Department of Physiology and Cellular Biophysics

Displaying 101 - 150 of 232CSV
Weng, J., Zhou, X., Wiriyasermkul, P., Ren, Z., Chen, K., Gil-Iturbe, E., Zhou, M., & Quick, M. (2023). Insight into the mechanism of H + -coupled nucleobase transport. Proceedings of the National Academy of Sciences, 120(33). https://doi.org/10.1073/pnas.2302799120
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Rybkina, K., Bell, J. N., Bradley, M. C., Wohlbold, T., Scafuro, M., Meng, W., Korenberg, R. C., Davis-Porada, J., Anderson, B. R., Weller, R. J., Milner, J. D., Moscona, A., Porotto, M., Luning Prak, E. T., Pethe, K., Connors, T. J., & Farber, D. L. (2023). SARS-CoV-2 infection and recovery in children: Distinct T cell responses in MIS-C compared to COVID-19. Journal of Experimental Medicine, 220(8). https://doi.org/10.1084/jem.20221518
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Feng, J., Hsu, P.-F., Esteva, E., Labella, R., Wang, Y., Khodadadi-Jamayran, A., Pucella, J., Liu, C. Z., Arbini, A. A., Tsirigos, A., Kousteni, S., & Reizis, B. (2023). Haplodeficiency of the 9p21 tumor suppressor locus causes myeloid disorders driven by the bone marrow microenvironment. Blood, 142(5), 460–476. https://doi.org/10.1182/blood.2022018512
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del Rivero Morfin, P. J., Marx, S. O., & Ben-Johny, M. (2023). Sympathetic Nervous System Regulation of Cardiac Calcium Channels. Voltage-Gated Ca2+ Channels: Pharmacology, Modulation and Their Role in Human Disease, 59–82. https://doi.org/10.1007/164_2022_632
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Gavin, A. C., & Colecraft, H. M. (2023). Design and Applications of Genetically-Encoded Voltage-Dependent Calcium Channel Inhibitors. Voltage-Gated Ca2+ Channels: Pharmacology, Modulation and Their Role in Human Disease, 139–155. https://doi.org/10.1007/164_2023_656
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Dridi, H., Liu, Y., Reiken, S., Liu, X., Argyrousi, E. K., Yuan, Q., Miotto, M. C., Sittenfeld, L., Meddar, A., Soni, R. K., Arancio, O., Lacampagne, A., & Marks, A. R. (2023). Heart failure-induced cognitive dysfunction is mediated by intracellular Ca2+ leak through ryanodine receptor type 2. Nature Neuroscience, 26(8), 1365–1378. https://doi.org/10.1038/s41593-023-01377-6
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Murari, A., Rhooms, S.-K., Vimal, D., Hossain, K. F. B., Saini, S., Villanueva, M., Schlame, M., & Owusu-Ansah, E. (2023). Phospholipids can regulate complex I assembly independent of their role in maintaining mitochondrial membrane integrity. Cell Reports, 42(8), 112846. https://doi.org/10.1016/j.celrep.2023.112846
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Martuscello, R. T., Chen, M.-L., Reiken, S., Sittenfeld, L. R., Ruff, D. S., Ni, C.-L., Lin, C.-C., Pan, M.-K., Louis, E. D., Marks, A. R., Kuo, S.-H., & Faust, P. L. (2023). Defective cerebellar ryanodine receptor type 1 and endoplasmic reticulum calcium ‘leak’ in tremor pathophysiology. Acta Neuropathologica, 146(2), 301–318. https://doi.org/10.1007/s00401-023-02602-z
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Su, R., Zeng, J., Marcink, T. C., Porotto, M., Moscona, A., & O’Shaughnessy, B. (2023). Host Cell Membrane Capture by the SARS-CoV-2 Spike Protein Fusion Intermediate. ACS Central Science, 9(6), 1213–1228. https://doi.org/10.1021/acscentsci.3c00158
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Saini, S., & Owusu-Ansah, E. (2023). Dissecting the mechanism of regulation of a ferroptosis-like form of cell death in Drosophila melanogaster. Frontiers in Cell Death, 2. https://doi.org/10.3389/fceld.2023.1209641
