Oh, S., Khani-Habibabadi, F., O’Connor, K. C., & Payne, A. S. (2025). Composition and function of AChR chimeric autoantibody receptor T cells for antigen-specific B cell depletion in myasthenia gravis. Science Advances, 11(9). https://doi.org/10.1126/sciadv.adt0795

Merkel, R., Hernandez, N. S., Weir, V., Zhang, Y., Caffrey, A., Rich, M. T., Crist, R. C., Reiner, B. C., & Schmidt, H. D. (2025). An endogenous GLP-1 circuit engages VTA GABA neurons to regulate mesolimbic dopamine neurons and attenuate cocaine seeking. Science Advances, 11(9). https://doi.org/10.1126/sciadv.adr5051

Verde, E. M., Antoniani, F., Mediani, L., Secco, V., Crotti, S., Ferrara, M. C., Vinet, J., Sergeeva, A., Yan, X., Hoege, C., Stuani, C., Paron, F., Kao, T.-T., Shrivastava, R., Polanowska, J., Bailly, A., Rosa, A., Aronica, E., Goswami, A., … Carra, S. (2025). SUMO2/3 conjugation of TDP-43 protects against aggregation. Science Advances, 11(8). https://doi.org/10.1126/sciadv.adq2475

Orouji, S., Liu, M. C., Korem, T., & Peters, M. A. K. (2024). Domain adaptation in small-scale and heterogeneous biological datasets. Science Advances, 10(51). https://doi.org/10.1126/sciadv.adp6040

Gomez-Gonzalez, P.-J., Gupta, A., Drought, L. G., Patel, A., Okombo, J., van der Watt, M., Walker-Gray, R., Schindler, K. A., Burkhard, A. Y., Yeo, T., Narwal, S. K., Bloxham, T. S., Flueck, C., Walker, E. M., Rey, J. A., Fairhurst, K. J., Reader, J., Park, H., Pollard, H. G., … Baker, D. A. (2024). Inhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission. Science Advances, 10(49). https://doi.org/10.1126/sciadv.adq1383

del Rivero Morfin, P. J., Chavez, D. S., Jayaraman, S., Yang, L., Geisler, S. M., Kochiss, A. L., Tuluc, P., Colecraft, H. M., Marx, S. O., Liu, X. S., Rajadhyaksha, A. M., & Ben-Johny, M. (2024). A genetically encoded actuator boosts L-type calcium channel function in diverse physiological settings. Science Advances, 10(44). https://doi.org/10.1126/sciadv.adq3374

Ardanaz, C. G., de la Cruz, A., Minhas, P. S., Hernández-Martín, N., Pozo, M. Á., Valdecantos, M. P., Valverde, Á. M., Villa-Valverde, P., Elizalde-Horcada, M., Puerta, E., Ramírez, M. J., Ortega, J. E., Urbiola, A., Ederra, C., Ariz, M., Ortiz-de-Solórzano, C., Fernández-Irigoyen, J., Santamaría, E., Karsenty, G., … Solas, M. (2024). Astrocytic GLUT1 reduction paradoxically improves central and peripheral glucose homeostasis. Science Advances, 10(42). https://doi.org/10.1126/sciadv.adp1115

Zhang, Y., Karagiannis, D., Liu, H., Lin, M., Fang, Y., Jiang, M., Chen, X., Suresh, S., Huang, H., She, J., Shi, F., Liu, J., Luo, D., Angel, J. C., Lin, G., Yang, P., El-Rifai, W., Zaika, A., Oro, A. E., … Que, J. (2024). Epigenetic regulation of p63 blocks squamous-to-neuroendocrine transdifferentiation in esophageal development and malignancy. Science Advances, 10(41). https://doi.org/10.1126/sciadv.adq0479

Gretarsson, K. H., Abini-Agbomson, S., Gloor, S. L., Weinberg, D. N., McCuiston, J. L., Kumary, V. U. S., Hickman, A. R., Sahu, V., Lee, R., Xu, X., Lipieta, N., Flashner, S., Adeleke, O. A., Popova, I. K., Taylor, H. F., Noll, K., Windham, C. L., Maryanski, D. N., Venters, B. J., … Lu, C. (2024). Cancer-associated DNA hypermethylation of Polycomb targets requires DNMT3A dual recognition of histone H2AK119 ubiquitination and the nucleosome acidic patch. Science Advances, 10(35). https://doi.org/10.1126/sciadv.adp0975

Shaman, J., Kandula, S., Pei, S., Galanti, M., Olfson, M., Gould, M., & Keyes, K. (2024). Quantifying suicide contagion at population scale. Science Advances, 10(31). https://doi.org/10.1126/sciadv.adq4074

Lee, J., Jeong, Y., Park, S., Kim, S., Oh, H., Jin, J.-A., Sohn, J.-W., Kim, D., Shin, H.-S., & Do Heo, W. (2024). Phospholipase C beta 1 in the dentate gyrus gates fear memory formation through regulation of neuronal excitability. Science Advances, 10(27). https://doi.org/10.1126/sciadv.adj4433

Roy, R. K., Yao, Y., Green, I. K., Aitken, A. V., Biancardi, V. C., Silver, R., & Stern, J. E. (2024). Blood flows from the SCN toward the OVLT within a new brain vascular portal pathway. Science Advances, 10(25). https://doi.org/10.1126/sciadv.adn8350

Su, Z., Liu, Y., Xia, Z., Rustgi, A. K., & Gu, W. (2024). An unexpected role for the ketogenic diet in triggering tumor metastasis by modulating BACH1-mediated transcription. Science Advances, 10(23). https://doi.org/10.1126/sciadv.adm9481

Serra-Cardona, A., Hua, X., McNutt, S. W., Zhou, H., Toda, T., Jia, S., Chu, F., & Zhang, Z. (2024). The PCNA–Pol δ complex couples lagging strand DNA synthesis to parental histone transfer for epigenetic inheritance. Science Advances, 10(23). https://doi.org/10.1126/sciadv.adn5175

Cullati, S. N., Akizuki, K., Chen, J.-S., Johnson, J. L., Yaron-Barir, T. M., Cantley, L. C., & Gould, K. L. (2024). Substrate displacement of CK1 C-termini regulates kinase specificity. Science Advances, 10(19). https://doi.org/10.1126/sciadv.adj5185

Kim, J., Kratz, A. F., Chen, S., Sheng, J., Kim, H. K., Zhang, L., Singh, B. K., & Chavez, A. (2024). High-throughput tagging of endogenous loci for rapid characterization of protein function. Science Advances, 10(18). https://doi.org/10.1126/sciadv.adg8771

Nadezhdin, K. D., Neuberger, A., Khosrof, L. S., Talyzina, I. A., Khau, J., Yelshanskaya, M. V., & Sobolevsky, A. I. (2024). TRPV3 activation by different agonists accompanied by lipid dissociation from the vanilloid site. Science Advances, 10(18). https://doi.org/10.1126/sciadv.adn2453

Chen, F., Tang, C., Yang, F., Ekpenyong, A., Qin, R., Xie, J., Momen-Heravi, F., Saba, N. F., & Teng, Y. (2024). HSP90 inhibition suppresses tumor glycolytic flux to potentiate the therapeutic efficacy of radiotherapy for head and neck cancer. Science Advances, 10(8). https://doi.org/10.1126/sciadv.adk3663

Reyes Nieva, H., Bakken, S., & Elhadad, N. (2024). Mining the health disparities and minority health bibliome: A computational scoping review and gap analysis of 200,000+ articles. Science Advances, 10(4). https://doi.org/10.1126/sciadv.adf9033

Kim, C., Wang, X.-D., Liu, Z., Hao, J., Wang, S., Li, P., Zi, Z., Ding, Q., Jang, S., Kim, J., Luo, Y., Huffman, K. E., Pal Choudhuri, S., del Rio, S., Cai, L., Liang, H., Drapkin, B. J., Minna, J. D., & Yu, Y. (2024). Induced degradation of lineage-specific oncoproteins drives the therapeutic vulnerability of small cell lung cancer to PARP inhibitors. Science Advances, 10(3). https://doi.org/10.1126/sciadv.adh2579

Mok, S., Yeo, T., Hong, D., Shears, M. J., Ross, L. S., Ward, K. E., Dhingra, S. K., Kanai, M., Bridgford, J. L., Tripathi, A. K., Mlambo, G., Burkhard, A. Y., Ansbro, M. R., Fairhurst, K. J., Gil-Iturbe, E., Park, H., Rozenberg, F. D., Kim, J., Mancia, F., … Fidock, D. A. (2023). Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness. Science Advances, 9(45). https://doi.org/10.1126/sciadv.adi2364

Herb, B. R., Glover, H. J., Bhaduri, A., Colantuoni, C., Bale, T. L., Siletti, K., Hodge, R., Lein, E., Kriegstein, A. R., Doege, C. A., & Ament, S. A. (2023). Single-cell genomics reveals region-specific developmental trajectories underlying neuronal diversity in the human hypothalamus. Science Advances, 9(45). https://doi.org/10.1126/sciadv.adf6251

Li, P., Zhen, Y., Kim, C., Liu, Z., Hao, J., Deng, H., Deng, H., Zhou, M., Wang, X.-D., Qin, T., & Yu, Y. (2023). Nimbolide targets RNF114 to induce the trapping of PARP1 and synthetic lethality in BRCA -mutated cancer. Science Advances, 9(43). https://doi.org/10.1126/sciadv.adg7752

Wang, L., Hall, C. E., Uchikawa, E., Chen, D., Choi, E., Zhang, X., & Bai, X. (2023). Structural basis of insulin fibrillation. Science Advances, 9(37). https://doi.org/10.1126/sciadv.adi1057

Parks, R. M., Kontis, V., Anderson, G. B., Baldwin, J. W., Danaei, G., Toumi, R., Dominici, F., Ezzati, M., & Kioumourtzoglou, M.-A. (2023). Short-term excess mortality following tropical cyclones in the United States. Science Advances, 9(33). https://doi.org/10.1126/sciadv.adg6633

Thomas, J. F., Valencia-Sánchez, M. I., Tamburri, S., Gloor, S. L., Rustichelli, S., Godínez-López, V., De Ioannes, P., Lee, R., Abini-Agbomson, S., Gretarsson, K., Burg, J. M., Hickman, A. R., Sun, L., Gopinath, S., Taylor, H. F., Sun, Z.-W., Ezell, R. J., Vaidya, A., Meiners, M. J., … Armache, K.-J. (2023). Structural basis of histone H2A lysine 119 deubiquitination by Polycomb repressive deubiquitinase BAP1/ASXL1. Science Advances, 9(32). https://doi.org/10.1126/sciadv.adg9832

Zheng, C., Wei, Y., Zhang, Q., Sun, M., Wang, Y., Hou, J., Zhang, P., Lv, X., Su, D., Jiang, Y., Gumin, J., Sahni, N., Hu, B., Wang, W., Chen, X., McGrail, D. J., Zhang, C., Huang, S., Xu, H., … Chen, Y. (2023). Multiomics analyses reveal DARS1-AS1 /YBX1–controlled posttranscriptional circuits promoting glioblastoma tumorigenesis/radioresistance. Science Advances, 9(31). https://doi.org/10.1126/sciadv.adf3984

Armada-Moreira, A., Dar, A. M., Zhao, Z., Cea, C., Gelinas, J., Berggren, M., Costa, A., Khodagholy, D., & Stavrinidou, E. (2023). Plant electrophysiology with conformable organic electronics: Deciphering the propagation of Venus flytrap action potentials. Science Advances, 9(30). https://doi.org/10.1126/sciadv.adh4443

Zhang, N., Zhang, H., Khan, L. A., Jafari, G., Eun, Y., Membreno, E., & Gobel, V. (2023). The biosynthetic-secretory pathway, supplemented by recycling routes, determines epithelial membrane polarity. Science Advances, 9(26). https://doi.org/10.1126/sciadv.ade4620

Mashiko, S., Shihab, R. R., See, S. B., Schahadat, L. G. Z., Aguiar, T. F. M., Roy, P., Porcheray, F., & Zorn, E. (2023). Broad responses to chemical adducts shape the natural antibody repertoire in early infancy. Science Advances, 9(19). https://doi.org/10.1126/sciadv.ade8872

Patterson, V., Ullah, F., Bryant, L., Li, D., Griffin, J. N., Sidhu, A., Saliganan, S., Blaile, M., Saenz, M. S., Smith, R., Ellingwood, S., Grange, D. K., Hu, X., Mireguli, M., Luo, Y., Shen, Y., Mulhern, M., Zackai, E., Ritter, A., … Bhoj, E. (2023). Abrogation of MAP4K4 protein function causes congenital anomalies in humans and zebrafish. Science Advances, 9(17). https://doi.org/10.1126/sciadv.ade0631

Vogt, M. C., & Hobert, O. (2023). Starvation-induced changes in somatic insulin/IGF-1R signaling drive metabolic programming across generations. Science Advances, 9(14). https://doi.org/10.1126/sciadv.ade1817

Langelier, M.-F., Lin, X., Zha, S., & Pascal, J. M. (2023). Clinical PARP inhibitors allosterically induce PARP2 retention on DNA. Science Advances, 9(12). https://doi.org/10.1126/sciadv.adf7175

Savage, T. M., Vincent, R. L., Rae, S. S., Huang, L. H., Ahn, A., Pu, K., Li, F., de los Santos-Alexis, K., Coker, C., Danino, T., & Arpaia, N. (2023). Chemokines expressed by engineered bacteria recruit and orchestrate antitumor immunity. Science Advances, 9(10). https://doi.org/10.1126/sciadv.adc9436

Sheppard, S. E., Bryant, L., Wickramasekara, R. N., Vaccaro, C., Robertson, B., Hallgren, J., Hulen, J., Watson, C. J., Faundes, V., Duffourd, Y., Lee, P., Simon, M. C., de la Cruz, X., Padilla, N., Flores-Mendez, M., Akizu, N., Smiler, J., Pellegrino Da Silva, R., Li, D., … Stessman, H. A. F. (2023). Mechanism of KMT5B haploinsufficiency in neurodevelopment in humans and mice. Science Advances, 9(10). https://doi.org/10.1126/sciadv.ade1463

Gouveia Roque, C., Chung, K. M., McCurdy, E. P., Jagannathan, R., Randolph, L. K., Herline-Killian, K., Baleriola, J., & Hengst, U. (2023). CREB3L2-ATF4 heterodimerization defines a transcriptional hub of Alzheimer’s disease gene expression linked to neuropathology. Science Advances, 9(9). https://doi.org/10.1126/sciadv.add2671

de Prisco, N., Ford, C., Elrod, N. D., Lee, W., Tang, L. C., Huang, K.-L., Lin, A., Ji, P., Jonnakuti, V. S., Boyle, L., Cabaj, M., Botta, S., Õunap, K., Reinson, K., Wojcik, M. H., Rosenfeld, J. A., Bi, W., Tveten, K., Prescott, T., … Gennarino, V. A. (2023). Alternative polyadenylation alters protein dosage by switching between intronic and 3′UTR sites. Science Advances, 9(7). https://doi.org/10.1126/sciadv.ade4814

Marcink, T. C., Zipursky, G., Cheng, W., Stearns, K., Stenglein, S., Golub, K., Cohen, F., Bovier, F., Pfalmer, D., Greninger, A. L., Porotto, M., des Georges, A., & Moscona, A. (2023). Subnanometer structure of an enveloped virus fusion complex on viral surface reveals new entry mechanisms. Science Advances, 9(6). https://doi.org/10.1126/sciadv.ade2727

Pappalardo, A., Alvarez Cespedes, D., Fang, S., Herschman, A. R., Jeon, E. Y., Myers, K. M., Kysar, J. W., & Abaci, H. E. (2023). Engineering edgeless human skin with enhanced biomechanical properties. Science Advances, 9(4). https://doi.org/10.1126/sciadv.ade2514

Hsu, D. J., Gao, J., Yamaguchi, N., Pinzaru, A., Wu, Q., Mandayam, N., Liberti, M., Heissel, S., Alwaseem, H., Tavazoie, S., & Tavazoie, S. F. (2023). Arginine limitation drives a directed codon-dependent DNA sequence evolution response in colorectal cancer cells. Science Advances, 9(1). https://doi.org/10.1126/sciadv.ade9120

