Department of Physiology and Cellular Biophysics

Displaying 51 - 100 of 232CSV
Moore, M. P., Wang, X., Kennelly, J. P., Shi, H., Ishino, Y., Kano, K., Aoki, J., Cherubini, A., Ronzoni, L., Guo, X., Chalasani, N. P., Khalid, S., Saleheen, D., Mitsche, M. A., Rotter, J. I., Yates, K. P., Valenti, L., Kono, N., Tontonoz, P., & Tabas, I. (2024). Low MBOAT7 expression, a genetic risk for MASH, promotes a profibrotic pathway involving hepatocyte TAZ upregulation. Hepatology. https://doi.org/10.1097/hep.0000000000000933
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Zuo, H., Park, J., Frangaj, A., Ye, J., Lu, G., Manning, J. J., Asher, W. B., Lu, Z., Hu, G., Wang, L., Mendez, J., Eng, E., Zhang, Z., Lin, X., Grassucci, R., Hendrickson, W. A., Clarke, O. B., Javitch, J. A., Conigrave, A. D., & Fan, Q. R. (2024). Promiscuous G-protein activation by the calcium-sensing receptor. Nature, 629(8011), 481–488. https://doi.org/10.1038/s41586-024-07331-1
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Cater, R. J., Mukherjee, D., Gil-Iturbe, E., Erramilli, S. K., Chen, T., Koo, K., Santander, N., Reckers, A., Kloss, B., Gawda, T., Choy, B. C., Zhang, Z., Katewa, A., Larpthaveesarp, A., Huang, E. J., Mooney, S. W. J., Clarke, O. B., Yee, S. W., Giacomini, K. M., … Mancia, F. (2024). Structural and molecular basis of choline uptake into the brain by FLVCR2. Nature, 629(8012), 704–709. https://doi.org/10.1038/s41586-024-07326-y
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Chua, E. Y. D., Alink, L. M., Kopylov, M., Johnston, J. D., Eisenstein, F., & de Marco, A. (2024). Square beams for optimal tiling in transmission electron microscopy. Nature Methods, 21(4), 562–565. https://doi.org/10.1038/s41592-023-02161-x
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Wang, X., Zhang, C., Yang, L., Jin, M., Goldberg, M. E., Zhang, M., & Qian, N. (2024). Perisaccadic and attentional remapping of receptive fields in lateral intraparietal area and frontal eye fields. Cell Reports, 43(3), 113820. https://doi.org/10.1016/j.celrep.2024.113820
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Wright, K. M., Nathan, S., Jiang, H., Xia, W., Kim, H., Chakouri, N., Nwafor, J. N., Fossier, L., Srinivasan, L., Chen, Z., Boronina, T., Post, J., Paul, S., Cole, R. N., Ben-Johny, M., Cole, P. A., & Gabelli, S. B. (2024). NEDD4L intramolecular interactions regulate its auto and substrate NaV1.5 ubiquitination. Journal of Biological Chemistry, 300(3), 105715. https://doi.org/10.1016/j.jbc.2024.105715
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Dai, Z., Liang, L., Wang, W., Zuo, P., Yu, S., Liu, Y., Zhao, X., Lu, Y., Jin, Y., Zhang, F., Ding, D., Deng, W., & Yin, Y. (2024). Structural insights into the ubiquitylation strategy of the oligomeric CRL2FEM1B E3 ubiquitin ligase. The EMBO Journal, 43(6), 1089–1109. https://doi.org/10.1038/s44318-024-00047-y
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Asarnow, D., Becker, V. A., Bobe, D., Dubbledam, C., Johnston, J. D., Kopylov, M., Lavoie, N. R., Li, Q., Mattingly, J. M., Mendez, J. H., Paraan, M., Turner, J., Upadhye, V., Walsh, R. M., Gupta, M., & Eng, E. T. (2024). Recent advances in infectious disease research using cryo-electron tomography. Frontiers in Molecular Biosciences, 10. https://doi.org/10.3389/fmolb.2023.1296941
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Todd, J. J., Lawal, T. A., Chrismer, I. C., Kokkinis, A., Grunseich, C., Jain, M. S., Waite, M. R., Biancavilla, V., Pocock, S., Brooks, K., Mendoza, C. J., Norato, G., Cheung, K., Riekhof, W., Varma, P., Colina-Prisco, C., Emile-Backer, M., Meilleur, K. G., Marks, A. R., … Mohassel, P. (2024). Rycal S48168 (ARM210) for RYR1-related myopathies: a phase one, open-label, dose-escalation trial. EClinicalMedicine, 68, 102433. https://doi.org/10.1016/j.eclinm.2024.102433
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Hagenah, L. M., Dhingra, S. K., Small-Saunders, J. L., Qahash, T., Willems, A., Schindler, K. A., Rangel, G. W., Gil-Iturbe, E., Kim, J., Akhundova, E., Yeo, T., Okombo, J., Mancia, F., Quick, M., Roepe, P. D., Llinás, M., & Fidock, D. A. (2024). Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum physiology. MBio, 15(1). https://doi.org/10.1128/mbio.01832-23
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Papa, A., del Rivero Morfin, P. J., Chen, B.-X., Yang, L., Katchman, A. N., Zakharov, S. I., Liu, G., Bohnen, M. S., Zheng, V., Katz, M., Subramaniam, S., Hirsch, J. A., Weiss, S., Dascal, N., Karlin, A., Pitt, G. S., Colecraft, H. M., Ben-Johny, M., & Marx, S. O. (2024). A membrane-associated phosphoswitch in Rad controls adrenergic regulation of cardiac calcium channels. Journal of Clinical Investigation, 134(5). https://doi.org/10.1172/jci176943
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Souidi, M., Resta, J., Dridi, H., Sleiman, Y., Reiken, S., Formoso, K., Colombani, S., Amédro, P., Meyer, P., Charrabi, A., Vincenti, M., Liu, Y., Soni, R. K., Lezoualc’h, F., Stéphane Blot, D. V. M., Rivier, F., Cazorla, O., Parini, A., Marks, A. R., … Meli, A. C. (2024). Ryanodine receptor dysfunction causes senescence and fibrosis in Duchenne dilated cardiomyopathy. Journal of Cachexia, Sarcopenia and Muscle, 15(2), 536–551. Portico. https://doi.org/10.1002/jcsm.13411
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Liu, B., Xie, D., Huang, X., Jin, S., Dai, Y., Sun, X., Li, D., Bennett, A. M., Diano, S., & Huang, Y. (2024). Skeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1α. Diabetologia, 67(4), 724–737. https://doi.org/10.1007/s00125-023-06073-5
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Brown, K. L., Ramlall, V., Zietz, M., Gisladottir, U., & Tatonetti, N. P. (2024). Estimating the heritability of SARS-CoV-2 susceptibility and COVID-19 severity. Nature Communications, 15(1). https://doi.org/10.1038/s41467-023-44250-7
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Wang, L., Hoang, A., Gil-Iturbe, E., Laganowsky, A., Quick, M., & Zhou, M. (2024). Mechanism of anion exchange and small-molecule inhibition of pendrin. Nature Communications, 15(1). https://doi.org/10.1038/s41467-023-44612-1
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Rasmussen, A. L., Gronvall, G. K., Lowen, A. C., Goodrum, F., Alwine, J., Andersen, K. G., Anthony, S. J., Baines, J., Banerjee, A., Broadbent, A. J., Brooke, C. B., Campos, S. K., Caposio, P., Casadevall, A., Chan, G. C., Cliffe, A. R., Collins-McMillen, D., Connell, N., Damania, B., … Yurochko, A. (2024). Virology—the path forward. Journal of Virology, 98(1). https://doi.org/10.1128/jvi.01791-23
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del Rivero Morfin, P. J., Kochiss, A. L., Liedl, K. R., Flucher, B. E., Fernández-Quintero, M. L. I., & Ben-Johny, M. (2024). Asymmetric contribution of a selectivity filter gate in triggering inactivation of CaV1.3 channels. Journal of General Physiology, 156(2). https://doi.org/10.1085/jgp.202313365
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Tong, C., Moayedi, Y., & Lumpkin, E. A. (2024). Merkel cells and keratinocytes in oral mucosa are activated by mechanical stimulation. Physiological Reports, 12(2). Portico. https://doi.org/10.14814/phy2.15826
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Smith, N., Reznik, E., Bisikirska, B., Polychronidou, V., Wang, Q., Zask, A., Forouhar, F., Califano, A., & Stockwell, B. R. (2023). Kinases Controlling Stability of the Oncogenic MYCN Protein. ACS Medicinal Chemistry Letters, 14(12), 1664–1672. https://doi.org/10.1021/acsmedchemlett.3c00274
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Wang, X., Moore, M. P., Shi, H., Miyata, Y., Donnelly, S. K., Radiloff, D. R., & Tabas, I. (2023). Hepatocyte-targeted siTAZ therapy lowers liver fibrosis in NASH diet-fed chimeric mice with hepatocyte-humanized livers. Molecular Therapy - Methods & Clinical Development, 31, 101165. https://doi.org/10.1016/j.omtm.2023.101165
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Nygaard, R., Graham, C. L. B., Belcher Dufrisne, M., Colburn, J. D., Pepe, J., Hydorn, M. A., Corradi, S., Brown, C. M., Ashraf, K. U., Vickery, O. N., Briggs, N. S., Deering, J. J., Kloss, B., Botta, B., Clarke, O. B., Columbus, L., Dworkin, J., Stansfeld, P. J., Roper, D. I., & Mancia, F. (2023). Structural basis of peptidoglycan synthesis by E. coli RodA-PBP2 complex. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-40483-8