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Muller, S. Z., Abbott, L. F., & Sawtell, N. B. (2023). A mechanism for differential control of axonal and dendritic spiking underlying learning in a cerebellum-like circuit. Current Biology, 33(13), 2657-2667.e4. https://doi.org/10.1016/j.cub.2023.05.040
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Bergman, S., Cater, R. J., Plante, A., Mancia, F., & Khelashvili, G. (2023). Substrate binding-induced conformational transitions in the omega-3 fatty acid transporter MFSD2A. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-39088-y
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Chen, L., Fu, L., Sun, J., Huang, Z., Fang, M., Zinkle, A., Liu, X., Lu, J., Pan, Z., Wang, Y., Liang, G., Li, X., Chen, G., & Mohammadi, M. (2023). Structural basis for FGF hormone signalling. Nature, 618(7966), 862–870. https://doi.org/10.1038/s41586-023-06155-9
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Menale, C., Trinchese, G., Aiello, I., Scalia, G., Dentice, M., Mollica, M. P., Yoon, N. A., & Diano, S. (2023). Nutrient-Dependent Mitochondrial Fission Enhances Osteoblast Function. Nutrients, 15(9), 2222. https://doi.org/10.3390/nu15092222
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Moore, M. P., Wang, X., Shi, H., Meroni, M., Cherubini, A., Ronzoni, L., Parks, E. J., Ibdah, J. A., Rector, R. S., Valenti, L., Dongiovanni, P., & Tabas, I. (2023). Circulating indian hedgehog is a marker of the hepatocyte-TAZ pathway in experimental NASH and is elevated in humans with NASH. JHEP Reports, 5(5), 100716. https://doi.org/10.1016/j.jhepr.2023.100716
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Poggio, E., Vallese, F., Hartel, A. J. W., Morgenstern, T. J., Kanner, S. A., Rauh, O., Giamogante, F., Barazzuol, L., Shepard, K. L., Colecraft, H. M., Clarke, O. B., Brini, M., & Calì, T. (2023). Perturbation of the host cell Ca2+ homeostasis and ER-mitochondria contact sites by the SARS-CoV-2 structural proteins E and M. Cell Death & Disease, 14(4). https://doi.org/10.1038/s41419-023-05817-w
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Cole, C. L., Yu, V. X., Perry, S., Seenauth, A., Lumpkin, E. A., Troche, M. S., Pitman, M. J., & Moayedi, Y. (2022). Healthy Human Laryngopharyngeal Sensory Innervation Density Correlates with Age. The Laryngoscope, 133(4), 773–784. Portico. https://doi.org/10.1002/lary.30287
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Fritschi, C. J., Anang, S., Gong, Z., Mohammadi, M., Richard, J., Bourassa, C., Severino, K. T., Richter, H., Yang, D., Chen, H.-C., Chiu, T.-J., Seaman, M. S., Madani, N., Abrams, C., Finzi, A., Hendrickson, W. A., Sodroski, J. G., & Smith, A. B. (2023). Indoline CD4-mimetic compounds mediate potent and broad HIV-1 inhibition and sensitization to antibody-dependent cellular cytotoxicity. Proceedings of the National Academy of Sciences, 120(13). https://doi.org/10.1073/pnas.2222073120
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Padavannil, A., Murari, A., Rhooms, S.-K., Owusu-Ansah, E., & Letts, J. A. (2023). Resting mitochondrial complex I from Drosophila melanogaster adopts a helix-locked state. ELife, 12. CLOCKSS. https://doi.org/10.7554/elife.84415
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Labella, R., Vujačić, M., & Trivanović, D. (2023). Bone Marrow Adipose Tissue: Regulation of Osteoblastic Niche, Hematopoiesis and Hematological Malignancies. Stem Cell Reviews and Reports, 19(5), 1135–1151. https://doi.org/10.1007/s12015-023-10531-3
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Xue, N., Liu, X., Zhang, D., Wu, Y., Zhong, Y., Wang, J., Fan, W., Jiang, H., Zhu, B., Ge, X., Gonzalez, R. V. L., Chen, L., Zhang, S., She, P., Zhong, Z., Sun, J., Chen, X., Wang, L., Gu, Z., … Zhang, X. (2023). Improving adenine and dual base editors through introduction of TadA-8e and Rad51DBD. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-36887-1
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Galindo, S. E., Wood, A. J., Cooney, P. C., Hammond, L. A., & Grueber, W. B. (2023). Axon–axon interactions determine modality-specific wiring and subcellular synaptic specificity in a somatosensory circuit. Development, 150(5). https://doi.org/10.1242/dev.199832
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Schilperoort, M., Ngai, D., Katerelos, M., Power, D. A., & Tabas, I. (2023). PFKFB2-mediated glycolysis promotes lactate-driven continual efferocytosis by macrophages. Nature Metabolism, 5(3), 431–444. https://doi.org/10.1038/s42255-023-00736-8
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Moayedi, Y., Xu, S., Obayashi, S. K., Hoffman, B. U., Gerling, G. J., & Lumpkin, E. A. (2023). The cellular basis of mechanosensation in mammalian tongue. Cell Reports, 42(2), 112087. https://doi.org/10.1016/j.celrep.2023.112087
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Marcink, T. C., Zipursky, G., Cheng, W., Stearns, K., Stenglein, S., Golub, K., Cohen, F., Bovier, F., Pfalmer, D., Greninger, A. L., Porotto, M., des Georges, A., & Moscona, A. (2023). Subnanometer structure of an enveloped virus fusion complex on viral surface reveals new entry mechanisms. Science Advances, 9(6). https://doi.org/10.1126/sciadv.ade2727
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Zou, X., Wu, X., Sampson, K. J., Colecraft, H. M., Larsson, H. P., & Kass, R. S. (2022). Pharmacological rescue of specific long QT variants of KCNQ1/KCNE1 channels. Frontiers in Physiology, 13. https://doi.org/10.3389/fphys.2022.902224
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Vimal, D., D’Souza, L. C., Rai, V., Lal, S., Sharma, A., & Gupta, S. C. (2023). Efficacy of Cannabis and its Constituents in Disease Management: Insights from Clinical Studies. Current Medicinal Chemistry, 30(2), 178–202. https://doi.org/10.2174/0929867329666220525124818
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Good, P. I., Li, L., Hurst, H. A., Serrano Herrera, I., Xu, K., Rao, M., Bateman, D. A., Al-Awqati, Q., D’Agati, V. D., Costantini, F., & Lin, F. (2023). Low nephron endowment increases susceptibility to renal stress and chronic kidney disease. JCI Insight, 8(3). https://doi.org/10.1172/jci.insight.161316
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Jayaraman, S., Alacay, T.-L., Rivero Morfin, P. J. del, Lauris Kochiss, A., & Ben-Johny, M. (2023). FacePalm: Probing dynamic S-palmitoylation of CaV channel complexes using engineered depalmitoylases. Biophysical Journal, 122(3), 310a. https://doi.org/10.1016/j.bpj.2022.11.1744
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Hussey, J. W., DeMarco, E., DiSilvestre, D., Jensen, H. H., Ben-Johny, M., Nyegaard, M., Overgaard, M. T., & Dick, I. E. (2023). Disease-associated calmodulin variants impair regulation of neuronal voltage-gated calcium channels. Biophysical Journal, 122(3), 105a. https://doi.org/10.1016/j.bpj.2022.11.754
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Petrou, V. I., Ashraf, K. U., Rosario-Garrido, S., & Mancia, F. (2023). The structural basis of lipid A modification with aminoarabinose revealed by cryoEM structures of S. enterica ArnT. Biophysical Journal, 122(3), 447a. https://doi.org/10.1016/j.bpj.2022.11.2411
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Karasawa, A., Liu, H., Quick, M., Hendrickson, W. A., & Liu, Q. (2023). Crystallographic Characterization of Sodium Ions in a Bacterial Leucine/Sodium Symporter. Crystals, 13(2), 183. https://doi.org/10.3390/cryst13020183