Ratanatharathorn, A., Chibnik, L. B., Koenen, K. C., Weisskopf, M. G., & Roberts, A. L. (2022). Association of maternal polygenic risk scores for mental illness with perinatal risk factors for offspring mental illness. Science Advances, 8(50). https://doi.org/10.1126/sciadv.abn3740

Cheng, F., Zheng, W., Liu, C., Barbuti, P. A., Yu-Taeger, L., Casadei, N., Huebener-Schmid, J., Admard, J., Boldt, K., Junger, K., Ueffing, M., Houlden, H., Sharma, M., Kruger, R., Grundmann-Hauser, K., Ott, T., & Riess, O. (2022). Intronic enhancers of the human SNCA gene predominantly regulate its expression in brain in vivo. Science Advances, 8(47). https://doi.org/10.1126/sciadv.abq6324

Iturria-Medina, Y., Adewale, Q., Khan, A. F., Ducharme, S., Rosa-Neto, P., O’Donnell, K., Petyuk, V. A., Gauthier, S., De Jager, P. L., Breitner, J., & Bennett, D. A. (2022). Unified epigenomic, transcriptomic, proteomic, and metabolomic taxonomy of Alzheimer’s disease progression and heterogeneity. Science Advances, 8(46). https://doi.org/10.1126/sciadv.abo6764

Marcink, T. C., Kicmal, T., Armbruster, E., Zhang, Z., Zipursky, G., Golub, K. L., Idris, M., Khao, J., Drew-Bear, J., McGill, G., Gallagher, T., Porotto, M., des Georges, A., & Moscona, A. (2022). Intermediates in SARS-CoV-2 spike–mediated cell entry. Science Advances, 8(33). https://doi.org/10.1126/sciadv.abo3153

Skendros, P., Germanidis, G., Mastellos, D. C., Antoniadou, C., Gavriilidis, E., Kalopitas, G., Samakidou, A., Liontos, A., Chrysanthopoulou, A., Ntinopoulou, M., Kogias, D., Karanika, I., Smyrlis, A., Cepaityte, D., Fotiadou, I., Zioga, N., Mitroulis, I., Gatselis, N. K., Papagoras, C., … Lambris, J. D. (2022). Complement C3 inhibition in severe COVID-19 using compstatin AMY-101. Science Advances, 8(33). https://doi.org/10.1126/sciadv.abo2341

Miotto, M. C., Weninger, G., Dridi, H., Yuan, Q., Liu, Y., Wronska, A., Melville, Z., Sittenfeld, L., Reiken, S., & Marks, A. R. (2022). Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment. Science Advances, 8(29). https://doi.org/10.1126/sciadv.abo1272

Yang, J.-M., Ren, Y., Kumar, A., Xiong, X., Das, J. K., Peng, H.-Y., Wang, L., Ren, X., Zhang, Y., Ji, C., Cheng, Y., Zhang, L., Alaniz, R. C., de Figueiredo, P., Fang, D., Zhou, H., Liu, X., Wang, J., & Song, J. (2022). NAC1 modulates autoimmunity by suppressing regulatory T cell–mediated tolerance. Science Advances, 8(26). https://doi.org/10.1126/sciadv.abo0183

Meng, Z., Li, F.-L., Fang, C., Yeoman, B., Qiu, Y., Wang, Y., Cai, X., Lin, K. C., Yang, D., Luo, M., Fu, V., Ma, X., Diao, Y., Giancotti, F. G., Ren, B., Engler, A. J., & Guan, K.-L. (2022). The Hippo pathway mediates Semaphorin signaling. Science Advances, 8(21). https://doi.org/10.1126/sciadv.abl9806

Zhu, C., Langley, J. A., Ziska, L. H., Cahoon, D. R., & Megonigal, J. P. (2022). Accelerated sea-level rise is suppressing CO 2 stimulation of tidal marsh productivity: A 33-year study. Science Advances, 8(20). https://doi.org/10.1126/sciadv.abn0054

Serra-Cardona, A., Duan, S., Yu, C., & Zhang, Z. (2022). H3K4me3 recognition by the COMPASS complex facilitates the restoration of this histone mark following DNA replication. Science Advances, 8(18). https://doi.org/10.1126/sciadv.abm6246