Indoline CD4-mimetic compounds mediate potent and broad HIV-1 inhibition and sensitization to antibody-dependent cellular cytotoxicity

Fritschi, C. J., Anang, S., Gong, Z., Mohammadi, M., Richard, J., Bourassa, C., Severino, K. T., Richter, H., Yang, D., Chen, H.-C., Chiu, T.-J., Seaman, M. S., Madani, N., Abrams, C., Finzi, A., Hendrickson, W. A., Sodroski, J. G., & Smith, A. B. (2023). Indoline CD4-mimetic compounds mediate potent and broad HIV-1 inhibition and sensitization to antibody-dependent cellular cytotoxicity. Proceedings of the National Academy of Sciences, 120(13). https://doi.org/10.1073/pnas.2222073120
Authors:
Christopher J Fritschi
Saumya Anang
Zhen Gong
Mohammadjavad Mohammadi
Jonathan Richard
Catherine Bourassa
Kenny T Severino
Hannah Richter
Derek Yang
Hung-Ching Chen
Ta-Jung Chiu
Michael S Seaman
Navid Madani
Cameron Abrams
Andrés Finzi
Wayne A Hendrickson
Joseph G Sodroski
Amos B Smith
Affiliated Authors:
Zhen Gong
Wayne A Hendrickson
Subjects:
HIV-1 (MeSH)
Author Keywords:
antibody-dependent cellular cytotoxicity
antiretroviral therapy
entry inhibitor
gp120
structure-based drug design
Publication Type:
Article
Unique ID:
10.1073/pnas.2222073120
PMID:
Publication Date:
Data Source:
PubMed

Record Created: