., Montelione, G. T., Szyperski, T., Xu, Y., & Hunt, J. F. (2022). Oligomeric interactions maintain active‐site structure in a noncooperative enzyme family. The EMBO Journal, 41(17). Portico. https://doi.org/10.15252/embj.2021108368
Publication Date
Marcink, T. C., Kicmal, T., Armbruster, E., Zhang, Z., Zipursky, G., Golub, K. L., Idris, M., Khao, J., Drew-Bear, J., McGill, G., Gallagher, T., Porotto, M., des Georges, A., & Moscona, A. (2022). Intermediates in SARS-CoV-2 spike–mediated cell entry. Science Advances, 8(33). https://doi.org/10.1126/sciadv.abo3153
Publication Date
McIntyre, S., Hauser, S. C., Kusztor, A., Boehme, R., Moungou, A., Isager, P. M., Homman, L., Novembre, G., Nagi, S. S., Israr, A., Lumpkin, E. A., Abnousi, F., Gerling, G. J., & Olausson, H. (2022). The Language of Social Touch Is Intuitive and Quantifiable. Psychological Science, 33(9), 1477–1494. https://doi.org/10.1177/09567976211059801
Publication Date
Melville, Z., Dridi, H., Yuan, Q., Reiken, S., Wronska, A., Liu, Y., Clarke, O., & Marks, A. (2022). A drug and ATP binding site in type 1 ryanodine receptor. Acta Crystallographica Section A Foundations and Advances, 78(a1), a315–a315. https://doi.org/10.1107/s205327332209684x
Publication Date
Miotto, M. C., Weninger, G., Dridi, H., Yuan, Q., Liu, Y., Wronska, A., Melville, Z., Sittenfeld, L., Reiken, S., & Marks, A. R. (2022). Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment. Science Advances, 8(29). https://doi.org/10.1126/sciadv.abo1272
Publication Date
Vallese, F., Kim, K., Yen, L. Y., Johnston, J. D., Noble, A. J., Calì, T., & Clarke, O. B. (2022). Architecture of the human erythrocyte ankyrin-1 complex. Nature Structural & Molecular Biology, 29(7), 706–718. https://doi.org/10.1038/s41594-022-00792-w
Publication Date
Melville, Z., Dridi, H., Yuan, Q., Reiken, S., Wronska, A., Liu, Y., Clarke, O. B., & Marks, A. R. (2022). A drug and ATP binding site in type 1 ryanodine receptor. Structure, 30(7), 1025-1034.e4. https://doi.org/10.1016/j.str.2022.04.010
Publication Date
Miotto, M. C., & Marks, A. R. (2022). Catching the next wave of recombinant RyR2 cryo-EM structures. Commentary on “Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations.” Cell Calcium, 105, 102614. https://doi.org/10.1016/j.ceca.2022.102614
Publication Date
Owji, A. P., Wang, J., Kittredge, A., Clark, Z., Zhang, Y., Hendrickson, W. A., & Yang, T. (2022). Structures and gating mechanisms of human bestrophin anion channels. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-31437-7
Publication Date
Pouliopoulos, A. N., Murillo, M. F., Noel, R. L., Batts, A. J., Ji, R., Kwon, N., Yu, H., Tong, C.-K., Gelinas, J. N., Araghy, D. K., Hussaini, S. A., & Konofagou, E. E. (2022). Non-invasive optogenetics with ultrasound-mediated gene delivery and red-light excitation. Brain Stimulation, 15(4), 927–941. https://doi.org/10.1016/j.brs.2022.06.007
Publication Date
Klemm, B. P., Sikkema, A. P., Hsu, A. L., Horng, J. C., Hall, T. M. T., Borgnia, M. J., & Schaaper, R. M. (2022). High-resolution structures of the SAMHD1 dGTPase homolog from Leeuwenhoekiella blandensis reveal a novel mechanism of allosteric activation by dATP. Journal of Biological Chemistry, 298(7), 102073. https://doi.org/10.1016/j.jbc.2022.102073
Publication Date
Nobre, R. N., Esteves, A. M., Borges, N., Rebelo, S., Liu, Y., Mancia, F., & Santos, H. (2022). Production and Purification of Phosphatidylinositol Mannosides from Mycobacterium smegmatis Biomass. Current Protocols, 2(6). Portico. https://doi.org/10.1002/cpz1.458
Publication Date
Schmitz, K. S., Lange, M. V., Gommers, L., Handrejk, K., Porter, D. P., Alabi, C. A., Moscona, A., Porotto, M., de Vries, R. D., & de Swart, R. L. (2022). Repurposing an In Vitro Measles Virus Dissemination Assay for Screening of Antiviral Compounds. Viruses, 14(6), 1186. https://doi.org/10.3390/v14061186
Publication Date
Schmitz, K. S., Geers, D., de Vries, R. D., Bovier, T. F., Mykytyn, A. Z., Geurts van Kessel, C. H., Haagmans, B. L., Porotto, M., de Swart, R. L., & Moscona, A. (2022). Potency of Fusion-Inhibitory Lipopeptides against SARS-CoV-2 Variants of Concern. MBio, 13(3). https://doi.org/10.1128/mbio.01249-22
Publication Date
Chakouri, N., Rivas, S., Roybal, D., Yang, L., Diaz, J., Hsu, A. L., Mahling, R., Chen, B.-X., Owoyemi, J. O., DiSilvestre, D., Sirabella, D., Corneo, B., Tomaselli, G. F., Dick, I. E., Marx, S. O., & Ben-Johny, M. (2022). Fibroblast growth factor homologous factors serve as a molecular rheostat in tuning arrhythmogenic cardiac late sodium current. Nature Cardiovascular Research, 1(5), 1–13. https://doi.org/10.1038/s44161-022-00060-6