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Romagnoli, A., D’Agostino, M., Pavoni, E., Ardiccioni, C., Motta, S., Crippa, P., Biagetti, G., Notarstefano, V., Rexha, J., Perta, N., Barocci, S., Costabile, B. K., Colasurdo, G., Caucci, S., Mencarelli, D., Turchetti, C., Farina, M., Pierantoni, L., La Teana, A., … Di Marino, D. (2023). SARS-CoV-2 multi-variant rapid detector based on graphene transistor functionalized with an engineered dimeric ACE2 receptor. Nano Today, 48, 101729. https://doi.org/10.1016/j.nantod.2022.101729
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Qian, N., Goldberg, M. E., & Zhang, M. (2023). Tuning curves vs. population responses, and perceptual consequences of receptive-field remapping. Frontiers in Computational Neuroscience, 16. https://doi.org/10.3389/fncom.2022.1060757
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Chaplain, C., Fritschi, C. J., Anang, S., Gong, Z., Richard, J., Bourassa, C., Liang, S., Mohammadi, M., Park, J., Finzi, A., Madani, N., Sodroski, J. G., Abrams, C. F., Hendrickson, W. A., & Smith, A. B. (2022). Structural and Functional Characterization of Indane-Core CD4-Mimetic Compounds Substituted with Heterocyclic Amines. ACS Medicinal Chemistry Letters, 14(1), 51–58. https://doi.org/10.1021/acsmedchemlett.2c00376
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Qian, J., Guan, X., Xie, B., Xu, C., Niu, J., Tang, X., Li, C. H., Colecraft, H. M., Jaenisch, R., & Liu, X. S. (2023). Multiplex epigenome editing of MECP2 to rescue Rett syndrome neurons. Science Translational Medicine, 15(679). https://doi.org/10.1126/scitranslmed.add4666
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Labella, R., Ali, A., Mosialou, I., De Angelis, J., Vgenopoulou, P., Zhao, J., Vanderberg, A., Rabadan, R., Raza, A., & Kousteni, S. (2023). 2013 – MESENCHYMAL STROMAL CELL MITOCHONDRIAL TRANSFER FUELS MDS TO AML TRANSFORMATION. Experimental Hematology, 124, S43. https://doi.org/10.1016/j.exphem.2023.06.050
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Krzisch, M. A., Wu, H., Yuan, B., Whitfield, T. W., Liu, X. S., Fu, D., Garrett-Engele, C. M., Khalil, A. S., Lungjangwa, T., Shih, J., Chang, A. N., Warren, S., Cacace, A., Andrykovich, K. R., Rietjens, R. G. J., Wallace, O., Sur, M., Jain, B., & Jaenisch, R. (2023). Fragile X Syndrome Patient–Derived Neurons Developing in the Mouse Brain Show FMR1-Dependent Phenotypes. Biological Psychiatry, 93(1), 71–81. https://doi.org/10.1016/j.biopsych.2022.08.020
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Wronska, A. (2022). The Role of microRNA in the Development, Diagnosis, and Treatment of Cardiovascular Disease: Recent Developments. Journal of Pharmacology and Experimental Therapeutics, 384(1), 123–132. https://doi.org/10.1124/jpet.121.001152
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Gong, Z., Wang, W., El Omari, K., Lebedev, A. A., Clarke, O. B., & Hendrickson, W. A. (2022). Crystal structure of LGR ligand α2/β5 from Caenorhabditis elegans with implications for the evolution of glycoprotein hormones. Proceedings of the National Academy of Sciences, 120(1). https://doi.org/10.1073/pnas.2218630120
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Hossain, K. F. B., Murari, A., Mishra, B., & Owusu-Ansah, E. (2022). The membrane domain of respiratory complex I accumulates during muscle aging in Drosophila melanogaster. Scientific Reports, 12(1). https://doi.org/10.1038/s41598-022-26414-5
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Young, B. D., Cook, M. E., Costabile, B. K., Samanta, R., Zhuang, X., Sevdalis, S. E., Varney, K. M., Mancia, F., Matysiak, S., Lattman, E., & Weber, D. J. (2022). Binding and Functional Folding (BFF): A Physiological Framework for Studying Biomolecular Interactions and Allostery. Journal of Molecular Biology, 434(23), 167872. https://doi.org/10.1016/j.jmb.2022.167872
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