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Blomquist, V. G., Niu, J., Choudhury, P., Al Saneh, A., Colecraft, H. M., & Ahern, C. A. (2023). Transfer RNA-mediated restoration of potassium current and electrical correction in premature termination long-QT syndrome hERG mutants. Molecular Therapy - Nucleic Acids, 34, 102032. https://doi.org/10.1016/j.omtn.2023.102032
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Sleiman, Y., Reiken, S., Charrabi, A., Jaffré, F., Sittenfeld, L. R., Pasquié, J.-L., Colombani, S., Lerman, B. B., Chen, S., Marks, A. R., Cheung, J. W., Evans, T., Lacampagne, A., & Meli, A. C. (2023). Personalized medicine in the dish to prevent calcium leak associated with short-coupled polymorphic ventricular tachycardia in patient-derived cardiomyocytes. Stem Cell Research & Therapy, 14(1). https://doi.org/10.1186/s13287-023-03502-5
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Kanade-Mehta, P., Bengtson, M., Stoeckmann, T., McGuire, J., Ghez, C., & Scheidt, R. A. (2023). Spatial mapping of posture-dependent resistance to passive displacement of the hypertonic arm post-stroke. Journal of NeuroEngineering and Rehabilitation, 20(1). https://doi.org/10.1186/s12984-023-01285-7
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Rummell, B. P., Bikas, S., Babl, S. S., Gogos, J. A., & Sigurdsson, T. (2023). Altered corollary discharge signaling in the auditory cortex of a mouse model of schizophrenia predisposition. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-42964-2
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Ferguson, L. P., Gatchalian, J., McDermott, M. L., Nakamura, M., Chambers, K., Rajbhandari, N., Lytle, N. K., Rosenthal, S. B., Hamilton, M., Albini, S., Wartenberg, M., Zlobec, I., Galván, J. A., Karamitopoulou, E., Vavinskaya, V., Wascher, A., Lowy, A. M., Schürch, C. M., Puri, P. L., … Reya, T. (2023). Smarcd3 is an epigenetic modulator of the metabolic landscape in pancreatic ductal adenocarcinoma. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-35796-7
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Ngai, D., Schilperoort, M., & Tabas, I. (2023). Efferocytosis-induced lactate enables the proliferation of pro-resolving macrophages to mediate tissue repair. Nature Metabolism, 5(12), 2206–2219. https://doi.org/10.1038/s42255-023-00921-9
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Sulaiman, I., Wu, B. G., Chung, M., Isaacs, B., Tsay, J.-C. J., Holub, M., Barnett, C. R., Kwok, B., Kugler, M. C., Natalini, J. G., Singh, S., Li, Y., Schluger, R., Carpenito, J., Collazo, D., Perez, L., Kyeremateng, Y., Chang, M., Campbell, C. D., … Segal, L. N. (2023). Lower Airway Dysbiosis Augments Lung Inflammatory Injury in Mild-to-Moderate Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine, 208(10), 1101–1114. https://doi.org/10.1164/rccm.202210-1865oc
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Mok, S., Yeo, T., Hong, D., Shears, M. J., Ross, L. S., Ward, K. E., Dhingra, S. K., Kanai, M., Bridgford, J. L., Tripathi, A. K., Mlambo, G., Burkhard, A. Y., Ansbro, M. R., Fairhurst, K. J., Gil-Iturbe, E., Park, H., Rozenberg, F. D., Kim, J., Mancia, F., … Fidock, D. A. (2023). Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness. Science Advances, 9(45). https://doi.org/10.1126/sciadv.adi2364
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Dridi, H., Yehya, M., Barsotti, R., Liu, Y., Reiken, S., Azria, L., Yuan, Q., Bahlouli, L., Soni, R. K., Marks, A. R., Lacampagne, A., & Matecki, S. (2023). Aberrant mitochondrial dynamics contributes to diaphragmatic weakness induced by mechanical ventilation. PNAS Nexus, 2(11). https://doi.org/10.1093/pnasnexus/pgad336
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Chernak, B., Galan-Diez, M., Ali, A. M., Cuesta-Dominguez, A., Chen, Z., Koehnke, T., Majeti, R., Carroll, M., Raza, A., & Kousteni, S. (2023). Serum Amyloid A1 (SAA1) Secreted By the Stromal Microenvironment Drives Malignant Clonal Proliferation in Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML). Blood, 142(Supplement 1), 4118–4118. https://doi.org/10.1182/blood-2023-174485
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Citterio, C. E., Kim, K., Rajesh, B., Pena, K., Clarke, O. B., & Arvan, P. (2023). Structural features of thyroglobulin linked to protein trafficking. Protein Science, 32(11). Portico. https://doi.org/10.1002/pro.4784