Publication Date
Balnis, J., Drake, L. A., Singer, D. V., Vincent, C. E., Korponay, T. C., D’Armiento, J., Lee, C. G., Elias, J. A., Singer, H. A., & Jaitovich, A. (2022). Deaccelerated Myogenesis and Autophagy in Genetically Induced Pulmonary Emphysema. American Journal of Respiratory Cell and Molecular Biology, 66(6), 623–637. https://doi.org/10.1165/rcmb.2021-0351oc
Publication Date
Trumpff, C., Owusu-Ansah, E., Klein, H.-U., Lee, A. J., Petyuk, V., Wingo, T. S., Wingo, A. P., Thambisetty, M., Ferrucci, L., Seyfried, N. T., Bennett, D. A., De Jager, P. L., & Picard, M. (2022). Mitochondrial respiratory chain protein co-regulation in the human brain. Heliyon, 8(5), e09353. https://doi.org/10.1016/j.heliyon.2022.e09353
Publication Date
Hoffman, B. U., Baba, Y., Lee, S. A., Tong, C.-K., Konofagou, E. E., & Lumpkin, E. A. (2022). Focused ultrasound excites action potentials in mammalian peripheral neurons in part through the mechanically gated ion channel PIEZO2. Proceedings of the National Academy of Sciences, 119(21). https://doi.org/10.1073/pnas.2115821119
Publication Date
Sun, L., Tong, C.-K., Morgenstern, T. J., Zhou, H., Yang, G., & Colecraft, H. M. (2022). Targeted ubiquitination of sensory neuron calcium channels reduces the development of neuropathic pain. Proceedings of the National Academy of Sciences, 119(20). https://doi.org/10.1073/pnas.2118129119
Publication Date
Murari, A., Goparaju, N. S. V., Rhooms, S.-K., Hossain, K. F. B., Liang, F. G., Garcia, C. J., Osei, C., Liu, T., Li, H., Kitsis, R. N., Patel, R., & Owusu-Ansah, E. (2022). IDH2-mediated regulation of the biogenesis of the oxidative phosphorylation system. Science Advances, 8(19). https://doi.org/10.1126/sciadv.abl8716
Publication Date
Duncan, H. F., Kobayashi, Y., Yamauchi, Y., Quispe-Salcedo, A., Chao Feng, Z., Huang, J., Partridge, N. C., Nakatani, T., D’Armiento, J., & Shimizu, E. (2022). The Critical Role of MMP13 in Regulating Tooth Development and Reactionary Dentinogenesis Repair Through the Wnt Signaling Pathway. Frontiers in Cell and Developmental Biology, 10. https://doi.org/10.3389/fcell.2022.883266
Publication Date
Labella, R., Little-Letsinger, S., Avilkina, V., Sarkis, R., Tencerova, M., Vlug, A., & Palmisano, B. (2022). Next Generation Bone Marrow Adiposity Researchers: Report From the 1st BMAS Summer School 2021. Frontiers in Endocrinology, 13. https://doi.org/10.3389/fendo.2022.879588
Publication Date
Giordano, E., Tesone, A., Trinchese, G., Dentice, M., Mollica, M. P., Diano, S., & Menale, C. (2022). Mitochondria dynamics and function dictate osteoblast metabolism in response to nutrients. Bone Reports, 16, 101541. https://doi.org/10.1016/j.bonr.2022.101541
Publication Date
Reiken, S., Sittenfeld, L., Dridi, H., Liu, Y., Liu, X., & Marks, A. R. (2022). Alzheimer’s‐like signaling in brains of COVID‐19 patients. Alzheimer’s & Dementia, 18(5), 955–965. Portico. https://doi.org/10.1002/alz.12558
Publication Date
Ashraf, K. U., Nygaard, R., Vickery, O. N., Erramilli, S. K., Herrera, C. M., McConville, T. H., Petrou, V. I., Giacometti, S. I., Dufrisne, M. B., Nosol, K., Zinkle, A. P., Graham, C. L. B., Loukeris, M., Kloss, B., Skorupinska-Tudek, K., Swiezewska, E., Roper, D. I., Clarke, O. B., Uhlemann, A.-C., … Mancia, F. (2022). Structural basis of lipopolysaccharide maturation by the O-antigen ligase. Nature, 604(7905), 371–376. https://doi.org/10.1038/s41586-022-04555-x
Publication Date
Mederacke, I., Filliol, A., Affo, S., Nair, A., Hernandez, C., Sun, Q., Hamberger, F., Brundu, F., Chen, Y., Ravichandra, A., Huebener, P., Anke, H., Shi, H., Martínez García de la Torre, R. A., Smith, J. R., Henderson, N. C., Vondran, F. W. R., Rothlin, C. V., Baehre, H., … Schwabe, R. F. (2022). The purinergic P2Y14 receptor links hepatocyte death to hepatic stellate cell activation and fibrogenesis in the liver. Science Translational Medicine, 14(639). https://doi.org/10.1126/scitranslmed.abe5795
Publication Date
Ampomah, P. B., Cai, B., Sukka, S. R., Gerlach, B. D., Yurdagul, A., Wang, X., Kuriakose, G., Darville, L. N. F., Sun, Y., Sidoli, S., Koomen, J. M., Tall, A. R., & Tabas, I. (2022). Macrophages use apoptotic cell-derived methionine and DNMT3A during efferocytosis to promote tissue resolution. Nature Metabolism, 4(4), 444–457. https://doi.org/10.1038/s42255-022-00551-7
Publication Date