Department of Genetics and Development

Displaying 351 - 400 of 413CSV
de Prisco, N., Botta, S., Lee, W., Rezazadeh, S., Chemiakine, A., & Gennarino, V. A. (2022). Determining the effects of loss of function mutations in human cell lines. STAR Protocols, 3(2), 101232. https://doi.org/10.1016/j.xpro.2022.101232
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Wang, Q., de Prisco, N., Tang, J., & Gennarino, V. A. (2022). Protocol for recording epileptiform discharges of EEG and behavioral seizures in freely moving mice. STAR Protocols, 3(2), 101245. https://doi.org/10.1016/j.xpro.2022.101245
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Alvarez, S., da Silva Almeida, A. C., Albero, R., Biswas, M., Barreto-Galvez, A., Gunning, T. S., Shaikh, A., Aparicio, T., Wendorff, A., Piovan, E., Van Vlierberghe, P., Gygi, S., Gautier, J., Madireddy, A., & A. Ferrando, A. (2022). Functional mapping of PHF6 complexes in chromatin remodeling, replication dynamics, and DNA repair. Blood, 139(23), 3418–3429. https://doi.org/10.1182/blood.2021014103
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Simunovic, M., Siggia, E. D., & Brivanlou, A. H. (2022). In vitro attachment and symmetry breaking of a human embryo model assembled from primed embryonic stem cells. Cell Stem Cell, 29(6), 962-972.e4. https://doi.org/10.1016/j.stem.2022.05.001
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Chakouri, N., Rivas, S., Roybal, D., Yang, L., Diaz, J., Hsu, A. L., Mahling, R., Chen, B.-X., Owoyemi, J. O., DiSilvestre, D., Sirabella, D., Corneo, B., Tomaselli, G. F., Dick, I. E., Marx, S. O., & Ben-Johny, M. (2022). Fibroblast growth factor homologous factors serve as a molecular rheostat in tuning arrhythmogenic cardiac late sodium current. Nature Cardiovascular Research, 1(5), 1–13. https://doi.org/10.1038/s44161-022-00060-6
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Minns, H. E., Padilla, O., Wei, H.-J., Webster-Carrion, A., Tazhibi, M., McQuillan, N., Zhang, X., Yeh, R., Zhang, Z., Szalontay, L., Pavisic, J., Garty, G., Garvin, J., Zacharoulis, S., Canoll, P., Vanpouille-Box, C. I., Menon, V., Olah, M., Rabadan, R., … Gartrell, R. D. (2022). DIPG-45. Radiation induces a robust interferon response in Diffuse Midline Glioma (DMG), improving the potential for combination immunotherapy. Neuro-Oncology, 24(Supplement_1), i28–i29. https://doi.org/10.1093/neuonc/noac079.102
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Webster Carrion, A., Wei, H.-J., McQuillan, N., Tazhibi, M., Kokossis, D., Berg, X., Minns, H., Zhang, X., Zhang, Z., Wang, J., Fernandez, E. C., Jan, C.-I., Padilla, O., Gartrell, R. D., Becher, O., Jr, J. H. G., Pavisic, J., Szalontay, L., Konofagou, E. E., … Wu, C.-C. (2022). MODL-24. Focused ultrasound-mediated blood-brain barrier opening and panobinostat in a thalamic syngeneic murine DMG model is feasible and safe. Neuro-Oncology, 24(Supplement_1), i174–i174. https://doi.org/10.1093/neuonc/noac079.647
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Hisamori, S., Mukohyama, J., Koul, S., Hayashi, T., Rothenberg, M. E., Maeda, M., Isobe, T., Valencia Salazar, L. E., Qian, X., Johnston, D. M., Qian, D., Lao, K., Asai, N., Kakeji, Y., Gennarino, V. A., Sahoo, D., Dalerba, P., & Shimono, Y. (2022). Upregulation of BMI1-suppressor miRNAs (miR-200c, miR-203) during terminal differentiation of colon epithelial cells. Journal of Gastroenterology, 57(6), 407–422. https://doi.org/10.1007/s00535-022-01865-9
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McQuillan, N., Tazhibi, M., Wei, H.-J., Pouliopoulos, A., Bendau, E., Carrion, A. W., Berg, A., Kokossis, D., Zhang, X., Zhang, Z., Englander, Z., Yoh, N., Jan, C.-I., Gartrell, R. D., Garvin, J., Szalontay, L., Konofagou, E., Zacharoulis, S., & Wu, C.-C. (2022). MODL-25. Radiation and focused ultrasound–mediated blood–brain barrier opening for DMG: safety and feasibility of combinatorial therapy. Neuro-Oncology, 24(Supplement_1), i174–i174. https://doi.org/10.1093/neuonc/noac079.648
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Köttgen, A., Cornec-Le Gall, E., Halbritter, J., Kiryluk, K., Mallett, A. J., Parekh, R. S., Rasouly, H. M., Sampson, M. G., Tin, A., Antignac, C., Ars, E., Bergmann, C., Bleyer, A. J., Bockenhauer, D., Devuyst, O., Florez, J. C., Fowler, K. J., Franceschini, N., Fukagawa, M., … Gharavi, A. G. (2022). Genetics in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney International, 101(6), 1126–1141. https://doi.org/10.1016/j.kint.2022.03.019
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Meng, Z., Li, F.-L., Fang, C., Yeoman, B., Qiu, Y., Wang, Y., Cai, X., Lin, K. C., Yang, D., Luo, M., Fu, V., Ma, X., Diao, Y., Giancotti, F. G., Ren, B., Engler, A. J., & Guan, K.-L. (2022). The Hippo pathway mediates Semaphorin signaling. Science Advances, 8(21). https://doi.org/10.1126/sciadv.abl9806
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Pal, I., Grilo, A. M. S., Gaspary, A., Das Sharma, S., Scotto, L., O’Connor, O. A., Jovanovic, M., Deng, C., & Berchowitz, L. E. (2022). Inhibition of casein kinase 1δ disrupts translation initiation and exerts potent antilymphoma activity. Blood Advances, 6(14), 4157–4161. https://doi.org/10.1182/bloodadvances.2021006833
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Karsenty, G., & Khosla, S. (2022). The crosstalk between bone remodeling and energy metabolism: A translational perspective. Cell Metabolism, 34(6), 805–817. https://doi.org/10.1016/j.cmet.2022.04.010
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Cambuli, F., Foletto, V., Alaimo, A., De Felice, D., Gandolfi, F., Palumbieri, M. D., Zaffagni, M., Genovesi, S., Lorenzoni, M., Celotti, M., Bertossio, E., Mazzero, G., Bertossi, A., Bisio, A., Berardinelli, F., Antoccia, A., Gaspari, M., Barbareschi, M., Fiorentino, M., … Lunardi, A. (2022). Intra‐epithelial non‐canonical Activin A signaling safeguards prostate progenitor quiescence. EMBO Reports, 23(5). Portico. https://doi.org/10.15252/embr.202154049
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Herod, S. G., Dyatel, A., Hodapp, S., Jovanovic, M., & Berchowitz, L. E. (2022). Clearance of an amyloid-like translational repressor is governed by 14-3-3 proteins. Cell Reports, 39(5), 110753. https://doi.org/10.1016/j.celrep.2022.110753
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Chen, H., Hu, B., Horth, C., Bareke, E., Rosenbaum, P., Kwon, S. Y., Sirois, J., Weinberg, D. N., Robison, F. M., Garcia, B. A., Lu, C., Pastor, W. A., & Majewski, J. (2022). H3K36 dimethylation shapes the epigenetic interaction landscape by directing repressive chromatin modifications in embryonic stem cells. Genome Research. https://doi.org/10.1101/gr.276383.121
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Ronaldson-Bouchard, K., Teles, D., Yeager, K., Tavakol, D. N., Zhao, Y., Chramiec, A., Tagore, S., Summers, M., Stylianos, S., Tamargo, M., Lee, B. M., Halligan, S. P., Abaci, E. H., Guo, Z., Jacków, J., Pappalardo, A., Shih, J., Soni, R. K., Sonar, S., … Vunjak-Novakovic, G. (2022). A multi-organ chip with matured tissue niches linked by vascular flow. Nature Biomedical Engineering, 6(4), 351–371. https://doi.org/10.1038/s41551-022-00882-6
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Gavade, J. N., Puccia, C. M., Herod, S. G., Trinidad, J. C., Berchowitz, L. E., & Lacefield, S. (2022). Identification of 14-3-3 proteins, Polo kinase, and RNA-binding protein Pes4 as key regulators of meiotic commitment in budding yeast. Current Biology, 32(7), 1534-1547.e9. https://doi.org/10.1016/j.cub.2022.02.022
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Han, H., Wang, Y., Curto, J., Gurrapu, S., Laudato, S., Rumandla, A., Chakraborty, G., Wang, X., Chen, H., Jiang, Y., Kumar, D., Caggiano, E. G., Capogiri, M., Zhang, B., Ji, Y., Maity, S. N., Hu, M., Bai, S., Aparicio, A. M., … Giancotti, F. G. (2022). Mesenchymal and stem-like prostate cancer linked to therapy-induced lineage plasticity and metastasis. Cell Reports, 39(1), 110595. https://doi.org/10.1016/j.celrep.2022.110595
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Valet, C., Magnen, M., Qiu, L., Cleary, S. J., Wang, K. M., Ranucci, S., Grockowiak, E., Boudra, R., Conrad, C., Seo, Y., Calabrese, D. R., Greenland, J. R., Leavitt, A. D., Passegué, E., Méndez-Ferrer, S., Swirski, F. K., & Looney, M. R. (2022). Sepsis promotes splenic production of a protective platelet pool with high CD40 ligand expression. Journal of Clinical Investigation, 132(7). https://doi.org/10.1172/jci153920
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Myers, M. F., Bergner, A., Conway, L., Duquette, D., Durst, A. L., Yashar, B. M., Zhang, X., & Campion, M. (2021). A report of the AGCPD task force to evaluate associations between select admissions requirements, demographics, and performance on ABGC certification examination. Journal of Genetic Counseling, 31(2), 302–315. Portico. https://doi.org/10.1002/jgc4.1537
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Galán-Díez, M., Borot, F., Ali, A. M., Zhao, J., Gil-Iturbe, E., Shan, X., Luo, N., Liu, Y., Huang, X.-P., Bisikirska, B., Labella, R., Kurland, I., Roth, B. L., Quick, M., Mukherjee, S., Rabadán, R., Carroll, M., Raza, A., & Kousteni, S. (2022). Subversion of Serotonin Receptor Signaling in Osteoblasts by Kynurenine Drives Acute Myeloid Leukemia. Cancer Discovery, 12(4), 1106–1127. https://doi.org/10.1158/2159-8290.cd-21-0692
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Zernant, J., Lee, W., Wang, J., Goetz, K., Ullah, E., Nagasaki, T., Su, P.-Y., Fishman, G. A., Tsang, S. H., Tumminia, S. J., Brooks, B. P., Hufnagel, R. B., Chen, R., & Allikmets, R. (2022). Rare and common variants in ROM1 and PRPH2 genes trans-modify Stargardt/ABCA4 disease. PLOS Genetics, 18(3), e1010129. https://doi.org/10.1371/journal.pgen.1010129
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Zazhytska, M., Kodra, A., Hoagland, D. A., Frere, J., Fullard, J. F., Shayya, H., McArthur, N. G., Moeller, R., Uhl, S., Omer, A. D., Gottesman, M. E., Firestein, S., Gong, Q., Canoll, P. D., Goldman, J. E., Roussos, P., tenOever, B. R., Jonathan B. Overdevest, & Lomvardas, S. (2022). Non-cell-autonomous disruption of nuclear architecture as a potential cause of COVID-19-induced anosmia. Cell, 185(6), 1052-1064.e12. https://doi.org/10.1016/j.cell.2022.01.024
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Hirsch, S. M., Edwards, F., Shirasu-Hiza, M., Dumont, J., & Canman, J. C. (2022). Functional midbody assembly in the absence of a central spindle. Journal of Cell Biology, 221(3). https://doi.org/10.1083/jcb.202011085
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Iannello, G., Patel, A., Sirabella, D., Corneo, B., & Thaker, V. V. (2022). Derivation and characterization of the induced pluripotent stem cell line CUIMCi004-A from a patient with a novel frameshift variant in exon 18a of OCRL. Stem Cell Research, 59, 102635. https://doi.org/10.1016/j.scr.2021.102635
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Evrin, C., Serra‐Cardona, A., Duan, S., Mukherjee, P. P., Zhang, Z., & Labib, K. P. M. (2022). Spt5 histone binding activity preserves chromatin during transcription by RNA polymerase II. The EMBO Journal, 41(5). Portico. https://doi.org/10.15252/embj.2021109783
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Bao, K., Shan, C.-M., Chen, X., Raiymbek, G., Monroe, J. G., Fang, Y., Toda, T., Koutmou, K. S., Ragunathan, K., Lu, C., Berchowitz, L. E., & Jia, S. (2022). The cAMP signaling pathway regulates Epe1 protein levels and heterochromatin assembly. PLOS Genetics, 18(2), e1010049. https://doi.org/10.1371/journal.pgen.1010049
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Green, T. E., Motelow, J. E., Bennett, M. F., Ye, Z., Bennett, C. A., Griffin, N. G., Damiano, J. A., Leventer, R. J., Freeman, J. L., Harvey, A. S., Lockhart, P. J., Sadleir, L. G., Boys, A., Scheffer, I. E., Major, H., Darbro, B. W., Bahlo, M., Goldstein, D. B., Kerrigan, J. F., … Hildebrand, M. S. (2022). Sporadic hypothalamic hamartoma is a ciliopathy with somatic and bi-allelic contributions. Human Molecular Genetics, 31(14), 2307–2316. https://doi.org/10.1093/hmg/ddab366
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Smeeton, J., Natarajan, N., Anderson, T., Tseng, K.-C., Fabian, P., & Crump, J. G. (2022). Regeneration of Jaw Joint Cartilage in Adult Zebrafish. Frontiers in Cell and Developmental Biology, 9. https://doi.org/10.3389/fcell.2021.777787
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Lopez-Bujanda, Z. A., Haffner, M. C., Chaimowitz, M. G., Chowdhury, N., Venturini, N. J., Patel, R. A., Obradovic, A., Hansen, C. S., Jacków, J., Maynard, J. P., Sfanos, K. S., Abate-Shen, C., Bieberich, C. J., Hurley, P. J., Selby, M. J., Korman, A. J., Christiano, A. M., De Marzo, A. M., & Drake, C. G. (2021). Castration-mediated IL-8 promotes myeloid infiltration and prostate cancer progression. Nature Cancer, 2(8), 803–818. https://doi.org/10.1038/s43018-021-00227-3
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Song, L., Bekdash, R., Morikawa, K., Quejada, J. R., Klein, A. D., Aina-Badejo, D., Yoshida, K., Yamamoto, H. E., Chalan, A., Yang, R., Patel, A., Sirabella, D., Lee, T. M., Joseph, L. C., Kawano, F., Warren, J. S., Soni, R. K., Morrow, J. P., & Yazawa, M. (2022). Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome. Nature Cardiovascular Research, 1(2), 142–156. https://doi.org/10.1038/s44161-021-00016-2
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Sheidley, B. R., Malinowski, J., Bergner, A. L., Bier, L., Gloss, D. S., Mu, W., Mulhern, M. M., Partack, E. J., & Poduri, A. (2021). Genetic testing for the epilepsies: A systematic review. Epilepsia, 63(2), 375–387. Portico. https://doi.org/10.1111/epi.17141
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Meron, E., Thaysen, M., Angeli, S., Antebi, A., Barzilai, N., Baur, J. A., Bekker-Jensen, S., Birkisdottir, M., Bischof, E., Bruening, J., Brunet, A., Buchwalter, A., Cabreiro, F., Cai, S., Chen, B. H., Ermolaeva, M., Ewald, C. Y., Ferrucci, L., Florian, M. C., … Scheibye-Knudsen, M. (2022). Meeting Report: Aging Research and Drug Discovery. Aging, 14(2), 530–543. https://doi.org/10.18632/aging.203859
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Lee, W., Zernant, J., Su, P.-Y., Nagasaki, T., Tsang, S. H., & Allikmets, R. (2022). A genotype-phenotype correlation matrix for ABCA4 disease based on long-term prognostic outcomes. JCI Insight, 7(2). https://doi.org/10.1172/jci.insight.156154
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Martinez-Pastor, B., Silveira, G. G., Clarke, T. L., Chung, D., Gu, Y., Cosentino, C., Davidow, L. S., Mata, G., Hassanieh, S., Salsman, J., Ciccia, A., Bae, N., Bedford, M. T., Megias, D., Rubin, L. L., Efeyan, A., Dellaire, G., & Mostoslavsky, R. (2021). Assessing kinetics and recruitment of DNA repair factors using high content screens. Cell Reports, 37(13), 110176. https://doi.org/10.1016/j.celrep.2021.110176
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Chiu, N., Lee, W., Liu, P.-K., Levi, S. R., Wang, H.-H., Chen, N., Kang, E. Y.-C., Seo, G. H., Lee, H., Liu, L., Wu, W.-C., Tsai, S. H., & Wang, N.-K. (2021). A homozygous in-frame duplication within the LRRCT consensus sequence of CFAP410 causes cone-rod dystrophy, macular staphyloma and short stature. Ophthalmic Genetics, 43(3), 378–384. https://doi.org/10.1080/13816810.2021.2010773
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