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Rajbhandari, N., Hamilton, M., Quintero, C. M., Ferguson, L. P., Fox, R., Schürch, C. M., Wang, J., Nakamura, M., Lytle, N. K., McDermott, M., Diaz, E., Pettit, H., Kritzik, M., Han, H., Cridebring, D., Wen, K. W., Tsai, S., Goggins, M. G., Lowy, A. M., … Reya, T. (2023). Single-cell mapping identifies MSI+ cells as a common origin for diverse subtypes of pancreatic cancer. Cancer Cell, 41(11), 1989-2005.e9. https://doi.org/10.1016/j.ccell.2023.09.008
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Tang, S., De Jesus, A. C., Chavez, D., Suthakaran, S., Moore, S. K. L., Suthakaran, K., Homami, S., Rathnasinghe, R., May, A. J., Schotsaert, M., Britto, C. J., Bhattacharya, J., & Hook, J. L. (2023). Rescue of alveolar wall liquid secretion blocks fatal lung injury due to influenza-staphylococcal coinfection. Journal of Clinical Investigation, 133(19). https://doi.org/10.1172/jci163402
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Citterio, C. E., Kim, K., Rajesh, B., Pena, K., Clarke, O. B., & Arvan, P. (2023). OR14-01 Contact Between Thyroglobulin Opposite Domains Assists Its Upstream Regions In Intracellular Trafficking For Thyroid Hormonogenesis. Journal of the Endocrine Society, 7(Supplement_1). https://doi.org/10.1210/jendso/bvad114.1917
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Schilperoort, M., Ngai, D., Sukka, S. R., Avrampou, K., Shi, H., & Tabas, I. (2023). The role of efferocytosis‐fueled macrophage metabolism in the resolution of inflammation. Immunological Reviews, 319(1), 65–80. Portico. https://doi.org/10.1111/imr.13214
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Liu, Y., Reiken, S., Dridi, H., Yuan, Q., Mohammad, K. S., Trivedi, T., Miotto, M. C., Wedderburn-Pugh, K., Sittenfeld, L., Kerley, Y., Meyer, J. A., Peters, J. S., Persohn, S. C., Bedwell, A. A., Figueiredo, L. L., Suresh, S., She, Y., Soni, R. K., Territo, P. R., … Guise, T. A. (2023). Targeting ryanodine receptor type 2 to mitigate chemotherapy-induced neurocognitive impairments in mice. Science Translational Medicine, 15(715). https://doi.org/10.1126/scitranslmed.adf8977
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Dridi, H., Santulli, G., Bahlouli, L., Miotto, M. C., Weninger, G., & Marks, A. R. (2023). Mitochondrial Calcium Overload Plays a Causal Role in Oxidative Stress in the Failing Heart. Biomolecules, 13(9), 1409. https://doi.org/10.3390/biom13091409
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Schaffer, E. S., Mishra, N., Whiteway, M. R., Li, W., Vancura, M. B., Freedman, J., Patel, K. B., Voleti, V., Paninski, L., Hillman, E. M. C., Abbott, L. F., & Axel, R. (2023). The spatial and temporal structure of neural activity across the fly brain. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-41261-2
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Meszaros, J., Geggier, P., Manning, J. J., Asher, W. B., & Javitch, J. A. (2023). Methods for automating the analysis of live-cell single-molecule FRET data. Frontiers in Cell and Developmental Biology, 11. https://doi.org/10.3389/fcell.2023.1184077
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Feldmann, C., Schänzler, M., Ben-Johny, M., & Wahl-Schott, C. (2023). Protocol for deriving proximity, affinity, and stoichiometry of protein interactions using image-based quantitative two-hybrid FRET. STAR Protocols, 4(3), 102459. https://doi.org/10.1016/j.xpro.2023.102459
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Dai, W., Zhang, H., Lund, H., Zhang, Z., Castleberry, M., Rodriguez, M., Kuriakose, G., Gupta, S., Lewandowska, M., Powers, H. R., Valmiki, S., Zhu, J., Shapiro, A. D., Hussain, M. M., López, J. A., Sorci-Thomas, M. G., Silverstein, R. L., Ginsberg, H. N., Sahoo, D., … Zheng, Z. (2023). Intracellular tPA–PAI-1 interaction determines VLDL assembly in hepatocytes. Science, 381(6661). https://doi.org/10.1126/science.adh5207
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Zou, X., Shanmugam, S. K., Kanner, S. A., Sampson, K. J., Kass, R. S., & Colecraft, H. M. (2023). Divergent regulation of KCNQ1/E1 by targeted recruitment of protein kinase A to distinct sites on the channel complex. ELife, 12. CLOCKSS. https://doi.org/10.7554/elife.83466
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